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Leukemia, ExperimentalLeukemiaLeukemia, Myeloid, AcuteLeukemia, Lymphocytic, Chronic, B-CellLeukemia, LymphoidLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia Virus, MurinePrecursor Cell Lymphoblastic Leukemia-LymphomaLeukemia, T-CellLeukemia, Monocytic, AcuteMoloney murine leukemia virusLeukemia, Hairy CellLeukemia L1210Leukemia, B-CellLeukemia Virus, BovineLeukemia Virus, FelineGene Expression Regulation, LeukemicLeukemia, Radiation-InducedMyeloid-Lymphoid Leukemia ProteinLeukemia P388Leukemia, Biphenotypic, AcuteFriend murine leukemia virusHL-60 CellsLeukemia-Lymphoma, Adult T-CellCytarabineLeukemia, Megakaryoblastic, AcuteAKR murine leukemia virusFusion Proteins, bcr-ablLeukemia, Myeloid, Chronic-PhaseBone MarrowAcute DiseaseRemission InductionPrecursor B-Cell Lymphoblastic Leukemia-LymphomaAntineoplastic AgentsDaunorubicinTumor Cells, CulturedLeukemia, Plasma CellLeukemia, Myeloid, Accelerated PhaseKaryotypingK562 CellsLeukemia, Basophilic, AcuteGranzymesBasophilsReceptors, IgEMast CellsPerforinCytoplasmic GranulesQuercetinInflammationIrritantsSleepAlzheimer DiseaseEthnobotanyExercise
Mononuclear cell leukemiaSprague-DawleyMiceTumorsF344Sciatic nerveToxicity StudyTissueLungVitroInhalationAdultAcuteExosomesCarcinogenicityLymphoidHumansLymphomasMaleConcentrationsChronic myeloidExpressionFemaleStudyStomachCompoundsCellsCellLaboratoryAnimalsJuvenileStudiesBodyKinaseClinicalCompositionProteinModelResearchContentGroupsGroupCommonGeneHigh
Mononuclear cell leukemia1
  • According to the European Commission's summary report, 1,4-benzenediol was originally proposed as a Category 2 carcinogen based on the evidence of development of kidney adenomas and mononuclear cell leukemia in rats and liver adenomas in mice. (gc.ca)
Sprague-Dawley1
  • CFC-12 was tested by inhalation on Sprague-Dawley rats and Swiss Mice using whole body exposure. (europa.eu)
Mice11
  • TARS-1 and TART-1, but not TARL-2 were transplantable into newborn syngeneic rats and nude mice. (rupress.org)
  • the response in male rats was inconclusive and there was no such response in mice. (epa.gov)
  • However, the kinetics of nitrate secretion in rat saliva appear to have been less well studied than in humans, and even less is known concerning salivary secretion in mice. (inchem.org)
  • It can cooperate with pentobarbital sodium to extend the sleep time of experimental mice. (tcmly.com)
  • The doses selected for the 14-day studies ranged from 12.5 to 200 mg/kg THPS for rats and mice, 9.4 to 150 mg/kg THPC for rats, and 18.8 to 300 mg/kg THPC for mice. (nih.gov)
  • There was hind limb paralysis in some rats and mice dosed at the highest concentrations of THPS and THPC. (nih.gov)
  • doses of THPC ranged from 3.75 to 60 mg/kg in rats and from 1.5 to 135 mg/kg in mice. (nih.gov)
  • Hind limb paralysis was noted in rats and mice receiving the highest dose of THPC, and axonal degeneration, characterized by swollen axon sheaths, missing or fragmented axons, and some proliferation of neurolemma cells, was observed in rats. (nih.gov)
  • The increased incidences of hematopoietic system lesions observed in these studies were not considered biologically related to chemical exposure because the increases were marginal, no dose-response relationship was observed, and the incidences of these lesions are highly variable in untreated rats and mice. (nih.gov)
  • The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice. (wakeup-world.com)
  • A subsequent study proven that Pim-1 transgenic mice are predisposed to the development of experimental T cell lymphoma in assistance with c-Myc and N-Myc[10]. (biongenex.com)
Tumors3
  • Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin. (rupress.org)
  • However, the majority of European Commission's experts agreed to classify it as a Category 3 carcinogen as only benign tumors were produced following exposure to this substance in experimental animals. (gc.ca)
  • Success of conventional chemotherapeutic regiment is based on the principle that tumors with high growth fractions (such as acute myelogenous leukemia and the lymphomas, including Hodgkin's disease) are more sensitive to chemotherapy because a larger proportion of the targeted cells are undergoing cell division at any given time. (justia.com)
F3441
  • Two-year studies were conducted in F344/N rats by administering 0, 5, or 10 mg/kg THPS or 0, 3.75, or 7.5 mg/kg THPC in deionized water by gavage to groups of 49 or 50 animals of each sex, 5 days per week for 103 or 104 weeks. (nih.gov)
Sciatic nerve2
  • Citation: Ding Z, Cao J, Shen Y, Zou Y, Yang X, Zhou W, Guo Q and Huang C (2018) Resveratrol Promotes Nerve Regeneration via Activation of p300 Acetyltransferase-Mediated VEGF Signaling in a Rat Model of Sciatic Nerve Crush Injury. (vinomis.com)
  • Inactivation of p300 acetyltransferase reversed the resveratrol-induced expression of VEGFs and motor repair in rats that had undergone sciatic nerve crush injury. (vinomis.com)
Toxicity Study2
  • Inhalation Toxicity Study of Nitrous Oxide and Halothane in Rats. (cdc.gov)
  • This ADI was based on a NOEL for sodium nitrate of 500 mg/kg bw/day derived from a long-term toxicity study in rats and a short-term toxicity study in dogs together with a safety factor of 100. (inchem.org)
Tissue3
  • Tissue masses and wartlike lesions were observed in the ears, nose, axilla, back, and legs of experimental and control rats. (cdc.gov)
  • Reducing the content of total cholesterol, triacylglycerol, and low-density lipoprotein cholesterol in the serum and liver tissue of experimental hyperlipidemia rats, and increasing the content of high-density lipoprotein cholesterol. (tcmly.com)
  • The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue - Evid Based Complement Alternat Med. (qualitycounts.com)
Lung3
  • Inhibiting the proliferation of human adrenocortical carcinoma ACC SW-13 cells, melanoma B16 cells, lung cancer A549 cells, and inducing apoptosis of leukemia HL-60 cells and lung cancer H460 cells. (tcmly.com)
  • I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. (wakeup-world.com)
  • Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. (ca.gov)
Vitro1
  • These results strongly indicate that HTLV not only immortalizes, but also transforms rat T cells in vitro. (rupress.org)
Inhalation2
  • The animals were exposed by inhalation, 4 hours daily, 5 days weekly, for 104 weeks (rats: Exp. (europa.eu)
  • The purpose of this study was to assess the effect of chronic inhalation exposure to mixtures of nitrous - oxide (10024972) (NO) and halothane (151677) (HT) on the reticuloendothelial malignancies in rats. (cdc.gov)
Adult2
  • Cocultivation of spleen cells, lymph node cells, and thymocytes of female Wistar-King-Aptekman rats with short-term cultured male adult T cell leukemia (ATL) cells in the presence of 5-bromo-2'-deoxyuridine (BrdUrd) resulted in the establishment of rat lymphoid cell lines, TARS-1, TARL-2, and TART-1. (rupress.org)
  • Adult rats immunized with either TARS-1 or TARL-2 produced antibodies specific for HTLV. (rupress.org)
Acute1
  • These include, but are not limited to, (1) preventing hyperacute rejection, (2) preventing acute vascular rejection, (3) facilitating immune accommodation, (4) inducing immune tolerance, (5) preventing the transmission of viruses from xenografts into humans, and (6) addressing the ethical issues surrounding animal sources for xenografts and the appropriate selection of recipients (given that xenotransplantation remains experimental). (medscape.com)
Exosomes1
  • The aim of this work is to estimate the effect of Imatinib, exosomes, and Imatinib-exosomes mixture in chronic myeloid leukemia (CML). (bvsalud.org)
Carcinogenicity2
  • TCE is reasonably anticipated to be a human carcinogen based on limited evidence of carcinogenicity from studies in humans and sufficient evidence of carcinogenicity from studies in experimental animals. (cdc.gov)
  • Tetrachloroethylene (Perc) is probably carcinogenic to humans (Group 2A) with the working group finding limited evidence in humans for the carcinogenicity of Perc and sufficient evidence in experimental animals for the carcinogenicity of Perc. (who.int)
Lymphoid1
Humans2
  • There is now sufficient evidence from studies in humans to show that individuals with higher measures of exposure to formaldehyde are at increased risk for certain types of rare cancers, including nasopharyngeal (the nasopharnyx is the upper part of the throat behind the nose), sinonasal, as well as a specific cancer of the white blood cells known as myeloid leukemia. (sciencedaily.com)
  • The Bovine Leukemia Virus ( BLV ), for example, is lethal to cows but not humans. (beyondweird.com)
Lymphomas1
  • Pim-2 was similarly identified as a proviral integration site in Moloney murine leukemia virus-induced T cell lymphomas[11] and may synergize with c-Myc-induced Calcifediol lymphomagenesis[8]. (biongenex.com)
Male2
  • The aim of this study was to evaluate the effect of 12 weeks aerobic training and oral green tea extract on cardiac caspase-3 expression in aged male rats. (ac.ir)
  • Methodology: In this study, 32 aged male rats were randomly divided into 4 groups: control, exercise, supplement and exercise + supplement. (ac.ir)
Concentrations1
  • During the period of incubation, LSD dissolved in sterile distilled water was added to the experimental cultures in various concentrations. (druglibrary.net)
Chronic myeloid1
  • The tyrosine kinase (TK) inhibitor (TKI) imatinib provides a highly effective treatment for chronic myeloid leukemia (CML) targeting at the causative oncogenic TK BCR-ABL1. (intechopen.com)
Expression1
  • We have studied the cytotoxic activity of rat basophilic leukemia (RBL) cells transfected with cDNAs for the cytotoxic T lymphocyte (CTL) granule components, cytolysin (perforin), granzyme A, and granzyme B. With red cell targets, cytolysin expression conferred potent hemolytic activity, which was not influenced by coexpression of granzymes. (rupress.org)
Female2
  • Cytogenetic analysis of the three cell lines showed a female rat karyotype with 42 chromosomes. (rupress.org)
  • Experimental data reported in the literature were used, corresponding to four trials of a human leukemia xenograft in BALB/c female rats over a period of forty days. (bvsalud.org)
Study4
  • No adverse effects were observed in a 2-year chronic study in rats administered 15 or 150 mg/kg/day by gavage. (europa.eu)
  • 2007). Another recent case-control study found no association between Perc exposure and risk of leukemia (Costantini et al. (who.int)
  • The study aim was to evaluate the cytotoxic activity, using the MTT test [3-(4,5-Dimethilthiazol-2-yl)-2,5-diphenil tetrazolium bromide], from the crude extract of Picrasma crenata (Pau Tenente) and its isolated compounds, quassin and parain, in culture of rat liver tumor cells (HTC). (scielo.br)
  • In this study, we wanted to examine the efficacy of periocular injection of human umbilical cord-derived MSC-Exo in a rat EAU model. (nature.com)
Stomach2
  • Ingested nitrate is rapidly absorbed from the rat upper small intestine with little if any absorption from the stomach and lower intestine (terminal ileum, caecum and proximal colon). (inchem.org)
  • Effect of oxidative stress on Rho kinase II and smooth muscle contraction in rat stomach. (cusabio.com)
Compounds1
  • Treatment options are often limited to combining antimicrobials or experimental compounds that have unproven efficacy (12-14). (cdc.gov)
Cells4
  • The surface phenotypes of TARS-1 and TART-1 were those of rat T cells. (rupress.org)
  • Finally, the fifth group comprises papers focusing on the possible link between LSD and the development of malignant changes in cells, especially in the case of leukemia. (druglibrary.net)
  • We previously demonstrated that mesenchymal stem cells (MSCs) ameliorated experimental autoimmune uveoretinitis (EAU) in rats. (nature.com)
  • Pim-3 was first identified as a novel gene induced by membrane depolarization or forskolin in rat Personal computer12 pheochromocytoma cells and was designated as kinase induced by depolarization (KID-1)[12]. (biongenex.com)
Cell1
  • The cell lines continuously produced a type C retrovirus, human T cell leukemia virus (HTLV) and expressed ATL-associated antigens. (rupress.org)
Laboratory1
  • Formaldehyde was first listed in the 2nd Report on Carcinogens as a substance that was reasonably anticipated to be a human carcinogen, after laboratory studies showed it caused nasal cancer in rats. (sciencedaily.com)
Animals2
  • however, in the absence of a fully elucidated mode of action it cannot be precluded that tumours observed in experimental animals resulted from direct interaction with genetic material. (gc.ca)
  • The housing and the diet of the animals were the same highly standardized ones adopted in the BT Experimental Unit during the last 15 years before the beginning of this experiment. (europa.eu)
Juvenile2
  • Here, we describe a new juvenile rat model to face this challenge. (intechopen.com)
  • Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. (ca.gov)
Studies3
  • Studies have found that its saponins can improve the deficits of spatial memory and habit learning in rats. (tcmly.com)
  • Some are independent experimental studies which have yielded negative results, others criticize the original papers for serious conceptual and methodological inadequacies. (druglibrary.net)
  • there were at that time no experimental or clinical observations that would suggest the need for such studies. (druglibrary.net)
Body1
  • Mean body weights of rats dosed with THPS or THPC were comparable to those of the vehicle controls. (nih.gov)
Kinase2
  • Pim-3 is a member of the provirus integration site for Moloney murine leukemia computer virus (Pim) family proteins that show serine/threonine kinase activity. (biongenex.com)
  • Olsson PO, Gustafsson R, In 't Zandt R, Friman T, Maccarana M, Tykesson E, Oldberg Å, Rubin K, Kalamajski S. The Tyrosine Kinase Inhibitor Imatinib Augments Extracellular Fluid Exchange and Reduces Average Collagen Fibril Diameter in Experimental Carcinoma. (lu.se)
Clinical1
  • Aging Clinical and Experimental Research. (edu.au)
Composition1
  • physical activity [Term] id: XCO:0000009 name: controlled atmosphere composition def: "An experimental condition in which the amount of one or more of the gases which make up the air surrounding an organism are controlled, or in which additional components are added to the air surrounding an organism, as part of the experiment on that organism. (mcw.edu)
Protein1
  • Rats with EAU induced by immunization with interphotoreceptor retinol-binding protein 1177-1191 peptide were treated by periocular injections of increasing doses of MSC-Exo starting at the disease onset for 7 consecutive days. (nature.com)
Model1
  • The anti-obesity effects of lemon fermented products in 3T3-L1 preadipocytes and in a rat model with high-calorie diet-induced obesity. (nutr-metab-pu.org)
Research1
  • Leukemia Research (2014) 38 (4): 447. (karger.com)
Content2
  • experimental condition [Term] id: XCO:0000010 name: air oxygen content def: "A condition in which the oxygen level of the air surrounding an organism or breathed by the organism is controlled as part of the experiment. (mcw.edu)
  • experimental condition [Term] id: XCO:0000014 name: controlled content diet def: "A regimen of solid food in which the amount of one or more elements of the diet are controlled. (mcw.edu)
Groups1
  • Monocytic leukemia was the most common neoplasm in all three groups, occurring in 13.8 percent of the males and 9.7 percent of the females. (cdc.gov)
Group2
  • Fischer-344-rats were exposed to 50 parts per million (ppm) NO and 1ppm HT (Group 2), or 500ppm NO and 10ppm HT (Group 3), for 7 hours per day, 5 days per week, for 104 weeks. (cdc.gov)
  • Each group contained 100 rats. (cdc.gov)
Common1
  • TARL-2 was only positive for rat Ia and leukocyte common antigens. (rupress.org)
Gene1
  • gene Calcifediol was first discovered like a proviral insertion site in Moloney murine leukemia computer virus[9]. (biongenex.com)
High1
  • Lemon fermented products prevent obesity in high-fat diet-fed rats by modulating lipid metabolism and gut microbiota. (nutr-metab-pu.org)