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  • liver
  • We evaluated the role of sildenafil in a rat liver ischemia-reperfusion model. (hindawi.com)
  • Use of sildenafil as a preconditioning agent in a rat model of liver I/R exerted a protective effect. (hindawi.com)
  • Liver resections under some type of vascular control are currently favored by many surgeons since they can ensure a less hemorrhagic surgical field by taking advantage of liver tolerance to normothermic warm ischemia [ 1 , 2 ]. (hindawi.com)
  • Adult male SD rats ( n = 8/each group) were randomized: group 1 (sham-operated control), group 2 (IR, 30-min ischemia/72 h reperfusion), group 3 (IR-SS31 (2 mg intra-peritoneal injection at 30 min/24 h/48 h after IR)), group 4 (IR-mitochondria (2 mg/derived from donor liver/intra-venous administration/30 min after IR procedure)), and group 5 (IR-SS31-mitochondria). (mdpi.com)
  • group
  • 3 rats from I/R group and 1 from PCr group were excluded within 24 h while the remaining ones were regarded as successful models. (hindawi.com)
  • Rat hearts were randomly divided into 5 groups: control (0 min ischemia), I-10 (10 min ischemia), I-20 (20 min ischemia), I-30 (30 min ischemia), and I-40 (40 min ischemia) groups ( n = 3 per group, respectively). (rsc.org)
  • In the ischemia-reperfusion group, testicular detorsion was performed after 2 hours of left testicular torsion. (hindawi.com)
  • E-selectin protein expression, myeloperoxidase activity, and malondialdehyde level were significantly increased, and testicular spermatogenesis was significantly decreased in the ipsilateral testes in the ischemia-reperfusion group, compared with the control group. (hindawi.com)
  • The probucol-treated group showed significant decreases in E-selectin protein expression, myeloperoxidase activity, and malondialdehyde level and significant increase in testicular spermatogenesis in the ipsilateral testes, compared with the ischemia-reperfusion group. (hindawi.com)
  • Methods Fifty-six male SD rats were randomly assigned to four groups: shame group, ischaemia and reperfusion group, valsartan group (valsartan 10mg/kg) and valsartan + LY294002 group (valsartan 10mg/kg, LY294002 0.3mg/kg). (bmj.com)
  • The rats were randomly allotted to control group, I/R group, or I/R + valproic acid (VPA) group with or without an HO-1 activity inhibitor (zinc protoporphyrin IX) (n = 6 per group). (asahq.org)
  • A group received 17β-estradiol (280 μg/kg, i.v., single dose) at 30 min of ischemia. (ovid.com)
  • A total of 60 rats were randomly divided into the normal group (N), the sham operation group (S), the dimethyl sulfoxide control group (D) and the curcumin treatment group (C). For group D and C, 12 (T1), 24 (T2) and 72 h (T3) of reperfusion were performed after 2 h ischemia. (spandidos-publications.com)
  • apoptotic
  • Two hours after reperfusion, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured and histopathological examination of the lobes subjected to ischemia as well as TUNEL staining for apoptotic bodies was performed. (hindawi.com)
  • lower limb
  • It is concluded that saffron extract and its constituents show a protective effect against lower limb I/R in rat. (hindawi.com)
  • A. Hossny, "Blunt popliteal artery injury with complete lower limb ischemia: is routine use of temporary intraluminal arterial shunt justified? (hindawi.com)
  • coronary
  • The proximal portion of the left coronary artery was surgically occluded for 30 minutes through ligation with a suture (size 6.0) followed by coronary reperfusion through release of the tie. (ahajournals.org)
  • Transient ventricular arrhythmias were evoked in all rats ≈5 minutes after coronary occlusion, but these usually disappeared after 10 minutes of occlusion. (ahajournals.org)
  • After coronary reperfusion, the tie was left loose on the surface of the heart, the chest was closed, and the intratracheal tube and ECG electrodes were removed. (ahajournals.org)
  • sham operation
  • Rats were implanted with subcutaneous miniosmotic pumps that continuously delivered lidocaine (2 mg·kg -1 ·h -1 ), bupivacaine (0.4 mg·kg -1 ·h -1 ), tetracaine (1 mg·kg -1 ·h -1 ), or saline vehicle, and 6 h later the rats were subjected to 30 min of renal ischemia or to sham operation. (physiology.org)
  • artery
  • I/R was induced by the clamping of the superior mesenteric artery for 45 min, followed by 2 h of reperfusion. (ovid.com)
  • triggers
  • There is mounting evidence that reperfusion triggers 'early' components such as release of stored factors (like P-selectin and cytokines), and subsequent 'late' components are more likely to be mediated by changes in de novo protein synthesis and expression. (ahajournals.org)