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  • strains
  • Similar to its reported effect in other rat strains, maternal separation increased the anxiety-like behaviour of WKY (decreased open arm entries) but not SHR. (nih.gov)
  • Broadhurst PL (1975) The Maudsley reactive and nonreactive strains of rats: a survey. (springer.com)
  • Courvoisier H, Moisan M-P, Sarrieau A, Hendley ED, Mormède P (1996) Behavioral and neuroendocrine reactivity to stress in the WKHA/WKY inbred rat strains: a multifactorial and genetic analysis. (springer.com)
  • Heart weight relative to body weight remained greater in SHR when compared to WKY throughout the 28-day study period, but cell numbers became equal in the two strains by the 2nd week. (uab.edu)
  • Hypertension
  • We assess dynamics of junctional adhesion molecule-A (JAM-A) expression in rat models of hypertension and test whether JAM-A expression could be driven by angiotensin (ANG) II and whether JAM-A contributes to the progression of hypertension. (biomedsearch.com)
  • In Goldblatt 2K-1C hypertensive rats, JAM-A expression was augmented before any increase in blood pressure, and similarly JAM-A upregulation preceded hypertension caused by peripheral and central ANG II infusions. (biomedsearch.com)
  • CONCLUSION: Body-wide upregulation of JAM-A in genetic and induced models of hypertension in the rat precedes the stable elevation of arterial pressure. (biomedsearch.com)
  • Stress
  • Basal plasma corticosterone was found to correlate positively with an active response to a novel environment and inescapable stress across all rats. (nih.gov)
  • Cullinan WE, Herman JP, Battaglia DF, Akil H, Watson SJ (1995) Pattern and time course of immediate early gene expression in rat brain following acute stress. (springer.com)
  • Chronic psychosocial stress induces reversible mitochondrial damage and corticotropin-releasing factor receptor type-1 upregulation in the rat inte. (nih.gov)
  • Epithelial permeability and conductance were increased in CS rats, effect that lasted for up to 7 days after stress cessation. (nih.gov)
  • behavior
  • This effect seems to reflect different motivational factors driving the rat behavior, which clearly suggests that the diverse emotional reactivity of RHA/Verh and RLA/Verh rats is a result of different activation of the fear/anxiety circuit. (springer.com)
  • Boguszewski P, Meyza K, Zagrodzka J (2005) The effect of socialization on intermale behavior in old rats. (springer.com)
  • Individual phenotypic dispersion (PDi) was calculated as the average of absolute differences between behavior in each segment within session and the average behavior for the entire session as , where is the operant behavior for rat i within segment j (from 1-5) and is the average behavior for the rat within the complete session. (nih.gov)
  • A selective-satiety outcome devaluation procedure followed by a choice test in extinction revealed outcome-insensitive habitual behavior in SHR rats. (frontiersin.org)
  • Outcome-sensitive goal-directed behavior was restored in SHR rats following injection prior to the choice test of the dopamine D2 receptor agonist Quinpirole or dopamine D1 receptor antagonist SCH23390, whereas WKY rats showed habitual responding following exposure to these drugs. (frontiersin.org)
  • responses
  • We have defined the specificity of the proliferative T cell responses to Bhsp65 during the course of AA in the Lewis rat. (nih.gov)
  • During the early phase of the disease (6-9 d after onset of AA), Lewis rats raised T cell responses to many determinants within Bhsp65, spread throughout the molecule. (nih.gov)
  • Moreover, arthritic rats in the late phase of AA also raised vigorous T cell responses to those carboxy-terminal determinants within self(rat) hsp65 (Rhsp65) that correspond in position to the above BCTD. (nih.gov)
  • In WKY rats, vigorous responses to the BCTD, to which the Lewis rat responded only in the late phase of AA, were observed very early, 10 d after injection of M. tuberculosis, Strikingly, pretreatment with the peptides comprising the set of BCTD, but not its amino-terminal determinants, provided significant protection to naive Lewis rats from subsequent induction of AA. (nih.gov)
  • Thus, T cell responses to the BCTD are involved in regulating inflammatory arthritis in the Lewis rat and in conferring resistance to AA in the WKY rat. (nih.gov)
  • Responses to the BCTD were observed in repeat experiments in WKY rats tested 10-13 d after M. tuberculosis injection (data not shown). (nih.gov)
  • The results given in Fig. 3 clearly demonstrate that 10 d after immunization with M. tuberculosis, WKY rats raised T cell responses to several determinants within Bhsp65. (nih.gov)
  • Phenyldiguanide elicited dose-dependent bradycardic and hypotensive responses in WKY rats, but these were significantly attenuated in SHR. (austin.org.au)
  • awake
  • To investigate what benefits sleep may bring at the cellular level, we profiled gene expression in awake and sleeping rats by using high-density microarrays. (nih.gov)
  • renal
  • Transdifferentiation was also apparent in the proximal tubules of diabetic rats and in a renal biopsy from a patient with type 1 diabetes. (austin.org.au)
  • Effects of extract from Clerodendron trichotomum on blood pressure and renal function in rats and dogs. (biomedsearch.com)
  • To assess the action of the herb on blood pressure and renal function, the extract was administered to rats and dogs. (biomedsearch.com)
  • Intravenous
  • Intravenous administration of anti-alpha-rANP antiserum caused an obvious rise of mean blood pressure and cardiac output in both SHR and WKY compared with rats administered with normal rabbit serum. (biomedsearch.com)
  • Blood Pressure
  • Effects of hyperbaric oxygenation on blood pressure levels of spontaneously hypertensive rats. (biomedsearch.com)
  • The baroreceptor heart rate reflex, elicited by phenylephrine- and nitroprusside-induced changes in blood pressure, had a reduced range and lower heart rate plateau in SHR than in WKY rats, which suggests impaired vagal control of the heart rate in SHR. (austin.org.au)
  • The effect of ET-3 on blood pressure and heart rats was investigated for four doses equal to 250 ng, 500 ng, 1000 ng and 2000 ng of ET-3. (biomedsearch.com)
  • Chronic daily administration for 6 weeks prevented the increase in blood pressure of spontaneously hypertensive rats. (biomedsearch.com)
  • Rats receiving the wild-type AT 1A receptor showed no change in blood pressure, whereas animals receiving the [N111G]AT 1A receptor displayed an increase in blood pressure that persisted for 3 to 4 days before returning to basal levels. (ahajournals.org)
  • Heart weight and blood pressure were elevated in SHR when compared to WKY at birth. (uab.edu)
  • Increase in SHR cell size occurred at a time when blood pressures were not different, suggesting that greater cell size in SHR than in WKY was not due to differences in blood pressure. (uab.edu)
  • genetic
  • Effects of early life trauma are dependent on genetic predisposition: a rat study. (nih.gov)
  • Roman
  • Psychogenetically selected Roman high (RHA/Verh) and Roman low (RLA/Verh) avoidance rats constitute a well-recognized model of diverse emotional reactivity. (springer.com)
  • Corda MG, Lecca D, Piras G, Di Chiara G, Giorgi O (1997) Biochemical parameters of dopaminergic and GABAergic neurotransmission in the CNS of Roman high-avoidance and Roman low-avoidance rats. (springer.com)
  • autoimmune
  • Peripheral blood CD8αα+CD11c+MHC-II+CD3- cells attenuate autoimmune glomerulonephritis in rats. (nih.gov)
  • Thus, PBMC CD8αα+CD3- cells of Lewis rats were able to terminate ongoing autoimmune inflammation in the glomeruli. (nih.gov)
  • diabetic
  • The AGE cross-link breaker, phenyl-4,5-dimethylthiazolium bromide (ALT 711) reduced transdifferentiation in diabetic rats in association with reduced tubular AGE and TGF-beta expression. (austin.org.au)
  • Lewis
  • Adjuvant arthritis (AA) induced in the Lewis rat (RT-1(l)) by injection of Mycobacterium tuberculosis serves as an experimental model for human rheumatoid arthritis (RA). (nih.gov)
  • In an anti-glomerular basement membrane (GBM) glomerulonephritis (GN) model, GN-resistant Lewis rats naturally recover from early glomerular inflammation. (nih.gov)
  • behaviour
  • The effects of maternal separation (removal of pups from dam for 3 h/day during the first 2 weeks of life) on anxiety-like behaviour (elevated-plus maze) and depressive-like behaviour (forced swim test) were assessed in prepubescent rats (postnatal day 28 and 31). (nih.gov)
  • effects
  • Indeed, AT 1 R are expressed in cultured, purified rat brain astrocytes, 10 and the effects of Ang II on neuronal function may involve the activation of non-neuronal AT 1 R. 11 Thus, the cellular context in which Ang II modulates activity in the RVLM is unclear. (ahajournals.org)
  • injection
  • Weekly, 5 rats per group were sacrificed with a lethal injection of pentobarbital, and their kidneys were removed, decapsulated and weighed. (biomedcentral.com)
  • basal
  • Overall, SHR showed a more active response in the elevated plus-maze and forced swim test than WKY, regardless of treatment, and were also found to have higher basal plasma corticosterone compared to WKY. (nih.gov)
  • Basal plasma corticosterone levels of SHR and WKY males (M) and females (F), maternally separated (MS) or non-maternally separated (nMS). (nih.gov)
  • Basal levels of cGMP were lower in hypertensive rat atria. (ox.ac.uk)
  • higher
  • SHR/NCrl rats had higher PDi than WKY/Nico controls for impulsiveness and inattention. (nih.gov)
  • heart
  • The beating rabbit heart exhibited cyclic changes in [NO], peaking at 2.7+/-0.1 micromol/L near the endocardium and 0.93+/-0.20 micromol/L in the midventricular myocardium (concentrations were 15+/-4% lower in the rat heart). (biomedsearch.com)
  • novel environment
  • Maternal separation increased the activity of SHR in the novel environment of the elevated plus-maze, while it decreased that of WKY. (nih.gov)
  • study
  • Boguszewski P, Zagrodzka J (2005) Expression of c-Fos in response to stressogenic stimuli in the amygdala of old vs. young rats: a preliminary study. (springer.com)
  • The treated rats remained healthy with normal weight gain during the study. (ox.ac.uk)
  • RESULTS
  • These results indicate that endogenous ANP has an important physiological role in the regulation of hemodynamics and water-electrolyte balance in both SHR and WKY. (biomedsearch.com)
  • models
  • The proteasome inhibitor VELCADE reduces infarction in rat models of f" by Nils Henninger, Kenneth M. Sicard et al. (umassmed.edu)
  • effect
  • The effect of maternal separation on SHR and WKY differed in a number of behavioural measures. (nih.gov)
  • cell
  • Here we report specific binding of (125)I-AGE-BSA to cell membranes prepared from a rat proximal tubule cell line and show that the binding site was RAGE. (austin.org.au)
  • Cell maturation occurred earlier in SHR than in WKY as indicated by an earlier development of binucleate myocytes and there was an earlier initiation of hypertrophic myocyte growth in SHR. (uab.edu)
  • Therefore, when compared to the WKY, the SHR had three phases of altered cell growth: a first phase of accelerated hyperplastic growth during the fetal period, and a second phase (6 to 12 days of age) of earlier initiation of hypertrophic cell growth and increased myocyte size. (uab.edu)