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  • Mice
  • Mice and rats used in the laboratory derive from a variety of sources. (jax.org)
  • Therefore, they should not be referred to by species name, but rather as laboratory mice or by use of a specific strain or stock name. (jax.org)
  • In other studies, however, benzodiazepines did not change the defensive behavior of rats [ 6 , 10 ] or mice [ 1 , 10 ] exposed to cat odor. (biomedcentral.com)
  • Inductions of FABP in hepatic cytosol by administration of tiadenol and clofibric acid were studied in rats, mice and guinea-pigs. (biomedsearch.com)
  • In rats and mice, [1-14C]oleic acid-binding capacity of hepatic cytosol was increased, in association with induction of peroxisomal beta-oxidation, by the administration of either the two peroxisome proliferators. (biomedsearch.com)
  • The peroxisome proliferators caused an induction of acyl-CoA hydrolase of lower-molecular-weight form alone in hepatic cytosol of mice, although inductions of two long-chain acyl-CoA hydrolases (higher- and lower-molecular-weight form) were brought about in hepatic cytosol of rats. (biomedsearch.com)
  • normotensive
  • The purported DRY were never intended torepresent genetically appropriate controls for any strain, in particular SHR.Instead, they were intended simply as inbred normotensive controls, unrelatedto SHR and used to maximize the informativeness of the linkage analyses. (ahajournals.org)
  • To investigate this possibility, we replaced a region of chromosome 1 in the SHR (defined by the markers D1Mit3 and Igf2 ) with the corresponding chromosome segment from the normotensive Brown-Norway (BN) strain. (ahajournals.org)
  • 9 To confirm the presence of a putative BP QTL on chromosome 1 and to begin fine genetic mapping of specific variants responsible for increased blood pressure, we replaced an SHR chromosome 1 segment defined by the markers D1Mit3 and Igf2 with the corresponding chromosome region from the normotensive BN strain. (ahajournals.org)
  • 1995
  • The diets have been supplemented with minerals and vitamins according to the recommendations of the National Research Council for rats (1995), in order to avoid deficiencies. (orgprints.org)
  • Lewis
  • Accompanying documentation attributed specific geneticbiochemical profiles of the DRY strain to these animals and differentiatedthem from the F344, BUF (Buffalo), and LEW (Lewis) strains. (ahajournals.org)
  • generations
  • Strains can be termed inbred if they have been mated brother x sister for 20 or more consecutive generations, and individuals of the strain can be traced to a single ancestral pair at the 20th or subsequent generation. (jax.org)
  • Other breeding schemes are acceptable provided that the inbreeding is equivalent to 20 successive generations of sib mating ( Green 1981 ). (jax.org)
  • After 10 generations of selective back-crossing to the SHR progenitor strain, the differential chromosome segment was fixed using the markers D1Mit3 (a microsatellite marker that maps close to C ) and Igf2 and maintained in the homozygous state by brother×sister mating and selective inbreeding of the offspring. (ahajournals.org)
  • findings
  • These findings suggest that the beneficial effect of FCE 22178 on the dyslipoproteinemia of nephrotic MNS rats is secondary to the amelioration in kidney function and to the reduction of proteinuria produced by this drug. (unimore.it)
  • secretion
  • Intraduodenal instillation of acid and hyperosmolal solution suppresses pentagastrin-stimulated acid secretion but not histamine mobilization in the rat stomach. (curehunter.com)
  • In chronic gastric fistula rats provided with a duodenal loop anastomosed to the jejunum (Roux-en-Y), maximal stimulation of acid secretion by continuous intravenous infusion of pentagastrin produced a 15-fold increase of gastric histidine decarboxylase activity. (curehunter.com)
  • effects
  • Brandt, Kirsten and Ritskes-Hoitinga, Merel (2003) The effects of organically and conventionally cultivated plant feed on fertility and health in two inbred rat strains. (orgprints.org)
  • In this experiment we study the effects of various culturing methods of plant based foods on health and fertility parameters in a two-generation study in rats. (orgprints.org)
  • genes
  • Therefore, despite linkage studies showing a BP QTL in the region of the Sa and Scnn1b genes, the identification and physical location of a BP QTL on rat chromosome 1 is far from certain. (ahajournals.org)
  • administration
  • We have previously shown that the administration of a thromboxane A(2) (TXA(2)) synthase inhibitor (FCE 22178) reduced the progression of glomerular lesions and proteinuria in MNS rats, an inbred strain which develops an age-related nephrotic syndrome. (unimore.it)
  • found
  • A significant increase of apo A-I/apo E ratio was found in C-MNS rats from 28 (2.28+/-0.36) to 48 weeks of age (3.84+/-0.9) but not in T-MNS rats. (unimore.it)
  • highly
  • Origin: Developed in 1972 at the Institute of Cytology and Genetics, Russian Academy of Sciences (Novosibirsk) by Salganik and Solovyova from Wistar stock by selection for susceptibility to cataractogenic effect of galactose-rich diet and brother-sister mating of highly susceptible rats ( Solovyova et al 1975 ). (jax.org)
  • The results of DNA fingerprint and PCR microsatellite tests have confirmed that the SHR progenitor strain is highly inbred. (ahajournals.org)
  • addition
  • In addition, a macroscopical pathological evaluation of all rats at autopsy will be performed, after the reproductional phase of the first litter has been finished. (orgprints.org)
  • different
  • These results suggest that the type of stress experienced by LEW and SHR strains exposed to cat odor is different from that elicited by exposure to classical models of anxiety such as the elevated plus-maze, black/white box and open-field tests. (biomedcentral.com)
  • However
  • However, since this S symbol has previously been used to designate the Dahl Salt Sensitive strain the symbol assigned to the strain is now: OXYS. (jax.org)
  • study
  • In the present study we investigated the effect of FCE 22178 on the plasma lipoproteins of MNS rats at 28 weeks of age (with mild proteinuria and moderate dyslipoproteinemia) and at 48 weeks of age (with heavy proteinuria and severe dyslipoproteinemia). (unimore.it)
  • The objective of the present study was to compare the LEW and SHR strains in the COT, with or without the presence of the predator's odor. (biomedcentral.com)
  • It was the aim of the present study to find out if a common mechanism exists by which the vasoconstrictive hormones angiotension II, noradrenaline and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC) increase prostaglandin E2 (PGE2) synthesis in cultures of rat renal mesangial cells. (uni-regensburg.de)
  • brother
  • Inbred strains must be continuously mated brother x sister (or equivalent) thereafter. (jax.org)
  • This progenitor strain of SHR is commercially available in Europe and has been maintained by brother×sister mating at the Czech Academy of Sciences in Prague for more than 15 years. (ahajournals.org)
  • available
  • All animals were kept in collective plastic cages (5 rats/cage) with food and water available ad libitum under a 12-h light/dark cycle (lights on at 07:00 h) at 21 ± 2°C. (biomedcentral.com)
  • animals
  • Recently, Dr Tanaseindicated that the animals supplied to Melbourne and Tokyo that had beenlabeled as DRY were instead likely to be F344 rats. (ahajournals.org)
  • suggest
  • The entirety of these data leads us to suggest that vasoconstrictor-evoked synthesis of PGE2 in rat mesangial cells is mediated by the subsequent activation of phospholipase C and protein kinase C. The activation of protein kinase C by diacylglycerol is likely to be involved in the increase of the calcium permeability of the plasma membrane which is a prerequisite for PGE2 synthesis induced by vasoconstrictive hormones. (uni-regensburg.de)
  • direct
  • Zangrossi and File [ 11 ] reported that chlordiazepoxide reduced anxiety evaluated in the social interaction and elevated plus-maze tests after exposure to cat odor, but it had only a limited effect on the direct responses of rats exposed to cat odor. (biomedcentral.com)
  • To our knowledge, no direct comparisons of rat strains contrasting for their emotionality levels have been carried out in the COT, which would shed some light on the psychological significance of this test. (biomedcentral.com)
  • symbol
  • An inbred strain should be designated by a unique brief symbol made up of uppercase, Roman, letters, or a combination of letters and numbers beginning with a letter. (jax.org)
  • otherwise
  • In this manner either an interesting phenotype, or a defined chromosomal region assayed by genotype, is passed from the donor strain onto an otherwise uniform recipient background. (wikipedia.org)
  • feature
  • FCE 22178 reduced the elevation in plasma HDL(1) (by 17.4%) and HDL(2) levels (by 30%), a key feature of nephrotic dyslipoproteinemia in the rat. (unimore.it)