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  • liver
  • Orotic acid, nucleotide-pool imbalance, and liver-tumor promotion: a possible mechanism for the mitoinhibitory effects of orotic acid in isolated rat hepatocytes. (biomedsearch.com)
  • 5-Aminolaevulinic acid was intravenously injected to male Fisher rats with HCC at a dose of 500 mg x kg(-1), and the fluorescence intensity in each tissue sample excised from liver was measured with a spectrofluorometer at 1, 3 and 6 h after administration. (nih.gov)
  • As already mentioned, naturally occurring pyrrolizidine alkaloids, including RS, are known for their ability to promote the growth of early hepatic nodules in initiated rat liver . (nih.gov)
  • As predicted, multiple pre-neoplastic and neoplastic hepatocellular lesions, ranging in size from a few mm to 2.5 cm in diameter, were observed in all animals exposed to this protocol (figure 1, panel A). Furthermore, histological analysis confirmed the pre-sence of large, advanced hepatocyte nodules in all liver samples in this group, while trabecular HCC was diagnosed in 4 out of 8 rats (figure 1, panel B). (nih.gov)
  • Fischer
  • In the present study, one bout of in vivo heat treatment applied to 24-mo-old Fischer 344 rats improved insulin-stimulated glucose uptake after 24 h in slow-twitch soleus muscles. (biomedsearch.com)
  • Fischer rat thyroid (FRT) cells constitute an ideal model to test this hypothesis, since they missort both endogenous and transfected GPI-anchored proteins to the basolateral plasma membrane and fail to incorporate them into cholesterol/glycosphingolipid clusters. (nih.gov)
  • toxicity
  • A rat model with dose-limiting toxicity profiles that are similar to those observed in patients treated with CPT-11 was developed and used to evaluate the role of interleukin 15 (IL-15) in the modulation of the therapeutic selectivity of CPT-11 in normal rats and rats bearing advanced colorectal cancer. (biomedsearch.com)
  • adult rat
  • Transplantation of astrocytes derived from embryonic glial-restricted precursors (GRPs) promoted robust axon growth and restoration of locomotor function after acute transection injuries of the adult rat spinal cord. (nih.gov)
  • Transplantation of GDAs into stab-wound lesions of the dorsal column white matter pathways of adult rat spinal cord (Figure 1a-c) resulted in the growth of the majority of the cut ascending dorsal column axons into the lesion center (Figures 2 and 3a), with 66% of these axons extending further beyond the lesion site into adjacent white matter (Figures 2 and 3a,b,e,f). (nih.gov)
  • effects
  • Analysis of endocrine effects in rats after 15 days of treatment revealed a strong reduction of the weights of prostates and seminal vesicles and a significant rise of testosterone serum levels as a result of the interference with central feedback mechanisms. (uni-regensburg.de)
  • effectively
  • 0.05).The tissue engineering nerve composed of acellular allogenic nerve scaffold and Schwann cells-like cells can effectively repair the nerve defect in rats and its effect was similar to that of the autogenous nerve grafts. (nih.gov)
  • A strain is inbred when it has undergone at least 20 generations of brother x sister or offspring x parent mating, at which point at least 98.6% of the loci in an individual of the strain will be homozygous, and each individual can be treated effectively as clones. (wikipedia.org)
  • analysis
  • Regional analysis of brain neurotransmitter, neurotransmitter precursor and metabolite concentrations revealed significantly elevated levels of dopamine metabolites in the corpus striatum and nucleus accumbens of the satiated rats. (biomedsearch.com)
  • A) Western blot analysis showing expression levels in the gut epithelium of SIRT1 in ad libitum-fed (AL) or calorie restricted (CR) rats. (nih.gov)
  • cells
  • As cultured rat preadipocytes became differentiated, FFA transfer into preadipocytes increased and was more rapid in single perirenal than in epididymal cells matched for lipid content. (biomedsearch.com)
  • Intravenous Infusion of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Erectile Dysfunction Following Cavernous Nerve Injury in Rats. (kyoto-u.ac.jp)
  • Intravenous infusion of mesenchymal stem cells inhibits intracranial hemorrhage after recombinant tissue plasminogen activator therapy for transient middle cerebral artery occlusion in rats. (kyoto-u.ac.jp)
  • Fibromodulin Expression in Folliculostellate Cells and Pericytes Is Promoted by TGFβ Signaling in Rat Anterior Pituitary Gland. (kyoto-u.ac.jp)
  • Combination of acellular nerve graft and schwann cells-like cells for rat sciatic nerve regeneration. (nih.gov)
  • specific
  • Adipose-specific fatty acid binding protein (aP2) and keratinocyte lipid binding protein abundance was higher in differentiated rat perirenal than in epididymal preadipocytes. (biomedsearch.com)
  • levels
  • Furthermore, levels of Il-6 increased in rats exposed to the carcinogenic protocol, while they returned to near control values in the group receiving hepatocyte transplantation. (nih.gov)
  • We observed that rats on a CR diet have ∼2-fold higher levels of SIRT1 in the gut epithelium relative to ad lib-fed controls (Fig. 1A). (nih.gov)
  • development
  • The development of HCC in rats exposed to DENA+RS and killed after one year. (nih.gov)
  • Enhanced Expression of Trib3 during the Development of Myelin Breakdown in dmy Myelin Mutant Rats. (kyoto-u.ac.jp)
  • line
  • To define Ly-49D-ligand interactions, we transfected the mouse Ly-49D receptor into the rat NK line, RNK-16 (RNK.mLy-49D). (nih.gov)
  • strain
  • The mutation was propagated in the C57BL/6J inbred strain by backcrossing for more than 45 generations. (janvier-labs.com)
  • It is an albino strain, easy-to-handle, it is however slower learner than Long Evans rat. (janvier-labs.com)
  • A strain is inbred when it has undergone at least 20 generations of brother x sister or offspring x parent mating, at which point at least 98.6% of the loci in an individual of the strain will be homozygous, and each individual can be treated effectively as clones. (wikipedia.org)
  • Thus outbred strains of most laboratory animals are also available, where an outbred strain is a strain of an organism that is effectively wildtype in nature, where there is as little inbreeding as possible. (wikipedia.org)
  • One type of inbred strain that either has been altered, or naturally mutated so that it is different at a single locus. (wikipedia.org)
  • Such strains are useful in the analysis of variance within an inbred strain or between inbred strains because any differences would be due to the single genetic change, or to a difference in environmental conditions between two individuals of the same strain, one of the more specific uses of Drosophila inbred strains are the use of Gal4/UAS lines in research. (wikipedia.org)
  • model
  • Certain plants including the genetic model organism Arabidopsis thaliana naturally self pollinate, which makes it quite easy to create inbred strains in the laboratory (other plants, including important genetic models such as Maize require transfer of pollen from one flower to another). (wikipedia.org)
  • One of the key strengths of using inbred strains as a model is that strains are readily available for whatever study one is performing and that there are resources such as the Jackson Laboratory, and Flybase, where one can look up strains with specific phenotypes or genotypes, from among inbred lines, recombinant lines, and Coisogenic strains. (wikipedia.org)
  • function
  • Transplantation of astrocytes derived from embryonic glial-restricted precursors (GRPs) promoted robust axon growth and restoration of locomotor function after acute transection injuries of the adult rat spinal cord. (nih.gov)
  • growth
  • Transplantation of GDAs into stab-wound lesions of the dorsal column white matter pathways of adult rat spinal cord (Figure 1a-c) resulted in the growth of the majority of the cut ascending dorsal column axons into the lesion center (Figures 2 and 3a), with 66% of these axons extending further beyond the lesion site into adjacent white matter (Figures 2 and 3a,b,e,f). (nih.gov)