• Uncovering the mechanisms regulating hematopoietic specification not only would overcome current limitations related to hematopoietic stem and progenitor cell (HSPC) transplantation, but also advance cellular immunotherapies. (bvsalud.org)
  • The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
  • Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)
  • The latter represents a conformationally modified form of a normal cellular PrP C , which is a normal host protein found on the surface of many cells, in particular neurons. (medscape.com)
  • Preferential activation of microsomal diacylglycerol/protein kinase C signaling during glucose treatment (De Novo phospholipid synthesis) of rat adipocytes. (jci.org)
  • Glucose has been reported to increase the de novo synthesis of diacylglycerol (DAG) and translocate and activate protein kinase C (PKC) in rat adipocytes. (jci.org)
  • In the pancreatic acinar cell CN plays a role in mediating the action of elevated Ca 2+ to stimulate cell division, pancreatic growth and protein synthesis. (pancreapedia.org)
  • CnA ( Figure 1 ) contains the catalytic domain, which is homologous to other serine/threonine protein phosphatases (4). (pancreapedia.org)
  • Introduction of the identified PMPCB variants into the homologous S. cerevisiae Mas1 protein resulted in a severe growth and MPP processing defect leading to the accumulation of mitochondrial precursor proteins and early impairment of the biogenesis of iron-sulfur clusters, which are indispensable for a broad range of crucial cellular functions. (regenerativemedicine.net)
  • Methods Seventeen Wistar rats were divided randomly into three groups. (alljournal.net.cn)
  • A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. (lookformedical.com)
  • When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (lookformedical.com)
  • In preclinical studies, tamoxifen restored normal apoptosis in mutated hematopoietic stem/progenitor cells (HSPCs). (bvsalud.org)
  • The power of the thiol proteinases to cleave a multitude of substrates in response to calcium mineral activation allows their involvement in a variety of cell processes offering cell motility, sign transduction, apoptosis, cell differentiation and legislation of the cytoskeleton (3). (exposed-skin-care.net)
  • Mechanistically, over-expression of PTTG3P up-regulated PTTG1, activated PI3K/AKT signaling and its downstream signals including cell cycle progression, cell apoptosis and epithelial-mesenchymal transition (EMT)-associated genes. (biomedcentral.com)
  • Natural product anticancer agents enhance intracellular levels of ceramide, a sphingolipid that promotes cell apoptosis. (sphingolipidclub.com)
  • T regulatory (Treg) cells, T helper cell balances, dendritic cells, macrophages, B cells, and natural killer (NK) cells can be considered as the most determinant dysregulated mediators in immunomodulatory status. (hindawi.com)
  • and the innate immune cells contain natural killer (NK) cells and dendritic cells (DCs) (Fig. 1 ). (biomedcentral.com)
  • Ligustrazine and Danshensu levels in the heart, liver, spleen, lung, kidney, and brain were detected at different time points by ultra-high performance liquid chromatography/ tandem mass spectrometry. (alljournal.net.cn)
  • Liver Transplantation for Porto-Sinusoidal Vascular Liver Disorder: Long-term Outcome. (liver.at)
  • The impact of COVID-19 on liver transplantation programs in Austria. (liver.at)
  • We now report that MT-Exendin mice develop extensive tissue lymphocytic infiltration with increased numbers of CD4 + and CD8a + cells in the liver and/or kidney and increased numbers of B220 + cells present in the pancreas and liver. (diabetesjournals.org)
  • Due to the different sources and potential paracrine effects, studying the effect of ROS on certain cell types and tissues is rather complex. (frontiersin.org)
  • The epidemic of obesity, closely associated with increases in diabetes, hypertension, hyperlipidemia, cancer and other disorders, has propelled a major interest in adipose cells and tissues. (bioseek.eu)
  • Adipose tissues contain two distinct types of fat cells, white and brown. (bioseek.eu)
  • Results Ligustrazine and Danshensu were widely distributed and peaked rapidly in tissues of AMI rats after intravenous injection. (alljournal.net.cn)
  • The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. (lookformedical.com)
  • Solid organ transplantation is an important therapeutic option for children with a variety of end stage diseases. (stanford.edu)
  • High-dimensional profiling of pediatric immune responses to solid organ transplantation. (stanford.edu)
  • It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (lookformedical.com)
  • There are several comprehensive reviews on Cn (4, 68), more recent brief updates (3, 37, 44), information on Cn inhibitors (42, 55), and disease- or organ/tissue-specific reviews relating to Cn in the neurosciences (29), muscle (65), islet cells (35). (pancreapedia.org)
  • Cancer is not a chaotic malignant cell mass, but a delicate "hostile" organ, where many other cells are recruited and domesticated to become "accomplices", thereby protecting themselves from recognition and attack by the immune system [ 1 ]. (biomedcentral.com)
  • Multiple sclerosis and T1D have distinct target organs, genetic risk factors, onset ages, and female to male ratios, but target organ-specific T cells as initiators unite these diseases. (frontiersin.org)
  • Sequential rounds of division and differentiation give rise to an enormous amplification of cell numbers, necessary for the production of mature blood cells. (justia.com)
  • This process of division and differentiation is subject to regulation at many levels to control cell production. (justia.com)
  • Conversely, ectopic expression of PRDM16 in myoblasts induces their differentiation into brown fat cells. (bioseek.eu)
  • We demonstrate that TRPC6 deficiency in mice not only results in anxious and depressive behavior, but also reduces excitability of hippocampal CA1 pyramidal neurons and dentate gyrus granule cells. (afpm.org.my)
  • According to current challenges, there is a need to explore innovative immunotherapies, maximize the tumor-killing efficacy of γδ T cells, and attenuate or eliminate tumor immunosuppression. (explorationpub.com)
  • Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
  • γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
  • However, the clinical application of tumor-infiltrating γδ T cells has certain limitations. (explorationpub.com)
  • Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)
  • These cells may be a key factor ultimately mediating the deviation of the antagonistic response between tumor inhibition and tumor promotion. (explorationpub.com)
  • In addition to tumor cells, there are also important stromal components in tumor niche. (biomedcentral.com)
  • Among the components of TME, distinct populations of innate and adaptive immune cells consist of tumor immune microenvironment (TIME). (biomedcentral.com)
  • The intent of vaccination is to induce a combined antibody and T-cell anti-HER-2 immune response, which is intended to target HER-2-expressing tumor cells, and may induce tumor regression or slow progression of disease. (stanford.edu)
  • The primary purpose of this study is to determine whether breast cancer tumors respond (as measured by pathologic complete response: the absence of microscopic evidence of invasive tumor cells in the breast) to combined chemotherapy of AC(doxorubicin and cyclophosphamide) followed by paclitaxel plus trastuzumab or lapatinib or both given before surgery to patients with HER2-positive breast cancer. (stanford.edu)
  • RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. (stanford.edu)
  • It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. (lookformedical.com)
  • FMT refers to the transplantation of functional bacteria in the feces of healthy donors into the gastrointestinal tract of the patient to restore the balance of the intestinal microecology, which subsequently treats diseases associated with disorders of intestinal microorganisms. (hindawi.com)
  • However, generating functional human induced pluripotent stem cell (hiPSC)-derived HSPCs and their derivatives has been elusive, necessitating a better understanding of the developmental mechanisms that trigger HSPC specification. (bvsalud.org)
  • γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. (explorationpub.com)
  • At present, the phenotypic heterogeneity and functional variation of human γδ T cells are increasing. (explorationpub.com)
  • Finally, it retrospectively analyze the activation strategies and clinical relevance of existing γδ T cell adoptive immunotherapies. (explorationpub.com)
  • Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
  • When stimulated to divide, they give rise to more committed, differentiated daughter cells with less proliferative potential, called "early progenitor" cells. (justia.com)
  • Current treatments to manage the problems that result from prolonged bone marrow suppression include the reinfusion of a patient's own previously harvested hematopoietic stem and progenitor cells. (justia.com)
  • In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
  • Wang S, Tasch J, Kheradmand T , Ulaszek J, Ely S, Zhang X, Hering BJ, Miller SD, Luo X. Transient B-cell depletion combined with apoptotic donor splenocytes induces xeno-specific T- and B-cell tolerance to islet xenografts. (uchicago.edu)
  • Chen G, Kheradmand T , Bryant J, Wang S, Tasch J, Wang JJ, Zhang Z, Luo X. Intragraft CD11b(+) IDO(+) cells mediate cardiac allograft tolerance by ECDI-fixed donor splenocyte infusions. (uchicago.edu)
  • By making normal cells more resistant to chemotherapeutic agents, a patient's tolerance for cytotoxicity is improved, which, in turn, also improves the effectiveness of chemotherapy. (justia.com)
  • An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)
  • Lerret NM, Houlihan JL, Kheradmand T , Pothoven KL, Zhang ZJ, Luo X. Donor-specific CD8+ Foxp3+ T cells protect skin allografts and facilitate induction of conventional CD4+ Foxp3+ regulatory T cells. (uchicago.edu)
  • Here, we focus on the development of NOX in phagocytic cells, where the so-called respiratory burst in phagolysosomes contributes to the elimination of ingested microorganisms. (frontiersin.org)
  • In addition, distinct NOX homologs expressed by non-phagocytic cells and mitochondrial ROS are interlinked with phagocytic NOX functions and thus affect the overall redox state of the tissue and the cellular activity in a complex fashion. (frontiersin.org)
  • Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. (lookformedical.com)
  • and foreign particles by phagocytic cells (PHAGOCYTES). (lookformedical.com)
  • The term mononuclear phagocyte system has replaced the former reticuloendothelial system, which also included less active phagocytic cells such as fibroblasts and endothelial cells. (lookformedical.com)
  • Here, we reveal that early activation of the Nod1-Ripk2-NF-kB inflammatory pathway in endothelial cells (ECs) primes them to switch fate towards definitive hemogenic endothelium, a pre-requisite to specify HSPCs. (bvsalud.org)
  • ECM is a macromolecular substance secreted by cells into the extracellular space and constitutes a complex network that supports tissue structure and the physiological activities of cells, including collagen, elastin fibrils, proteinases, proteoglycans (PGs), glycoproteins and glycosaminoglycans (GAGs). (biomedcentral.com)
  • Upon discovery of ROS, their radical function was primarily considered to damage exposed cells and tissue structures. (frontiersin.org)
  • Objective To investigate the difference in tissue distribution of ligustrazine hydrochloride and Salvia miltiorrhiza (Danshen) in acute myocardial ischemia (AMI) model rats. (alljournal.net.cn)
  • TME consists of cell component, the extracellular matrix (ECM) and abundant soluble signaling molecules. (biomedcentral.com)
  • Organisms usually contain large numbers of sphingolipid subspecies (for a pathway based compilation, see www.sphingomap.org) and knowledge about the types and amounts is imperative because they influence membrane structure, interactions with the extracellular matrix and neighboring cells, vesicular traffic and the formation of specialized structures such as phagosomes and autophagosomes, as well as participate in intracellular and extracellular signaling. (sphingolipidclub.com)
  • First, we are interested in Epstein Barr Virus-mediated mechanisms of immune evasion with particular emphasis on pathways that promote survival and proliferation of EBV B cell lymphomas, the characterization of the human T cell and NK cell response to EBV and the identification of novel therapeutics for treatment of EBV B cell lymphomas. (stanford.edu)
  • Here, we briefly discuss resistance mechanisms based on cell interactions and secreted soluble factors in the hematopoietic niche and provide an overview of niche-related therapeutic targets currently undergoing preclinical and clinical investigation which may help improve the outcome in AML therapy. (bvsalud.org)
  • First, γδ T cells exposed to complicated cytokine networks are potentially affected by multiple inhibitory mechanisms. (explorationpub.com)
  • Laboratory work has centered on the mechanisms of how cells acquire specific fates during growth and development, providing insights into normal and abnormal mechanisms of growth control. (stanford.edu)
  • Objective Explore euscaphic acid uptake and transport mechanisms in Caco-2 cells. (alljournal.net.cn)
  • Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
  • Research on vitamin D regulation of thymocyte selection, Th1 and Th17 cells, T-cell programed cell death, and T-regulatory (Treg) cells is summarized and integrated into model mechanisms. (frontiersin.org)
  • Finally, unanswered questions relating to vitamin D mechanisms in CD4 + T cells are highlighted to promote further research that may lead to a deeper understanding of autoimmune disease molecular etiology. (frontiersin.org)
  • Leukemia stem cells (LSC) are thought to be the basis of leukemia progression since they are highly resistant to conventional chemotherapy. (bvsalud.org)
  • They can also be used for increasing white blood cell survival and for chemotherapy. (justia.com)
  • After harvesting, the patient is given high dose chemotherapy or radiotherapy and the bone marrow function is reconstituted by infusion of the cells harvested earlier. (justia.com)
  • The use of high-dosage chemotherapy or radiotherapy for bone marrow ablation requires subsequent incorporation of hematopoietic stem cells into the patient, in which case prior harvesting of such cells is required. (justia.com)
  • The induced differential stress resistance results in improved resistance to cytotoxicity in normal cells, which, in turn, reduces cytotoxic side-effects due to chemotherapy, as well as improved effectiveness of chemotherapeutic agents. (justia.com)
  • In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)
  • Because chemotherapy affects cell division, both normal and cancerous cells are susceptible to the cytotoxic effects of chemotherapeutic agents. (justia.com)
  • Success of conventional chemotherapeutic regiment is based on the principle that tumors with high growth fractions (such as acute myelogenous leukemia and the lymphomas, including Hodgkin's disease) are more sensitive to chemotherapy because a larger proportion of the targeted cells are undergoing cell division at any given time. (justia.com)
  • Another method of the invention comprises administering a cell growth inhibitor to the subject and administering to the subject a chemotherapy agent. (justia.com)
  • In another aspect, the invention features methods of contacting a cancer cell with a chemotherapy agent and methods of increasing resistance of a non-cancer cell to a chemotherapy agent. (justia.com)
  • Growing evidence demonstrates that various cancer treatment modalities, including chemotherapy, radiation therapy, targeted therapy, immunotherapy, hormone therapy, stem cell or bone marrow transplant, and surgery [ 3 - 5 ] , cause premature senescence, as reviewed elsewhere [ 6 - 8 ] . (oaepublish.com)
  • However, multidrug-resistant (MDR) cancer cells may avoid the cytotoxic effects of chemotherapy by glycosylating ceramide. (sphingolipidclub.com)
  • Commensurate with the known truth that HuR improved the great quantity of adhesion substances VLA-4 on Th17 cells, knockout of HuR impaired splenic Th17 cell migration towards the central anxious program and abolished the condition. (globaltechbiz.com)
  • Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3 + CD4 + T-regulatory cell and CD4 + T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. (frontiersin.org)
  • The bi-stable switch would enable T cells to integrate signals from pathogens, hormones, cell-cell interactions, and soluble mediators and respond in a biologically appropriate manner. (frontiersin.org)
  • This review further emphasizes the diversified cross-talk between γδ T cells and other immune cells. (explorationpub.com)
  • TIME primarily consists of myeloid cells, lymphocytes and some other innate immune cells. (biomedcentral.com)
  • Substantial cells are divided into immune cells and non-immune cells. (biomedcentral.com)
  • The infiltrating immune cells in the TME constitute the main body of TIME. (biomedcentral.com)
  • Unfortunately, scientists have yet to be able to locate specific features of malignant and immune cells that would make them uniquely targetable (barring some recent examples, such as the Philadelphia chromosome as targeted by imatinib). (justia.com)
  • Recently, fecal microbiota transplantation (FMT) has been defined as the transfer of distal gut microbial communities from a healthy individual to a patient's intestinal tract to cure some immune disorders (mainly inflammatory bowel diseases). (hindawi.com)
  • a case report of inflammatory pseudotumor of the spleen]. (liverpool.ac.uk)
  • They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (lookformedical.com)
  • a technique of derivatization of proline (pro) and 4-hydroxyproline (hyp) by 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole permitted the measurement of pro and hyp radioactivities, concentrations, and specific activities in the main fractions separated from cultures of fibroblast cells (extracellular collagen and non-collagen proteins, intracellular free pro and hyp, pro- and hyp-containing peptides, procollagen, and non-collagen proteins). (liverpool.ac.uk)
  • Mitochondria isolated from two fibroblast cell lines and induced pluripotent stem cells derived from one affected individual and differentiated neuroepithelial stem cells showed reduced PMPCB levels and accumulation of the processing intermediate of frataxin, a sensitive substrate for MPP dysfunction. (regenerativemedicine.net)
  • Results Rat body weight, the relative abundance of intestinal probiotics, and fecal butyric acid and valeric acid contents were decreased in rats in the model group compared with the normal group, while the abdominal withdrawal reflex score, fecal water content, and relative abundance of Blautia spp. (alljournal.net.cn)
  • Until recently, the treatment of cancer has been largely focused on the development of therapeutic agents or techniques that kill cancer cells. (justia.com)
  • We validated the model using experimental data and used it to quantify the effects of cell components on its behavior. (globaltechbiz.com)
  • Computational approaches to model cell deformation through microfluidic products as complementary of experimental investigations are prominent for multiple reasons. (globaltechbiz.com)
  • T-bet, therefore reducing the amount of pathogenic IL-17+IFN-+Compact disc4+ T cells in the spleen during experimental autoimmune encephalomyelitis (EAE). (globaltechbiz.com)
  • A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. (lookformedical.com)
  • Over the past two decades, a series of significant advances have been achieved in exploring the biogenesis, abundance, and function of lncRNAs across different species and cell types. (biomedcentral.com)
  • Four wild-type (drug-sensitive) human breast cancer cell lines (MCF-7, T47D,MDA-MB-231, MDA-MB-435) were used to evaluate the influence of acute and chronic exposure to ceramide and ceramide metabolites on MDR1 mRNA,P-gp, and resistance to chemotherapeutic agents. (sphingolipidclub.com)
  • Here we show by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myogenic lineage. (bioseek.eu)
  • We also demonstrate that the transcriptional regulator PRDM16 (PRD1-BF1-RIZ1 homologous domain containing 16) controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells. (bioseek.eu)
  • Due to their likely hematopoietic stem cell (HSC) origin, LSCs have surface antigens that are similar to HSC. (bvsalud.org)
  • or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
  • This review will summarize the most recent strategies to identify AAV vectors with enhanced tropism and transduction in cell types that harbor viral reservoirs. (biomedcentral.com)
  • In diabetic rodents, GLP-1 increases β-cell mass via proliferative, neogenic, and antiapoptotic actions ( 1 ). (diabetesjournals.org)
  • As a hematologist he continued in his research in the metabolism of iron, an essential component of red blood cells. (wikipedia.org)
  • a study of collagen metabolism in cell cultures by fluorometric determination of proline and hydroxyproline. (liverpool.ac.uk)
  • Objective To explore the alterations in the gut microbiota-short-chain fatty acid metabolism axis in a rat model of diarrhea-predominant irritable bowel syndrome (IBS-D), and to explore the effect of sodium butyrate on this axis. (alljournal.net.cn)
  • Similar to αβ T cells, γδ T cells also develop in embryos, and their intra-thymic development shows strict regulation and flexible plasticity [ 2 ]. (explorationpub.com)
  • Cornell School Of Veterinary Medicine (Ithaca, NY) Embryological Collection About 150 boxes, 12 binders, collection includes human, rat, mouse and guinea pig embryos. (edu.au)
  • The most prominent example is the changes in cell biology and morphology when it evolves from a healthy to a cancerous state [1, 3]. (globaltechbiz.com)
  • Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. (lookformedical.com)
  • LSCs could be separated from other cells using magnetic selection (MS) or flow cytometry selection (FCS) methods using these markers. (bvsalud.org)
  • Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. (justia.com)
  • In many cases, successfully mobilization is not effected in the patient and inadequate numbers of hematopoietic stem cells are harvested from these patients using current methods. (justia.com)
  • Firstly, such modeling methods give an insight into how cell parts function under stress. (globaltechbiz.com)
  • This invention relates to methods of inducing differential stress resistance in a subject with cancer by starving the subject for a short term, administering a cell growth inhibitor to the subject, or reducing the caloric or glucose intake by the subject. (justia.com)
  • Methods A rat model of AMI was induced by subcutaneous injection of isoproterenol hydrochloride solution. (alljournal.net.cn)
  • from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed. (lookformedical.com)
  • The complexity of the sphingolipidome is hard to imagine, but one hopes that, when partnered with other systems biology approaches, the causes and consequences of the complexity will explain how these intriguing compounds are involved in almost every aspect of cell behavior and the malfunctions of many diseases. (sphingolipidclub.com)
  • Evidence for CD4 + T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4 + T lymphocytes is summarized to support the thesis that calcitriol is sunlight's main protective signal transducer in autoimmune disease risk. (frontiersin.org)
  • Enforced expression of PTTG3P significantly promoted cell proliferation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo. (biomedcentral.com)
  • It plays a part in cell viscosity, twisting resistance, and incompressibility. (globaltechbiz.com)
  • The present invention provides a novel approach to cancer therapy by providing a method to differentially enhance the resistance of normal cells to chemotherapeutic agents, thereby, improving the effectiveness of chemotherapeutic agents in killing cancerous cells. (justia.com)
  • These cells not only demonstrated a 3-foldincrease in resistance to doxorubicin and a 9-fold increase in resistance to paclitaxel, but also showed increased efflux of rhodamine. (sphingolipidclub.com)
  • 6 Center for Stem Cell & Regenerative Medicine, The University of Texas Health Science Center of Houston, TX 77030, USA. (oaepublish.com)
  • Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells. (lookformedical.com)
  • Yet, NOX participates in cellular signaling in a cell-intrinsic and -extrinsic manner, e.g., via the release of ROS into the extracellular space. (frontiersin.org)
  • elasticity, viscosity) and have little or no regard to the variations in intrinsic properties of these cells. (globaltechbiz.com)
  • Such a conception would of necessityassume that these structures, as such, were in some way intrinsic in the cells of the pharyngeal entoderm metamerically arranged. (edu.au)
  • Currently, as a means of intestinal microecological regulation in addition to microecological preparations, fecal microbiota transplantation (FMT) has become popular in recent years. (hindawi.com)