AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceHealth Care
Rats, Inbred F344Drugs, Chinese HerbalDisease Models, AnimalGingival HypertrophyToluene 2,4-DiisocyanateElectroacupunctureRats, Sprague-DawleyRats, WistarMedicine, Chinese TraditionalMedicine, KampoYin DeficiencyRats, Inbred OLETFPhytotherapyRandom AllocationCarbon TetrachlorideMalondialdehydeDiseasePlant ExtractsGenetic Diseases, InbornRNA, MessengerBody WeightF FactorMice, Inbred C57BLF2-IsoprostanesNeurodegenerative DiseasesMice, TransgenicPhenotypeHuntington DiseaseMutationMice, KnockoutModels, GeneticSignal TransductionModels, BiologicalAmino Acid SequenceGene Expression RegulationInduced Pluripotent Stem CellsMolecular Sequence DataCell LineMice, Inbred BALB CGenetic Predisposition to DiseaseNervous System DiseasesGenome, HumanProbability TheoryDrug Evaluation, PreclinicalParkinson DiseaseBrainAutoimmune Diseases1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineNeuronsAnimals, Genetically ModifiedCells, CulturedNeuroprotective AgentsInflammationChromosome MappingProstaglandins FAlzheimer DiseasePolymorphism, Single NucleotideComputer SimulationGene Expression ProfilingEpistasis, GeneticGene TargetingGenotypeAllelesEthylnitrosoureaGenetic VariationNeoplasmsGenetic LinkageZebrafishFluorodeoxyglucose F18CytokinesGene ExpressionTime FactorsModels, AnimalParkinsonian DisordersCell DifferentiationProtein BindingCommunicable DiseasesAdenoviruses, PorcineDatabases, GeneticGenetic MarkersMice, Mutant StrainsGenetic VectorsGenome-Wide Association StudyNerve Tissue ProteinsApoptosisTransgenesalpha-SynucleinMice, Inbred DBAEncephalomyelitis, Autoimmune, ExperimentalLinkage DisequilibriumComputational BiologyGenomicsBase SequenceReverse Transcriptase Polymerase Chain ReactionOxidopamineSpecies SpecificityNerve DegenerationTranscription FactorsDopaminergic NeuronsPeptide Fragments
Sprague-DawleyStrainsTransgenic rat modelInflammationBehavioral ResponsesGeneticallyDimethylhydrazineGenesAlbinoSensitivityProgressionMale2019ExperimentalClinicalFischerCentersGenetic BackgroundPositionalOrganismInvestigateLaboratoryCuresLungExposuresStrainPeripheralMiceArtificialChemicalsEffectStudyContributionsReductionKidney diseaseColonTherapeuticDiabetesDietAnimalsAnalysisDietaryInjuryTreatDrugCellsStudiesJournalResearchGroupsPatientsLevels
Sprague-Dawley2
  • Genetic contributions were assessed using three strains of male rats with different genetic backgrounds [Fischer-344 (F344), Sprague-Dawley (SD), Brown-Norway (BN)] maintained on a standard or high fat (HF) diet for 24 wk. (cdc.gov)
  • Accordingly, male Sprague-Dawley (SD) and Brown Norway (BN) rats were maintained on either regular (Reg) or high fat (HF) diets for 24wk. (cdc.gov)
Strains2
  • Effect of diet and occupational exposure in different rat strains on serum biomarkers and peripheral blood mononuclear cell telomere length: development of an animal model to examine the exposome. (cdc.gov)
  • Generally, the exposome components of diet and WF exposure had the greater influence on the parameters measured compared to the changes associated with rat strain except for the body weight changes observed with the HF diet that were more pronounced in the inbred F344 and BN strains. (cdc.gov)
Transgenic rat model2
  • In order to determine mechanisms contributing to persistent podocyte loss, we used a human diphtheria toxin transgenic rat model. (umich.edu)
  • In an HLA-B27 transgenic rat model repetitive dosing of HD5 reduced the expansion of pro-inflammatory CD4+ T-cells, and decreased the levels of soluble TNF and number of cell-surface B272 molecules. (ox.ac.uk)
Inflammation1
  • Collectively, HF diet appeared to have a greater impact on global immune status and exposure-induced lung injury in SD rats, but a more pronounced effect on inflammation resolution in BN rats. (cdc.gov)
Behavioral Responses2
  • Selective Involvement of a Subset of Spinal Dorsal Horn Neurons Operated by a Prodynorphin Promoter in Aβ Fiber-Mediated Neuropathic Allodynia-Like Behavioral Responses in Rats. (kyoto-u.ac.jp)
  • Neuropathic pain in aged rats: behavioral responses and astrocytic activation. (omeka.net)
Genetically1
  • The use of ET has recently increased owing to the production of many types of genetically modified laboratory animals for the study of human diseases 12 , 13 . (nature.com)
Dimethylhydrazine2
  • 1980. Inhibition by bran of the colonic cocarcinogenicity of bile salts in rats given dimethylhydrazine. (cdc.gov)
  • Strain susceptibility and resistance to 1,2-dimethylhydrazine-induced enteric tumors in germfree rats (40146). (cdc.gov)
Genes6
  • Positional cloning of rat mutant genes reveals new functions of these genes. (kyoto-u.ac.jp)
  • Hypertension-Associated Genes in the Mesenteric Artery of Three Spontaneously Hypertensive Rat Substrains Identified Using a DNA Array Method. (kyoto-u.ac.jp)
  • Rats bearing mutant genes which are phenotypically expressed in the animals. (lookformedical.com)
  • Positional cloning of lymphopenia ( lyp ) in the BB rat revealed a frameshift mutation in Gimap5 , a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome 4q24. (hindawi.com)
  • Our aim was to clone and sequence the cDNA of the BB diabetes prone (DP) and diabetes resistant (DR) alleles of all seven Gimap genes in the congenic DR. lyp rat line with 2 Mb of BB DP DNA introgressed onto the DR genetic background. (hindawi.com)
  • Gimap5 is a member of at least seven related GTPase Immune Associated Protein ( Gimap ) genes located within 150 Kilobases (Kb) on rat chromosome (RNO) 4 [ 2 , 3 ]. (hindawi.com)
Albino1
  • A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. (lookformedical.com)
Sensitivity1
  • We used the Bennett and Xie (1988) model of chronic neuropathic pain to study the effect of age on thermal and tactile sensitivity and on astrocytic activation in the dorsal horn of the spinal cord after nerve injury. (omeka.net)
Progression4
  • Angiotensin II-dependent persistent podocyte loss from destabilized glomeruli causes progression of end stage kidney disease. (umich.edu)
  • Progression is the process by which progressive glomerulosclerosis leads to end stage kidney disease (ESKD). (umich.edu)
  • Onset and progression of disease profiles were monitored during therapy. (ox.ac.uk)
  • Background Hydrogen/oxygen therapy contribute to ameliorate dyspnea and disease progression in patients with respiratory diseases. (researchgate.net)
Male6
  • Circuit and cell-specific contributions to decision making involving risk of explicit punishment in male and female rats. (ufl.edu)
  • Touchscreen-Based Cognitive Training Alters Functional Connectivity Patterns in Aged But Not Young Male Rats. (ufl.edu)
  • Age-related impairments on the touchscreen paired associates learning (PAL) task in male rats. (ufl.edu)
  • Each of 60 weanling male rats was assigned to one of 6 experimental diet groups: Fermented and unfermented camel milk with AOM, fermented and unfermented bovine milk with AOM and positive (PC, AOM only) and negative (NC, saline vehicle only) control groups. (scialert.net)
  • Age related changes of social memory/recognition in male Fischer 344 rats. (omeka.net)
  • Two different habituation-dishabituation test paradigms were used to evaluate differences in social memory/recognition among 3-, 15- and 22-month-old male Fischer 344 rats. (omeka.net)
20192
  • In this multisite, observational, matched cohort study of more than 80,000 pregnant people, receipt of an mRNA monovalent coronavirus disease 2019 (COVID-19) booster vaccination in pregnancy was not associated with increased risk for thrombocytopenia, myocarditis, venous thromboembolism, ischemic stroke, or other serious adverse events within 21 or 42 days after booster vaccination. (cdc.gov)
  • Therefore, we hypothesized that hydrogen/oxygen therapy for ordinary coronavirus disease 2019 (COVID-19) patients might reduce the length of hospitalization and increase hospital discharge rates. (researchgate.net)
Experimental4
  • Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat. (kyoto-u.ac.jp)
  • A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. (lookformedical.com)
  • The goal was to develop an experimental model of the exposome by collecting biological samples during critical life stages of an exposed animal that are applicable to worker populations. (cdc.gov)
  • experimental models, including potential limitations and data gaps. (cdc.gov)
Clinical8
  • The Michigan George M. O'Brien Kidney Translational Core Center (MKTCC) invites investigators to submit proposals to fund new and innovative approaches - clinical, translational and basic - in the field of kidney disease research through its pilot and feasibility grant program. (umich.edu)
  • Genetic and pharmacological interventions have successfully extended healthspan and lifespan in animals, but their genetic interventions are not appropriate options for human applications and pharmacological intervention needs more solid clinical evidence. (mdpi.com)
  • Reply to the letter to the editor regarding "a clinical prediction model to assess surgical outcome in patients with cervical spondylotic myelopathy: Internal and external validation using the prospective multicenter AOSpine North American and International datasets of 743 patients. (illinois.edu)
  • Systematic Reviews of Animal Experiments DemonstratePoor Human Clinical and Toxicological Utility Animal Consultants International, London, UK Summary - The assumption that animal models are reasonably predictive of human outcomes provides the basis for their widespread use in toxicity testing and in biomedical research aimed at developing cures for human diseases. (drugstorepdfsearch.com)
  • To investigate the validity of this assumption, the comprehensive Scopus biomedical bibliographic databases were searched for published systematic reviews of the human clinical or toxico- logical utility of animal experiments. (drugstorepdfsearch.com)
  • In 20 reviews in which clinical utility was examined, the authors con- cluded that animal models were either significantly useful in contributing to the development of clinical interventions, or were substantially consistent with clinical outcomes, in only two cases, one of which was contentious. (drugstorepdfsearch.com)
  • These included reviews of the clinical utility of experiments expected by ethics committees to lead to medical advances, of highly-cited experiments published in major journals, and of chimpanzee experiments - those involving the species considered most likely to be predictive of human outcomes. (drugstorepdfsearch.com)
  • The poor human clinical and toxicological utility of most animal models for which data exists, in conjunction with their generally sub- stantial animal welfare and economic costs, justify a ban on animal models lacking scientific data clearly establishing their human predictivity or utility. (drugstorepdfsearch.com)
Fischer1
  • This study was conducted to investigate the chemopreventive potential of camel ( Camelus dromedarius ) and bovine milk as well as the impact of fermenting these milks with Lactobacillus acidophilus and Streptococcus thermophilus against early colon carcinogenesis as measured by the reduction of aberrant crypt foci (ACF) in azoxymethane (AOM)-treated Fischer 344 rats. (scialert.net)
Centers2
  • Substances and Disease Registry, Centers for Disease Control. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
Genetic Background1
  • rats, where 2 Mb of DP DNA was introgressed onto the BB diabetes resistant (DR) genetic background, are lymphopenic and 100% develop spontaneous T1D by 84 days of age [ 4 ]. (hindawi.com)
Positional1
  • The positional cloning and subsequent identification of the Gimap5 gene on RNO4 were in part established through generation of the DR. lyp congenic rat line along with recombination events following our method of marker assisted breeding of DP with F344 rats [ 2 , 4 , 5 ]. (hindawi.com)
Organism1
  • A viral etiology is suspected, the isolated organism being usually the human papillomavirus. (lookformedical.com)
Investigate3
  • NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
  • This study was performed to produce reference data for eye toxicity tests and to investigate the ophthalmic diseases of 408 ICR mice and 119 BALB/c mice, which are commonly used as subjects in toxicity tests. (go.jp)
  • These studies were designed to investigate how the aging process alters the spinal antinociceptive efficacy of mu (mu), delta (delta) and epsilon (epsilon) opioid receptor agonists administered intrathecally (i.t.) in rats. (omeka.net)
Laboratory2
  • Rats, Inbred WF are a strain of laboratory rats that are commonly used in medical research due to their consistent genetic makeup and susceptibility to various diseases. (lookformedical.com)
  • The 2003 EC proposal for the In the USA, laboratory animal use is federally reg- Registration, Evaluation and Authorisation of ulated by the Animal Welfare Act 1966 (amended in Chemicals (REACH), similarly aims to assess the 1985), which excludes laboratory-bred mice and toxicity of chemicals produced or imported in high rats, as well as non-mammals, from consideration quantities (15-20). (drugstorepdfsearch.com)
Cures1
  • Mapping of the exposome could improve the understanding of disease and aid in prevention strategies and possible cures of many diseases. (cdc.gov)
Lung2
  • however, diet appeared to preferentially impact SD rats at this time point, as several inflammatory markers (lymph node cellularity, lung neutrophils) were further elevated in HF over Reg animals. (cdc.gov)
  • More importantly, the small molecular properties of hydrogen enable it can rapidly reaches the alveoli, suggest a unique advantage for lung disease [18]. (researchgate.net)
Exposures1
  • An animal model can be useful in the study of the exposome as external lifetime exposures can be easily controlled and adverse health outcomes measured. (cdc.gov)
Strain5
  • A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR). (lookformedical.com)
  • A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke. (lookformedical.com)
  • Mutant strain of Rattus norvegicus which is used as a disease model of kernicterus. (lookformedical.com)
  • A strain of Rattus norvegicus which is a model for spontaneous insulin-dependent diabetes mellitus (DIABETES MELLITUS, INSULIN-DEPENDENT). (lookformedical.com)
  • A separate set of rats from each strain were allowed to recover from WF exposure until the end of the 24 wk period. (cdc.gov)
Peripheral1
  • Effect of aging on the substance P receptor, NK-1, in the spinal cord of rats with peripheral nerve injury. (omeka.net)
Mice2
  • In mice and rats, females require mating stimulation for the maintenance of pregnancy. (nature.com)
  • The production of female mice with pseudopregnancy induced using sonic vibration was as efficient as rats. (nature.com)
Artificial2
  • We developed a method, named Easy-ET, to induce pseudopregnancy in female rats by artificial stimulation using sonic vibration instead of mating with vasectomized males. (nature.com)
  • Gimap5 was identified as the lyp gene in the BBDP rat through a frameshift mutation and premature truncation of the Gimap5 protein [ 2 , 6 ] and can be rescued in a P1-derived artificial chromosome (PAC) transgenic rat [ 7 ]. (hindawi.com)
Chemicals3
  • The overall objectives of the IPCS are to establish the scientific basis for assessment of the risk to human health and the environment from exposure to chemicals, through international peer review processes, as a prerequisite for the promotion of chemical safety, and to provide technical assistance in strengthening national capacities for the sound management of chemicals. (inchem.org)
  • The purpose of the IOMC is to promote coordination of the policies and activities pursued by the Participating Organizations, jointly or separately, to achieve the sound management of chemicals in relation to human health and the environment. (inchem.org)
  • Likely benefits would include, the greater selection of models truly pre- dictive of human outcomes, increased safety of people exposed to chemicals that have passed toxicity tests, increased efficiency during the development of human pharmaceuticals and other therapeutic interven- tions, and decreased wastage of animal, personnel and financial resources. (drugstorepdfsearch.com)
Effect2
  • 3H-dialkylhydrazines in the neuroendocrine system and their antigonadotropic effect in rats. (cdc.gov)
  • The immune modulating effect of HD5 was tested in HLA-B27 transgenic rats. (ox.ac.uk)
Study4
  • In this study, the uptake mechanisms of 18F-fluorodeoxyglucose (18F-FDG), 18F-fluoroethyltyrosine (18F-FET) and 18F-fluoromethylcholine (18F-FCho) positron emission tomography (PET) tracers were investigated in a F98 GB and RN rat model applying kinetic modeling (KM) and graphical analysis (GA) to clarify our previous results. (nih.gov)
  • A comparative study of mesenchymal stem cell transplantation and NTG-101 molecular therapy to treat degenerative disc disease. (kyoto-u.ac.jp)
  • They are used as study models for human diseases. (lookformedical.com)
  • Rats were euthanized at 7, 12, and 24wk to evaluate local and systemic immune markers corresponding to the baseline, exposure, and recovery phases of the study, respectively. (cdc.gov)
Contributions1
  • The National Institute of Environmental Health Sciences (NIEHS) is expanding and accelerating its contributions to scientific knowledge of human health and the environment, and to the health and well-being of people everywhere. (nih.gov)
Reduction1
  • Caloric restriction (CR), reduction of calorie intake to a level that does not compromise overall health, has been considered as being one of the most promising dietary interventions to extend lifespan in humans. (mdpi.com)
Kidney disease1
  • Several kidney biomarkers are used successfully in drug development, however cost-efficient, and reliable kidney biomarkers are urgently needed for monitoring farm animals for early signs of kidney disease. (frontiersin.org)
Colon1
  • 1987. The influence of physical activity in 1 ,2dimethylhydrazine induced colon carcinogenesis in the rat. (cdc.gov)
Therapeutic2
  • This review summarizes currently available data regarding the protective role of hydrogen, provides an outline of recent advances in research on the use of hydrogen as a therapeutic medical gas in diverse models of disease and discusses the feasibility of hydrogen as a therapeutic strategy. (researchgate.net)
  • In recent years, molecular hydrogen treatment has the potential to preventive and therapeutic applications against many diseases due to its extensive effects, such as antioxidant, anti-inflammatory, antiapoptotic [16, 17]. (researchgate.net)
Diabetes1
  • Lymphopenia ( lyp ) is a prerequisite for spontaneous type 1 diabetes (T1D) in the BioBreeding (BB) diabetes prone (DP) rat [ 1 ]. (hindawi.com)
Diet1
  • In BN rats, resolution of immune alterations was further compromised by HF diet, as many exposure-induced alterations in local/systemic immune markers were still evident in HF/WF animals at 24wk. (cdc.gov)
Animals1
  • At 7wk, HF-fed animals exhibited several immune alterations (blood leukocyte/neutrophil number, lymph node B-cell proportionality)-effects which were more pronounced in SD rats. (cdc.gov)
Analysis1
  • Analysis of the lyp phenotype in the F344 DNA recombinant rats helped us define the critical lyp interval as a region of approximately 33 Kb between D4Rhw6 (76.83 Mb) and IIsnp3 (77.16 Mb) containing Gimap1 , Gimap5 , and Gimap3 (formerly known as Ian2 , Ian5 , and Ian4 , resp. (hindawi.com)
Dietary1
  • Consequently, dietary manipulations are the only practical and probable strategies to promote health and longevity in humans. (mdpi.com)
Injury1
  • Microglial proliferation in the spinal cord of aged rats with a sciatic nerve injury. (omeka.net)
Treat2
  • Use of plants or herbs to treat diseases or to alleviate pain. (lookformedical.com)
  • Thus, camel milk is used in alternative medical practices to treat many diseases, including cancer 16 . (scialert.net)
Drug1
Cells4
  • Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model. (kyoto-u.ac.jp)
  • HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats. (ox.ac.uk)
  • CONCLUSION: HD5 predominantly inhibits early TNF production and expansion of pro-inflammatory CD4+ T-cells in HLA-B27 transgenic rats. (ox.ac.uk)
  • Both GIMAP4 and GIMAP7 from human Jurkat cells [ 3 ] localize to the endoplasmic reticulum and Golgi apparatus while mouse Gimap3 from murine IL-3-dependent 32D myeloid precursor cells was expressed at the outer mitochondrial membrane [ 15 ]. (hindawi.com)
Studies1
  • A workshop cosponsored by the National Institute of Environmental Health Sciences and the studies and/or human reports (Table 1). (cdc.gov)
Journal1
Research1
  • Prof. Wright's research has contributed to our understanding of the physiology of sleep and circadian rhythms in humans, explaining the health and safety consequences of sleep loss and circadian misalignment-such as metabolic dysregulation and impaired cognition-and applying that knowledge to improve public health and safety. (colorado.edu)
Groups1
  • At termination, all rats were euthanized, colons were harvested and the ACF counts were determined for all tested groups. (scialert.net)
Patients1
  • The presence of B272 can be detected on leukocytes of HLA-B27+ Ankylosing spondylitis (AS) patients and HLA-B27 transgenic rats. (ox.ac.uk)
Levels1
  • Substance P (SP) levels in the spinal cords of very old rats are less than the levels in younger rats (Bergman et al. (omeka.net)