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  • excretion
  • EVALUATION FOR ACCEPTABLE DAILY INTAKE BIOCHEMICAL ASPECTS Absorption, distribution and excretion Various comprehensive studies in mouse, rat, and guinea-pig have dealt with the pharmacodynamic and biochemical aspects of fenitrothion and its metabolites (Nishizawa et al. (inchem.org)
  • 5,000
  • Feed consumption by male and female rats exposed to 5,000 ppm TBBC was markedly lower than that by the controls throughout the study. (nih.gov)
  • radioactivity
  • 1968). Fenitrothion is presumably rapidly absorbed from the mammalian intestinal tract as evidenced by the appearance of radioactivity in blood from guinea-pigs and rats administered phosphorus 32 -labelled fenitrothion orally. (inchem.org)
  • Metabolism
  • Significantly, C. difficile is among only a few bacteria able to ferment tyrosine to p -cresol, a phenolic compound that is toxic to other microbes via its ability to interfere with metabolism. (microbiologyresearch.org)
  • The results from metabolism studies in rats show that, like other monocyclic aromatic amines, the metabolism of o-toluidine involves many competing activating and deactivating pathways, including N-acetylation, N-oxidation and N-hydroxylation, and ring oxidation. (wikipedia.org)
  • renal
  • Renal tubule adenomas occurred in three rats in the 15,000 ppm group, and the incidence exceeded the historical control range. (nih.gov)
  • One additional renal tubule adenoma was found in a 15,000 ppm rat in an extended examination of kidney step sections. (nih.gov)
  • Studies
  • Studies in rats have shown that p-cresol is primarily conjugated with glucuronide to produce p-cresylglucuronide, though this may not be applicable to humans. (wikipedia.org)
  • No human or animal studies have shown harmful effects from cresols on reproduction. (wikipedia.org)
  • Studies on rats have shown that those who were exposed to sidestream smoke while in utero and following the period directly after, had differences in airway sensitivity in comparison to those that had been exposed to sidestream smoke only while in utero or only following the period after. (wikipedia.org)
  • mixture
  • These forms occur separately or as a mixture, which can also be called cresol or more specifically, tricresol. (wikipedia.org)
  • Dose
  • A dose-related significant increase in forelimb and hindlimb grip strength was observed in exposed male and female rats. (nih.gov)
  • high
  • When cresols are inhaled, ingested, or applied to the skin at very high levels, they can be very harmful. (wikipedia.org)
  • Breathing high levels of cresols for a short time results in irritation of the nose and throat. (wikipedia.org)
  • Surprising, it was shown that Clostridium sordellii also has a high tolerance to p -cresol, suggesting an overlap in the tolerance pathways in these clostridial species. (microbiologyresearch.org)
  • produce
  • Therefore, the ability of different C. difficile strains to produce and tolerate p -cresol may play an important role in the development and severity of C. difficile -associated disease. (microbiologyresearch.org)
  • chemical
  • In 1892, dinitro-ortho-cresol (2,4-dinitro-6-methylphenol), a chemical compound closely related to dinoseb, was discovered in Germany and first used as an insecticide. (wikipedia.org)
  • cause
  • The 2,6-Di-Tert-Butyl-P-Cresol component (1%) may cause irritation, urticarial reactions, andeczematous dermatitis. (healthdrugpdf.com)