ApoptosisRadiotherapyOxidativeCisplatinHeart Failure in RatsRadiation inducedWistarReperfusion inducedToxicityMiceExtractPathwaysNeuropathic painInflammationSeverityDoxorubicinNrf2ChemotherapeuticVivoMucositisCytokinesHistoneEvaluateDysfunctionIntestinalTissuePhosphorylationMetabolicAntioxidantTreatmentNeuropathyObesityImmune responsesCellsResults showedTherapyOocytesMelatoninPatientsPathwayDiabetesRespiratoryEffectsFeverActivity
Apoptosis7
- which otherwise induce apoptosis of the cells. (wikipedia.org)
- Radiotherapies and chemotherapies can cause apoptosis of ovarian follicles, causing premature ovarian failure, and so S1P is of great interest in fertility preservation. (wikipedia.org)
- However, its mechanism of inhibiting the sphingomyelin apoptotic pathway may also interfere with the apoptosis action of chemotherapy drugs. (wikipedia.org)
- Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis. (cancerindex.org)
- SYVN1/GPX5 axis affects ischemia/reperfusion induced apoptosis of AC16 cells by regulating ROS generation. (e-century.us)
- Exosomes containing miR-122-5p secreted by LPS-induced neutrophils regulate the apoptosis and permeability of brain microvascular endothelial cells by targeting OCLN. (e-century.us)
- Paclitaxel triggers anti-mitotic actions by impeding the cell cycle in the late Everolimus mTOR inhibitor stages of mitosis, backing microtubule formation, and eventually inducing apoptosis. (gp120-inhibitors.com)
Radiotherapy4
- Bosset JF, Collette L, Calais G. Chemotherapy with preoperative radiotherapy in rectal cancer. (novapublishers.com)
- The radiation-induced lung injury is a common complication from radiotherapy in lung cancer. (biomedcentral.com)
- Intestinal mucositis is a common side effect of chemotherapy and radiotherapy. (biomedcentral.com)
- [15] The field of virotherapy was nearly abandoned for a time, as the technology required to modify viruses didn't exist whereas chemotherapy and radiotherapy technology enjoyed early success. (privacytools.io)
Oxidative12
- Cisplatin (cis-diamminedichloroplatinum II, CDDP) is a chemotherapeutic agent that induces nephrotoxicity associated with oxidative/nitrosative stress. (weeksmd.com)
- SFN attenuated CDDP-induced renal dysfunction, structural damage, oxidative/nitrosative stress, glutathione depletion, enhanced urinary hydrogen peroxide excretion and the decrease in antioxidant enzymes (catalase, glutathione peroxidase and glutathione-S-transferase). (weeksmd.com)
- The renoprotective effect of SFN on CDDP-induced nephrotoxicity was associated with the attenuation in oxidative/nitrosative stress and the preservation of antioxidant enzymes. (weeksmd.com)
- Thus, treatment targeting mitochondrial-induced oxidative stress is very crucial in suppressing DCM. (encyclopedia.pub)
- It is worth noting that we have found the key upstream target of DOX-induced HF, PTP1B, which inhibits the expression of HIF-1α by inhibiting the phosphorylation of IRS, leading to disorders of fatty acid metabolism and glycolysis, which together with the decrease of Nrf2, SOD, Cytc, and AK4 proteins lead to oxidative stress. (frontiersin.org)
- Due to its high antioxidant content, GSE can help prevent disease and protect against oxidative stress, tissue damage, and inflammation. (healthline.com)
- Administration of Gln to the DSS-induced colitis mice led to a clearly reduction in oxidative stress-induced injury. (ac.ir)
- Ziziphus spina-christi fruit extract suppresses oxidative stress and p38 MAPK expression in ulcerative colitis in rats via induction of Nrf2 and HO-1 expression. (ac.ir)
- 5. Yan H, Wang H, Zhang X, Li X, Yu J. Ascorbic acid ameliorates oxidative stress and inflammation in dextran sulfate sodium-induced ulcerative colitis in mice. (ac.ir)
- Enteral glutamine and/or arginine supplementation have favorable effects on oxidative stress parameters in neonatal rat intestine. (ac.ir)
- Glutamine with probiotics attenuates intestinal inflammation and oxidative stress in a rat burn injury model through altered iNOS gene aberrant methylation. (ac.ir)
- Lung inflammatory reaction and oxidative stress are promoted in the initiation of radiation-induced pneumonia. (biomedcentral.com)
Cisplatin4
- The efficiency of blackberry loaded AgNPs, AuNPs and Ag@AuNPs mediated pectin in the treatment of cisplatin-induced cardiotoxicity. (greenmedinfo.com)
- Sulforaphane protects against cisplatin-induced nephrotoxicity. (weeksmd.com)
- Patients undergoing chemotherapy with cisplatin (CIS) develop neuropathy in addition to other symptoms such as, anxiety, depression, muscle wasting and body weight loss. (mdpi.com)
- Oxytocin alleviates cisplatin-induced renal damage in rats. (biossantibodies.com)
Heart Failure in Rats1
- Exosomes released from mesenchymal stem cells overexpressing microRNA-30e ameliorate heart failure in rats with myocardial infarction. (e-century.us)
Radiation induced5
- S1P has protected ovarian tissue xenografts in SCID mouse models from radiation induced atresia. (wikipedia.org)
- This study aimed to examine the effect of CpG ODN on acute radiation-induced lung injury in mice. (biomedcentral.com)
- The mouse model of radiation-induced lung injury was established by a single dose of 20 Gy X-rays exposure to the left lung. (biomedcentral.com)
- The study demonstrated that CpG ODN has preventive effects of acute radiation-induced lung injury in mice. (biomedcentral.com)
- Radiation therapy is one of the most important treatments for the chest tumors, but common complications from such treatments include radiation-induced lung injuries and dose-limiting side effects [ 1 ]. (biomedcentral.com)
Wistar2
- Methods: Experimentally, diabetes was induced by a single administration of streptozotocin at 50 mg/kg intraperitoneally in Wistar rats. (bvsalud.org)
- In the in vivo studies, CDDP was given to Wistar rats as a sole i.p. injection at a dose of 7.5 mg/kg. (weeksmd.com)
Reperfusion induced1
- Three cycles of 5-min ischemia/5-min reperfusion induced by a blood pressure cuff served as RIPC stimulus. (silverchair.com)
Toxicity2
- This study investigated the effect of nasturtium officinale extract on the ovarian function following the toxicity induced by doxorubicin in female rats. (ac.ir)
- Manjula Vinayak [email protected] toxicity. (pi3k-inhibitors.com)
Mice9
- An alcohol-free fermented blueberry and blackberry beverage extract attenuates diet-induced obesity and blood glucose in mice. (greenmedinfo.com)
- Following the cecal ligation and puncture (CLP) procedure, intravenous dosing of AVR-25 (10 mg/kg, 6-12 h post-CLP) alone and in combination with antibiotic imipenem protected both young adult (10-12 week old) and aged (16-18 month old) mice against polymicrobial infection, organ dysfunction, and death. (nature.com)
- Simultaneous targeting of 5-LOX-COX and ODC block NNK-induced lung adenoma progression to adenocarcinoma in A/J mice. (biossantibodies.com)
- Surgical incision induces learning impairment in mice partially through inhibition of the brain-derived neurotrophic factor signaling pathway in the hippocampus and amygdala. (biossantibodies.com)
- In this study, we investigated the role and mechanism of action of TBHQ on 5-fluorouracil-induced (5-FU-induced) human intestinal epithelial cell (HIEC) injury and intestinal mucositis in mice. (biomedcentral.com)
- 2013). Same combination in polymeric micelles reduced the doxorubicin-induced cardiotoxicity in SKOV-3 and H9C2 cells as well as in mice, suggesting to limit the adverse effects of chemotherapy (Cote et al. (pi3k-inhibitors.com)
- We show that-in both rats and mice-PB contains few GABAergic neurons, and that most of its GABAergic inputs arise from CeA. (iasp-pain.org)
- CRISPLD2 attenuates pro-inflammatory cytokines production in HMGB1-stimulated monocytes and septic mice. (e-century.us)
- Animal reservoirs are generally rats and mice, but domestic livestock, monkeys, and other primates may also serve as intermediate hosts. (medscape.com)
Extract1
- The nasturtium officinale extract attenuated the toxic effect of doxorubicin on the rat ovaries and protected the cell division in the follicles and the oocytes maturation. (ac.ir)
Pathways4
- Correlation analysis showed that DOX-induced HF mainly affected phenylalanine, tyrosine, and tryptophan biosynthesis, D-glutamine and D-glutamate metabolism, phenylalanine metabolism, biosynthesis of unsaturated fatty acids, and other metabolic pathways, suggesting abnormal amino acid metabolism, fatty acid metabolism, and glycerol phospholipid metabolism. (frontiersin.org)
- Here, we used ultra-high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) to analyze DOX-induced HF in rats, to explain the toxicological pathways of DOX to the heart, especially the combined proteomic technology, to provide more information for the study of its pathogenesis. (frontiersin.org)
- Proteomics Analysis of Hepatocyte Proliferation Regulated by FGF, PDGF, Insulin, Oncostatin M and Interleukin 2 Signaling Pathways during Rat Liver Regeneration. (biossantibodies.com)
- Here, we define multiple pathways by which the gut microbiome protects mammalian hosts from SARS-CoV-2 intranasal infection, both locally and systemically, via production of short-chain fatty acids (SCFAs). (rockefeller.edu)
Neuropathic pain3
- We have recently reported that chronic pain is associated with amplified activity of PB neurons in a rat model of neuropathic pain. (iasp-pain.org)
- However, none of the drugs has been shown to totally attenuate neuropathic pain. (gp120-inhibitors.com)
- Cannabinoids curb neuropathic pain induced by traumatic nerve damage, harmful insults and metabolic changes. (gp120-inhibitors.com)
Inflammation1
- Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
Severity2
- Coadministration of palifermin within 24 hr of chemotherapy resulted in increased severity and duration of oral mucositis. (medscape.com)
- The chemotherapeutic agent used, dosing schedule, type of cancer, and presence of additional medical complications make a difference to the occurrence and severity of chemotherapy-induced neuropathy. (gp120-inhibitors.com)
Doxorubicin1
- Therefore, we think that PTP1B may play an important role in the development of heart failure induced by doxorubicin and can be used as a potential target for the treatment of heart failure. (frontiersin.org)
Nrf21
- SFN is able to induce cytoprotective enzymes through the transcription factor Nrf2. (weeksmd.com)
Chemotherapeutic1
- Administration of S1P has been shown to protect oocytes from chemotherapeutic agents in vitro, as well as in vivo from chemotherapeutic and radiation therapies. (wikipedia.org)
Vivo1
- Sphingolipid-targeting drugs have been tested alone or in combination with chemotherapy, exhibiting antitumor activity alone and in synergism with chemotherapy in vitro and in vivo . (frontiersin.org)
Mucositis4
- Ferroptosis was shown to be involved in 5-FU-induced intestinal mucositis, and TBHQ markedly hampered its activation. (biomedcentral.com)
- TBHQ attenuates ferroptosis in 5-FU-induced intestinal mucositis, making it a potential novel protective agent against intestinal mucositis. (biomedcentral.com)
- Very few drugs can ameliorate 5-FU-induced intestinal mucositis, making the development of effective drugs highly important. (biomedcentral.com)
- However, its role in chemotherapy-related intestinal mucositis has not yet been elucidated. (biomedcentral.com)
Cytokines1
- However, the administration of NP dramatically reversed all of the Cyp-induced alterations, inducing reductions in serum marker levels, stress level, the production of cytokines, and caspase expression. (bvsalud.org)
Histone1
- Histone demethylase RBP2 induced by Helicobactor Pylori CagA participates in the malignant transformation of gastric epithelial cells. (biossantibodies.com)
Evaluate3
- Aim: The present study aimed to evaluate the anti-diabetic activity in chemically induced experimental rats and explore the nature of phytocomponents that may produce this activity. (bvsalud.org)
- The purpose of this study was to evaluate whether SFN induces a cytoprotective effect on the CDDP-induced nephrotoxicity. (weeksmd.com)
- This will help provide evidence to evaluate chemotherapy and vaccine efficacy to these diseases especially in co-infection situations. (scirp.org)
Dysfunction2
- Lipoic acid increases the abundance of other protective antioxidants while improving mitochondrial function and preventing glycation-induced damage in the kidney and blood vessels of those with diabetes-thus defending against diabetic kidney disease, vision loss, and vascular dysfunction. (lifeextension.com)
- Chemotherapy agents can cause ovarian dysfunction and eventually lead to infertility. (ac.ir)
Intestinal2
- 7. Wang J, Li Y, Qi Y. Effect of glutamine-enriched nutritional support on intestinal mucosal barrier function, MMP-2, MMP-9 and immune function in patients with advanced gastric cancer during perioperative chemotherapy. (ac.ir)
- A major adverse effect of chemotherapy drugs is their impact on the intestinal mucosa. (biomedcentral.com)
Tissue2
- The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue - Evid Based Complement Alternat Med. (qualitycounts.com)
- In this study, proteomics and metabonomics techniques were used to analyze the tissue and plasma of DOX-induced heart failure (HF) in rats and to clarify the molecular mechanism of the harmful effects of DOX on cardiac metabolism and function in rats from a new point of view. (frontiersin.org)
Phosphorylation3
- and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. (biossantibodies.com)
- Ghrelin protects the myocardium with hypoxia/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and promoting the phosphorylation of protein kinase B. Int. J. Mol. (biossantibodies.com)
- Ghrelin protects the myocardium with hypoxia/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and promoting the phosphorylation of protein kinase B. (2018) Int.J.Mol.Med. (biossantibodies.com)
Metabolic1
- Lipoic acid displays striking benefits in components of metabolic syndrome, including inducing weight loss, improving insulin resistance, and lowering blood pressure. (lifeextension.com)
Antioxidant1
- The present findings suggested that NP exhibits potent antioxidant and anti-inflammatory activities that can protect rats' livers against Cyp-induced liver damage through hepatoprotective activities. (bvsalud.org)
Treatment2
- Until recently, there was no efficacious treatment for S. aureus -induced mastitis in either humans or animals. (oncotarget.com)
- To date, there are no effective and well-tolerated cytostatics for the palliative treatment of patients who are not suitable for aggressive anthracycline-based chemotherapy. (spandidos-publications.com)
Neuropathy2
- As the underlying cellular mechanisms remain incompletely understood pharmacotherapies for chemotherapy-induced neuropathy are limited. (gp120-inhibitors.com)
- Gabapentin, amytriptyline and opioids are used to treat chemotherapy-induced neuropathy. (gp120-inhibitors.com)
Obesity1
- This nutrient protects vital cellular energy and shields against diabetes, obesity, cardiovascular disease, and neurodegeneration. (lifeextension.com)
Immune responses1
- Adenoviruses can be genetically modified to increase their infectivity or improve the anti-cancer immune responses induced by the virus, e.g., through the expression of immunostimulatory molecules. (helsinki.fi)
Cells3
- Preincubation of LLC-PK1 cells with 0.5-5 microM SFN by 24 h was able to prevent, in a concentration-dependent way, CDDP-induced cell death. (weeksmd.com)
- Aung HH, Mehendale SR, Wang CZ, Xie JT, McEntee E. Cisplatin's tumoricidal effect on human breast carcinoma MCF-7 cells was not attenuated by American ginseng. (novapublishers.com)
- Lower DRI values may protect normal cells while selectively destroying tumor cells (Chou 2010). (pi3k-inhibitors.com)
Results showed1
- Our results showed that LYSO-induced S. aureus bacteriostasis increased with increasing concentrations of baicalin, and that baicalin binding to LYSO synergistically increased the antibacterial activity of LYSO. (oncotarget.com)
Therapy1
- Live-attenuated vaccines should be avoided for at least 3mo after cessation of immunosuppressive therapy. (medscape.com)
Oocytes1
- In animal models these protected oocytes have been used to produce healthy live young. (wikipedia.org)
Melatonin2
- The Effects of Melatonin on the Descending Pain Inhibitory System and Neural Plasticity Markers in Breast Cancer Patients Receiving Chemotherapy: Randomized, Double-Blinded, Placebo-Controlled Trial is het volledige studierapport vrij in te zien. (kanker-actueel.nl)
- This randomized, double-blinded, placebo-controlled trial tested the hypothesis that 20mg of melatonin before and during the first cycle of adjuvant chemotherapy for breast cancer (ACBC) reduced the side effects associated with cognitive impairment. (kanker-actueel.nl)
Patients2
- Today, it constitutes the standard of care for many cancer patients, along with surgery and chemotherapy. (springer.com)
- This symptomatology greatly weakens patients and may even lead to adjournment of chemotherapy. (mdpi.com)
Pathway1
- Leucine attenuates muscle atrophy and autophagosome formation by activating PI3K/AKT/mTOR signaling pathway in rotator cuff tears. (biossantibodies.com)
Diabetes1
- 2Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Spain. (faksignaling.com)
Respiratory1
- Moreover, the ketolides are associated with a low potential for inducing resistance, making them promising first-line agents for respiratory tract infections. (cdc.gov)
Effects1
- Adenoviruses, particularly, have shown to be safe, inducing only mild adverse side effects in clinical trials, making them a great candidate for further clinical development. (helsinki.fi)
Fever1
- Protects Against Malaria - Ginger root and ginger oil are effective against yellow fever and malaria as they have mosquito repelling qualities. (motherjai.com)
Activity1
- To test whether this binding increased LYSO activity, we assessed LYSO-induced bacteriostasis in the presence of baicalin. (oncotarget.com)