Rats apoptotic ischemia reperfusion. Medical search. Frequent questions

Sprague-Dawley (SD) rats were subjected to bilateral renal artery clamping for 45 min followed by perfusion restoration for establishing a simulated renal IRI model. (frontiersin.org)
Specific pathogen-free male Sprague-Dawley (SD) rats, weighing 200-250 g were purchased from the Laboratory Animal Center of Nanchang University (Nanchang, Jiangxi, China). (frontiersin.org)
Male Sprague-Dawley rats (270-330g) were divided into 4 groups randomly and were anesthetized by sodium pentobarbital (50-60 mg/kg-ip). (vin.com)
Forty male Sprague Dawley rats were randomized into 4 groups. (sci-rep.com)
Sprague Dawley rats were randomly assigned into 3 groups: Control, PAF-induced AR and PAF-induced AR with TRF treatment. (tocotrienolresearch.org)
The effect of propolis along with paclitaxel on 7,12 dimethyl benz(a)anthracene (DMBA) induced experimental breast cancer was investigated in female Sprague Dawley rats. (propoleo.cl)
Female Sprague Dawley rats were divided into five groups of six animals each. (propoleo.cl)
Forty Sprague Dawley (SD) rats were divided into four groups, and they were sham operation (Sham), sham + Anwu, II/R, and II/R + Anwu groups. (phcog.com)
MATERIALS AND METHODS: The inbred male Sprague-Dawley rats (age 65 days, weighing 190 ± 10 g) were used. (greenmedinfo.com)
METHODS: Male Sprague-Dawley rats (220-250 g) were divided into three groups, namely, sham, IR, and GSP groups (n = 8 each). (jnk-receptor.com)

Global cerebral ischemia followed by reperfusion, which leads to extensive neuronal damage, particularly the neurons in the hippocampal CA1 region. (springer.com)
Here we investigated whether remifentanil postconditioning exerts neuroprotective effects against global cerebral ischemia/reperfusion injury in rats and its potential mechanisms. (springer.com)
Global cerebral ischemia was performed via 10 min of four-vessel occlusion. (springer.com)
The results suggest that remifentanil postconditioning exhibits neuroprotective effects against global cerebral ischemia/reperfusion injury in rats, and its mechanisms might involve inhibition of neuronal apoptosis through the PI3K pathway. (springer.com)
Liang HW, Qiu SF, Shen J et al (2008) Genistein attenuates oxidative stress and neuronal damage following transient global cerebral ischemia in rat hippocampus. (springer.com)
Wang JY, Shen J, Gao Q et al (2008) Ischemic postconditioning protects against global cerebral ischemia/reperfusion-induced injury in rats. (springer.com)
The present study was designed to investigate the expression changes of PPAR-alpha, -beta, -gamma and NF-kappa B in the hippocampus of rats with global cerebral ischemia/reperfusion injury (GCIRI) after treatment with agonists or antagonists of PPAR-gamma. (biomedcentral.com)
Global cerebral ischemia/reperfusion injury (GCIRI) occurs in patients who are successfully resuscitated from various clinical conditions such as cardiac arrest, asphyxia and shock, which are frequently accompanied by inflammation and can lead to serious neuronal injury, and further to neurodegeneration and learning and memory impairment [ 12 ]. (biomedcentral.com)
Global cerebral ischemia is associated with delayed neuronal death. (asahq.org)
Its effects were evaluated on neuronal cell death and outcome after global cerebral ischemia. (asahq.org)
Global cerebral ischemia was induced by cardiocirculatory arrest. (asahq.org)

To evaluate the effects of dexmedetomidine on myocardial ischemia-reperfusion injury in rats and its anti-apoptotic role, as well as the mechanism by which it regulates Janus kinase 2/signal transducers and activators of transcription 3 signal. (ijpsonline.com)
Dexmedetomidine pretreatment can obviously relieve myocardial ischemia-reperfusion injury and cardiomyocyte apoptosis in rats probably by activating the Janus kinase 2/signal transducers and activators of transcription 3 signaling pathway. (ijpsonline.com)
When subjected to myocardial ischemia-reperfusion injury, Caspase3 transgenic mice showed increased infarct size and a pronounced susceptibility to die. (uniroma5.it)

Thirty Wistar rats were selected and divided into three groups (n = 10): acute ischemia-reperfusion (I/R) group, acute ischemia-reperfusion and treated with atorvastatin group and sham-operated group. (ac.ir)
METHODS: Hydroethanolic extract of P. crenulata leaves and fruits were tested for their analgesic potential in rodent models for algesia by tail immersion test, tail flick test, Eddy's hot plate model, and formalin induced paw irritation test in Wistar rats. (bvsalud.org)
Material and Methods: Twentyfour adult Wistar albino rats were divided into four groups after retinal ischemia was induced by elevating the intraocular pressure to 120 mmHg. (yeditepe.edu.tr)
039;s male wistar rats were divided into four groups of ischemia-reperfusion (IR), honey + ischemia-reperfusion (HIR), Busulfan (B) and Busulfan intraperitoneally+ honey (BH). (greenmedinfo.com)
Male Wistar rats were randomly divided into four groups (n = 6/each): healthy, healthy-troxerutin, diabetic, and diabetic-troxerutin. (kjpp.net)
Adult 18-month old female Wistar rats were allocated into sham-operated and OVX/D-Gal groups that were either left untreated or treated with DMF for 56 days starting three weeks after sham-operation or ovariectomy. (fue.edu.eg)

Inhaled methane limits mitochondrial electron transport chain dysfunction and confers protection against mitochondrial dysfunction during experimental liver ischemia-reperfusion injury [ 11 ]. (hindawi.com)
AIM: To explore the effect of grape seed proanthocyanidin (GSP) in liver ischemia/reperfusion selleckchem (IR) injury and alleviation of endoplasmic reticulum stress. (jnk-receptor.com)

Considering these results, we conclude that L-carnitine has a protective effect against cardiac ischemic reperfusion injuries as a reduction of apoptotic cardiomyocytes. (vin.com)
However, reperfusion following a period of prolonged ischemia can often cause myocardial ischemia-reperfusion (I/R) injury, leading to damage of cardiac tissues ( 5 ). (spandidos-publications.com)
Cardiac ischemia-reperfusion injury (IRI) occurs intra-operatively during heart transplantation (HTx), underpinning graft survival. (uwo.ca)
Cardiac ischemia-reperfusion injury (IRI) occurs when transplanting a heart from donor to recipient. (uwo.ca)
The "ischemia" phase of cardiac IRI occurs when the donor heart is being collected and blood/oxygen is not going to the heart. (uwo.ca)
This is known as the "reperfusion" phase in cardiac IRI. (uwo.ca)
It has been shown that the Fas pathway is functional in cardiac myocytes and plays a critical role in myocardial death due to ischemia-reperfusion in vivo [ 4 ]. (ac.ir)
In lpr mice, a naturally occurring mutant deficient in Fas, there is marked reduction in infarct size and abundance of apoptotic cardiac myocytes following ischemia and reperfusion that also signifies the importance of Fas pathway in ischemia-reperfusion injury [ 5 ]. (ac.ir)
Pretreating the rats with simvastatin 18 hour prior to the induction of ischemiareperfusion has been shown to reduce cardiac dysfunction and improve coronary flow [ 7 ]. (ac.ir)
In this study, rat model of cardiac fibrosis was induced by injected with 150 mg/kg/d Dgalactose for 8 weeks. (kjpp.net)
These results showed that mangiferin could ameliorate cardiac fibrosis in D-galactose-induced aging rats possibly via inhibiting TGF-β/p38/MK2 signaling pathway. (kjpp.net)
Therefore, the aim of this study was to investigate apoptosis in various cardiac diseases: in hyperlipidemia induced atherosclerosis, in acute rejected heart transplants, in ischemia and reperfusion as well as in chronic hypoxia. (uni-frankfurt.de)
Results: Twenty-one days after establishing ischemia- reperfusion, the right eyes were enucleated after cardiac glutaraldehyde perfusion method, and then submitted to histological evaluation. (yeditepe.edu.tr)
Expression of baculovirus p35 can improve survival after cardiac arrest in rats, but the mode and site of action remain to be elucidated. (asahq.org)
Cardiac tissue-specific overexpression of the proapoptotic gene Caspase3 was induced by using the rat promoter of a-myosin heavy chain, a model that may represent a unique tool for investigating new molecules and antiapoptotic therapeutic strategies. (uniroma5.it)

Thus, pioglitazone ameliorates renal IRI by inhibiting the NF-κB signaling pathway and inflammatory response in rats. (frontiersin.org)
Therefore, in this study, we aimed to investigate the molecular mechanisms underlying pioglitazone hydrochloride-mediated amelioration of renal IRI with respect to the nuclear factor-kappaB (NF-κB) signaling pathway and inflammatory response using a rat model. (frontiersin.org)
This study has investigated the effect of a potent bioflavonoid, troxerutin, on diabetes-induced changes in pro-inflammatory mediators and expression of microRNA-146a and nuclear factor-kappa-B (NF-κB) signaling pathway in aortic tissue of type-I diabetic rats. (kjpp.net)

Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney injury. (frontiersin.org)
Renal ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon in clinical settings. (frontiersin.org)
Hence, treatment strategies for orchitis should focus on the balance of inflammatory cytokines, removal of oxidative and apoptotic injury, and regulation of the PK2/PKR1 pathway. (hindawi.com)
has been demonstrated to attenuate renal ischemia‑reperfusion (I/R) injury. (spandidos-publications.com)
The neuroprotective effects of remifentanil preconditioning against cerebral ischemia/reperfusion injury have been recently reported. (springer.com)
We found remifentanil postconditioning markedly improved the spatial learning and memory as well as attenuated neuronal apoptosis in hippocampus caused by cerebral ischemia/reperfusion injury. (springer.com)
Zhou Y, Fathali N, Lekic T et al (2012) Remote limb ischemic postconditioning protects against neonatal hypoxic-ischemic brain injury in rat pups by the opioid receptor/Akt pathway. (springer.com)
Zhang Y, Irwin MG, Wong TM (2004) Remifentanil preconditioning protects against ischemic injury in the intact rat heart. (springer.com)
Yuan Y, Guo Q, Ye Z et al (2011) Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway. (springer.com)
Proinflammatory cytokines, such as interleukin (IL)-1β, IL-6 and tissue necrosis factor (TNF)-α, have been implicated as important mediators of injury following cerebral ischemia [ 13 ] and contribute to pathogenesis, exacerbating brain tissue damage following ischemia/reperfusion (I/R) injury [ 14 ]. (biomedcentral.com)
Compared to the myocardial ischemia group, the DOEO pretreatment groups had lower levels of myocardial injury, creatinine kinase, lactate dehydrogenase, alanine transaminase, aspartate transaminase, hydrogen peroxide, and nitric oxide, and higher levels of glutathione and superoxide dismutase. (wjtcm.net)
Atorvastatin has been shown to be cardioprotective in ischemia-reperfusion (I/R) injury. (ac.ir)
In addition, it has been shown that atorvastatin can protect the isolated mouse heart against reperfusion-induced injury [ 6 ]. (ac.ir)
It was shown that functional Fas system contributes to apoptotic myocardial cell death in response to ischemia/reperfusion injury [ 4 , 5 ]. (ac.ir)
Perinatal hypoxic-ischemic injury increased apoptotic cell death in the hippocampus, resulting in impaired short-term memory with decreased cAMP levels. (einj.org)
Neuronal apoptosis is closely associated with brain damage induced by ischemia/reperfusion injury [ 3 - 5 ]. (einj.org)
Ischemia reperfusion injury is one of the important injury factors in the process of cerebral infarction, and its pathological process is very complicated. (crimsonpublishers.com)
In the treatment of acute cerebral infarction, it is possible to remove the arterial thrombosis as early as possible, make the occlusion of the cerebral artery repasses, restore or improve the blood supply of the infarct area, prevent the ischemia reperfusion injury, save the ischemic penumbra, prevent the irreversible injury of ischemic brain tissue, and reduce the mortality and the rate of disability. (crimsonpublishers.com)
Safflower injection can correct the imbalance of thromboxane (TXA2) HJNKM / prostacyclin (PGI2) and abnormal changes of the ultrastructure of brain tissue in circulating blood after cerebral ischemia-reperfusion, and reduce the injury of cerebral ischemia reperfusion. (crimsonpublishers.com)
Apoptosis is an important way of neuronal death after cerebral ischemia-reperfusion injury. (crimsonpublishers.com)
Purpose: This study applies treatment methods to rat retina subjected to acute ischemia-reperfusion injury and compares by histopathological examination the efficacy of Memantine and hyperbaric oxygen therapy. (yeditepe.edu.tr)
The injury an organ sustains during recovery, preservation, and transplantation occurs primarily as a result of ischemia and hypothermia. (medscape.com)
Intestinal ischemia/reperfusion (II/R) can cause injury of remote organs, including acute renal injury. (phcog.com)
Therefore, we were curious to know if Anwu can have a protective effect on remote organ injury after II/R. The purpose of the present study was to examine the effect of Anwu on the remote renal injury induced by II/R in rats and investigate its mechanism. (phcog.com)
Anwu has a protective effect against the II/R-induced remote renal injury in rats, which may be related to its regulation of antioxidant, anti-inflammatory, and antiapoptotic pathways. (phcog.com)
PMID: 29791311 Abstract Title: Protective effects of persian honey, Apis Mellifera Meda Skorikov on side effects of chemotherapy and ischemia/reperfusion induced testicular injury. (greenmedinfo.com)
Abstract: Introduction The aim of the present study was to survey the protective effect of pretreatment with Persian honey on amelioration of side effects of chemotherapy and ischemia/reperfusion induced testicular injury. (greenmedinfo.com)
Mitochondrial dysfunction plays a central role in mediating both the necrotic and apoptotic components of reperfusion injury. (elsevierpure.com)
We also simultaneously investigated the nano-mechanical changes in rat heart mitochondria by injury using force-distance curve measurements. (elsevierpure.com)
Mild ischemia-reperfusion (IR) injury to diabetic peripheral nerve is known to cause severe ischemic fiber degeneration. (elsevierpure.com)
Protection of the heart against injury from acute ischemia remains challenging for emergency physicians and cardiologists because there are no therapies proven to directly protect the heart against the deleterious effects of ischemia in humans. (mcw.edu)
We also implicate Caspase3 in determining myocardial infarct size after ischemia-reperfusion injury, because its cardiomyocyte-specific overexpression increases infarct size. (uniroma5.it)

We investigated the effects of nilvadipine and amlodipine on the cerebral ischemia-induced impairment of spatial memory in 8-arm radial maze performance and hippocampal CA1 apoptosis in rats. (elsevierpure.com)

H9c2 rat cardiomyocyte cell line was obtained from the American Type Culture Collection (Manassas, VA, USA. (spandidos-publications.com)
Results were confirmed via H9C2 (rat cardiomyocyte) cell lines. (uwo.ca)
Upregulation of Fas expression in myocardial ischemia-reperfusion can induce cardiomyocyte apoptosis, and atorvastatin can significantly inhibit cardiomyocyte apoptosis by inhibiting Fas expression. (ac.ir)
Despite inducing ultrastructural damage, Caspase3 does not trigger a full apoptotic response in the cardiomyocyte. (uniroma5.it)

Perinatal hypoxic-ischemia is accompanied by neurodegeneration, including necrotic and apoptotic neuronal death [ 1 , 2 ]. (einj.org)

It has been proved that inhalation of methane also modulates leukocyte activation, affects key events of ischemia-reperfusion-induced oxidative stress, and has anti-inflammatory effects against ischemia-reperfusion damage [ 12 ]. (hindawi.com)
Rosiglitazone, a PPAR-gamma agonist, plays a protective role in hippocampal neuron damage of GCIRI rats by inhibiting the oxidative stress response and inflammation. (biomedcentral.com)
In this study, we evaluated oxidative stress and apoptosis of SC following mild IR, using immunohistochemistry in streptozotocin (STZ)-induced diabetic rats. (elsevierpure.com)
oxidative stress marker), caspase-3 (apoptotic executor), and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) activity (apoptotic indicator). (elsevierpure.com)

Cerebral infarction (cerebral infarction), also known as acute ischemic stroke (acute cerebral ischemic stroke), refers to the necrosis of the localized brain tissue caused by cerebral blood circulation disorder, ischemia and hypoxia. (crimsonpublishers.com)
Group 2: Memantine treatment group, animals were given single dose of intravenous 25 mg/ kg Memantine by tail vein route after inducing acute retinal ischemia. (yeditepe.edu.tr)
Group 3: Hyperbaric oxygen (HBO) therapy group, in two hours following acute retinal ischemia HBO treatment was applied for nine days. (yeditepe.edu.tr)
Group 4: Acute retinal ischemia model but without treatment (ARI). (yeditepe.edu.tr)
Conclusion: The present study shows that Memantine and HBO therapy was effective in reducing the damage induced by acute ischemiareperfusion in rat retina. (yeditepe.edu.tr)

The balance between pro-apoptotic and antiapoptotic Bcl-2 family members determines the mitochondrial response to apoptotic stimuli [ 11 ]. (einj.org)
We tested the hypothesis that 8-Br is also protective under clinically relevant conditions (regional ischaemia) when applied either before ischemia or at the beginning of reperfusion, and this effect is associated with the mitochondrial permeability transition pore (MPTP). (mdpi.com)

Abstract: CONTEXT: Effects of a radioprotective, standardized leaf extract (code SBL-1) from traditional medicinal plant, sea buckthorn [Hippophae rhamnoides L. (Elaeagnaceae)], on neurotransmitters and brain injuries in rats showing radiation-induced conditioned taste aversion (CTA), are not known. (greenmedinfo.com)

In rat renal tissue, pioglitazone treatment decreased the serum levels of post-renal IRI creatinine and urea nitrogen, as well as necrosis. (frontiersin.org)

In vitro, HL-1 cells (mouse cardiomyocytes) received chamber hypoxia-oxygenation reperfusion (H/R) for 24H4R with/without DLC1β plasmid, before collection for protein/mRNA analyses. (uwo.ca)
Numerous apoptotic cardiomyocytes were found in ischemic fields in ischemia-reperfusion groups and werent observed in the sham-operated group. (ac.ir)
Apoptosis of the cardiomyocytes has been demonstrated in animal models with coronary artery occlusion [ 1 ], and experimental evidence suggests that myocardial cells are able to undergo apoptosis during ischemia followed by reperfusion [ 2 ]. (ac.ir)

Danielisova V, Gottlieb M, Nemethova M et al (2009) Bradykinin postconditioning protects pyramidal CA1 neurons against delayed neuronal death in rat hippocampus. (springer.com)
We investigated the effects of pentoxifylline, a methylxanthine derivative and type-4 phosphodiesterase inhibitor, on short-term memory and apoptotic neuronal cell death in the hippocampus following perinatal hypoxic-ischemia in newborn rats. (einj.org)
Pentoxifylline treatment improved short-term memory by suppressing apoptotic cell death in the hippocampus with elevated cAMP levels. (einj.org)
According to the data, safflower injection has an obvious anti apoptotic effect on hippocampus in rats with cerebral infarction. (crimsonpublishers.com)
These results suggest that nilvadipine improved the memory impairment in repeated ischemia by reducing bax and CPP 32 expression and suppressing the induction of apoptosis in the hippocampus. (elsevierpure.com)

The production of antioxidant enzymes that scavenge free radicals in ischemic tissue is then impaired, thereby exacerbating the damage caused by these free radicals in the post ischemic reperfusion tissue. (frontiersin.org)

Ding ZM, Wu B, Zhang WQ et al (2012) Neuroprotective Effects of Ischemic Preconditioning and Postconditioning on Global Brain Ischemia in Rats through the same effect on inhibition of apoptosis. (springer.com)

A rat GCIRI model was established by occlusion of bilateral common carotid arteries and cervical vena retransfusion. (biomedcentral.com)
On the other hand, repeated cerebral ischemia (10 min ischemia × 2, 1 h interval) impaired spatial memory and induced hippocampal apoptosis 7 days after the final occlusion/reperfusion. (elsevierpure.com)

Methane-rich saline (MS), which is safer and more portable than methane gas, also has powerful anti-inflammatory, antioxidative, and anti-apoptotic properties [ 15 ]. (hindawi.com)
Recent basic and clinical research has revealed that hydrogen is an important physiological regulatory factor with antioxidant, anti-inflammatory and anti-apoptotic protective effects on cells and organs. (researchgate.net)

It was found that methane significantly prolonged rat survival, decreased the W/D ratio, alleviated LPS-induced histological changes, and reduced apoptotic cells in the testes. (hindawi.com)
OBJECTIVE: This study investigated the levels of neurotransmitters, antioxidant defences and histological changes in rats showing radiation CTA, and their modification by SBL-1. (greenmedinfo.com)

Fas expression was significantly higher in the ischemia-reperfusion group as compared to sham-operated group, but was decreased significantly in atorvastatin treated group as compared with I/R group. (ac.ir)
The average severity scores of AR were significantly higher in the PAF-induced AR rats compared to both control and PAF-induced AR with TRF treatment. (tocotrienolresearch.org)

Rosiglitazone treatment significantly protected rats from SLM function impairment and neuron death, and resulted in higher expressions of SOD activity and NF-kappa B, but lower contents of MDA and inflammatory factors. (biomedcentral.com)

Rats were randomly assigned into sham, model, experimental and control groups. (ijpsonline.com)
After reperfusion or sham operation, blood and kidneys were collected from the rats for the detection of relative biochemical parameters. (phcog.com)

To this end, the authors generated a transgenic rat line expressing baculovirus p35, a broad-spectrum caspase inhibitor, in central neurons. (asahq.org)
However, no differences were observed either in the number of terminal deoxynucleotidyltransferase-mediated d-uracil triphosphate-biotin nick end-labeling-positive cells or viable neurons in the cornu ammonis 1 sector or in the neurologic deficit score when comparing surviving transgenic and nontransgenic rats. (asahq.org)

Da in der Zellkultur protektive Effekte von NO gezeigt werden konnten, wurde deren physiologische Relevanz in der durch Ischämie/Reperfusion induzierten Apoptose ex vivo im Langendorff-Rattenherzen untersucht. (uni-frankfurt.de)

Protein extraction and purification kits, along with rabbit anti-rat peroxisome proliferator-activated receptor-gamma (anti-PPAR-γ), IκB kinase beta phosphorylation (anti-p-IKK-β), and inhibitor κB-alfa (IκB-α) antibodies were purchased from Wuhan Boster Biological Technology, Ltd., (Hubei, China). (frontiersin.org)
Zhang Y, Chen ZW, Girwin M et al (2005) Remifentanil mimics cardioprotective effect of ischemic preconditioning via protein kinase C activation in open chest of rats. (springer.com)
Moreover, immunohistochemical experiments showed that DOEO remarkably increased the protein levels of NF-E2-related nuclear factor 2 (Nrf2) and heme oxygenase-1 (HO-1) and reduced the expression of apoptotic caspases, including caspase 3 and caspase 9. (wjtcm.net)
Bcl-2 proteins are classified into 2 groups: the antiapoptotic protein Bcl-2 and the pro-apoptotic protein Bax [ 10 ]. (einj.org)
The expression levels of the apoptotic protein, cleaved caspase-3, were raised, while the B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated x protein (Bax) ratio was reduced. (phcog.com)

Restoration of blood supply, termed reperfusion, has been used to treat ischemic myocardium and prevent further tissue damage. (spandidos-publications.com)
Both ischemic and reperfused rat myocardium can undergo apoptotic cell death, however the myocardium, which is subjected to ischemia followed by reperfusion, undergoes accelerated apoptosis [ 3 ]. (ac.ir)

Ren C, Yan Z, Wei D et al (2009) Limb remote ischemic postconditioning protects against focal ischemia in rats. (springer.com)

Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling positive cells and expression of Bcl-2 and Bax in the hippocampal CA1 region were assessed after reperfusion. (springer.com)
In addition, remifentanil postconditioning enhanced the expression of anti-apoptotic gene Bcl-2 while suppressed the expression of pro-apoptotic gene Bax in hippocampal CA1 region. (springer.com)
In these rats, nilvadipine, but not amlodipine, significantly improved memory, concomitantly decreased hippocampal apoptosis, and suppressed both bax and CPP 32 expression. (elsevierpure.com)

However, one month treatment of diabetic rats with troxerutin restored glucose and insulin levels, significantly decreased expression of inflammatory genes and pro-inflammatory mediators and increased microRNA level in comparison to diabetic group (p (kjpp.net)
Beside slight improvement of hyperglycemia, troxerutin prevented the activation of NF-κB-dependent inflammatory signaling in the aorta of diabetic rats, and this response may be regulated by microRNA-146a. (kjpp.net)

Saccharin-preferring rats were selected using standard procedure and divided into groups. (greenmedinfo.com)
But, apoptotic cells in IR and B groups significantly increased (p<0.001), while in HIR and BH groups, the number of apoptotic cells decreased and the positive cells of TUNEL (TdT-mediated dUTP-X nick end labelling) staining were detected in spermatocytes and spermatid. (greenmedinfo.com)
Rats were randomly divided into 3 groups: control group (n=3), myocardial ischemia without reperfusion (PI group, n=3), and myocardial ischemia with reperfusion (IR group, n=4). (elsevierpure.com)

The cAMP analogue 8-Br-cAMP-AM (8-Br) confers marked protection against global ischaemia/reperfusion of isolated perfused heart. (mdpi.com)

Accordingly, the present study aimed to evaluate the effect of DMF on an experimental model of Alzheimer disease (AD) using D-galactose (D-Gal) administered to ovariectomized (OVX) rats, resembling a postmenopausal dementia paradigm. (fue.edu.eg)

Contusions may lead to local edema and ischemia with resultant neurologic deterioration, increased intracranial pressure (ICP) and intracranial hypertension, and brain herniation. (medscape.com)

Pentoxifylline ameliorated perinatal hypoxic-ischemia in rat pups. (einj.org)

Therefore, we hypothesized that DLC1β overexpression (OE) had anti-apoptotic effects. (uwo.ca)

At the end of reperfusion, Immunohistochemical detection of apoptotic cells was performed by using an in situ apoptosis detection kit. (vin.com)
The survival rate was assessed every 12 h until 72 h after LPS induction, and surviving rats were sacrificed for further detection. (hindawi.com)

The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)

Charron C, Messier C, Plamondon H (2008) Neuroprotection and functional recovery conferred by administration of kappa- and delta 1-opioid agonists in a rat model of global ischemia. (springer.com)

We aimed to determine the cellular stresses interaction that mediates PERK-induced apoptosis in tramadol-treated rats and to assess the effect of thyme in enhancing the antioxidant defense system in the face of such stresses. (sci-rep.com)

The left anterior descending coronary artery was ligated to construct the model of myocardial ischemia-reperfusion. (ijpsonline.com)
This study aimed to investigate the beneficial effects of intranasal Tocotrienol-rich fraction (TRF) on PAF-induced AR in a rat model. (tocotrienolresearch.org)

The histologic examination of the nasal structures showed moderate degree of inflammation and polymorphonuclear cells infiltration in the lamina propria, mucosa damage and vascular congestion in the PAF-induced AR rats. (tocotrienolresearch.org)

There are not enough reports about its anti-apoptotic effects during ischemia/reperfusion. (vin.com)
In this study, effects of L-Carnitine on apoptosis in the ischemic isolated rat hearts were investigated. (vin.com)
Jeong S, Kim SJ, Jeong C et al (2012) Neuroprotective effects of remifentanil against transient focal cerebral ischemia in rats. (springer.com)
DOEO has a therapeutic effect on MI by inhibiting the oxidant and apoptotic effects. (wjtcm.net)

Adult male rats were intraperitoneally (i.p.) injected with methane-rich saline (MS, 20 mL/kg) following LPS (5 mg/kg, i.p. (hindawi.com)

In healthy rats, troxerutin had significant reducing effect only on NF-κB, TNF-α and COXII levels (p (kjpp.net)

Anatomy34

Organisms13

Diseases30

Chemicals and Drugs107

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes40

Disciplines and Occupations1

Health Care2

Sprague-Dawley10

Global cerebral ischemia11

Myocardial ischemia-reperfusion injury3

Wistar6

Liver ischemia-reperfusion2

Cardiac15

Signaling pathway3

Injury32

Apoptosis in rats1

Cardiomyocyte4

Necrotic and apoptotic1

Oxidative4

Acute5

Mitochondrial2

Abstract1

Renal1

Cardiomyocytes3

Hippocampus5

Ischemic reperfusion1

Inhibition1

Occlusion2

Anti-inflammatory2

Histological changes2

Significantly higher2

Impairment1

Sham2

Transgenic2

Vivo1

Protein5

Myocardium2

Protects1

Hippocampal3

Diabetic rats2

Groups3

Confers1

Experimental1

Neurologic1

Pups1

Overexpression1

Detection2

Tissue1

Agonists1

Antioxidant1

Model2

Damage1

Effects4

Adult1

Effect1