• Strain susceptibility and resistance to 1,2-dimethylhydrazine-induced enteric tumors in germfree rats (40146). (cdc.gov)
  • 2001. beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol. . (oregonstate.edu)
  • The effect of the synthetic pineal peptide Epitalon® (Ala-Glu-Asp-Gly) on proliferative activity in colon tumors, and in mucosal epithelial cells adjacent to and located far from tumors was studied in rats. (spandidos-publications.com)
  • DMH induced proliferation of the secretory epithelium, and this phenomenon was accompanied by a decrease in the size of the stromal area and the area of lymph infiltration in colon tumors and in the colon mucosa adjacent to the tumors (group 1). (spandidos-publications.com)
  • Kossoy G, Zandbank J, Tendler E, Anisimov V, Khavinson V, Popovich I, Zabezhinski M, Zusman I and Ben-Hur H: Epitalon and colon carcinogenesis in rats: Proliferative activity and apoptosis in colon tumors and mucosa. (spandidos-publications.com)
  • 2. Russell-jone G, Mctavish K, Mcewan J, Rice J, Nowotnik D. Vitamin-mediated targeting as a potential mechanism to increase drug uptake by tumors. (jptcp.com)
  • As well, apple pectin decreases the incidence and number of dimethylhydrazine- and azoxymethane-induced colon tumors in rats. (indexarticles.com)
  • As with the former investigate, the rats fed whey protein concentrate confirmed much less tumors and a lowered pooled space of tumors (tumor mass index). (omineiro.net)
  • Symmetrical dimethylhydrazine is a potent carcinogen that acts as a DNA methylating agent. (wikipedia.org)
  • Rats in group 3 were treated with Epitalon after termination of the carcinogen injections. (spandidos-publications.com)
  • Experts fed rats different proteins and then subjected them to the highly effective carcinogen dimethylhydrazine. (omineiro.net)
  • Male Sprague Dawley rats were given subcutaneous injections of DMH (4 × 40 mg/kg body weight) (G1-G3) or vehicle (G4-G5) twice a week (weeks 3-4). (ugr.es)
  • Combination chemotherapy with 5-fluorouracil (5FU) and 1,3-bis(2-chloro-ethyl)-1-nitrosourea (BCNU) prolongs survival of rats with dimethylhydrazine-induced colon cancer. (bmj.com)
  • 2 Overall risk of colon cancer is approximately 5% in the general population without family history, with 92% of colorectal cancers diagnosed after age 50. (naturalmedicinejournal.com)
  • Those at greatest risk for colon cancer are carriers of 1 of 2 familial genetic disorders, familial adenomatous polyposis (FAP) or hereditary non-polyposis colon cancer (HNPCC), also known as Lynch syndrome. (naturalmedicinejournal.com)
  • In present investigation colon targeted AEQI formulation was prepared and evaluated by in vitro drug release study and in vivo study using 1,2-dimethylhydrazine(DMH) induced colon cancer in rats with or without diabetes. (biomedcentral.com)
  • Abbreviations used: ACF: aberrant crypt foci, CC: colon cancer, DMH: 1,2-dimethyl hydrazine, GSH: glutathione, IL-6: Interleukin-6, TNF-α: Tumor necrosis factor-alpha. (manipal.edu)
  • Overexpression of cyclin D1 and cyclin E in 1,2-dimethylhydrazine dihydrochloride-induced rat colon carcinogenesis. (ewha.ac.kr)
  • To investigate the expression pattern of G1 cyclins in 1,2- dimethyl-hydrazine dihydrochloride (DMH)-induced rat colon carcinogenesis, we studied the expression of cyclin D1 and cyclin E by quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis and immunohistochemistry (IHC). (ewha.ac.kr)
  • 1980. Inhibition by bran of the colonic cocarcinogenicity of bile salts in rats given dimethylhydrazine. (cdc.gov)
  • 15. Sharma SH, Chellappan DR, Chinnaswamy P, Nagarajana S. Protective effect of p-coumaric acid against 1,2 dimethylhydrazine induced colonic preneoplastic lesions in experimental rats. (jptcp.com)
  • Smith T, Mithen R, Johnson IT (2003) Effects of Brassica vegetable juice on the induction of apoptosis and aberrant crypt foci in rat colonic mucosal crypts in vivo . (quadram.ac.uk)
  • After 3.5 weeks on the experimental diets, the animals were given 2 injections of dimethylhydrazine, 25 mg/kg i.p. (usda.gov)
  • Weekly subcutaneous injections of 1,2-dimethethyhydrazine into 6-week-old rats markedly increased thymidylate synthetase (TS) in the poorly differentiated, and thymidine kinase in the well-differentiated adenocarcinomas of the colon. (cancerprev.org)
  • Eighty 2-month-old male LIO rats were exposed weekly to five subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg body weight. (spandidos-publications.com)
  • 1987. The influence of physical activity in 1 ,2dimethylhydrazine induced colon carcinogenesis in the rat. (cdc.gov)
  • OBJECTIVE: We investigated the effects of sambar as a preventive measure for 1,2-dimethyl hydrazine (DMH)-induced CC in Wistar albino rats. (manipal.edu)
  • A Buckwheat Protein Product Suppresses 1,2-Dimethylhydrazine-Induced Colon Carcinogenesis in Rats by Reducing Cell Proliferation. (healwithfood.org)
  • 1991. Control of 1,2-dimethylhydrazine-induced crypt hyperplasia by naturalkiller cells and its relevance to carcinogenics. (cdc.gov)
  • This study investigated whether the DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine (aza-dC) would alter the effect of dietary selenium (Se) on the formation of aberrant crypts. (usda.gov)
  • Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number. (raw-milk-facts.com)
  • The suppressive effects of two kinds of protease inhibitors, leupeptin and dietary camostate (FOY-305), on tumorigenesis and progression in 1, 2-dimethylhydrazine (DMH)-induced rat colon neoplasm were examined in relation to tissue cathepsin B activity. (elsevierpure.com)
  • A long-term cross-sectional analysis (2) of a cohort of 2512 Welshmen aged 45-59 living in Caerphilly, Wales between 1979 and 1983 found that lung function was linearly associated with dietary apple intake (Table 2). (indexarticles.com)
  • Various fractionations of dietary fiber are shown in Figure 10-1. (nationalacademies.org)
  • Unsymmetrical dimethylhydrazine 74-79-3 1,2-Dimethylhydrazine 1,2-Dimethylhydrazine from PubChem Record of 1,2-Dimethylhydrazin in the GESTIS Substance Database of the Institute for Occupational Safety and Health, accessed on 21 March 2008. (wikipedia.org)
  • Female Fischer-344-rats injected intraperitoneally with 60mg/kg unsymmetrical dimethyl- hydrazine (57147) (UDMH), 10mg/kg monomethyl- hydrazine (60344) (MMH) and/or 10mg/kg hydrazine (302012) did not have detectable amounts of these chemicals in their hair at 14, 30 or 42 days after injection. (cdc.gov)
  • Comparison of allergic parameters between whey protein concentrate and its hydrolysate in rat basophilic leukemia (RBL)-2H3 cells. (ircmj.com)
  • 1985. Spin-trapping of methyl radical in the oxidative metabolism of 1,2-dimethylhydrazine. (cdc.gov)
  • The in vivo antioxidant effects and the anti-inflammatory potential were tested on a rat turpentine oil-induced inflammation, by measuring serum nitric oxide (NOx) and TNF-alpha, total oxidative status (TOS), total antioxidant reactivity (TAR), oxidative stress index (OSI), 3-nitrothyrosine (3NT), malondialdehyde (MDA), and total thiols (SH). (hindawi.com)
  • The inhibition of cell proliferation and apoptosis on MDA-MB231 and MCF-7 cell lines occurred via the mitochondrial pathway and induction of oxidative damage to DNA through Bax/Bcl-2 modulation, decreased levels of procaspase-8, -9, -3, increased levels of cleaved caspase-3 and ROS, and also cell cycle arrest at S-phase (Jamali et al. (dieselok.md)
  • Lactobacillus plantarum TN627 significantly reduces complications of alloxan-induced diabetes in rats. (springer.com)
  • Buckwheat Protein Extract Ameliorates Atropine-Induced Constipation in Rats. (healwithfood.org)
  • This work was aimed at determining the antioxidant activity of an ethanol extract of Tetrapleura tetraptera fruits in rats administered DMH. (sarpublication.com)
  • Group 1 (positive control) contains rats without the administration of DMH, extract, or CMC. (sarpublication.com)
  • Group 2 (negative control) received DMH, 1 ml of 1% CMC, and no extract. (sarpublication.com)
  • The result showed that there was a significant increase in the activities of SOD, CAT, and GST in rats administered an extract of Tetrapleura tetraptera fruits compared to the negative control group. (sarpublication.com)
  • 1978. Effects of short-term administration of maleic hydrazide or hydrazine on rat hepatic microsomal enzymes. (cdc.gov)
  • 2006. Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats. . (oregonstate.edu)
  • Studies of the 'mucus-bicarbonate' barrier on rat fundic mucosa: the effects of luminal pH and a stable prostaglandin analogue. (bmj.com)
  • Biochem Biophys Res Commun 2:853-858. (cdc.gov)
  • The incidence ranges from 64.2 to 78.9 cases/100.000 person-years in the USA, and in Northern Europe, it is of 17 cases/100.000 person-years [ 2 ]. (hindawi.com)
  • Fischer 344 rats were fed these 16 diets, and we evaluated fecal and urinary fat oxidation and cytotoxicity, three biomarkers of heme-induced carcinogenesis promotion. (univ-toulouse.fr)
  • Carvacrol Exhibits Anti-oxidant and Anti-inflammatory Effects against 1, 2-dimethyl Hydrazine Plus Dextran Sodium Sulfate Induced Inflammation Associated Carcinogenicity in the colon of Fischer 344 Rats. (dieselok.md)
  • Studied factors, in a 2 × 2 × 2 × 2 design, were muscle color (a proxy for heme level), processing temperature, added nitrite, and packaging. (univ-toulouse.fr)
  • On the contrary, a significant rise in the liver nitrite levels was observed in the sambar-treated rats. (manipal.edu)
  • 2008. Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. . (oregonstate.edu)
  • Colorectal cancer (CRC) is the third most common cancer 1 and the second leading cause of cancer deaths in the United States. (naturalmedicinejournal.com)
  • These genetic disorders account for 1-2% and 3-5% of all colorectal cancers, respectively. (naturalmedicinejournal.com)
  • While IBD-related colorectal cancers account for only 1-2% of all CRC cases, CRC accounts for 10-15% of deaths in patients with IBD. (naturalmedicinejournal.com)
  • 2003. Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. . (oregonstate.edu)
  • Our results indicate that the overexpression of cyclin D1 and cyclin E may play an important role during the multistage process of rat colon carcinogenesis, at a relatively early stage, and may disturb cell-cycle control in benign adenomas, and thereafter, participate in tumor progression. (ewha.ac.kr)
  • Anti-ß-LGB antibodies, ZO-1, LPS, and sCD14 may be putative predictors of intestinal barrier dysfunction in these cohorts. (bvsalud.org)
  • 3H-dialkylhydrazines in the neuroendocrine system and their antigonadotropic effect in rats. (cdc.gov)
  • Epitalon attenuated this effect, especially when the treatment was continued throughout the experiment (group 2). (spandidos-publications.com)
  • Control rats (group 1) received saline at a dose of 0.1 ml during the entire experiment. (spandidos-publications.com)
  • Rats in group 2 were treated with Epitalon at a dose of 1 µg, five times a week, for 6 months, from the first injection of DMH till the end of the experiment. (spandidos-publications.com)
  • Despite the availability of multiple therapeutic options such as radiation, chemotherapy, curative resection, and immunotherapy, the early signs of GI cancers are generally undetectable and identified at an advanced stage, leaving patients with limited treatment options, and a poor prognosis ( 2 ). (frontiersin.org)
  • 1,2) Additionally, pectins and pectin-like rhamnogalacturonans found in apples have pronounced antimutagenic effects in vitro. (indexarticles.com)
  • Figure 1: Baseline muscle physiology from 8 week old mice. (angelisms.com)
  • Journal of Veterinary Science , 1 (2), 121-126. (ewha.ac.kr)
  • Journal of the Japanese Society of Nutrition and Food Science, 53 (2), 71-75. (healwithfood.org)
  • In the ME/CFS cohort, ZO-1 was positively correlated with the COMPASS-31 score (P (bvsalud.org)
  • Researchers (1) documented a statistically significant inverse relationship between lung cancer risk and food sources high in the flavonoid quercetin (onions and apples) after controlling for smoking and intakes of saturated fat and [beta]-carotene in a population-based, case-controlled study conducted in Hawaii (Table 1). (indexarticles.com)
  • doi:10.7287/peerj.9626v0.1/reviews/1, Soković, M., Glamoclija, J., and Ciric, A. Thymol also caused a decrease in cell viability of prostate cancer (PC-3 cell line), and provoked cytotoxic effects (Pathania et al. (dieselok.md)
  • The relation between antioxidants and degenerative diseases is a topic that focuses the attention of many researchers nowadays [ 1 ]. (hindawi.com)
  • Moreover, ellagic acid reduced the COX-2-induced exacerbation of inflammation. (hindawi.com)
  • Results: FM patients had significantly higher levels of anti-ß-LGB, ZO-1, LPS, and sCD14 than healthy controls (all P (bvsalud.org)
  • In the FM and ME/CFS cohorts, both anti-ß-LGB and ZO-1 correlated significantly with LPS and sCD14 (P (bvsalud.org)