Rationale bone marrow or peripheral chemotherapy with autologous stem cell transplantation. Medical search. Frequent questions

2. [High-dose therapy and hematopoietic cell autotransplantation in the treatment of adult gynecologic tumors]. (nih.gov)
14. Immune reconstitution after autologous hematopoietic stem cell transplantation in relation to underlying disease, type of high-dose therapy and infectious complications. (nih.gov)
18. [Is still there an indication for high-dose chemotherapy with hematopoietic stem-cell support in the treatment of germ-cell tumors? (nih.gov)
Slavin pioneered the use of immunotherapy mediated by allogeneic donor lymphocytes and innovative methods for stem cell transplantation for the cure of hematological malignancies and solid tumors, and using hematopoietic stem cells for induction of transplantation tolerance to bone marrow and donor allografts. (wikipedia.org)
The association of body composition parameters and outcomes has not been deeply investigated in patients with autologous hematopoietic stem cell transplantation (HSCT) recipients with non-Hodgkin lymphoma (NHL). (bvsalud.org)
While SC transplants are the standard of care for hematopoietic cancers and are gaining acceptance in the treatment of burns and corneal disorders, pioneering SC therapies directed at the regeneration of other tissues and organs (that is, the promise of regenerative medicine) are few in number, use adult rather than embryonic stem cells, and are in the early stages of clinical investigation. (biomedcentral.com)
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. (curehunter.com)
Compelling evidence for the efficacy of immunotherapy in eliminating minimal residual disease (MRD) is demonstrated by the improved outcomes after hematopoietic stem-cell transplantation (HSCT) due to donor T cells targeting AML and LSC. (broadcastmed.com)
Acute myeloid leukemia (AML) is a clonal hematopoietic stem cell disorder, usually characterized by ≥20% bone marrow blasts and is associated with significant mortality and morbidity. (ashpublications.org)

As such, innovative reduced intensity conditioning (RIC) or non-myeloablative stem cell transplantation (NST) was pioneered by Slavin for safer stem cell transplantation for the treatment of malignant and life-threatening non-malignant disorders correctable by using stem cells and post-transplant immunotherapy if indicated for all patients in need. (wikipedia.org)
Using a retrospective approach in DLBCL patients undergoing autologous stem cell transplant (AHSCT), we evaluated the association of hypomagnesemia with survival. (nature.com)
High pre-transplant VATD was associated with lower OS and higher NRM, and low pre-transplant VAT was associated with worse RFS in patients with NHL undergoing autologous HSCT. (bvsalud.org)
This study analyzed 69 participants who were receiving immunosuppressive therapy (IS) for solid organ transplant, bone marrow transplant, and/or chronic inflammatory disease. (covidreference.com)
3 In the majority of patients with AML, unless intense consolidative strategies such as allogeneic stem cell transplant are undertaken, the relapse rates are high. (ashpublications.org)
Importantly, the cells are not a permanent transplant and are ultimately cleared from the body, which also contributes to their consistent safety profile. (smithonstocks.com)

Few studies have reported whether a serum magnesium level below the reference range (RR) is associated with prognosis in patients with diffuse large B cell lymphoma (DLBCL). (nature.com)
Diffuse large B cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL) 1 . (nature.com)
Therapies that demonstrate durable, long-term responses with manageable safety and tolerability are needed for patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). (bvsalud.org)

In early 1987 Slavin introduced the concept of cancer immunotherapy using donor lymphocytes infusion (DLI) for the treatment and prevention of recurrent disease and pioneered the use of adaptive allogeneic cell-mediated immunotherapy and cytokine-activated lymphocytes for both treatment and prevention of relapse following allogeneic and autologous stem cell transplantation for hematologic malignancies and solid tumors. (wikipedia.org)
The article by Dr. Burt provides an excellent summary of the rationale for using high-dose therapy with autologous or allogeneic bone marrow transplantation (BMT) in patients with severe autoimmune diseases (SADS). (cancernetwork.com)
In this situation, only a replacementof the defective stem-cell compartment using allogeneic transplantationwould be likely to lead to long-term disease remissions. (cancernetwork.com)
Althoughthere is evidence that allogeneic transplantation can lead to long-termdisease remissions in patients with aplastic anemia and coincidental autoimmunedisease, given the 20% to 30% treatment-related mortality, it is unlikelythat this approach can be justified for the majority of patients with autoimmunedisease. (cancernetwork.com)
Since it remains unclear whether allogeneic transplantation will berequired for reversal of human autoimmune diseases, it seems prudent tofirst test its efficacy using the least toxic procedure. (cancernetwork.com)
We have previously shown that allogeneic umbilical cord blood-derived (UCB) regulatory T cells (Tregs) can resolve inflammation and treat acute and immune-mediated lung injuries. (bvsalud.org)

There have also been improvements in the therapy of those patients who relapse after AHSCT with the recent approval of CAR-T cell therapy 14 . (nature.com)
even with intensive myeloablative chemotherapy, relapse is common and almost uniformly fatal. (nih.gov)
These residual cells cause relapse, resulting in poor overall survival. (broadcastmed.com)
To increase relapse-free survival, the patient's AML cells are engineered to express a novel combination of immune-stimulatory proteins that stimulate the patient's immune system to kill residual AML. (broadcastmed.com)
A: There is an unmet need for new and effective therapies for AML because most patients relapse and die, despite initial chemotherapy-induced remission and consolidation. (broadcastmed.com)
This is because current treatments fail to eradicate quiescent leukemic stem cells (LSC) and AML blasts that are the source of relapse. (broadcastmed.com)

19. A phase I dose escalation study of high-dose thiotepa, melphalan and carboplatin (TMCb) followed by autologous peripheral blood stem cell transplantation (PBSCT) in patients with solid tumors and hematologic malignancies. (nih.gov)
These observations that confirmed the therapeutic benefits of cell therapy led to the development of new concepts for the treatment of hematologic malignancies and solid tumors focusing on utilizing well-tolerated non-myeloablative stem cell transplantation as a platform for cell therapy of cancer targeting killer cells against chemotherapy-resistant malignant cells. (wikipedia.org)

Upon returning to Jerusalem, he opened the first Bone Marrow Transplantation Center at the Hadassah University Hospital, which was later recognized as Israel's National Bone Marrow Transplantation and & Cancer Immunotherapy Center. (wikipedia.org)
The urgent need for novel treatments inspired me to pursue a research project in adoptive immunotherapy, genetically modifying Tcells to express artificial T cell receptors, termed chimeric antigen receptors (CARs), that target AML specific antigens. (stanford.edu)
Besides modeling cancer, the further applications of this technology includes high-throughput drug screening, epigenetic reprogramming of cancer cell state to normal, immunotherapy and regenerative cell therapies. (biomedcentral.com)

In summary, the SFB1530 will undertake a holistic and interdisciplinary effort, which will create a comprehensive inventory of the major patho-mechanisms that define high-risk B cell malignancies in their specific microenvironment as a molecular framework for mechanism-based therapies. (sfb1530.de)

This phase I trial studies the best dose and side effects of CD19/CD22 chimeric antigen receptor (CAR) T cells when given together with chemotherapy, and to see how well they work in treating children or young adults with CD19 positive B acute lymphoblastic leukemia that has come back or does not respond to treatment. (stanford.edu)
Giving CD19/CD22-CAR T cells and chemotherapy may work better in treating children or young adults with B acute lymphoblastic leukemia. (stanford.edu)

7. Curative cancer chemotherapy. (nih.gov)
RIC or NST made it possible to apply much safer curative stem cell transplantation for every patient in need with no lower or upper age restriction, including patients with less than optimal clinical conditions that would not be eligible for the standard myeloablative stem cell transplantation. (wikipedia.org)
Although chemotherapy has been effective in eradicating micrometastatic disease in some conditions and remains a principal determinant of success, the toxicity associated with current cytotoxics is substantial, and current agents have not proven curative in several clinical groups. (medscape.com)

8. Long-term results of first-line sequential high-dose etoposide, ifosfamide, and cisplatin chemotherapy plus autologous stem cell support for patients with advanced metastatic germ cell cancer: an extended phase I/II study of the German Testicular Cancer Study Group. (nih.gov)
11. Long-term haematological recovery following high-dose chemotherapy with autologous bone marrow transplantation or peripheral stem cell transplantation in patients with solid tumours. (nih.gov)
1] Furthermore,early reports from Europe imply that unmanipulated peripheral blood orbone marrow autografts are inadequate, as all of the patients who receivedsuch grafts developed disease recurrence after high-dose chemotherapy. (cancernetwork.com)
All patients will receive 4 VRD cycles as induction and undergo peripheral blood stem cell mobilization and harvesting. (biomedcentral.com)
Merchant and colleagues also suggest that T-cell-depleting cancer therapies may eliminate beneficial immune responses and that immune reconstitution of patients with lymphopenic cancer could prevent metastatic recurrence of solid tumors. (medscape.com)
We conducted a retrospective cohort study of 264 NHL patients who received autologous HSCT. (bvsalud.org)
With greater accessibility and an increased number of patients being treated with CAR T cell therapy, real-world toxicity continues to remain a significant challenge to its widespread adoption. (bvsalud.org)
Patients must have received at least one prior chemotherapy regimen for their acute myeloid leukemia (AML) and they may have received any type of chemotherapy. (survivornet.com)
Dr. Karin Gaensler's pursuit of a therapeutic cancer vaccine continues with the development of TriLeukeVax (TLV), an engineered autologous leukemia vaccine for stimulating cytolytic immune responses to residual leukemic stem cells, to provide a new option for older patients relapsing with adult acute myelogenous leukemia-also known as acute myeloid leukemia (AML). (broadcastmed.com)
Most older patients with AML have dismal outcomes due to the persistence of residual AML cells. (broadcastmed.com)
A liposomal formulation of AraC and anthracycline (Vyxeos) has shown promise in patients with secondary AML evolving after prior chemotherapy. (broadcastmed.com)
Small study (n = 12), showing that immune responses to SARS-CoV-2 mRNA vaccines are induced in most patients who have been treated with CAR-T cell therapies targeting B cell lineage antigens. (covidreference.com)
S-specific T cells were polyfunctional but expressed more activation markers in patients than in controls. (covidreference.com)
Typically, patients with AML-MRC experience low remission rates following intensive chemotherapy and a median overall survival of merely 9-12 months. (encyclopedia.pub)
As a result of the unique properties of the special cells that comprise MultiStem, material taken from the bone marrow of a single, healthy donor can be expanded to create enough product to treat hundreds of thousands or millions of patients. (smithonstocks.com)
We analyzed ERG , BAALC , and MN1 expression levels in a cohort of 210 patients with CN-AML who received intensive chemotherapy. (ascopubs.org)

More recently, he's been working on the use of multi-potent mesenchymal stem cells (MSCs) in regenerative medicine for the treatment of neurological, systemic, and orthopedic disorders. (wikipedia.org)
The discovery of human embryonic stem cells (hESCs) in the year 1998 has revolutionized the field of stem cells and regenerative medicine because of the remarkable potential of hESCs to differentiate into any cell types of the body [ 3 ]. (biomedcentral.com)
The main focus of the company is in regenerative medicine and cell therapy. (smithonstocks.com)

The backbone of cancer therapy in pediatric oncology has been stepwise integration of multimodality therapies (eg, chemotherapy, surgery, radiation therapy) into carefully designed treatment regimens tested sequentially through multicenter randomized trials. (medscape.com)
Furthermore, it is often less responsive to standard intensive induction chemotherapy regimens, likely due to both disease biology and clinical characteristics of the patient population that it affects [ 6 ] . (encyclopedia.pub)

Thereafter they will be treated with high dose melphalan therapy plus autologous stem cell transplantation followed by 2 cycles of VRD consolidation and lenalidomide maintenance. (biomedcentral.com)
This phase III trial is designed to evaluate whether the addition of elotuzumab to an intensified treatment concept with high dose melphalan chemotherapy plus autologous stem cell transplantation and induction, consolidation and maintenance treatment with bortezomib and lenalidomide is able to improve PFS compared to the same concept without elotuzumab. (biomedcentral.com)

Acute myeloid leukemia (AML) is a disease of the myeloid lineage of blood cells that results in a block in differentiation of myeloid cells and uninhibited growth of leukemic blasts that constrain the growth of normal blood cells [ 1 ] Clinical sequelae often include malaise and fatigue, infections, bleeding and/or bruising, and possibly bone pain [ 1 ] . (encyclopedia.pub)
The 2008 WHO defined AML-MRC as ≥20% myeloid blasts in the bone marrow or peripheral blood and one or more of the following features: a prior history of myelodysplastic syndrome (MDS) or an MDS/myeloproliferative neoplasm (MPN) overlap syndrome, dysplasia in 50% or more of the cells in two or more myeloid lineages, or myelodysplasia-related cytogenetic abnormalities (Table 1) [ 5 ] . (encyclopedia.pub)

The purpose of this initiative is to encourage research aimed at providing a better understanding of the differences between stem/progenitor cells from different sources such as bone marrow, peripheral circulation of children and adults and placental/cord blood. (nih.gov)
6. Bone marrow and peripheral blood stem cell transplantation for malignancy. (nih.gov)
9. Randomized trial of high-dose chemotherapy with autologous peripheral-blood stem-cell support compared with standard-dose chemotherapy in women with metastatic breast cancer: NCIC MA.16. (nih.gov)
17. Rationale for very high-dose chemotherapy with peripheral blood stem cell support in advanced ovarian cancer. (nih.gov)
The cells that have the inherent property of innate and adaptive immunity within the body are present at different sites including the blood, lymphatic system (lymph, lymphoid nodules and lymphoid organs), epithelium, and connective tissues. (medscape.com)
AML is a blood cancer in which the bone marrow makes many abnormal blood cells. (broadcastmed.com)
The haematological neoplasms originate by the myeloid or the lymphoid cell lines, historically named leukaemias or lymphomas, based on the prevalent location in the blood or the lymph nodes, respectively. (hindawi.com)
Systemic VSV therapy reduced systemic C1498-green fluorescent protein (GFP) tumor burden in the blood, bone marrow, spleen, and liver of mice with AML. (ashpublications.org)
They then release proteins that promote local cell growth and also aid in the creation of new blood vessels to nourish the local tissue. (smithonstocks.com)

1. [High-dose chemotherapy with stem cell support for solid tumors in adults]. (nih.gov)
3. [High-dose chemotherapy and autologous bone marrow transplantation in solid tumors. (nih.gov)
12. High-dose chemotherapy with stem cell reinfusion and growth factor support for solid tumors. (nih.gov)
16. High-dose chemotherapy with bone marrow support for solid tumors. (nih.gov)

For autologous transplantation to be successful, the reinfusion of alymphocyte-purged product appears to be essential. (cancernetwork.com)

Baxter International recognized the potential of cell therapy and signed an agreement which resulted in significant investment with Slavin at Hadassah Medical Center for further development of new approaches based on cell therapy for the treatment of cancer, autoimmune diseases, and organ transplantation based on new methods for regulation rather than non-specific suppression of the immune system. (wikipedia.org)

Multiple myeloma (MM) is a malignancy of plasma cells and is the second most common hematological malignancy. (biomedcentral.com)

Even though these cells are taken from a human donor, they do not trigger an immune response when given to an unrelated patient and do not require the concomitant use of immunosuppressive drugs. (smithonstocks.com)

In 1975-1978, Slavin trained in clinical immunology/rheumatology at the Division of Immunology, Stanford University School of Medicine and later on in 1978, trained in clinical bone marrow transplantation under the late E.D. Thomas at the Fred Hutchinson Cancer Research Center in Seattle, Washington. (wikipedia.org)
Stem cell (SC) therapies hold remarkable promise for many diseases, but there is a significant gulf between public expectations and the reality of progress toward clinical application. (biomedcentral.com)
In parallel to my clinical training, I constructed an AML specific CAR and demonstrated its ability to redirect T cell function mediating eradication of AML cells. (stanford.edu)
I don't know if Athersys and Neuralstem have the best approaches to stem cell therapies, as I have not carefully analyzed most of the companies in the space and clinical trial data across the industry is limited at this early stage of development. (smithonstocks.com)

Stem cell (SC) therapies hold remarkable promise, particularly in the management of diseases and conditions for which there are currently limited or no treatment options [ 1 ]. (biomedcentral.com)

Important studies to be pursued entail the characterization of stem/progenitor cells for self-renewal, proliferation, and expansion and the mechanisms involved in these processes. (nih.gov)

Improved patient outcomes can only be achieved in an interdisciplinary approach and strengthening of synergies towards the discovery of pathomechanisms and the identification of innovative therapeutic strategies beyond the lymphoma cell-autonomous level. (sfb1530.de)

In doing so, the overarching goal of the Collaborative Research Center is to create and strengthen synergies towards the discovery of patho-mechanisms and the identification of innovative therapeutic strategies beyond the lymphoma cell-autonomous level. (sfb1530.de)
The SFB1530 brings together the synergistic combination of efficient disruption of lymphoma cell-intrinsic oncogenic programs and a specific modulation of the lymphoma (immune) microenvironment. (sfb1530.de)
Macrophages in the B-cell lymphoma microenvironment represent a functional node in progression and therapeutic response. (sfb1530.de)
Pentose phosphate pathway (PPP) inhibition by specific compounds and shRNA targeting induced increased phagocytic lymphoma cell clearance. (sfb1530.de)
Moreover, macrophages provided decreased support for survival of lymphoma cells. (sfb1530.de)
Addition of the PPP inhibitor S3 to antibody therapy achieved significantly prolonged overall survival in an aggressive B-cell lymphoma mouse model. (sfb1530.de)
Sixty-six cases with lymphoma (in the majority of cases B-cell neoplasms), 28 with leukaemia (chronic lymphocytic form in 9), 14 with multiple myeloma plus one solitary IgM plasmocytoma, and 16 with myeloproliferative disorders were found. (hindawi.com)

However, aberrant cell death can interfere with such programs and cause organ failure. (sfb1530.de)

RATIONALE: Drugs used in chemotherapy, such as idarubicin and cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. (survivornet.com)
Pravastatin may also help idarubicin and cytarabine work better by making cancer cells more sensitive to the drugs. (survivornet.com)
Giving idarubicin and cytarabine together with pravastatin may kill more cancer cells. (survivornet.com)

This is my initial report on Athersys (ATHX) and its adult stem cell therapy product MultiStem. (smithonstocks.com)
Stem cell therapy has been the object of intense media and investor interest. (smithonstocks.com)
The first thing that comes to mind with the mention of stem cell therapy is the transplantation of stem cells that form (i.e. differentiate into) other tissues and permanently engraft into the body. (smithonstocks.com)
In vivo evaluation of the bystander effect in mouse models demonstrated that for effective therapy, at least 1% of tumor cells need to be delivered with TK-NTR-encoding MCs. (regenerativemedicine.net)
These results suggest that MC delivery via microvesicles can mediate gene transfer to an extent that enables effective prodrug conversion and tumor cell death such that it comprises a promising approach to cancer therapy. (regenerativemedicine.net)

Evidence currently suggests that the mechanisms responsible for resistance to cytotoxic agents generally do not confer resistance to immune-mediated mechanisms of tumor-cell killing. (medscape.com)
T cells are potent tumor cell killers that recognize peptides derived from the target cell (extracellular or intracellular) but must be presented by major histocompatibility complex (MHC) molecules. (medscape.com)

Drugs used in chemotherapy, such as fludarabine phosphate and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (stanford.edu)
However, MultiStem does not engraft and it has other properties that make it more like small molecule drugs than products based on living cells. (smithonstocks.com)

Innate immunity includes the role of toll-like receptors (TLRs) in improving antitumor and vaccine responses, muramyl tripeptide phosphatidylethanolamine (MTP-PE) in osteosarcoma, and natural killer (NK) cell-killer immunoglobulinlike receptor (KIR) mismatch. (medscape.com)
Our team uses the patient's cancer cells to create a personalized vaccine that will be given after chemotherapy to stimulate the body's immune response to attack any residual leukemia cells the body may still harbor. (broadcastmed.com)
These irradiated, engineered AML cells would be injected as a vaccine after chemotherapy. (broadcastmed.com)

In contrast, a patient with systemic sclerosis who was transplantedwith a CD34-selected, T-cell-depleted autograft (0.04 ×10 6 CD3 cells/kg body weight) after conditioning with 200 mg/kg of cyclophosphamide(Cytoxan, Neosar) showed significant disease improvement, although clearlylonger-term follow-up will be required to confirm this effect. (cancernetwork.com)

This initiative, Human Stem Cell Sources and Transplantation Biology, is related to the priority area of maternal and infant health and cancer. (nih.gov)
Induced Pluripotent Stem Cells (iPSCs) technology has catapulted the field of stem-cell biology through ectopic expression of reprogramming factors. (biomedcentral.com)

If the triggering environmental stimulus persists and there is an inherentpropensity of the stem cells to produce autoreactive lymphocytes due tothis antigen, there is little chance that a more aggressive form of immunosuppressioncould completely eradicate the disease. (cancernetwork.com)
B cells are professional antigen-presenting cells (APCs) that generate antibodies in response to a foreign antigen. (medscape.com)

Short hairpin RNA (shRNA)-mediated knockdown of ALK expression in neuroblastoma cell lines with the F1174L mutation also resulted in apoptosis and impaired cell proliferation. (nih.gov)
Expression levels of ERG , BAALC , and MN1 were determined in bone marrow samples by using oligonucleotide microarrays. (ascopubs.org)
We demonstrated that MCs can be loaded into shed microvesicles with greater efficiency than their parental plasmid counterparts and that microvesicle-mediated MC delivery led to significantly higher and more prolonged transgene expression in recipient cells than microvesicles loaded with the parental plasmid. (regenerativemedicine.net)
Microvesicles loaded with MCs encoding a thymidine kinase (TK)/nitroreductase (NTR) fusion protein produced prolonged TK-NTR expression in mammary carcinoma cells. (regenerativemedicine.net)

Using procedures developed by Slavin and his team, treatment of cancer is based on bright rather than aggressive treatment with conventional chemotherapy, which is associated with immediate and late procedure-related toxicity and mortality, aiming at selective elimination of all malignant cells including cancer stem cells. (wikipedia.org)
In contrast, if temporary exposure to an environmental trigger led toautoreactivity, aggressive immunosuppression followed by the replacementof autologous stem cells might be sufficient for long-term control. (cancernetwork.com)

The ultimate goal is to identify the most appropriate cell populations capable of sustaining long-term hematopoiesis in humans treated for malignant and non-malignant diseases. (nih.gov)

Reprogramming somatic cells has a long history back in the year 1966 when adult frog was developed by nuclear transplantation of differentiated somatic cell nuclei. (biomedcentral.com)
After success of nuclear transfer technology in frog, various animal models including sheep which has resulted in the generation of Dolly from cells derived from the adult mammary glands [ 2 ]. (biomedcentral.com)
I have previously written on another adult stem cell company, Neuralstem (CUR), and I am following with this report on Athersys. (smithonstocks.com)
Athersys' lead product MultiStem is an adult stem cell that has very interesting properties. (smithonstocks.com)

Also to be studied are the immune cells present in the different tissue sources, and the mechanisms of their action in graft vs. host disease, and in graft vs. leukemia effect. (nih.gov)

3] Sinceapproaches to remove lymphocytes that have little impact on treatment-relatedtoxicity are available,[4] the theoretical benefit from these purging proceduresseems to be warranted if autologous transplantation is used. (cancernetwork.com)

These cells referred to as induced pluripotent stem cells (iPSCs) exhibit similar morphological, proliferative, genomic and phenotypic characteristics as hESCs as well as express analogous cell surface antigens. (biomedcentral.com)

In vitro, abrogation of cFLIP cleavage sensitizes cells to tumor necrosis factor(TNF)-induced necroptosis and apoptosis by favoring complex-II formation. (sfb1530.de)

Neuroblastoma, an embryonal tumour of the peripheral sympathetic nervous system, accounts for approximately 15% of all deaths due to childhood cancer. (nih.gov)
Pravastatin may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. (survivornet.com)
A CAR is a genetically-engineered receptor made so that immune cells (T cells) can attack cancer cells by recognizing and responding to the CD19/CD22 proteins. (stanford.edu)
Cancer Cell November 15, 2021. (covidreference.com)
The foremost question is what makes a cancer cell a cancer cell? (biomedcentral.com)

Anatomy29

Organisms9

Diseases55

Chemicals and Drugs43

Analytical, Diagnostic and Therapeutic Techniques and Equipment85

Psychiatry and Psychology1

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