• Replacement of GH in adults with GHD markedly reduces central obesity and substantially reduces total cholesterol levels but has produced little change in other risk factors, particularly insulin resistance and dyslipidemia. (medscape.com)
  • [ 13 ] For these patients, concerns are the persistent insulin resistance and dyslipidemia, together with the elevated plasma insulin and lipoprotein(a) levels observed with GH replacement. (medscape.com)
  • Furthermore, central obesity led to the progression of metabolic syndrome, defined as a tendency of hyperinsulinemia, insulin resistance, and dyslipidemia [ 10 ]. (biomedcentral.com)
  • HIV-infected patients treated with highly active antiretroviral therapy (HAART) commonly experience changes in fat distribution that include increased visceral and central fat accumulation [1], as well as loss of subcutaneous fat in association with insulin resistance and dyslipidemia [2,3]. (natap.org)
  • Obesity can induce type 2 diabetes mellitus, dyslipidemia, cardiovascular disease and other chronic disorders with high social and health costs. (benthamscience.com)
  • National rates of screening, awareness, and treatment with statins among individuals with FH or severe dyslipidemia are unknown. (cdc.gov)
  • Soon after the introduction of atypical antipsychotics, which antagonize serotonin receptors and dopamine D 2 receptors (D 2 R), numerous case reports appeared showing that the use of these drugs were associated with increased obesity and the development of type 2 diabetes mellitus (T2DM) ( 5 ). (frontiersin.org)
  • Obesity was firstly described in 2000 as a cardiometabolic disease, even before Metabolic Syndrome, type 2 diabetes mellitus and coronary disease were considered as such. (benthamscience.com)
  • Studies showed that 65% of the world's population live in countries where overweight and obesity kills more people than underweight (World Health Organization, 2012). (directcurrentmusic.com)
  • A notable feature of the global obesity epidemic is the appearance of overweight and obesity in childhood and early adulthood. (nature.com)
  • Epidemiologic investigations have consistently shown an independent increased risk for diabetes associated with overweight and obesity, with clear dose response patterning across categories of increasing body mass. (diabetesjournals.org)
  • Globally, 44% of the burden of disease due to diabetes, 23% of that due to ischaemic heart disease, and 7% to 41% for certain cancers, particularly breast cancer, are attributable to overweight and obesity. (who.int)
  • In addition, a prospective Quebec study has found that even with no increase in blood sugar, elevated insulin levels (i.e., insulin resistance) are associated with a risk of coronary heart disease. (healsens.com)
  • We aimed to investigate the gender difference in the association between changes in metabolic syndrome (MetS) and its components with the risk of cardiovascular disease (CVD) and coronary heart disease (CHD) among adult participants in the Tehran lipid and glucose study cohort. (biomedcentral.com)
  • Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland coronary prevention study. (mja.com.au)
  • In the European Region, the Eastern Mediterranean Region and the Region of the Americas this proportion exceeds 50%.1 The mean body mass index has increased over the past 20 years, leading to adverse metabolic effects on blood pressure, cholesterol and triglyceride concentrations, and insulin resistance, thereby increasing the risks of coronary heart disease, ischaemic stroke, type 2 diabetes and polycystic ovarian syndrome. (who.int)
  • The World Health Organisation (WHO) describes obesity as something that has "reached epidemic proportions globally" and currently states the fact that there are more than 1 billion overweight adults and 300 million obese people worldwide. (bodybuilding.com)
  • Its frequency has increased in parallel to that of global obesity and diabetes epidemic [1]. (scirp.org)
  • Obesity and metabolic syndrome (O&MS) due to the worldwide obesity epidemic affects children at all stages of chronic kidney disease (CKD) including dialysis and after kidney transplantation. (springer.com)
  • The epidemic of obesity, insulin resistance and type 2 diabetes has heightened the need to understand the mechanisms that contribute to their pathogenesis. (endocrine-abstracts.org)
  • We are living the midst a global epidemic of metabolic disease with rapidly escalating rates of obesity, type 2 diabetes and insulin resistance. (uni-luebeck.de)
  • Obesity is a rising epidemic affecting millions worldwide. (conceiveivf.com)
  • Insulin resistance, when diagnosed, is almost exclusively found in those who are clinically obese. (nursingcenter.com)
  • The aim of this study was to evaluate acylated ghrelin and obestatin levels and their ratio in obese and normal-weight children and adolescents, and their association with metabolic syndrome (MetS) parameters. (mdpi.com)
  • Glucocorticoid (GC) production rates are elevated in obese, insulin resistant individuals. (endocrine-abstracts.org)
  • Below, discover how doctors determine whether someone is obese, as well as causes and risk factors of obesity, treatment options for obesity, and much more. (everydayhealth.com)
  • This can lead some people to view obese individuals as greedy, unintelligent, unattractive, lazy or lacking in self-control, rather than acknowledge the fact that obesity is a highly complex issue involving a range of genetic, biological, environmental and social factors. (laparoscopic.md)
  • Obese women, especially those with central obesity, have been associated with impaired fecundity. (conceiveivf.com)
  • Insulin Resistance is linked to Anovulation and infertility in obese women. (conceiveivf.com)
  • In obese subjects, adipokines and miokines interact to promote reticulum stress, insulin resistance, metabolic inflexibility and endothelial dysfunction. (benthamscience.com)
  • GHD in adults is recognized as a distinct clinical syndrome that encompasses reduced psychological well-being and specific metabolic abnormalities. (medscape.com)
  • According to this group, the reasons for a new definition that could meet with universal acceptance, in contrast to that of the ATP-III, was to allow easy identification in clinical practice, worldwide, of those individuals with the syndrome, taking into account the different ethnics. (scirp.org)
  • Regarding the important impact on clinical outcomes of metabolic syndrome in patients with chronic kidney disease, clarification of the relationship between metabolic syndrome and adiponectin level is mandatory. (biomedcentral.com)
  • we have challenged the dogma that glucocorticoids cause insulin resistance in all tissues and demonstrated insulin sensitization both in vitro and in translational clinical studies selectively in human adipose tissue. (uni-luebeck.de)
  • Most recently, based upon observations in a patient with Cushing's disease without a clinical phenotype, we have identified a novel role for 11β-HSD1 in controlling the response to exogenous glucocorticoid excess raising the potential for therapeutic inhibition of 11β-HSD1 may not only as a treatment for Cushing's disease, but as an approach to the treatment of iatrogenic glucocorticoid excess to limit adverse metabolic effects. (uni-luebeck.de)
  • We have shown in cross-sectional and intervention clinical studies that 5α-reductase activity is dysregulated in metabolic disease including obesity and NAFLD and have postulated that this represents a compensatory mechanism to protect the liver form the adverse effects of cortisol. (uni-luebeck.de)
  • He embarked upon a career in Diabetes and Endocrinology and secured an MRC Clinical Training Fellowship in 2000 and obtained his PhD from University of Birmingham studying steroid metabolism and human obesity in 2003. (uni-luebeck.de)
  • Subsequently he obtained fellowships from the Wellcome Trust and most recently an MRC senior clinical fellowship investigating the pathogenesis of human obesity and insulin resistance. (uni-luebeck.de)
  • Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study. (mja.com.au)
  • PCOS is usually defined as a clinical syndrome, not by the presence of ovarian cysts. (merckmanuals.com)
  • A number of potential implications for clinical practice are derived from the cardiometabolic state underlying obesity and its comorbidities. (benthamscience.com)
  • [ 1 , 2 ] A study by Stuebe et al found this condition to be associated with persistent metabolic dysfunction in women at 3 years after delivery, separate from other clinical risk factors. (medscape.com)
  • These clinical observations regarding the detrimental health effects of central or upper body obesity were subsequently reinforced by the results of large prospective epidemiological studies of diabetes incidence, in which fat patterning of subjects was estimated using body surface measurements, specifically waist and hip circumferences and skinfold thicknesses ( 2 - 5 ). (diabetesjournals.org)
  • To formulate clinical practice guidelines for the assessment, treatment, and prevention of pediatric obesity. (medscape.com)
  • Waterpipe smoking, sex, low-density lipoprotein and wrist circumference were also associated with metabolic syndrome. (who.int)
  • Measures related to anthropometric and body composition, glucose, and insulin level, HOMA-IR, sex hormones, lipid profile, quality of life, dietary intake, physical activity, and Ferriman-Gallwey score of all participants will be accessed before and after the intervention. (biomedcentral.com)
  • This preferential lipid fuel usage and associated hyperglycemia with insulin resistance lead to a combined Gluco-lipotoxicity and higher free radical generation mediated cardiac injury leading to heart failure as a final sequel in obesity. (kauveryhospital.com)
  • Baseline testing includes carotid artery intimal-medial thickness, carotid MRI, lipid panel, complete blood count, comprehensive metabolic chemistry panel, Thyroid-stimulating hormone (TSH) and glucose tolerance test with plasma insulin and glucose responses. (druglib.com)
  • Using in vitro cell systems including primary cultures of adipose, liver and muscle, we have characterized the action of glucocorticoids upon insulin action and lipid metabolism. (uni-luebeck.de)
  • Conclusions: TH9507 reduced truncal fat, improved the lipid profile and did not increase glucose levels in HIV-infected patients with central fat accumulation. (natap.org)
  • Rheumatoid Arthritis (RA) is an inflammatory disease associated with high morbidity and increased cardiovascular disease, and Metabolic Syndrome (MS) is understood as a set of metabolic disorders that correlates with obesity and sedentary lifestyle. (scirp.org)
  • So, in 40 out of 70 percent of people with normal weight, doctors diagnose metabolic disorders. (healsens.com)
  • Metabolic syndrome is one of the most common disorders in industrialized countries. (druglib.com)
  • Although asthma and obesity, are two fast growing health problems of public health significance in developing countries, the relationship between these two disorders remains at best shrouded in mystery. (biomedcentral.com)
  • Obesity is also associated with infertility and menstrual irregularities, incontinence, and psychological disorders such as depression. (symptoma.com)
  • Studies using CT have documented notably stronger associations of VAT (compared with SAT) with metabolic disorders related to diabetes, specifically insulin resistance ( 7 - 11 ). (diabetesjournals.org)
  • Young people with insulin- dependent diabetes mellitus (IDDM) may have a higher prevalence of eating disorders, such as anorexia nervosa and bulimia, and adults with longstanding diabetes and major medical complications have a higher prevalence of symptoms of depression and anxiety. (cdc.gov)
  • Obesity is a chronic disease with high prevalence and associated comorbidities, making it a growing global concern. (mdpi.com)
  • [ 10 ] The increased rates of cardiovascular morbidity and mortality reinforce the close association between the syndromes. (medscape.com)
  • It must be noted that even a modest rise in body weight can cause a significant rise in the rate of cardiovascular morbidity and mortality. (kauveryhospital.com)
  • Cardiovascular morbidity and mortality associated with the metabolic syndrome. (mja.com.au)
  • As it is illustrated, phenotype A is the most severe, while phenotype D is the least one along an axis of metabolic and ovarian dysfunction. (biomedcentral.com)
  • According to a study, phenotypes A, B, and C are endocrine-metabolic syndromes, while phenotype D is non-hyperandrogenic PCOS which represents evidence of both oligo-anovulation and ovarian cysts [ 5 ]. (biomedcentral.com)
  • The molecular mechanisms underlying this obesity-induced cardiac phenotype disorder are not well understood. (kauveryhospital.com)
  • Adopting a truly translational, bench-to-bedside approach, my work has defined the role of pre-receptor glucocorticoid metabolism within key target tissues upon the development of global metabolic phenotype. (uni-luebeck.de)
  • Conversely, the D 2 R agonist bromocriptine, which has been used for over 40 years to treat Parkinson's disease and hyperprolactinemia ( 6 ), was found to lower blood glucose levels and improve insulin sensitivity in patients with T2DM ( 7 ). (frontiersin.org)
  • Krampe, S. , de Andrade, N. , da Silveira, L. and Brenol, C. (2020) Prevalence and Incidence of Metabolic Syndrome in a Cohort of Patients with Rheumatoid Arthritis: A Correlation between Body Mass Index and Disease Activity. (scirp.org)
  • Patients with another connective tissue disease (except for secondary Sjögren's syndrome) were excluded. (scirp.org)
  • In diabetic patients at baseline, the combination of systolic and diastolic blood pressure was the most important factor, and urinary albumin excretion rate clustered with fasting and 2-h PG levels. (diabetesjournals.org)
  • In patients with chronic kidney disease, metabolic syndrome has been demonstrated to be the culprit behind diverse complications. (biomedcentral.com)
  • Meanwhile, the relationship between adiponectin and metabolic syndrome in patients with chronic kidney disease has not been clarified. (biomedcentral.com)
  • The aim of this study was to elucidate the relationship between adiponectin level and metabolic syndrome in patients with chronic kidney disease. (biomedcentral.com)
  • The median adiponectin level was 10.7 μg/mL and 585 (44.3%) patients had metabolic syndrome. (biomedcentral.com)
  • Hypoadiponectinemia is independently associated with the presence of metabolic syndrome in patients with chronic kidney disease. (biomedcentral.com)
  • Patients with Cushing s syndrome develop central obesity, insulin resistance and in some cases type 2 diabetes (T2DM), yet circulating cortisol levels are not elevated in simple obesity. (endocrine-abstracts.org)
  • The purpose of this study is to evaluate the long-term effectiveness of chloroquine, a protein-activation medication, at reducing the progression of atherosclerosis in patients with the metabolic syndrome. (druglib.com)
  • Although a recent study ruled out shared genetic and environmental factors because family members of patients with OCD had the same metabolic and cardiovascular risk as the general population, patients with OCD have a 45% increased risk for any metabolic or cardiovascular complications. (psychiatrictimes.com)
  • Objective: To investigate the effects of TH9507, a novel growth hormone releasing factor, on abdominal fat accumulation, metabolic and safety parameters in HIV-infected patients with central fat accumulation. (natap.org)
  • Recent data suggest potentially increased cardiovascular disease and myocardial infarction rates in patients treated with prolonged antiretroviral therapy [4]. (natap.org)
  • In non-HIV-infected patients [6] and among HIV-infected patients with changes in fat distribution [7], increased waist-to-hip ratio (WHR) and central fat accumulation is related to increased metabolic risk indices. (natap.org)
  • Metabolic syndrome prevalence is high in the population of asthma patients studied. (biomedcentral.com)
  • This study aimed to examine the associations of dietary and serum omega-3 fatty acids with insulin resistance (IR) and body composition among PCOS patients. (frontiersin.org)
  • The multivariable linear regression model was applied to analyze the associations of dietary and serum omega-3 fatty acids with the levels of Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and body composition parameters among PCOS patients. (frontiersin.org)
  • Higher levels of dietary and serum omega-3 PUFAs, particularly long-chain omega PUFAs (DPA and DHA), might have beneficial effects on metabolic parameters and body composition among PCOS patients. (frontiersin.org)
  • however, recent data suggest that prescription rates for statins remain low in these patients. (cdc.gov)
  • The guidelines recommend insulin treatment in all patients who present with ketosis or extremely high blood glucose levels because it may not be clear initially whether these patients have type 2 or type 1 diabetes. (medscape.com)
  • Fingerstick self-glucose monitoring is recommended for all patients receiving insulin or sulfonylureas, those starting or changing therapy, and those who have not met treatment goals or who have intercurrent illness. (medscape.com)
  • Insulin therapy is indicated in symptomatic patients with persistent hyperglycemia, the presence of an HbA 1c of more than 9%, or ketoacidosis. (medscape.com)
  • He is a professor of Metabolic Endocrinology and consultant endocrinologist based in the Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford. (uni-luebeck.de)
  • Nearly 35 percent of U.S. adults are estimated to have metabolic syndrome, which significantly increases the risk of cardiovascular disease and type 2 diabetes. (medindia.net)
  • CONCLUSIONS -Insulin resistance alone does not underlie all features of the metabolic syndrome. (diabetesjournals.org)
  • Some researchers have noted that there is growing evidence of the influence of hyperglycaemia and hyper-insulinaemia which are key features of the metabolic syndrome on airway function and structure [ 7 ]. (biomedcentral.com)
  • This study aimed to determine the incidence of metabolic syndrome and its predicting factors in Zahedan city. (who.int)
  • Age-standardized incidence of metabolic syndrome was calcu- lated and its predictors were evaluated in a logistic regression analysis. (who.int)
  • The incidence of metabolic syndrome varied from 17.21% to 27.18% depending on the criteria used and it was higher in women. (who.int)
  • The incidence of metabolic syndrome has increased in Zahedan. (who.int)
  • The incidence of metabolic syndrome prived regions of the country and is situated in vicinity has been reported to range from 28 persons per 1000 of Pakistan and Afghanistan. (who.int)
  • A cohort study was conducted on the urban population unchanged, the incidence of metabolic syndrome will be of Zahedan city, south-eastern Islamic Republic of Iran. (who.int)
  • Age-standardized incidence of metabolic syndrome was calculated and its predictors were evaluated in a logistic regression analysis. (who.int)
  • The incidence of metabolic syndrome has been reported to range from 28 persons per 1000 persons-year to more than 70 per 1000 persons-year in different regions of the world (4,5). (who.int)
  • If the current trend in obesity and type 2 diabetes continues unchanged, the incidence of metabolic syndrome will be expected to increase, especially in developing countries (2,6). (who.int)
  • According to epidemiological studies, the incidence of metabolic syndrome is higher in women than men (5,7). (who.int)
  • In this CPR, we discuss the management of obesity and metabolic syndrome (O&MS) in children and adolescents with CKD stages 2-5 and on dialysis, as well as after kidney transplantation, focusing on non-pharmacological treatment (diet, physical activity and behavior modification). (springer.com)
  • Although metabolic syndrome generally affects older people, it is possible, with increasing childhood obesity, for metabolic syndrome to affect young adults and even adolescents and children. (mydr.com.au)
  • to evaluate the prevalence of obesity and the body fat topography in children and adolescents from both sexes aged 6 to 19 years old with Down syndrome, residents in the city of Campinas, São Paulo. (bvsalud.org)
  • the assessment of the prevalence of obesity and subcutaneous fat topography are important resources to support researchers, and practitioners who work directly on improving the quality of life of children and adolescents with Down syndrome. (bvsalud.org)
  • In children and adolescents with Down syndrome (DS), high obesity levels were also recorded from the 80's to the present days 5,6 . (bvsalud.org)
  • Thus, care with the obesity control in children and adolescents with DS should be redoubled, because excess body fat is one of the characteristics of the syndrome, which can seriously contribute to the increased incidence of several diseases. (bvsalud.org)
  • Therefore, the study of the body fat behavior through the assessment of the body composition, occupies an important space in the identification of the levels of obesity in various populations, especially in children and adolescents with Down syndrome. (bvsalud.org)
  • Metabolic syndrome is increasing among adolescents. (cdc.gov)
  • Pediatric obesity remains an ongoing serious international health concern affecting ~17% of US children and adolescents, threatening their adult health and longevity. (medscape.com)
  • Adolescents undergoing lifestyle therapy, medication regimens, or bariatric surgery for obesity will need cohesive planning to help them effectively transition to adult care, with continued necessary monitoring, support, and intervention. (medscape.com)
  • Because type 2 diabetes in children and adolescents is strongly associated with obesity and sedentary lifestyle, any intervention designed to increase physical activity and improve dietary habits should be encouraged. (medscape.com)
  • Increasing dopamine levels/signals are associated with improved insulin sensitivity, while decreasing dopamine and serotonin levels/signals are associated with weight gain and T2DM development. (frontiersin.org)
  • In multiple linear regression analysis, log adiponectin was positively associated with high-density lipoprotein cholesterol levels (β = 0.006), whereas it was negatively associated with serum albumin (β = −0.284), triglyceride (log β = −0.288), high sensitivity C-reactive protein (log β = −0.058) levels and estimated glomerular filtration rate (β = −0.005). (biomedcentral.com)
  • The interaction between GC metabolism and insulin sensitivity in the context of significant weight loss has not been explored. (endocrine-abstracts.org)
  • Weight problems with symptoms of associated complications are the major features of morbid obesity . (symptoma.com)
  • By changing your lifestyle, you can help delay or even prevent the complications of metabolic syndrome (heart disease, stroke and diabetes) from developing. (mydr.com.au)
  • screening for comorbidities of obesity should be applied in a hierarchal, logical manner for early identification before more serious complications result. (medscape.com)
  • In the literature, there is a link that NAFLD is the hepatic component of the metabolic syndrome diagnosis ( Takahashi & Fukosato, 2014 ). (nursingcenter.com)
  • Does a diagnosis of the metabolic syndrome provide additional prediction of cardiovascular disease and total mortality in the elderly? (mja.com.au)
  • It is pertinent to note that the presence of obesity creates unique challenges for the diagnosis and treatment of asthma. (biomedcentral.com)
  • We present a 17 year-old woman, with a previous genetic diagnosis of Prader-Willi syndrome and BMI of 74 Kg/m(2), that was admitted in anasarca, with marked cyanosis, dyspnea and oliguria. (symptoma.com)
  • The first step in the therapeutic strategy against obesity should be the correct diagnosis of its causes and the promotion of lifestyle changes including physical exercise and a healthy diet. (benthamscience.com)
  • The purpose of this study is to examine the effect of long-term treatment with low doses of chloroquine on atherosclerosis in people with metabolic syndrome. (druglib.com)
  • People with metabolic syndrome not only have an increased risk of heart disease, but their risk of stroke and diabetes is also higher than average. (mydr.com.au)
  • People with metabolic syndrome, who have a combination of several of these risk factors rolled into one, are at even higher risk of these problems. (mydr.com.au)
  • Insulin resistance and central obesity also put you at high risk of developing diabetes - people with metabolic syndrome have 5 times the risk of developing type 2 diabetes. (mydr.com.au)
  • Of total participants, 18% met the criteria for metabolic syndrome. (cdc.gov)
  • In addition to local paracrine actions and peripheral endocrine effects mediated through the bloodstream, gut hormones play a pivotal role relaying information on nutritional status to important appetite controlling centres within the central nervous system (CNS), such as the hypothalamus and the brainstem. (hindawi.com)
  • Obesity can not only lower quality of life during childhood but may increase the chance that the excess weight will persist into adulthood, says Sheila Perez-Colon, MD , who is a double-board-certified pediatric oncologist and practices at Elite Endocrine MD in San Juan and Dorado, Puerto Rico. (everydayhealth.com)
  • The predominance of central, viscerally deposited fat may alter the immunological, metabolic and endocrine milieu. (benthamscience.com)
  • Endocrine etiologies for obesity are rare and usually are accompanied by attenuated growth patterns. (medscape.com)
  • In this paper, we focus on the role of gut hormones and their related neuronal networks (the gut-brain axis) in appetite control, and their potentials as novel therapies for obesity. (hindawi.com)
  • Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. (scienceopen.com)
  • Obesity wreaks havoc with male and female hormones, disrupting normal cycles and function, and leading to difficulty or inability to conceive. (symptoma.com)
  • Hence, classifying a subject as having MS would require the presence of central obesity (with different cut-off points depending on the country and ethnic group) in addition to two other criteria, the same as those of the ATP-III. (scirp.org)
  • Nigeria is a developing country that is currently witnessing an upsurge in diabetes mellitus and obesity with its antecedent consequences. (biomedcentral.com)
  • Elderly persons who have non-insulin-dependent diabetes mellitus (NIDDM) and other symptomatic medical conditions may also have a higher risk of developing psychological problems. (cdc.gov)
  • Metabolic syndrome is an unhealthy metabolism that leads to fatal diseases such as heart attacks, diabetes , and cancer. (healsens.com)
  • Endogenous glucocorticoid (GC) production and metabolism have been implicated based upon parallels with Cushing s syndrome. (endocrine-abstracts.org)
  • This study was designed to evaluate the role of pre-receptor glucocorticoid metabolism in the development of insulin resistance and obesity. (endocrine-abstracts.org)
  • His work has focussed on glucocorticoid action and metabolism and in particular the role of the pre-receptor metabolizing enzymes to regulate metabolic function. (uni-luebeck.de)
  • Aims: we investigate whether insulin resistance is associated with an increased prevalence for chronic kidney disease irrespective of the concurrent presence of metabolic syndrome. (scirp.org)
  • The importance of the MS as a chronic cardiovascular risk factor and the role of insulin resistance (IR) as its principal underlying cause have been under discussion recently [7]. (scirp.org)
  • The present work was directed to analyse the information of an observational Spanish study in adult population (DESIRE study) [22] in order to investigate the association of insulin resistance with the risk of chronic kidney disease (CKD) in a non diabetic population. (scirp.org)
  • The most important modifiable risk factors for chronic migraine include overuse of acute migraine medication, ineffective acute treatment, obesity, depression and stressful life events. (nature.com)
  • Obesity is a multifactorial disease that is currently developing a threatening tendency towards becoming the main cause of chronic disease in the world. (benthamscience.com)
  • Obesity Obesity is a chronic, multifactorial, relapsing disorder characterized by excess body weight and defined as a body mass index (BMI) of ≥ 30 kg/m2. (msdmanuals.com)
  • Also, the microvascular tone and microvascular density are significantly impacted by obesity. (kauveryhospital.com)
  • The U.K. researchers found Montmorency tart cherry juice led to a significant, clinically-relevant reduction in systolic blood pressure when compared to the placebo 2 hours after consumption, and Montmorency tart cherry juice and Montmorency tart cherry capsules both lowered insulin levels significantly more than the placebo at 1 hour and 3 hours, respectively. (medindia.net)
  • The pulmonary function test was not significantly affected by presence of metabolic syndrome. (biomedcentral.com)
  • We used stepwise regression analysis to determine whether anthropometric measurements significantly predicted metabolic syndrome. (cdc.gov)
  • Excessive insulin production is directly related to the increased ovarian production of androgens and PCOS manifestations [ 11 ]. (biomedcentral.com)
  • Excessive insulin level is not only a potential cause of hyperandrogenemia but also one of the high-risk factors leading to metabolic syndromes among those with PCOS ( 6 ). (frontiersin.org)
  • The typical doctor will give women with PCOS potent diabetes drugs to help control insulin levels, but a much simpler, healthier and more direct solution is to eat differently and get some exercise. (virginiahopkinshealthwatch.com)
  • The rate of miscarriage has increased, and the risk for birth defects is also higher for babies born to mothers with PCOS. (postureclinic.in)
  • Obesity increases the chances that you'll experience severe illness, become hospitalized, or die if you contract COVID-19. (everydayhealth.com)
  • The syndrome substantially increases the risk of developing diabetes and vascular disease, but there is no clear unifying approach to treat this disorder. (druglib.com)
  • There is growing epidemiological evidence that obesity increases the risk of developing asthma. (biomedcentral.com)
  • There is growing evidence that early development of obesity increases cardiovascular risk later in life, but less is known about whether there are effects of long-term excess body weight on the biological drivers associated with the atherosclerotic pathway, particularly adipokines, inflammatory and endothelial markers. (nature.com)
  • Excess glucose (from sugar and carbohydrates) in the bloodstream, raises insulin levels which increases androgen (male hormone) levels in women. (virginiahopkinshealthwatch.com)
  • Unhealthy diets leading to an excessive calorie intake coupled with sedentary lifestyles are the most common causes of obesity and excess weight. (kauveryhospital.com)
  • For example, as well as causing high blood pressure, Cushing's syndrome frequently causes truncal obesity, glucose intolerance, moon face, a hump of fat behind the neck and shoulders (referred to as a buffalo hump), and purple abdominal stretch marks. (wikipedia.org)
  • In this article, we reviewed the evidence that eating, especially high-caloric foods, stimulates the limbic system, initiating Reward Deficiency Syndrome. (frontiersin.org)
  • High levels of insulin and glucose in the blood are highly correlated with the level of fat you store on your suprailiac (4). (bodybuilding.com)
  • Metabolic syndrome is an asymptomatic pathophysio- a relatively high socioeconomic status. (who.int)
  • Most studies on the incidence and risk factors of metabolic syndrome have been conducted in developed countries or regions where the populations have a relatively high socioeconomic status. (who.int)
  • The pathophysiology of OCD is uncertain, largely because of the heterogeneity of manifestations and the high rates of comorbidity (anxiety, depressive or bipolar disorder). (psychiatrictimes.com)
  • Obesity is also associated with Polycystic Ovarian Syndrome, along with symptoms of high male hormone secretion like hairiness and acne. (conceiveivf.com)
  • To investigate the endometrial transcriptome profile and the associated molecular pathway alterations, we established an ovariectomized C57BL/6 mouse model treated with subcutaneous implantation of 17-β estradiol (E2) pellet and/or high-fat diet (HFD) for 12 weeks to mimic sustained estrogen stimulation and insulin resistance. (scienceopen.com)
  • If you had high blood pressure which is now normal because it's controlled by medicine, then for the purposes of diagnosing metabolic syndrome you are still classed as having high blood pressure. (mydr.com.au)
  • In addition, high levels of insulin can contribute to the development of high blood pressure and help raise triglyceride levels. (mydr.com.au)
  • Alternatively, for high-risk women or in areas in which the prevalence of insulin resistance is 5% or higher (eg, the southwestern and southeastern United States), a 1-step approach can be used by proceeding directly to the 100-g, 3-hour OGTT. (medscape.com)
  • Hormonally, a woman with metabolic syndrome tends to have high androgen (male hormone) levels, high estrogen levels (the fat cells are making estrogen from androgens), high cortisol and low thyroid. (virginiahopkinshealthwatch.com)
  • Men with metabolic syndrome tend to have low testosterone and high estrogen. (virginiahopkinshealthwatch.com)
  • This was underscored in a Johns Hopkins study published in the American Journal of Epidemiology in September 2004 which showed that women with metabolic syndrome have high androgen levels. (virginiahopkinshealthwatch.com)
  • Because Katzmarzyk et al did not determine whether these cutpoints identified metabolic syndrome, we attempted to do so in a sample of predominantly African American adolescent girls who attended high school and who lived in an urban area. (cdc.gov)
  • Although some behavioral and pharmacotherapy studies report modest success, additional research into accessible and effective methods for preventing and treating pediatric obesity is needed. (medscape.com)
  • Furthermore, continued investigation into the most effective methods of preventing and treating obesity and into methods for changing environmental and economic factors that will lead to worldwide cultural changes in diet and activity should be priorities. (medscape.com)