HypertensionPolycystic ovary syDyslipidemiaHyperinsulinemiaWaist circumferenceAbdominal obesityType 2 diabetOverweight and obesityCoronary heart dEpidemicObeseClinicalCircumferencePathogenesisAbnormalLipidMetSComponents of metabolic syndromeAdiposityDisordersAssociated comorbiditiesMorbidity and mortaPrevalence of metabolic syndromePhenotypeAdipose tissueGlucose and insulin levelsPatientsDyslipidaemiaEndocrinologyRisk of cardiovascular diseaseFeatures of the metabolic syndromeIncidence of Metabolic SyndromeInclude insulin resistanceVisceral ObesityAdolescentsInfertilityFatty liverSensitivityComplicationsDiagnosisPeople with metabolic syndromeCriteria for metabolic syndromeCauses metabolic syndromeDysfunctionEndocrineHormonesPresence of central obesityDiabetes mellitusSerumMetabolismChronicCholesterolSignificantlyClustering of several cardiovascularPCOSIncreasesLevels are not elevatedInternational Diabetes FSedentaryHighExcessMethods
Hypertension15
- Obesity has definitely become a growing problem, but a lot of anti-obesity educations, with fen-peen as the best example, have proven to have very damaging side-effects like lung hypertension and heart valve condition (Fen Peen, 2010). (directcurrentmusic.com)
- The metabolic syndrome (MS) describes the association, in the same subject, of several traits such as central obesity, hypertension and dyslipidaemia, all of them very common conditions in developed countries. (scirp.org)
- Metabolic Syndrome" (MetS), refers to the clustering of abdominal obesity, impaired glucose tolerance, hypertriglyceridemia, diminished high density lipoprotein (HDL) cholesterol, and/or hypertension in an individual. (kauveryhospital.com)
- Essentially, metabolic syndrome is the simultaneous presence of several conditions, such as obesity, hyperlipidemia (abnormal levels of cholesterol and / or lipoproteins), diabetes and / or hypertension . (healsens.com)
- While previous studies on Montmorency tart cherries have explored individual aspects of metabolic syndrome - such as blood pressure and triglycerides - this is the first study to examine the full cluster of conditions that comprise metabolic syndrome, including insulin resistance, hypertension, and central obesity, or belly fat. (medindia.net)
- In societies with a higher potassium-to-sodium ratio-where people consume three or even four times more potassium than sodium-the rate of hypertension is far lower than in the US. (healthconfidential.com)
- Patients with glucocorticoid excess, Cushing's syndrome, develop a characteristic constellation of adverse metabolic features including central obesity, insulin resistance, proximal muscle wasting, hypertension and non-alcoholic fatty liver disease (NAFLD). (uni-luebeck.de)
- Metabolic syndrome (primarily abdominal obesity, dyslipidemia, type II diabetes mellitus) and cardiovascular conditions (primarily hypertension) are the most common co-occurring medical condition, with cumulative incidences at age 47 of 56.2% versus 34.4% in the general population. (psychiatrictimes.com)
- The metabolic syndrome is a cluster of risk factors that include hypertension, impaired glucose tolerance or diabetes mellitus, central obesity and dyslipidaemia. (biomedcentral.com)
- Metabolic Syndrome Metabolic syndrome is characterized by a large waist circumference (due to excess abdominal fat), hypertension, abnormal fasting plasma glucose or insulin resistance, and dyslipidemia. (merckmanuals.com)
- PCOS entails diseases such as type 2 diabetes, hypertension, cardiovascular disease, and endometrial cancer ( 3 , 4 ), and insulin resistance (IR) and hyperandrogenemia might be closely associated with the pathogenesis of PCOS ( 5 ). (frontiersin.org)
- 2 NAFLD is associated with obesity and features of metabolic syndrome, including hypertension, dyslipidemia, central adiposity, insulin resistance, or diabetes. (xiahepublishing.com)
- I believe studies of the LC diet will be forthcoming as related to diabetes, coronary disease, hypertension, and the metabolic syndrome, as well as obesity. (practicalpointers.org)
- Rates of hypertension increased significantly (p‹0.05) with age and concentration of serum PCBs and were higher in African-Americans (n=351) than in Caucasians (n=407). (cdc.gov)
- This makes it difficult to disentangle independent associations Covid-19 may have with single components of cardiometabolic multimorbidity, defined here as a group of main metabolic disorders that increase the risk of cardiovascular events, such as diabetes, hypertension and dyslipidaemia. (biomedcentral.com)
Polycystic ovary sy12
- Polycystic ovary syndrome (PCOS) is one of the most frequent endocrine disorders among women of fertile age. (biomedcentral.com)
- Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disorder, with a prevalence of 4-20% depending on the diagnostic criteria used, among reproductive-aged women [ 1 ]. (biomedcentral.com)
- Polycystic ovary syndrome (PCOS), a common cause of infertility, often coexists with obesity, too. (everydayhealth.com)
- Polycystic ovary syndrome is a clinical syndrome typically characterized by anovulation or oligo-ovulation, signs of androgen excess (eg, hirsutism, acne), and multiple ovarian cysts in the ovaries. (merckmanuals.com)
- Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome. (merckmanuals.com)
- Polycystic ovary syndrome has several significant potential complications. (merckmanuals.com)
- Polycystic ovary syndrome (PCOS) is strongly associated with abdominal obesity and insulin resistance and effective approaches to nutrition (e.g., omega-3 fatty acids intake) might improve the cardiometabolic risk profile. (frontiersin.org)
- Characterized by a series of manifestations of hyperandrogenemia, persistent anovulation, and ovarian polycystic changes ( 1 ), polycystic ovary syndrome (PCOS) is one of the most common endocrine-metabolic disorders that affects 5 to 10% of women of reproductive age ( 2 ). (frontiersin.org)
- High insulin and the resulting high androgens are the underlying cause of polycystic ovary syndrome (PCOS) which can cause terrible ovarian pain, PMS and excess hair growth. (virginiahopkinshealthwatch.com)
- If you have PCOS, or if you are a woman who has been diagnosed with Polycystic Ovary Syndrome , then this article will be helpful. (postureclinic.in)
- Polycystic ovary syndrome is a condition that affects women's menstrual cycles and fertility. (postureclinic.in)
- Physiotherapists can teach women with polycystic ovary syndrome (PCOS) movement patterns and exercise that will help them to manage the symptoms. (postureclinic.in)
Dyslipidemia6
- Replacement of GH in adults with GHD markedly reduces central obesity and substantially reduces total cholesterol levels but has produced little change in other risk factors, particularly insulin resistance and dyslipidemia. (medscape.com)
- [ 13 ] For these patients, concerns are the persistent insulin resistance and dyslipidemia, together with the elevated plasma insulin and lipoprotein(a) levels observed with GH replacement. (medscape.com)
- Furthermore, central obesity led to the progression of metabolic syndrome, defined as a tendency of hyperinsulinemia, insulin resistance, and dyslipidemia [ 10 ]. (biomedcentral.com)
- HIV-infected patients treated with highly active antiretroviral therapy (HAART) commonly experience changes in fat distribution that include increased visceral and central fat accumulation [1], as well as loss of subcutaneous fat in association with insulin resistance and dyslipidemia [2,3]. (natap.org)
- Obesity can induce type 2 diabetes mellitus, dyslipidemia, cardiovascular disease and other chronic disorders with high social and health costs. (benthamscience.com)
- National rates of screening, awareness, and treatment with statins among individuals with FH or severe dyslipidemia are unknown. (cdc.gov)
Hyperinsulinemia9
- Women with PCOS manifest clinical symptoms like menstrual dysfunction, hirsutism, insulin resistance, and hyperinsulinemia. (biomedcentral.com)
- As excessive amounts of insulin levels directly increase ovarian production of androgens, hyperinsulinemia and insulin resistance are considered as the pathogenesis factors of PCOS. (biomedcentral.com)
- Insulin resistance and concomitant hyperinsulinemia are presented in CKD patients in nondiabetic US adults [21]. (scirp.org)
- It is now known that Central/Visceral Obesity with its Insulin Resistance and or Hyperinsulinemia is central in the pathogenesis of MetS. (kauveryhospital.com)
- Hyperinsulinemia: the key feature of a cardiovascular and metabolic syndrome. (mja.com.au)
- The ovarian androgen excess may be because of an interaction between obesity-related, chronic hyperinsulinemia with genetic factors predisposing to the development of ovarian hyperandrogenism. (scienceopen.com)
- Hyperinsulinemia due to insulin resistance may be present and may contribute to increased ovarian production of androgens. (merckmanuals.com)
- In the first phase of insulin resistance a compensatory hyperinsulinemia develops. (benthamscience.com)
- PCOS can also be accompanied by obesity because central obesity could exaggerate IR and lead to hyperinsulinemia ( 7 ). (frontiersin.org)
Waist circumference11
- This is at least related to an increase in waist circumference or visceral obesity. (healsens.com)
- Central obesity or visceral obesity is readily assessed at waist circumference and is independently associated with each of the other components of metabolic syndrome. (healsens.com)
- and those with metabolic syndrome, a combination of disorders that includes insulin resistance, a high waist circumference (central obesity) and other factors. (healthconfidential.com)
- The International Diabetes Federation defines central obesity in people of European descent as a waist circumference of 94 cm or more in men and 80 cm or more in women. (mydr.com.au)
- We examined the utility of body mass index (BMI) and waist circumference to identify metabolic syndrome in adolescent girls. (cdc.gov)
- Participants were designated as having metabolic syndrome if they met criteria for 3 of 5 variables: 1) high blood pressure, 2) low high-density lipoprotein cholesterol level, 3) high fasting blood glucose level, 4) high waist circumference, and 5) high triglyceride level. (cdc.gov)
- We predicted the likelihood of the presence of metabolic syndrome by using previously established cutpoints of BMI and waist circumference. (cdc.gov)
- 001). Girls with a waist circumference above the cutpoint were more likely than girls with a waist circumference below the cutpoint to have metabolic syndrome ( P = .002). (cdc.gov)
- Stepwise regression showed that only waist circumference significantly predicted metabolic syndrome. (cdc.gov)
- Waist circumference was a better predictor of metabolic syndrome than was BMI in our study sample of predominantly African American female adolescents living in an urban area. (cdc.gov)
- Clinical diagnosis is made on the basis of the presence of 3 of 5 conditions: 1) high triglyceride level, 2) low high-density lipoprotein (HDL) cholesterol level, 3) high fasting blood glucose level, 4) presence of central obesity (ie, high waist circumference), and 5) high blood pressure ( 1 ). (cdc.gov)
Abdominal obesity4
- Methods: 1638 patients with abdominal obesity were selected. (scirp.org)
- Metabolic syndrome and abdominal obesity were defined according to the International Diabetes Federation criteria. (scirp.org)
- From the initial sample of 2341 subjects selected, 211 did not have the inclusion criteria (abdominal obesity by IDF criteria for European population and basal plasma glucose >90 mg/dl). (scirp.org)
- Metabolic syndrome describes an obese person with central or abdominal obesity (a fat stomach) who also tends to have a poor cholesterol profile, high blood sugar and insulin and the attendant insulin resistance, high blood pressure, and clogged arteries. (virginiahopkinshealthwatch.com)
Type 2 diabet2
- Soon after the introduction of atypical antipsychotics, which antagonize serotonin receptors and dopamine D 2 receptors (D 2 R), numerous case reports appeared showing that the use of these drugs were associated with increased obesity and the development of type 2 diabetes mellitus (T2DM) ( 5 ). (frontiersin.org)
- Obesity was firstly described in 2000 as a cardiometabolic disease, even before Metabolic Syndrome, type 2 diabetes mellitus and coronary disease were considered as such. (benthamscience.com)
Overweight and obesity4
- Studies showed that 65% of the world's population live in countries where overweight and obesity kills more people than underweight (World Health Organization, 2012). (directcurrentmusic.com)
- A notable feature of the global obesity epidemic is the appearance of overweight and obesity in childhood and early adulthood. (nature.com)
- Epidemiologic investigations have consistently shown an independent increased risk for diabetes associated with overweight and obesity, with clear dose response patterning across categories of increasing body mass. (diabetesjournals.org)
- Globally, 44% of the burden of disease due to diabetes, 23% of that due to ischaemic heart disease, and 7% to 41% for certain cancers, particularly breast cancer, are attributable to overweight and obesity. (who.int)
Coronary heart d4
- In addition, a prospective Quebec study has found that even with no increase in blood sugar, elevated insulin levels (i.e., insulin resistance) are associated with a risk of coronary heart disease. (healsens.com)
- We aimed to investigate the gender difference in the association between changes in metabolic syndrome (MetS) and its components with the risk of cardiovascular disease (CVD) and coronary heart disease (CHD) among adult participants in the Tehran lipid and glucose study cohort. (biomedcentral.com)
- Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland coronary prevention study. (mja.com.au)
- In the European Region, the Eastern Mediterranean Region and the Region of the Americas this proportion exceeds 50%.1 The mean body mass index has increased over the past 20 years, leading to adverse metabolic effects on blood pressure, cholesterol and triglyceride concentrations, and insulin resistance, thereby increasing the risks of coronary heart disease, ischaemic stroke, type 2 diabetes and polycystic ovarian syndrome. (who.int)
Epidemic6
- The World Health Organisation (WHO) describes obesity as something that has "reached epidemic proportions globally" and currently states the fact that there are more than 1 billion overweight adults and 300 million obese people worldwide. (bodybuilding.com)
- Its frequency has increased in parallel to that of global obesity and diabetes epidemic [1]. (scirp.org)
- Obesity and metabolic syndrome (O&MS) due to the worldwide obesity epidemic affects children at all stages of chronic kidney disease (CKD) including dialysis and after kidney transplantation. (springer.com)
- The epidemic of obesity, insulin resistance and type 2 diabetes has heightened the need to understand the mechanisms that contribute to their pathogenesis. (endocrine-abstracts.org)
- We are living the midst a global epidemic of metabolic disease with rapidly escalating rates of obesity, type 2 diabetes and insulin resistance. (uni-luebeck.de)
- Obesity is a rising epidemic affecting millions worldwide. (conceiveivf.com)
Obese8
- Insulin resistance, when diagnosed, is almost exclusively found in those who are clinically obese. (nursingcenter.com)
- The aim of this study was to evaluate acylated ghrelin and obestatin levels and their ratio in obese and normal-weight children and adolescents, and their association with metabolic syndrome (MetS) parameters. (mdpi.com)
- Glucocorticoid (GC) production rates are elevated in obese, insulin resistant individuals. (endocrine-abstracts.org)
- Below, discover how doctors determine whether someone is obese, as well as causes and risk factors of obesity, treatment options for obesity, and much more. (everydayhealth.com)
- This can lead some people to view obese individuals as greedy, unintelligent, unattractive, lazy or lacking in self-control, rather than acknowledge the fact that obesity is a highly complex issue involving a range of genetic, biological, environmental and social factors. (laparoscopic.md)
- Obese women, especially those with central obesity, have been associated with impaired fecundity. (conceiveivf.com)
- Insulin Resistance is linked to Anovulation and infertility in obese women. (conceiveivf.com)
- In obese subjects, adipokines and miokines interact to promote reticulum stress, insulin resistance, metabolic inflexibility and endothelial dysfunction. (benthamscience.com)
Clinical14
- GHD in adults is recognized as a distinct clinical syndrome that encompasses reduced psychological well-being and specific metabolic abnormalities. (medscape.com)
- According to this group, the reasons for a new definition that could meet with universal acceptance, in contrast to that of the ATP-III, was to allow easy identification in clinical practice, worldwide, of those individuals with the syndrome, taking into account the different ethnics. (scirp.org)
- Regarding the important impact on clinical outcomes of metabolic syndrome in patients with chronic kidney disease, clarification of the relationship between metabolic syndrome and adiponectin level is mandatory. (biomedcentral.com)
- we have challenged the dogma that glucocorticoids cause insulin resistance in all tissues and demonstrated insulin sensitization both in vitro and in translational clinical studies selectively in human adipose tissue. (uni-luebeck.de)
- Most recently, based upon observations in a patient with Cushing's disease without a clinical phenotype, we have identified a novel role for 11β-HSD1 in controlling the response to exogenous glucocorticoid excess raising the potential for therapeutic inhibition of 11β-HSD1 may not only as a treatment for Cushing's disease, but as an approach to the treatment of iatrogenic glucocorticoid excess to limit adverse metabolic effects. (uni-luebeck.de)
- We have shown in cross-sectional and intervention clinical studies that 5α-reductase activity is dysregulated in metabolic disease including obesity and NAFLD and have postulated that this represents a compensatory mechanism to protect the liver form the adverse effects of cortisol. (uni-luebeck.de)
- He embarked upon a career in Diabetes and Endocrinology and secured an MRC Clinical Training Fellowship in 2000 and obtained his PhD from University of Birmingham studying steroid metabolism and human obesity in 2003. (uni-luebeck.de)
- Subsequently he obtained fellowships from the Wellcome Trust and most recently an MRC senior clinical fellowship investigating the pathogenesis of human obesity and insulin resistance. (uni-luebeck.de)
- Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study. (mja.com.au)
- PCOS is usually defined as a clinical syndrome, not by the presence of ovarian cysts. (merckmanuals.com)
- A number of potential implications for clinical practice are derived from the cardiometabolic state underlying obesity and its comorbidities. (benthamscience.com)
- [ 1 , 2 ] A study by Stuebe et al found this condition to be associated with persistent metabolic dysfunction in women at 3 years after delivery, separate from other clinical risk factors. (medscape.com)
- These clinical observations regarding the detrimental health effects of central or upper body obesity were subsequently reinforced by the results of large prospective epidemiological studies of diabetes incidence, in which fat patterning of subjects was estimated using body surface measurements, specifically waist and hip circumferences and skinfold thicknesses ( 2 - 5 ). (diabetesjournals.org)
- To formulate clinical practice guidelines for the assessment, treatment, and prevention of pediatric obesity. (medscape.com)
Circumference1
Pathogenesis3
- The role of endogenous glucocorticoid (GC) production and metabolism in the pathogenesis of obesity, insulin resistance and type 2 diabetes remains unclear. (endocrine-abstracts.org)
- Dysregulation of the enzymes that control local tissue steroid metabolism has been implicated in the pathogenesis of obesity and insulin resistant states, however longitudinal changes in glucocorticoid metabolism over time have not been investigated. (endocrine-abstracts.org)
- His research investigates the pathogenesis of human obesity, insulin resistance and non-alcoholic fatty liver disease. (uni-luebeck.de)
Abnormal4
- Patients with RA, especially those with an active disease, have shown a tendency to present abnormal lipid profile with low levels of high-density lipoprotein cholesterol (HDL) and high levels of triglycerides, as well as less insulin sensitivity. (scirp.org)
- But for the purposes of this guide, we'll focus on the World Health Organization's (WHO) definition of obesity: abnormal or excessive fat accumulation in the body that may pose a risk to your health. (everydayhealth.com)
- It consists of abnormal serum lipids, glucose intolerance, elevated blood pressure, and central obesity in the setting of insulin resistance. (druglib.com)
- In males, obesity may result in decreased sperm count, no sperm in ejaculate, abnormal motility or morphology. (conceiveivf.com)
Lipid5
- Measures related to anthropometric and body composition, glucose, and insulin level, HOMA-IR, sex hormones, lipid profile, quality of life, dietary intake, physical activity, and Ferriman-Gallwey score of all participants will be accessed before and after the intervention. (biomedcentral.com)
- This preferential lipid fuel usage and associated hyperglycemia with insulin resistance lead to a combined Gluco-lipotoxicity and higher free radical generation mediated cardiac injury leading to heart failure as a final sequel in obesity. (kauveryhospital.com)
- Baseline testing includes carotid artery intimal-medial thickness, carotid MRI, lipid panel, complete blood count, comprehensive metabolic chemistry panel, Thyroid-stimulating hormone (TSH) and glucose tolerance test with plasma insulin and glucose responses. (druglib.com)
- Using in vitro cell systems including primary cultures of adipose, liver and muscle, we have characterized the action of glucocorticoids upon insulin action and lipid metabolism. (uni-luebeck.de)
- Conclusions: TH9507 reduced truncal fat, improved the lipid profile and did not increase glucose levels in HIV-infected patients with central fat accumulation. (natap.org)
MetS8
- However, insulin resistance is not considered to be part of the definition in MetS. (kauveryhospital.com)
- It is the pathophysiologic aspects of obesity coupled with MetS that leads to changes in hemodynamics, atherosclerosis and calcification, myocardial metabolism, microvascular dysfunction that culminates in myocardial infarction and heart failure. (kauveryhospital.com)
- There are limited data on the prevalence rate of Metabolic Syndrome (MetS) among college students attending any Historically Black College and University (HBCU), which are mostly attended by young African Americans (AA). (biomedcentral.com)
- Prevalence rates for MetS criteria varied depending on the definition used. (biomedcentral.com)
- Metabolic syndrome (MetS) refers to clustering of several cardiovascular disease (CVD) risk factors including central obesity, insulin resistance, high blood pressure (BP), reduced levels of serum high-density lipoprotein cholesterol (HDL-C) and increased level of serum triglycerides (TG) [ 1 ]. (biomedcentral.com)
- To assess whether a diagnosis of the metabolic syndrome (MetS) improves the prediction of cardiovascular disease or total mortality beyond that already provided by conventional risk factors. (mja.com.au)
- Crude CHD, ischaemic stroke, and total mortality rates were higher in the presence of MetS in men and women. (mja.com.au)
- Diet-induced obesity in C57BL/6 mice triggers common features of human metabolic syndrome (MetS). (scienceopen.com)
Components of metabolic syndrome2
- Both NAFLD and its progression into NASH are seen almost simultaneously, with at least some of the components of metabolic syndrome. (nursingcenter.com)
- All of the individual components of metabolic syndrome are risk factors for atherosclerosis (hardening and narrowing of the arteries). (mydr.com.au)
Adiposity4
- The primary risk factors of NASH include obesity (body mass index [BMI] >30), insulin resistance, Type II diabetes, "central adiposity" ( Paskos & Paletas, 2009 , para. (nursingcenter.com)
- In contrast, adiposity signals such as leptin and insulin are implicated in both short- and long-term energy homeostasis. (hindawi.com)
- Nonetheless, relative or absolute central adiposity may confer excess cardiovascular risk. (natap.org)
- Studies using higher dose, pharmacologic growth hormone (GH) administration have resulted in reduced visceral adiposity in this population, but are associated with increased insulin resistance and side effects [10-13]. (natap.org)
Disorders7
- Rheumatoid Arthritis (RA) is an inflammatory disease associated with high morbidity and increased cardiovascular disease, and Metabolic Syndrome (MS) is understood as a set of metabolic disorders that correlates with obesity and sedentary lifestyle. (scirp.org)
- So, in 40 out of 70 percent of people with normal weight, doctors diagnose metabolic disorders. (healsens.com)
- Metabolic syndrome is one of the most common disorders in industrialized countries. (druglib.com)
- Although asthma and obesity, are two fast growing health problems of public health significance in developing countries, the relationship between these two disorders remains at best shrouded in mystery. (biomedcentral.com)
- Obesity is also associated with infertility and menstrual irregularities, incontinence, and psychological disorders such as depression. (symptoma.com)
- Studies using CT have documented notably stronger associations of VAT (compared with SAT) with metabolic disorders related to diabetes, specifically insulin resistance ( 7 - 11 ). (diabetesjournals.org)
- Young people with insulin- dependent diabetes mellitus (IDDM) may have a higher prevalence of eating disorders, such as anorexia nervosa and bulimia, and adults with longstanding diabetes and major medical complications have a higher prevalence of symptoms of depression and anxiety. (cdc.gov)
Associated comorbidities1
- Obesity is a chronic disease with high prevalence and associated comorbidities, making it a growing global concern. (mdpi.com)
Morbidity and morta3
- [ 10 ] The increased rates of cardiovascular morbidity and mortality reinforce the close association between the syndromes. (medscape.com)
- It must be noted that even a modest rise in body weight can cause a significant rise in the rate of cardiovascular morbidity and mortality. (kauveryhospital.com)
- Cardiovascular morbidity and mortality associated with the metabolic syndrome. (mja.com.au)
Prevalence of metabolic syndrome3
- The study was conceived to determine the prevalence of metabolic syndrome among a population of asthmatics seen in our practice. (biomedcentral.com)
- The prevalence of metabolic syndrome was 17.7%, affecting 28 asthma patients. (biomedcentral.com)
- The most current data show that a 9.2% prevalence of metabolic syndrome from 1988 through 1994 increased to 12.7% from 1999 through 2000 ( 6 ). (cdc.gov)
Phenotype4
- As it is illustrated, phenotype A is the most severe, while phenotype D is the least one along an axis of metabolic and ovarian dysfunction. (biomedcentral.com)
- According to a study, phenotypes A, B, and C are endocrine-metabolic syndromes, while phenotype D is non-hyperandrogenic PCOS which represents evidence of both oligo-anovulation and ovarian cysts [ 5 ]. (biomedcentral.com)
- The molecular mechanisms underlying this obesity-induced cardiac phenotype disorder are not well understood. (kauveryhospital.com)
- Adopting a truly translational, bench-to-bedside approach, my work has defined the role of pre-receptor glucocorticoid metabolism within key target tissues upon the development of global metabolic phenotype. (uni-luebeck.de)
Adipose tissue2
- Those who are insulin resistant have an abundance of adipose tissue in their abdominal area. (nursingcenter.com)
- Visceral adipose tissue mass secretes a number of proinflammatory cytokines, adipokines and growth factors leading to low grade inflammatory process and insulin resistance. (benthamscience.com)
Glucose and insulin levels1
- You need to improve your glucose and insulin levels. (bodybuilding.com)
Patients23
- Conversely, the D 2 R agonist bromocriptine, which has been used for over 40 years to treat Parkinson's disease and hyperprolactinemia ( 6 ), was found to lower blood glucose levels and improve insulin sensitivity in patients with T2DM ( 7 ). (frontiersin.org)
- Krampe, S. , de Andrade, N. , da Silveira, L. and Brenol, C. (2020) Prevalence and Incidence of Metabolic Syndrome in a Cohort of Patients with Rheumatoid Arthritis: A Correlation between Body Mass Index and Disease Activity. (scirp.org)
- Patients with another connective tissue disease (except for secondary Sjögren's syndrome) were excluded. (scirp.org)
- In diabetic patients at baseline, the combination of systolic and diastolic blood pressure was the most important factor, and urinary albumin excretion rate clustered with fasting and 2-h PG levels. (diabetesjournals.org)
- In patients with chronic kidney disease, metabolic syndrome has been demonstrated to be the culprit behind diverse complications. (biomedcentral.com)
- Meanwhile, the relationship between adiponectin and metabolic syndrome in patients with chronic kidney disease has not been clarified. (biomedcentral.com)
- The aim of this study was to elucidate the relationship between adiponectin level and metabolic syndrome in patients with chronic kidney disease. (biomedcentral.com)
- The median adiponectin level was 10.7 μg/mL and 585 (44.3%) patients had metabolic syndrome. (biomedcentral.com)
- Hypoadiponectinemia is independently associated with the presence of metabolic syndrome in patients with chronic kidney disease. (biomedcentral.com)
- Patients with Cushing s syndrome develop central obesity, insulin resistance and in some cases type 2 diabetes (T2DM), yet circulating cortisol levels are not elevated in simple obesity. (endocrine-abstracts.org)
- The purpose of this study is to evaluate the long-term effectiveness of chloroquine, a protein-activation medication, at reducing the progression of atherosclerosis in patients with the metabolic syndrome. (druglib.com)
- Although a recent study ruled out shared genetic and environmental factors because family members of patients with OCD had the same metabolic and cardiovascular risk as the general population, patients with OCD have a 45% increased risk for any metabolic or cardiovascular complications. (psychiatrictimes.com)
- Objective: To investigate the effects of TH9507, a novel growth hormone releasing factor, on abdominal fat accumulation, metabolic and safety parameters in HIV-infected patients with central fat accumulation. (natap.org)
- Recent data suggest potentially increased cardiovascular disease and myocardial infarction rates in patients treated with prolonged antiretroviral therapy [4]. (natap.org)
- In non-HIV-infected patients [6] and among HIV-infected patients with changes in fat distribution [7], increased waist-to-hip ratio (WHR) and central fat accumulation is related to increased metabolic risk indices. (natap.org)
- Metabolic syndrome prevalence is high in the population of asthma patients studied. (biomedcentral.com)
- This study aimed to examine the associations of dietary and serum omega-3 fatty acids with insulin resistance (IR) and body composition among PCOS patients. (frontiersin.org)
- The multivariable linear regression model was applied to analyze the associations of dietary and serum omega-3 fatty acids with the levels of Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and body composition parameters among PCOS patients. (frontiersin.org)
- Higher levels of dietary and serum omega-3 PUFAs, particularly long-chain omega PUFAs (DPA and DHA), might have beneficial effects on metabolic parameters and body composition among PCOS patients. (frontiersin.org)
- however, recent data suggest that prescription rates for statins remain low in these patients. (cdc.gov)
- The guidelines recommend insulin treatment in all patients who present with ketosis or extremely high blood glucose levels because it may not be clear initially whether these patients have type 2 or type 1 diabetes. (medscape.com)
- Fingerstick self-glucose monitoring is recommended for all patients receiving insulin or sulfonylureas, those starting or changing therapy, and those who have not met treatment goals or who have intercurrent illness. (medscape.com)
- Insulin therapy is indicated in symptomatic patients with persistent hyperglycemia, the presence of an HbA 1c of more than 9%, or ketoacidosis. (medscape.com)
Dyslipidaemia2
- Few studies have logical condition characterized by high blood pressure, been done in more deprived regions and regions with low central obesity, insulin resistance, dyslipidaemia and income (9) . (who.int)
- Metabolic syndrome is an asymptomatic pathophysiological condition characterized by high blood pressure, central obesity, insulin resistance, dyslipidaemia and hyperglycaemia (1). (who.int)
Endocrinology1
- He is a professor of Metabolic Endocrinology and consultant endocrinologist based in the Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford. (uni-luebeck.de)
Risk of cardiovascular disease1
- Nearly 35 percent of U.S. adults are estimated to have metabolic syndrome, which significantly increases the risk of cardiovascular disease and type 2 diabetes. (medindia.net)
Features of the metabolic syndrome2
- CONCLUSIONS -Insulin resistance alone does not underlie all features of the metabolic syndrome. (diabetesjournals.org)
- Some researchers have noted that there is growing evidence of the influence of hyperglycaemia and hyper-insulinaemia which are key features of the metabolic syndrome on airway function and structure [ 7 ]. (biomedcentral.com)
Incidence of Metabolic Syndrome10
- This study aimed to determine the incidence of metabolic syndrome and its predicting factors in Zahedan city. (who.int)
- Age-standardized incidence of metabolic syndrome was calcu- lated and its predictors were evaluated in a logistic regression analysis. (who.int)
- The incidence of metabolic syndrome varied from 17.21% to 27.18% depending on the criteria used and it was higher in women. (who.int)
- The incidence of metabolic syndrome has increased in Zahedan. (who.int)
- The incidence of metabolic syndrome prived regions of the country and is situated in vicinity has been reported to range from 28 persons per 1000 of Pakistan and Afghanistan. (who.int)
- A cohort study was conducted on the urban population unchanged, the incidence of metabolic syndrome will be of Zahedan city, south-eastern Islamic Republic of Iran. (who.int)
- Age-standardized incidence of metabolic syndrome was calculated and its predictors were evaluated in a logistic regression analysis. (who.int)
- The incidence of metabolic syndrome has been reported to range from 28 persons per 1000 persons-year to more than 70 per 1000 persons-year in different regions of the world (4,5). (who.int)
- If the current trend in obesity and type 2 diabetes continues unchanged, the incidence of metabolic syndrome will be expected to increase, especially in developing countries (2,6). (who.int)
- According to epidemiological studies, the incidence of metabolic syndrome is higher in women than men (5,7). (who.int)
Include insulin resistance1
- Metabolic syndrome is a combination of conditions that include insulin resistance/Type II diabetes, HTN, hyperlipidemia, and obesity. (nursingcenter.com)
Visceral Obesity2
- However, despite the lack of knowledge, researchers have identified visceral obesity and insulin resistance as the most important causative factors. (healsens.com)
- Moreover, visceral obesity is the key trigger for most pathways involved in metabolic syndrome. (healsens.com)
Adolescents11
- In this CPR, we discuss the management of obesity and metabolic syndrome (O&MS) in children and adolescents with CKD stages 2-5 and on dialysis, as well as after kidney transplantation, focusing on non-pharmacological treatment (diet, physical activity and behavior modification). (springer.com)
- Although metabolic syndrome generally affects older people, it is possible, with increasing childhood obesity, for metabolic syndrome to affect young adults and even adolescents and children. (mydr.com.au)
- to evaluate the prevalence of obesity and the body fat topography in children and adolescents from both sexes aged 6 to 19 years old with Down syndrome, residents in the city of Campinas, São Paulo. (bvsalud.org)
- the assessment of the prevalence of obesity and subcutaneous fat topography are important resources to support researchers, and practitioners who work directly on improving the quality of life of children and adolescents with Down syndrome. (bvsalud.org)
- In children and adolescents with Down syndrome (DS), high obesity levels were also recorded from the 80's to the present days 5,6 . (bvsalud.org)
- Thus, care with the obesity control in children and adolescents with DS should be redoubled, because excess body fat is one of the characteristics of the syndrome, which can seriously contribute to the increased incidence of several diseases. (bvsalud.org)
- Therefore, the study of the body fat behavior through the assessment of the body composition, occupies an important space in the identification of the levels of obesity in various populations, especially in children and adolescents with Down syndrome. (bvsalud.org)
- Metabolic syndrome is increasing among adolescents. (cdc.gov)
- Pediatric obesity remains an ongoing serious international health concern affecting ~17% of US children and adolescents, threatening their adult health and longevity. (medscape.com)
- Adolescents undergoing lifestyle therapy, medication regimens, or bariatric surgery for obesity will need cohesive planning to help them effectively transition to adult care, with continued necessary monitoring, support, and intervention. (medscape.com)
- Because type 2 diabetes in children and adolescents is strongly associated with obesity and sedentary lifestyle, any intervention designed to increase physical activity and improve dietary habits should be encouraged. (medscape.com)
Infertility2
- Infertility is an important problem caused by obesity. (conceiveivf.com)
- Even loosing 5% of body weight can reduce obesity related infertility and other complications. (conceiveivf.com)
Fatty liver1
- The metabolic counterpart is excess lipolysis driving fatty acid levels, cathecholamine-induced peripheral, hepatic insulin resistance and fatty liver disease. (kauveryhospital.com)
Sensitivity3
- Increasing dopamine levels/signals are associated with improved insulin sensitivity, while decreasing dopamine and serotonin levels/signals are associated with weight gain and T2DM development. (frontiersin.org)
- In multiple linear regression analysis, log adiponectin was positively associated with high-density lipoprotein cholesterol levels (β = 0.006), whereas it was negatively associated with serum albumin (β = −0.284), triglyceride (log β = −0.288), high sensitivity C-reactive protein (log β = −0.058) levels and estimated glomerular filtration rate (β = −0.005). (biomedcentral.com)
- The interaction between GC metabolism and insulin sensitivity in the context of significant weight loss has not been explored. (endocrine-abstracts.org)
Complications3
- Weight problems with symptoms of associated complications are the major features of morbid obesity . (symptoma.com)
- By changing your lifestyle, you can help delay or even prevent the complications of metabolic syndrome (heart disease, stroke and diabetes) from developing. (mydr.com.au)
- screening for comorbidities of obesity should be applied in a hierarchal, logical manner for early identification before more serious complications result. (medscape.com)
Diagnosis5
- In the literature, there is a link that NAFLD is the hepatic component of the metabolic syndrome diagnosis ( Takahashi & Fukosato, 2014 ). (nursingcenter.com)
- Does a diagnosis of the metabolic syndrome provide additional prediction of cardiovascular disease and total mortality in the elderly? (mja.com.au)
- It is pertinent to note that the presence of obesity creates unique challenges for the diagnosis and treatment of asthma. (biomedcentral.com)
- We present a 17 year-old woman, with a previous genetic diagnosis of Prader-Willi syndrome and BMI of 74 Kg/m(2), that was admitted in anasarca, with marked cyanosis, dyspnea and oliguria. (symptoma.com)
- The first step in the therapeutic strategy against obesity should be the correct diagnosis of its causes and the promotion of lifestyle changes including physical exercise and a healthy diet. (benthamscience.com)
People with metabolic syndrome4
- The purpose of this study is to examine the effect of long-term treatment with low doses of chloroquine on atherosclerosis in people with metabolic syndrome. (druglib.com)
- People with metabolic syndrome not only have an increased risk of heart disease, but their risk of stroke and diabetes is also higher than average. (mydr.com.au)
- People with metabolic syndrome, who have a combination of several of these risk factors rolled into one, are at even higher risk of these problems. (mydr.com.au)
- Insulin resistance and central obesity also put you at high risk of developing diabetes - people with metabolic syndrome have 5 times the risk of developing type 2 diabetes. (mydr.com.au)
Criteria for metabolic syndrome1
Causes metabolic syndrome1
- What causes metabolic syndrome? (healsens.com)
Dysfunction1
- This syndrome involves anovulation or ovulatory dysfunction and androgen excess of unclear etiology. (merckmanuals.com)
Endocrine4
- In addition to local paracrine actions and peripheral endocrine effects mediated through the bloodstream, gut hormones play a pivotal role relaying information on nutritional status to important appetite controlling centres within the central nervous system (CNS), such as the hypothalamus and the brainstem. (hindawi.com)
- Obesity can not only lower quality of life during childhood but may increase the chance that the excess weight will persist into adulthood, says Sheila Perez-Colon, MD , who is a double-board-certified pediatric oncologist and practices at Elite Endocrine MD in San Juan and Dorado, Puerto Rico. (everydayhealth.com)
- The predominance of central, viscerally deposited fat may alter the immunological, metabolic and endocrine milieu. (benthamscience.com)
- Endocrine etiologies for obesity are rare and usually are accompanied by attenuated growth patterns. (medscape.com)
Hormones3
- In this paper, we focus on the role of gut hormones and their related neuronal networks (the gut-brain axis) in appetite control, and their potentials as novel therapies for obesity. (hindawi.com)
- Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. (scienceopen.com)
- Obesity wreaks havoc with male and female hormones, disrupting normal cycles and function, and leading to difficulty or inability to conceive. (symptoma.com)
Presence of central obesity1
Diabetes mellitus2
- Nigeria is a developing country that is currently witnessing an upsurge in diabetes mellitus and obesity with its antecedent consequences. (biomedcentral.com)
- Elderly persons who have non-insulin-dependent diabetes mellitus (NIDDM) and other symptomatic medical conditions may also have a higher risk of developing psychological problems. (cdc.gov)
Serum1
- Two-hour postload plasma glucose (2-h PG) and serum insulin and fasting plasma glucose were associated with the third factor. (diabetesjournals.org)
Metabolism4
- Metabolic syndrome is an unhealthy metabolism that leads to fatal diseases such as heart attacks, diabetes , and cancer. (healsens.com)
- Endogenous glucocorticoid (GC) production and metabolism have been implicated based upon parallels with Cushing s syndrome. (endocrine-abstracts.org)
- This study was designed to evaluate the role of pre-receptor glucocorticoid metabolism in the development of insulin resistance and obesity. (endocrine-abstracts.org)
- His work has focussed on glucocorticoid action and metabolism and in particular the role of the pre-receptor metabolizing enzymes to regulate metabolic function. (uni-luebeck.de)
Chronic6
- Aims: we investigate whether insulin resistance is associated with an increased prevalence for chronic kidney disease irrespective of the concurrent presence of metabolic syndrome. (scirp.org)
- The importance of the MS as a chronic cardiovascular risk factor and the role of insulin resistance (IR) as its principal underlying cause have been under discussion recently [7]. (scirp.org)
- The present work was directed to analyse the information of an observational Spanish study in adult population (DESIRE study) [22] in order to investigate the association of insulin resistance with the risk of chronic kidney disease (CKD) in a non diabetic population. (scirp.org)
- The most important modifiable risk factors for chronic migraine include overuse of acute migraine medication, ineffective acute treatment, obesity, depression and stressful life events. (nature.com)
- Obesity is a multifactorial disease that is currently developing a threatening tendency towards becoming the main cause of chronic disease in the world. (benthamscience.com)
- Obesity Obesity is a chronic, multifactorial, relapsing disorder characterized by excess body weight and defined as a body mass index (BMI) of ≥ 30 kg/m2. (msdmanuals.com)
Cholesterol2
- Even a small amount of weight loss can help improve insulin resistance, lower your blood pressure and correct your cholesterol levels. (mydr.com.au)
- This study highlights an imperative to improve the frequency of cholesterol screening and statin prescription rates to better identify and treat this high-risk population. (cdc.gov)
Significantly4
- Also, the microvascular tone and microvascular density are significantly impacted by obesity. (kauveryhospital.com)
- The U.K. researchers found Montmorency tart cherry juice led to a significant, clinically-relevant reduction in systolic blood pressure when compared to the placebo 2 hours after consumption, and Montmorency tart cherry juice and Montmorency tart cherry capsules both lowered insulin levels significantly more than the placebo at 1 hour and 3 hours, respectively. (medindia.net)
- The pulmonary function test was not significantly affected by presence of metabolic syndrome. (biomedcentral.com)
- We used stepwise regression analysis to determine whether anthropometric measurements significantly predicted metabolic syndrome. (cdc.gov)
Clustering of several cardiovascular1
- Metabolic syndrome is defined as clustering of several cardiovascular and metabolic risk factors. (cdc.gov)
PCOS4
- Excessive insulin production is directly related to the increased ovarian production of androgens and PCOS manifestations [ 11 ]. (biomedcentral.com)
- Excessive insulin level is not only a potential cause of hyperandrogenemia but also one of the high-risk factors leading to metabolic syndromes among those with PCOS ( 6 ). (frontiersin.org)
- The typical doctor will give women with PCOS potent diabetes drugs to help control insulin levels, but a much simpler, healthier and more direct solution is to eat differently and get some exercise. (virginiahopkinshealthwatch.com)
- The rate of miscarriage has increased, and the risk for birth defects is also higher for babies born to mothers with PCOS. (postureclinic.in)
Increases5
- Obesity increases the chances that you'll experience severe illness, become hospitalized, or die if you contract COVID-19. (everydayhealth.com)
- The syndrome substantially increases the risk of developing diabetes and vascular disease, but there is no clear unifying approach to treat this disorder. (druglib.com)
- There is growing epidemiological evidence that obesity increases the risk of developing asthma. (biomedcentral.com)
- There is growing evidence that early development of obesity increases cardiovascular risk later in life, but less is known about whether there are effects of long-term excess body weight on the biological drivers associated with the atherosclerotic pathway, particularly adipokines, inflammatory and endothelial markers. (nature.com)
- Excess glucose (from sugar and carbohydrates) in the bloodstream, raises insulin levels which increases androgen (male hormone) levels in women. (virginiahopkinshealthwatch.com)
Levels are not elevated1
- However, in simple obesity, circulating glucocorticoid levels are not elevated. (uni-luebeck.de)
International Diabetes F2
- The International Diabetes Federation (IDF) requires central obesity as a mandatory component. (biomedcentral.com)
- Metabolic syndrome was defined by the international diabetes Federation (IDF) criteria. (biomedcentral.com)
Sedentary1
- Unhealthy diets leading to an excessive calorie intake coupled with sedentary lifestyles are the most common causes of obesity and excess weight. (kauveryhospital.com)
High15
- For example, as well as causing high blood pressure, Cushing's syndrome frequently causes truncal obesity, glucose intolerance, moon face, a hump of fat behind the neck and shoulders (referred to as a buffalo hump), and purple abdominal stretch marks. (wikipedia.org)
- In this article, we reviewed the evidence that eating, especially high-caloric foods, stimulates the limbic system, initiating Reward Deficiency Syndrome. (frontiersin.org)
- High levels of insulin and glucose in the blood are highly correlated with the level of fat you store on your suprailiac (4). (bodybuilding.com)
- Metabolic syndrome is an asymptomatic pathophysio- a relatively high socioeconomic status. (who.int)
- Most studies on the incidence and risk factors of metabolic syndrome have been conducted in developed countries or regions where the populations have a relatively high socioeconomic status. (who.int)
- The pathophysiology of OCD is uncertain, largely because of the heterogeneity of manifestations and the high rates of comorbidity (anxiety, depressive or bipolar disorder). (psychiatrictimes.com)
- Obesity is also associated with Polycystic Ovarian Syndrome, along with symptoms of high male hormone secretion like hairiness and acne. (conceiveivf.com)
- To investigate the endometrial transcriptome profile and the associated molecular pathway alterations, we established an ovariectomized C57BL/6 mouse model treated with subcutaneous implantation of 17-β estradiol (E2) pellet and/or high-fat diet (HFD) for 12 weeks to mimic sustained estrogen stimulation and insulin resistance. (scienceopen.com)
- If you had high blood pressure which is now normal because it's controlled by medicine, then for the purposes of diagnosing metabolic syndrome you are still classed as having high blood pressure. (mydr.com.au)
- In addition, high levels of insulin can contribute to the development of high blood pressure and help raise triglyceride levels. (mydr.com.au)
- Alternatively, for high-risk women or in areas in which the prevalence of insulin resistance is 5% or higher (eg, the southwestern and southeastern United States), a 1-step approach can be used by proceeding directly to the 100-g, 3-hour OGTT. (medscape.com)
- Hormonally, a woman with metabolic syndrome tends to have high androgen (male hormone) levels, high estrogen levels (the fat cells are making estrogen from androgens), high cortisol and low thyroid. (virginiahopkinshealthwatch.com)
- Men with metabolic syndrome tend to have low testosterone and high estrogen. (virginiahopkinshealthwatch.com)
- This was underscored in a Johns Hopkins study published in the American Journal of Epidemiology in September 2004 which showed that women with metabolic syndrome have high androgen levels. (virginiahopkinshealthwatch.com)
- Because Katzmarzyk et al did not determine whether these cutpoints identified metabolic syndrome, we attempted to do so in a sample of predominantly African American adolescent girls who attended high school and who lived in an urban area. (cdc.gov)
Excess4
- As mentioned, obesity is generally associated with having excess weight. (everydayhealth.com)
- Obesity Obesity is excess body weight, defined as a body mass index (BMI) of ≥ 30 kg/m 2 . (merckmanuals.com)
- And speaking of metabolic syndrome, one of the key issues addressed in the "… Breast Cancer " book is the role of excess sugar and carbohydrates in setting the stage for breast cancer. (virginiahopkinshealthwatch.com)
- An aside: This study is particularly interesting because it showed that only excess "free" or bioavailable androgens were strongly associated with metabolic syndrome, which means that conventional blood tests didn't show this effect. (virginiahopkinshealthwatch.com)
Methods2
- Although some behavioral and pharmacotherapy studies report modest success, additional research into accessible and effective methods for preventing and treating pediatric obesity is needed. (medscape.com)
- Furthermore, continued investigation into the most effective methods of preventing and treating obesity and into methods for changing environmental and economic factors that will lead to worldwide cultural changes in diet and activity should be priorities. (medscape.com)