• Genetic contributions were assessed using three strains of male rats with different genetic backgrounds [Fischer-344 (F344), Sprague-Dawley (SD), Brown-Norway (BN)] maintained on a standard or high fat (HF) diet for 24 wk. (cdc.gov)
  • The RI strains were derived from the SHR (spontaneously hypertensive rat) and BN-Lx (Brown Norway rat) progenitors. (bvsalud.org)
  • In the beginning preimplantation blastocysts (embryonic day time 4.5) from an outbred strain of CD:VRL1 rats (also called Sprague-Dawley (SD)) and inbred strains of Fischer 344 and Brown-Norway (BN) rats were individually seeded onto mitomycin C-treated mouse embryonic fibroblast cells in N2B27 medium supplemented with 2i-LIF (Supplementary info Data S1 Number 1A and ?and1B).1B). (researchhunt.com)
  • We used a miRNA microarray platform to measure global miRNA expression in two insulin-target tissues: liver and adipose tissue from inbred rats of spontaneously diabetic (Goto-Kakizaki [GK]) and normoglycaemic (Brown-Norway [BN]) strains which are extensively used in genetic studies of T2D. (diabetestalk.net)
  • We report here the genome sequence of the Brown Norway (BN) rat strain. (nih.gov)
  • The Brown Norway (BN) rat model has been extensively characterized and appears to be among the best animal models thus far described. (indexarticles.com)
  • Accordingly, male Sprague-Dawley (SD) and Brown Norway (BN) rats were maintained on either regular (Reg) or high fat (HF) diets for 24wk. (cdc.gov)
  • An analysis of spontaneous hypertension in spontaneously hypertensive rats by means of new recombinant inbred strains. (mcw.edu)
  • The mode of blood pressure inheritance and some genetic markers of spontaneous hypertension were evaluated in a new set of recombinant inbred (RI) strains obtained by crossing of normotensive (BN.lx) and hypertensive (SHR) progenitor strains. (mcw.edu)
  • Recently, we identified a recessive mutation, an abnormal coat appearance in BXH6 strain, a member of the HXB/BXH set of recombinant inbred (RI) strains. (bvsalud.org)
  • The F344/Stm rat is a parental strain of the LEXF/FXLE recombinant inbred (RI) strains. (nig.ac.jp)
  • An automated electric arc wire thermal spray coating aerosol generator and inhalation exposure system was developed to simulate an occupational exposure and, using this system, male Sprague-Dawley rats were exposed to stainless steel PMET720 aerosols at 25mg/m(3)4h/day9 day. (cdc.gov)
  • Generally, the exposome components of diet and WF exposure had the greater influence on the parameters measured compared to the changes associated with rat strain except for the body weight changes observed with the HF diet that were more pronounced in the inbred F344 and BN strains. (cdc.gov)
  • The strain was developed by Shisa et al at the Saitama Cancer Center Research Institute from the F344/DuCrj strain (Charles River Japan, Inc.). The coat color is albino (c). (nig.ac.jp)
  • The polymorphic rate of our 357 SSLP makers is 85% against BN/SsNHsd strain and 73% against F344/Stm strain. (nig.ac.jp)
  • Rats, Inbred F344" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
  • P, Cervenka L, Falck JR, Imig JD, Kompanowska-Jezierska E. Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats. (uams.edu)
  • Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats. (uams.edu)
  • Whole genome sequencing of the mutant rats identified the 195875980 G/A mutation in the Tuft1 (tuftelin 1) gene on chromosome 2, which resulted in a premature stop codon. (bvsalud.org)
  • The genome of the final consomic strain is the same as that of the host strain, with the exception of the MSY from the donor strain. (comprehensivephysiology.com)
  • BAC clones are available from RIKEN BioResource Center by NBRP Rat Genome Information Upgrading Program ( Kyoto University , RIKEN Genomic Sciences Center, and Comparative Genomics Laboratory, National Institute of Genetics ) in Japan. (nig.ac.jp)
  • The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. (nih.gov)
  • 1982. Acute inhalation toxicity of ammonia in rats with variable exposure periods. (cdc.gov)
  • After 14 days, repeated allergen inhalation challenges were performed in the sensitized rats for 2 weeks. (indexarticles.com)
  • 9) Allergen inhalation in sensitized BN rats causes an increase in production of tumor necrosis factor (TNF)-[alpha] and nitric oxide (NO) by alveolar macrophage and airways epithelial cells, and it can be inhibited by dexamethasone. (indexarticles.com)
  • Age related changes of social memory/recognition in male Fischer 344 rats. (omeka.net)
  • Two different habituation-dishabituation test paradigms were used to evaluate differences in social memory/recognition among 3-, 15- and 22-month-old male Fischer 344 rats. (omeka.net)
  • Genetic analysis of susceptibility to endometrial adenocarcinoma in the BDII rat model. (mcw.edu)
  • BDII females were crossed to males from inbred strains with low EAC incidence (SPRD or BN). (mcw.edu)
  • Furthermore, it seems clear from the interstrain crosses not only that the onset of tumors depends on the presence of susceptibility alleles from the EAC-prone BDII strain, but also that tumor development is affected by the contribution of a genetic component derived from the nonsusceptible strains. (mcw.edu)
  • In the present work we used spectral karyotyping (SKY) to identify cancer-related aberrations in a well-characterized experimental model for spontaneous endometrial carcinoma in the BDII rat tumor model. (biomedcentral.com)
  • Of these, four develop EC spontaneously, of which females from the BDII/Han strain (hereafter BDII) is prone to develop tumors with the highest incidence (more than 90% among the virgin females) [ 12 , 13 ]. (biomedcentral.com)
  • EC development in BDII rats has similarities in pathogenesis, histopathological and molecular properties to human EC, and thus the inbred BDII strain represents a unique model for analysis of EC tumorigenesis [ 14 ]. (biomedcentral.com)
  • Effect of diet and occupational exposure in different rat strains on serum biomarkers and peripheral blood mononuclear cell telomere length: development of an animal model to examine the exposome. (cdc.gov)
  • In addition, mutant rats had lower serum MCP-1 and leptin levels, indicative of reduced inflammation. (bvsalud.org)
  • To elucidate whether allergic bronchitis interferes with vitamin A metabolism, we measured the vitamin A levels in the serum, the lung, and the liver following repeated allergen challenge in a rat model and compared them to normal rats. (indexarticles.com)
  • This suggestion was confirmed by the detection of significant difference in blood pressure between SHR and SHR.1N congenic strains. (mcw.edu)
  • Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. (mcw.edu)
  • Wistar rats were exposed for 30 min to a range of concentrations (10 to 300 mg/m3) of the well-known respiratory allergen trimellitic anhydride (TMA). (cdc.gov)
  • In BN rats, changes in breathing pat- tern were seen at levels of 29 mg/m3 and higher and decreases in frequency at 60 mg/m3 and higher, whereas in Wistar rats changes in both pattern and frequency (increases fol- lowed by decreases) were seen at levels of 34 mg/m3 and higher. (cdc.gov)
  • Forced swim test (FST) in adult male Wistar rats and tail suspension test (TST) in adult male Swiss albino mice were used to investigate antidepressant activity of vitamin D administered in single dose and multiple doses. (ijbcp.com)
  • The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. (nih.gov)
  • A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR). (wakehealth.edu)
  • A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke. (uams.edu)
  • If inbred animal models are used, then both the genetic constitution and environmental influences can be carefully controlled. (mcw.edu)
  • Consomic rat panel in which each of the 20 autosomes and the X and Y chromosomes from the BN strain were transferred onto the SS genetic background. (comprehensivephysiology.com)
  • Genetic differences in the tail-suspension test and its relationship to imipramine response among 11 inbred strains of mice. (ijbcp.com)
  • A separate set of rats from each strain were allowed to recover from WF exposure until the end of the 24 wk period. (cdc.gov)
  • Rats were euthanized at 7, 12, and 24wk to evaluate local and systemic immune markers corresponding to the baseline, exposure, and recovery phases of the study, respectively. (cdc.gov)
  • In BN rats, resolution of immune alterations was further compromised by HF diet, as many exposure-induced alterations in local/systemic immune markers were still evident in HF/WF animals at 24wk. (cdc.gov)
  • Collectively, HF diet appeared to have a greater impact on global immune status and exposure-induced lung injury in SD rats, but a more pronounced effect on inflammation resolution in BN rats. (cdc.gov)
  • Highly susceptible mouse strains such as SJL/N, A.SW, B10.S (H-2 s ) develop multiple autoimmune manifestations after exposure to inorganic mercury, including lymphoproliferation, elevated levels of autoantibodies, overproduction of IgG and IgE, and circulating immune complexes in kidney and vasculature. (biomedcentral.com)
  • Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)
  • Castagné V, Moser P, Roux S, Porsolt RD. Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice. (ijbcp.com)
  • The N2 rats that are determined by genotyping to be heterozygous along the target chromosome are then backcrossed for ∼4 to 8 generations [e.g., marker assister selection for rats with most SS (blue) alleles]. (comprehensivephysiology.com)
  • This yields offspring with an isogenic SS background for all but the target chromosome as shown in (B). Selected male and female rats are then mated resulting in approximately 25% of the offspring being homozygous for the chromosome of interest. (comprehensivephysiology.com)
  • These rats are then inbred to produce a stable inbred consomic strain with the substitution of one entire chromosome from the BN strain into the background of the SS strain. (comprehensivephysiology.com)
  • Example of reduced blood pressure salt sensitivity resulting from substitution of chromosome 13 from the BN into the SS/Mcwi strain (SS‐13 BN consomic rat). (comprehensivephysiology.com)
  • Conversely, substitution of chromosome 18 from SS to the BN strain (BN‐18 SS ) resulted in a relatively small increase in MAP in response to the high‐salt diet. (comprehensivephysiology.com)
  • The most recurrent numerical alterations were gains in rat chromosome 4 (RNO4) and losses in RNO15. (biomedcentral.com)
  • As the majority of the genes are conserved among mammals, the use of inbred animal model systems may serve as a tool for identification of underlying genes and pathways involved in tumorigenesis in humans. (biomedcentral.com)
  • The association between blood pressure and gene(s) within RT1 complex or gene(s) closely linked to it was found by RI strain analysis. (mcw.edu)
  • MiRNA data were integrated with gene expression data from the same rats to investigate how differentially expressed miRNAs affect the expression of predicted target gene transcripts. (diabetestalk.net)
  • Neuropathic pain in aged rats: behavioral responses and astrocytic activation. (omeka.net)
  • At 7wk, HF-fed animals exhibited several immune alterations (blood leukocyte/neutrophil number, lymph node B-cell proportionality)-effects which were more pronounced in SD rats. (cdc.gov)
  • Resulting F1 males are then backcrossed to a female from the host strain to generate the N2 generation. (comprehensivephysiology.com)
  • Males from the latter are backcrossed again to females from the host strain, the procedure being repeated ( n ) times. (comprehensivephysiology.com)
  • Effect of aging on the substance P receptor, NK-1, in the spinal cord of rats with peripheral nerve injury. (omeka.net)
  • however, diet appeared to preferentially impact SD rats at this time point, as several inflammatory markers (lymph node cellularity, lung neutrophils) were further elevated in HF over Reg animals. (cdc.gov)
  • Results: The study rats showed severe bronchoconstriction after allergen challenge compared to the naive rats, and ex vivo TNF-[alpha] and NO production was significantly higher in the sensitized rats. (indexarticles.com)
  • In the current study, we examined the transcriptome of primary rat microglial cells following incubation with alcohol alone, or alcohol together with a robust inflammatory stimulus. (biomedcentral.com)
  • Microglial proliferation in the spinal cord of aged rats with a sciatic nerve injury. (omeka.net)
  • Compared to wild-type BXH6 rats, BXH6-Tuft1 mutant rats exhibited lower body weight due to reduced visceral fat and ectopic fat accumulation in the liver and heart. (bvsalud.org)
  • The expression of 170 miRNAs was measured in liver and adipose tissue of GK and BN rats. (diabetestalk.net)
  • However, the vitamin A liver concentration in the study rats was significantly lower compared to the naive rats. (indexarticles.com)
  • 5) The asthmatic rats have early airway responses and late airway response in high prevalence, (6) showing high levels of specific IgE on active immunization (6) and airway eosinophilia. (indexarticles.com)
  • Rats will be given vanadium, as sodium orthvanadate or vanadyl sulfate, in a liquid diet and a number of insulin-sensitive activities of target tissues measured and compared to control animals. (diabetestalk.net)
  • The various other population had taken on the looks of flattened clones termed flattened rat ESCs (f-rESCs). (researchhunt.com)
  • Objective: To examine whether repeated allergen challenges could increase vitamin A consumption in a rat model. (indexarticles.com)
  • These studies were designed to investigate how the aging process alters the spinal antinociceptive efficacy of mu (mu), delta (delta) and epsilon (epsilon) opioid receptor agonists administered intrathecally (i.t.) in rats. (omeka.net)
  • Antidepressant-like effects of nicotine and mecamylamine in the mouse forced swim and tail suspension tests: role of strain, test and sex. (ijbcp.com)
  • An inbred strain of rat that is used for general BIOMEDICAL RESEARCH purposes. (jefferson.edu)
  • The highest level at which no acute airway irritation as based on both breathing pattern and frequency was observed in both rat strains was 14 mg/m3. (cdc.gov)
  • Acute adiponectin delivery is cardioprotective in the aged female rat heart. (jefferson.edu)
  • With transmission disequilibrium test analysis, significant association was detected in three chromosomal regions (on RNO1, RNO11, and RNO17) in the SPRD crosses and in the short arm of RNO20 in the BN crosses. (mcw.edu)
  • MiR-125a also showed over-expression in the GK vs. BN analysis within adipose tissue (FC = 1.97, P = 0.078, P adjusted = 0.99), as did the previously reported miR-29a (FC = 1.51, P = 0.05, P adjusted = 0.99). (diabetestalk.net)
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  • The rats were randomly assigned to either the test group (n = 12) or the control group (n = 12). (indexarticles.com)
  • Allergic bronchitis was induced in the test group rats at the beginning of the study according to a protocol described by Du et al. (indexarticles.com)
  • 20 mg/m3 x 3 hr/d x 4 d/wk x 5 wk) or filtered air until wk 12 at which time some animals from each strain were euthanized. (cdc.gov)
  • Substance P (SP) levels in the spinal cords of very old rats are less than the levels in younger rats (Bergman et al. (omeka.net)