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  • SOS1
  • RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth. (nih.gov)
  • Similarly, the mammalian orthologues of Sos, SOS1 and SOS2, function downstream of many growth factor and adhesion receptors. (wikipedia.org)
  • regulates
  • Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). (genecards.org)
  • The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. (genome.jp)
  • The activated transcription factor c-Jun regulates nuclear transcription via AP-1 to increase pro-apoptotic gene transcription. (wikipedia.org)
  • Mutations
  • In humans, other members of the Ras subfamilies carry mutations in human cancers. (wikipedia.org)
  • Phosphatidylinositol-3-kinase make contacts with both (6:11) switch I and II regions of ras and yeast adenylyl cyclase molecules carrying these mutations are rendered unactivatable by Ras in vitro. (wikipedia.org)
  • Adenylyl cyclase molecules carrying these mutations are rendered unactivatable by Ras in vitro with the Ras-associating domain-RA, not all RA domains bind RasGTP it is a primary Ras-binding site. (wikipedia.org)
  • Genes
  • RAS genes (e.g. (wikipedia.org)
  • A common feature of these genes is that their products have all been strongly implicated as positive regulators of the Ras/MAP kinase signal transduction pathway. (wikipedia.org)
  • receptor
  • Epidermal growth factor receptor immunohistochemistry: new opportunities in metastatic colorectal cancer. (genome.jp)
  • The role of the epidermal growth factor receptor in the mechanism and treatment of colorectal cancer. (genome.jp)
  • Ras guanine nucleotide exchange factors (RasGEFs) catalyze GTP loading of Ras and play a pivotal role in regulating receptor-ligand induced Ras activity. (frontiersin.org)
  • For example, when activated, fibroblast growth factor receptor 1 and epidermal growth factor receptor are RTKs that have phosphorylated tyrosines, which provide docking sites for PLCG1 SH2 domains. (wikipedia.org)
  • downstream
  • In this review we highlight how different lipid-based elements are generated by various enzymes downstream of the TCR and other receptors and how these dynamic and interrelated lipid products may fine-tune Ras activation by RasGEFs in developing T cells. (frontiersin.org)
  • bind
  • Of the two states M-Ras can switch between, M-Ras is predominantly found in its state 1 conformation, which does not bind Ras effectors. (wikipedia.org)
  • SEQUENCE
  • Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). (origene.com)
  • GRFs
  • Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB. (uniprot.org)