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  • Tumor
  • In mammals, several RasGAPs exhibit tumor suppressor activity by preventing excess RAS signal transduction. (uzh.ch)
  • A reduced miR-126 expression and an elevated Crk protein expression, alone or in combination, statistically correlated with aggressive clinicopathological characteristics, such as larger tumor size, deeper local invasion, more lymph node metastasis, advanced TNM stage, and poorer prognosis. (nih.gov)
  • effector proteins
  • However, these interactions are prevented when the lipids' head groups are masked by the recruitment of cytosolic effector proteins, whereas these effectors must also have sufficient mobility to maximize functional interactions. (nih.gov)
  • cytoplasmic proteins
  • It stands out from its cousins in almost exclusively deacetylating cytoplasmic proteins, in exerting deacetylation-independent effects and in the success that has been achieved in developing relatively isoform-specific inhibitors of its enzymatic action that have reached clinical trial. (clinsci.org)
  • Homolog
  • The newly identified proteins include the heavy chain of myosin-Va (dilute myosin), a motor protein thought to be involved in vesicle trafficking, and the mammalian homolog of the yeast septin protein cdc10, which is important for bud formation in yeast. (jneurosci.org)
  • regulator
  • GAP-3 is the predominant negative regulator of RAS during meiotic progression of the germ cells, while GAP-1 is the key inhibitor of RAS during vulval induction. (uzh.ch)
  • Inhibitory regulator of the Ras-cAMP pathway. (uniprot.org)
  • The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. (nih.gov)
  • mice
  • There is evidence of increased activation under resting and stimulated conditions in microglia prepared from CD200-deficient mice compared with wild-type mice, whereas activation of the receptor by CD200 fusion protein (CD200Fc) ameliorates inflammatory changes which are evident in the central nervous system (CNS) of the mouse model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE) and also in the hippocampus of aged rats. (biomedcentral.com)
  • To assess the function of this protein complex at neuronal cholinergic synapses in vivo , we examined ganglia in mice that lack PSD93. (jneurosci.org)
  • membrane-associated
  • Sec7-related guanine nucleotide exchange factors (GEFs) initiate vesicle budding from the Golgi membrane surface by converting the GTPase ARF to a GTP-bound, membrane-associated form. (embl-heidelberg.de)
  • Molecular
  • 2005 ). Ras acts as a molecular switch and is bound to GDP in its inactive state, and GTP in its active state. (springer.com)
  • interactions
  • We've also demonstrated that proinflammatory cytokine TNF via its receptor TNFR2 transactivates VEGFR2 (9 10 VEGFR2 activity can be regulated by immediate interactions with additional protein including co-receptor neuropilins (11) adhesion molecule vascular endothelial-cadherin (VE-cadherin) (12) and integrins (13). (neuroart2006.com)
  • Selective methylation on these motifs can modulate protein-protein interactions. (abcam.com)
  • Polyphosphoinositol lipids convey spatial information partly by their interactions with cellular proteins within defined domains. (nih.gov)
  • We find that the protein-lipid complexes retain a relatively rapid ( approximately 0.1-1 microm(2)/s) diffusion coefficient in the membrane, likely dominated by protein-protein interactions, but the limited time scale (seconds) of these complexes, dictated principally by lipid-protein interactions, limits their range of action to a few microns. (nih.gov)
  • metazoan
  • Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. (nature.com)
  • cellular
  • The small, membrane-tethered G-protein Ras plays an important role in many cellular processes, including growth, differentiation, and survival (Wennerberg et al. (springer.com)
  • Since Ras controls multiple cellular outcomes, its activity is tightly regulated. (springer.com)
  • inactive
  • The mutation causes mislocalization of RASA3 to the cytosol in scat red cells where it is inactive, leading to increased GTP-bound Ras. (pnas.org)
  • mutation
  • Local tumour progression after percutaneous ablation of colorectal liver metastases according to RAS mutation status. (nih.gov)
  • In contrast, there was only a minor effect of either mutation on NF1-334 affinity for wild-type Ha-Ras. (embl-heidelberg.de)
  • neuronal
  • Specifically, in both the sympathetic superior cervical ganglion (SCG) and the parasympathetic submandibular ganglion (SMG), PSD93 proteins localize to neuronal cholinergic synapses and form a complex with neuronal nAChRs in vivo . (jneurosci.org)
  • family
  • HDAC6 is one isoform of a family of HDAC enzymes that catalyse the removal of functional acetyl groups from proteins. (clinsci.org)
  • pleckstrin
  • The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. (genecards.org)