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  • Tumor
  • In mammals, several RasGAPs exhibit tumor suppressor activity by preventing excess RAS signal transduction. (uzh.ch)
  • A reduced miR-126 expression and an elevated Crk protein expression, alone or in combination, statistically correlated with aggressive clinicopathological characteristics, such as larger tumor size, deeper local invasion, more lymph node metastasis, advanced TNM stage, and poorer prognosis. (nih.gov)
  • ARHGEF39 promotes tumor growth and invasion by activating the Rac1-P38-ATF2 signaling pathway, as well as increasing the expression of Cyclin A2, Cyclin D1, and MMP2 in NSCLC cells. (nih.gov)
  • cytoplasmic proteins
  • It stands out from its cousins in almost exclusively deacetylating cytoplasmic proteins, in exerting deacetylation-independent effects and in the success that has been achieved in developing relatively isoform-specific inhibitors of its enzymatic action that have reached clinical trial. (clinsci.org)
  • MAPK
  • VEGF primarily utilizes its receptor VEGFR2 (also known as TAK-875 Flk-1 or KDR) to induce angiogenic responses by activating a variety of signaling cascades including activation of PI3K-Akt PLC-γ-PKC and MAPK (3). (neuroart2006.com)
  • mice
  • There is evidence of increased activation under resting and stimulated conditions in microglia prepared from CD200-deficient mice compared with wild-type mice, whereas activation of the receptor by CD200 fusion protein (CD200Fc) ameliorates inflammatory changes which are evident in the central nervous system (CNS) of the mouse model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE) and also in the hippocampus of aged rats. (biomedcentral.com)
  • To assess the function of this protein complex at neuronal cholinergic synapses in vivo , we examined ganglia in mice that lack PSD93. (jneurosci.org)
  • metazoan
  • Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. (nature.com)
  • regulation
  • SMO1 is therefore necessary for regulation of RAS activation required for conidial morphogenesis and septin-mediated plant infection. (genetics.org)
  • inactive
  • The mutation causes mislocalization of RASA3 to the cytosol in scat red cells where it is inactive, leading to increased GTP-bound Ras. (pnas.org)
  • 2005 ). Ras acts as a molecular switch and is bound to GDP in its inactive state, and GTP in its active state. (springer.com)
  • differentiation
  • The small, membrane-tethered G-protein Ras plays an important role in many cellular processes, including growth, differentiation, and survival (Wennerberg et al. (springer.com)
  • neuronal
  • Specifically, in both the sympathetic superior cervical ganglion (SCG) and the parasympathetic submandibular ganglion (SMG), PSD93 proteins localize to neuronal cholinergic synapses and form a complex with neuronal nAChRs in vivo . (jneurosci.org)
  • mass spectrometry
  • In this study, we have completed the identification of most major proteins in the PSD fraction with the use of an analytical method based on mass spectrometry coupled with searching of the protein sequence databases. (jneurosci.org)
  • mutation
  • Local tumour progression after percutaneous ablation of colorectal liver metastases according to RAS mutation status. (nih.gov)
  • family
  • HDAC6 is one isoform of a family of HDAC enzymes that catalyse the removal of functional acetyl groups from proteins. (clinsci.org)
  • cyclic
  • Moreover, microRNA-132 (miR-132) was constitutively expressed and secreted by SVPs and remarkably upregulated, together with its transcriptional activator cyclic AMP response element-binding protein, on stimulation by H/S or vascular endothelial growth factor B. We next investigated if SVP-secreted miR-132 acts as a paracrine activator of cardiac healing. (ahajournals.org)