2023KhaimahRheumatoidMutationsProteinsParallelsOncogenicInhibitorsInhibitionGenesFast-pacedNRASKRASEffectorCliniciansMutantMethotrexateArkestraSearchSurgeryAbstractAutoimmuneCertificationLungsEmployeePatientsPageTissueHumansEgyptianRelateVersusEscapeFamilyMakePotentiallyCancerWorkExperienceStiffnessResultsHighlyReview
20231
- Cite this: GLP-1 RAs Plus Bariatric Surgery: 'Promising Approach' for Obesity - Medscape - Nov 14, 2023. (medscape.com)
Khaimah7
- Waldorf Astoria Ras Al Khaimah is an ideal destination for an unforgettable getaway. (hilton.com)
- Waldorf Astoria Ras Al Khaimah is home to eight restaurants and bars, offering an exclusive range of dining and entertainment experiences to suit every mood and taste. (hilton.com)
- Explore the Middle East's jewel in Ras Al Khaimah, UAE, the northernmost part of the emirate, with a sandy white private beach and 18-hole championship golf course nearby. (hilton.com)
- Host an impressive business meeting, special occasion, or social gathering at Waldorf Astoria Ras Al Khaimah, where our experienced team will tailor your event to success. (hilton.com)
- Within the sanctuary of Wadi Khadeja, The Ritz-Carlton Ras Al Khaimah, Al Wadi Desert offers the chance to experience romance and relaxation, adventure and natural beauty. (ritzcarlton.com)
- Just north of Dubai, The Ritz-Carlton Ras Al Khaimah, Al Wadi Desert invites guests to connect with nature and culture amid the beauty of a 1,235-acre protected reserve. (ritzcarlton.com)
- Now, visitors can experience its tranquility, picturesque scenery and rich culture at The Ritz-Carlton Ras Al Khaimah, Al Wadi Desert. (ritzcarlton.com)
Rheumatoid6
- Drugs for rheumatoid arthritis , or RA, can slow it down. (webmd.com)
- Rheumatoid arthritis (RA) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. (medlineplus.gov)
- New proposed guidelines for managing rheumatoid arthritis (RA) recommend that methotrexate (MTX) be used aggressively before other treatment options. (medscape.com)
- Many studies show that women with rheumatoid arthritis (RA) have lower self-esteem, poorer body image, and are more dissatisfied with their bodies than healthy women. (arthritis.org)
- The introduction of tumor necrosis factor (TNF) inhibitors in the late 1990s revolutionized treatment of rheumatic diseases, such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA), providing patients with another treatment option when conventional therapies were ineffective. (medscape.com)
- In 2018, after returning to the No. 1 spot, 28-year-old Wozniacki was diagnosed with rheumatoid arthritis (RA) , an autoimmune condition that causes pain, swelling, and stiffness in our joints. (medlineplus.gov)
Mutations10
- Activating mutations of Ras genes are often observed in cancer. (nature.com)
- 76% of Ras-mutant cancer patients harbor KRAS mutations versus only 7% with HRAS mutations [ 1 ]. (nature.com)
- This is currently best expressed in the Ras "sweet-spot" model that suggests that Ras dosage (expression and signaling strength imparted by specific mutations) will be a major factor in influencing the availability of individual Ras family members to engage cancer pathways [ 4 ]. (nature.com)
- This work generated a comprehensive atlas of both co-occurring and mutually exclusive mutations among RAS and other genes at an unprecedented resolution. (news-medical.net)
- When treating patients who have RAS-mutant tumors, clinicians must consider clinical outcomes and the tumor's aggressiveness as well as co-mutations and patient characteristics such as gender, racial background and age, Anagnostou says. (news-medical.net)
- Our study shows that you need to consider who the host is and what the genetic makeup is of the tumor, because RAS-mutant tumors with different co-mutations have completely different profiles and clinical behavior. (news-medical.net)
- They first looked at the distribution and heterogeneity, or variations, of mutant RAS across cancer types and co-occurring mutations. (news-medical.net)
- Prevalence of the RAS mutations varied among cancer types - 74% in pancreatic cancers, 43.5% in colorectal cancers, 29.7% in non-small cell lung cancers, 25.3% in melanoma , 20.9% in cancer of unknown primary origin, 5.9% in precancerous blood and bone marrow diseases (myelodysplastic/myeloproliferative syndrome), and 1.5% in central nervous system tumors. (news-medical.net)
- Structural characterization disclosed how the newly identified RBD mutations cooperate and thereby enhance affinity with the effector- binding site in Ras compared with WT RBD. (bvsalud.org)
- These results revealed that the presence of Ras mutations was insufficient to predict sensitivity to Ras inhibition, suggesting that not all of these tumors required Ras signaling for proliferation. (bvsalud.org)
Proteins5
- Frank, would you like to summarize the data from your lab, and from the RAS Initiative here at the FNL, that have influenced your thinking about how RAS proteins might interact? (cancer.gov)
- We started hypothesizing that the most obvious interpretation of interference was from subunit poisoning by wild type proteins with mutant proteins into complexes, where maximum signal output would require both the proteins to be in the active state persistently, and that having a wild type protein would be like a sort of flat tire and would be a much less efficient complex than a sort of double barreled mutant RAS. (cancer.gov)
- And there's definitely something that looks like dimerization going on, but our complication has always been, as we first found in the Nan paper 5 and as Tommy Turbyville and colleagues at Frederick have repeated in much more depth, just the hypervariable regions of the RAS proteins are sufficient to give the same appearance as dimerization. (cancer.gov)
- There are three Ras genes that generate four almost identical proteins: HRAS, NRAS, KRAS4A and KRAS4B [ 2 ]. (nature.com)
- How does a family of Ras proteins that share a common set of activators and effectors generate isoform-specific engagement with cancer-associated signaling networks? (nature.com)
Parallels12
- The free online Parallels certification program is designed to boost Parallels partners' profitability by giving them the resources and knowledge they need to deploy, configure and support Parallels ® Remote Application Server (RAS). (parallels.com)
- Receive the training required to deploy, configure and maintain our Parallels RAS application and desktop delivery solution. (parallels.com)
- The Parallels RAS Technical Certification has a validity of 24 months from the date of issue. (parallels.com)
- This training provides the extended skills and knowledge necessary to implement, deploy and manage more advanced Parallels RAS features. (parallels.com)
- Parallels RAS exams certify a large set of skills for virtual desktop infrastructure (VDI), application delivery, and cloud deployment, matching the standard job description requirements for IT managers, IT architects, and system administrators. (parallels.com)
- Parallels RAS digital badges are presented by a digital image. (parallels.com)
- En representant för Parallels kommer att kontakta dig inom kort. (parallels.com)
- Parallels ® Remote Application Server (RAS) provides Windows device management capabilities. (parallels.com)
- With Parallels RAS, organizations can continue using Windows legacy OSs to securely run virtual applications while also restricting access to native OS features. (parallels.com)
- Session management allows administrators to interact with any ongoing connections from the Parallels RAS Console. (parallels.com)
- Shadowing (remote access) allows technicians to take control of Windows PCs directly from the Parallels RAS interface. (parallels.com)
- With Parallels RAS, admins can gain full access to a Windows desktop and control applications running locally on the device, as well as any remote applications published from Parallels RAS. (parallels.com)
Oncogenic3
- This suggests that dimerization is important for the full oncogenic transformation mediated by RAS. (cancer.gov)
- Finally, direct measurement of mutant versus wildtype KRAS protein abundance revealed a frequent imbalance that may suggest additional non-gene duplication mechanisms for optimizing oncogenic Ras dosage. (nature.com)
- Lower levels of expression will influence relative activity and be insufficient to initiate tumorigenesis, whilst too much Ras will induce oncogenic stress. (nature.com)
Inhibitors3
- Similar work was shared by Aymon and colleagues, in their abstract on the incidence of MACE in RA patients treated with janus kinase inhibitors (JAKi) compared to bDMARDs. (news-medical.net)
- Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. (bvsalud.org)
- In summary, by engineering the Ras /Raf interface of the CRAF-RBD, we identified potent and selective inhibitors of Ras in its active conformation that outcompete binding of Ras -signaling effectors. (bvsalud.org)
Inhibition2
- That may also be part of the reason why some patients have renin-angiotensin system (RAS) escape during chronic ACE inhibition. (medscape.com)
- Using these optimized RBD variants, we stratified patient -derived colorectal cancer organoids with known Ras mutational status according to their response to Ras inhibition. (bvsalud.org)
Genes6
- The protein products of the three Ras genes are almost identical. (nature.com)
- Ras genes are mutated in ~20% of all human cancer cases [ 1 ]. (nature.com)
- Researchers at the Johns Hopkins Kimmel Cancer Center, three other cancer centers and the Johns Hopkins Bloomberg School of Public Health compiled a comprehensive genetic architecture atlas for mutant RAS genes in human cancers. (news-medical.net)
- Their four-year study of the RAS family - including the KRAS , NRAS and HRAS genes that are mutated in approximately one-third of all human cancers - found that the frequency of mutant RAS genes differs among various tumor types, age, sex and racial groups, and co-mutation patterns among RAS genes and other genes potentially can result in different clinical outcomes or identify new areas for therapeutic intervention. (news-medical.net)
- During the study, researchers examined several characteristics of the RAS genes. (news-medical.net)
- Led by Robert Scharpf, Ph.D., associate professor of oncology at the Johns Hopkins Kimmel Cancer Center, the team developed novel analytical frameworks to assess the prevalence and co-mutation patterns of RAS genes in the AACR Project GENIE registry. (news-medical.net)
Fast-paced2
- Ra Ra Boom is an eye-catching, distinctive fast-paced four-player co-op beat 'em up driven by a meaningful and emotional coming-of-age narrative about a group of ninja cheerleaders from space in a fight to save the rest of humanity on Earth. (steampowered.com)
- As a quiz, Y Ras is fast-paced, and tries to cram in a lot into each episode. (ukgameshows.com)
NRAS2
- NRAS»HRAS protein expression in cells that correlate with the rank order of Ras mutation frequencies in cancer. (nature.com)
- We suggest that in most cases, being the most abundant Ras isoform correlates with occupying the sweet-spot and that HRAS and NRAS expression is usually insufficient to promote oncogenesis when mutated. (nature.com)
KRAS2
- However, for reasons that remain unclear, KRAS is far more frequently mutated than the other Ras isoforms in cancer and RASopathies. (nature.com)
- KRAS mRNA represents 70-99% of all Ras transcripts in mouse tissues [ 20 ]. (nature.com)
Effector2
- At the most fundamental level it must relate to the opportunity and capacity of each Ras isoform to interact with and activate key effector pathways. (nature.com)
- These variants bound with high affinity with the effector- binding site of Ras in an active conformation. (bvsalud.org)
Clinicians1
- The authors suggest that, in RA patients with a history of ASCVD, clinicians should consider that the risk of MACE with tofacitinib is higher versus TNFi, while efficacy is similar. (news-medical.net)
Mutant3
- In the paper we go into detail also to show that the mutation doesn't affect some of the other known properties of RAS, membrane localization or nucleotide exchange or GTP hydrolysis, etc., those were not impacted, meaning that we believe that the finding here is truly due to dimerization, and opens some hopefully new therapeutic avenues for RAS mutant cancers. (cancer.gov)
- First of all, congratulations on the paper, as Jim just said we've been interested in this phenomenon for a long time, largely because Allan Balmain, who first discovered the interference of wild type RAS on mutant RAS, is right next door to my office and we discuss this sort of stuff a lot. (cancer.gov)
- A couple of papers have shown that overexpression of wild-type RAS can interfere with mutant in some ways, but it's always been very complicated to interpret because obviously the wild type protein can signal as well, so seeing interference of the mutant is difficult. (cancer.gov)
Methotrexate2
- In a session titled, From hearts to lungs: comobidities in RA , Delcoigne and colleagues present new data on the risk of ACS in patients with RA who attained remission with methotrexate (MTX) or a tumor necrosis factor inhibitor (TNFi). (news-medical.net)
- One study published in 2004 compared monotherapy with the TNF inhibitor etanercept (Enbrel) to the combination of etanercept and anakinra (Kineret), an interleukin-1 (IL-1) antagonist, in 244 patients with active RA despite methotrexate therapy. (medscape.com)
Arkestra1
- On Halloween 2014, the Sun Ra Arkestra - complete with costumes inspired by Egyptian symbolism and science fiction - performed a rousing, out-of-this-world Tiny Desk Concert. (npr.org)
Search1
- Want a full history search for RA-33336 dating back to 1998? (flightaware.com)
Surgery7
- This wrist surgery may ease the pain of carpal tunnel syndrome in your hand and arm that sometimes can be caused by RA. (webmd.com)
- This surgery doesn't slow your RA or keep it from getting worse. (webmd.com)
- Endoscopic bariatric therapy included intragastric balloon insertion and endoscopic sleeve gastroplasty, and bariatric surgery included Roux-en-Y gastric bypass, gastric sleeve, and laparoscopic sleeve gastrectomy. (medscape.com)
- When asked to comment, Steven Grinspoon, MD, with Harvard University and Massachusetts General Hospital, Boston, told Medscape Medical News that though his level of confidence in the data is "not great," the study raises the "interesting question of whether the GLP-1 RAs could be combined with minimally invasive bariatric surgery techniques. (medscape.com)
- There currently is limited evidence on the weight loss effect of combining GLP-1 RAs with endoscopic bariatric therapy or bariatric surgery, which prompted Imam and colleagues to systematically review studies on the topic. (medscape.com)
- Despite these limitations, this review highlights a "promising approach" for managing obesity by combining GLP-1 RAs with endoscopic bariatric therapy - one that is expected to come with shorter hospital stays, fewer side effects, and longer-term weight loss benefits than surgery, Imam said. (medscape.com)
- The field is moving toward the question of whether these drugs could take the place of bariatric surgery, with the caveats that there is weight regain after you stop the GLP-1 RA and long-term safety has not been entirely established," Grinspoon said. (medscape.com)
Abstract2
- A second abstract from Buch and colleagues looked at the impact of cardiovascular comorbidities on the efficacy of tofacitinib versus TNFi in RA. (news-medical.net)
- It's like an abstract art show, but for RA. (healthline.com)
Autoimmune1
- RA is an autoimmune disease , which means the arthritis results from your immune system attacking your body's own tissues. (medlineplus.gov)
Certification1
- Intertek is an accredited certification body for GOTS and for the following Textile Exchange standards GRS, RCS, OCS and CCS, including supply chain companies for RDS, and RAF (RWS, RMS, RAS) with a secondary scope (i.e. all RDS sites after the slaughter site and all RAF sites after the farm). (intertek.com)
Lungs1
- RA can affect body parts besides joints, such as your eyes, mouth and lungs. (medlineplus.gov)
Employee1
- An employee or an employee's family member, health professional, or other representative may request a reasonable accommodation on behalf of an employee by contacting their immediate supervisor, a member of their management team, or the RA team. (cdc.gov)
Patients7
- The researchers defined and pooled cohorts of RA patients from registers in Norway and Sweden. (news-medical.net)
- Patients with RA who reach remission on MTX have a similar ACS risk as those reaching remission on TNFi. (news-medical.net)
- This was based on the observation that RA patients with a history of atherosclerotic cardiovascular disease (HxASCVD) have a higher risk of major adverse CV events (MACE) with tofacitinib versus TNFi, whereas risk difference is not detected in people with no HxASCVD. (news-medical.net)
- The researchers used data from ORAL Surveillance - an open-label, post-authorization safety study that included patients with active RA despite MTX, Everyone was aged 50 or older, and had at least one additional CV risk factor. (news-medical.net)
- RA patients with high or intermediate cardiovascular risk scores tended to be more likely to reach remission or low disease activity with tofacitinib versus TNFi, as were patient with low-borderline risk scores who received tofacitinib 10 mg twice daily. (news-medical.net)
- The study did not find a significantly higher risk of MACE in RA patients treated with JAKi compared to TNFi. (news-medical.net)
- In another RA trial , 121 patients were given etanercept 25 mg twice weekly and were randomly assigned to also receive a placebo or low-dose abatacept (Orencia), a T-cell co-stimulation inhibitor. (medscape.com)
Page2
- For more information on the declaration, record and payment dates, visit the RAS Dividend History page. (nasdaq.com)
- More information on Remedial Design/Remedial Action is available from the Superfund Program RD/RA web page. (epa.gov)
Tissue1
- It suggests that there is an optimal level of Ras activity in each tissue and genetic context that will promote cancer. (nature.com)
Humans2
- In time, however, Ra became angry with the humans because of their actions. (encyclopedia.com)
- Ra sent the lioness to earth to kill humans, but after she had caused massive bloodshed, he decided to save the humans that remained. (encyclopedia.com)
Egyptian3
- One of the most important deities in Egyptian mythology, the sun god Ra (or Re) was the supreme power in the universe. (encyclopedia.com)
- Some myths present Ra as the head of the Egyptian pantheon and ruler of all the gods. (encyclopedia.com)
- Ra remained the principal god throughout the history of ancient Egypt, and Egyptian kings claimed to be the sons of Ra in order to link themselves to him. (encyclopedia.com)
Relate1
- In addition, the RA will usually relate the findings within it to those of others, and may also examine issues of theory and/or methodology. (lu.se)
Versus1
- The extent to which DMARD-induced remission could reduce the risk of ACS in RA versus rates in the general population - and whether there are DMARD-specific beneficial effects on ACS risk - remain unknown. (news-medical.net)
Escape1
- For those interested in a winter escape, diving in Ras Gharib is year-round. (padi.com)
Family1
- It was an adjustment for my family to really listen and know where I was coming from with my RA. (medlineplus.gov)
Make1
- For independent travelers wishing to make their own way to Ras Gharib, the closest airports are Hurghada International Airport and Cairo International Airport. (padi.com)
Potentially1
- The RD/RA CD used by EPA and DOJ staff when negotiating an RD/RA judicial CD with potentially responsible parties under sections 106, 107, and 122 of CERCLA. (epa.gov)
Cancer2
- Our data provide support for the model of a sweet-spot of Ras dosage mediating isoform-specific contributions to cancer and development. (nature.com)
- Experiments with cancer cells showed that expression of these RBD variants inhibits Ras signaling, reducing cell growth and inducing apoptosis . (bvsalud.org)
Work3
- During that time, Ras also undertook remix work for Chanté Moore, George McCrae and The 49ers. (wikipedia.org)
- This model is for use by EPA and DOJ staff when negotiating a remedial design/remedial action (RD/RA) consent decree statement of work (SOW). (epa.gov)
- I say that because with RA what may work for you or me may not work for another person. (medlineplus.gov)
Experience1
- Many people with RA experience swelling, changes in the shape of their hands and feet, weight gain or loss, and difficulty walking. (arthritis.org)
Stiffness1
- I wasn't prepared for such a huge change in my life, and while I eventually became used to the pain and stiffness, there were many other things about living with RA that I would have to learn along the way. (healthline.com)
Results1
- The study results are publicly available online at ras-hallmarks.jhmi.edu/ and through the AACR Project GENIE registry. (news-medical.net)
Highly1
- Ra.One' was the most expensive, highly advanced film in terms of special effects. (indiatimes.com)
Review3
- Combining glucagon-like peptide 1 receptor agonists (GLP-1 RAs) with endoscopic bariatric therapy is a promising way to manage obesity , say the authors of a new review of relevant research. (medscape.com)
- To check your SBP coverage status, review your Retiree Account Statement (RAS) carefully. (dfas.mil)
- Combination therapies have been effective in treating leukemia and lymphoma as well as infection with HIV , writes Melek Yalçin Mutlu, MD, and colleagues from Friedrich Alexander University Erlangen-Nuremberg and the University Clinic Erlangen, Erlangen, Germany, in a review about combining biologic DMARDS in the treatment of RA and PsA. (medscape.com)