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  • GTPase
  • The catalytic p110 subunits of class 1 phosphoinositide 3-kinases (PI3Ks) have a conserved Ras binding domain (RBD), and an interaction has been noted between Ras guanosine triphosphatase (GTPase) and p110 PI3K in vitro and in overexpression systems. (sciencemag.org)
  • Mutations
  • More than 30 percent of all human cancers - including 95 percent of pancreatic cancers and 45 percent of colorectal cancers - are driven by mutations of the RAS family of genes. (cancer.gov)
  • created transgenic flies carrying a Dp110 (the only Drosophila p110) with mutations in the RBD that did not interact with Ras (either Ras1 or Ras2) but was otherwise biochemically normal. (sciencemag.org)
  • Genes
  • The abundance of these genes was higher in K-ras -transformed NIH 3T3 cells than in NIH 3T3 cells, as measured by real-time reverse transcription polymerase chain reaction assays. (sciencemag.org)
  • Methylated DNA immunoprecipitation assays showed that although the Fas promoter was hypermethylated in K-ras -transformed NIH 3T3 cells, it was not hypermethylated in any of the 28 cell lines, each of which expressed a single shRNA targeting one of the identified genes. (sciencemag.org)
  • At least 21 of the 28 genes identified by the screen were also required for the hypermethylation of 5 other genes that are known to be silenced in Ras -transformed cells. (sciencemag.org)
  • Signaling
  • A primary goal of the RAS Initiative at the Frederick National Laboratory for Cancer Research (FNLCR) is to develop assays for RAS activity, localization, and signaling and adapt those assays so they can be used for finding new drug candidates. (cancer.gov)
  • Although the interaction with Ras does not appear essential for PI3K signaling, it does appear to maximize the response. (sciencemag.org)
  • These two articles provide examples in which Ras may control the intensity of the PI3K signal in one context and provide selectivity to the signaling process in another. (sciencemag.org)
  • protein
  • This gene has become known as "ras," because it was originally isolated from rats with sarcoma, and it caused sarcomas and it's called that, and it's protein is called that. (accessexcellence.org)
  • The RA domain shares a similar structure with the highly characterized Ras-binding protein, Raf. (springer.com)
  • showed that the p110γ isoform, which is stimulated by G protein-coupled receptors through the action of Gβγ and an adaptor (in neutrophils the adaptor is p101), also appeared to be activated by Ras. (sciencemag.org)
  • They compared the neutrophil responsiveness to chemotactic agents fMLP or C5a, which are G protein-coupled receptor ligands, in cells isolated from mice in which p101 was knocked out to prevent Gβγ activation of p110γ or in which the RBD of p110γ was mutated (p110γ DASAA ) to prevent Ras activation. (sciencemag.org)
  • Cells
  • Brahma-related gene 1 inhibits proliferation and migration of human aortic smooth muscle cells by directly up-regulating Ras-related associated with diabetes in the pathophysiologic processes of aortic dissection. (springer.com)
  • transduced K-ras- transformed NIH 3T3 cells that did not express Fas on the cell surface with a library of retroviruses containing small hairpin RNAs (shRNAs) and used immunomagnetic beads to isolate cells that regained surface expression of Fas. (sciencemag.org)
  • Chromatin immunoprecipitation assays established that the DNA methyltransferase DNMT1 was associated with the Fas promoter in K-ras -transformed NIH-3T3 cells but that this association was decreased in all 28 shRNA-containing cell lines. (sciencemag.org)
  • Tumors in mice resulting from injection of any of 9 of the K-ras -transformed NIH 3T3 shRNA-containing cell lines were smaller than those in mice injected with K-ras -transformed NIH 3T3 cells. (sciencemag.org)
  • Cancer
  • Gaddy Getz and Matt Myerson and colleagues at the Broad Institute along with Bob Stephens, Jim Hartley and colleagues at the Frederick National Laboratory for Cancer Research are utilizing this diagram to develop a RAS-centric version of The Cancer Genome Atlas (TCGA). (cancer.gov)
  • The RAS Initiative was originally published by the National Cancer Institute. (cancer.gov)
  • aortic
  • Explain that for patients with aortic stenosis, outcomes improve with renin-angiotensin system (RAS) blockade, despite perceived contraindications to the medications in an observational study. (medpagetoday.com)
  • driven
  • To help solve the 30-year challenge of how to treat RAS-driven cancers, we need an open model of collaboration. (cancer.gov)
  • family
  • Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans. (springer.com)
  • Agathanggelou A, Cooper WN, Latif F (2005) Role of the Ras-association domain family 1 tumor suppressor gene in human cancers. (springer.com)
  • Dallol A., Latif F. (2015) Ras Association Domain Family 1. (springer.com)
  • robust
  • Parallels RAS supports robust authentication mechanisms, such as two-factor authentication, smart card authentication, and device and IP address granular filtering. (parallels.com)
  • Role
  • Two groups now report a physiological role for Ras interactions with PI3K in flies and mouse neutrophils. (sciencemag.org)
  • resources
  • With Parallels RAS built-in servers and gateways resources-based load balancing, financial institutions can provide consistent, fast, and reliable access to published resources anytime. (parallels.com)
  • community
  • We hope that this will provide useful data for the RAS community to investigate as well as reveal new and provocative functional relationships. (cancer.gov)
  • Whether you are a dedicated RAS expert or curious researcher, we encourage you to help advance the research by joining our RAS community. (cancer.gov)
  • provide
  • With Parallels RAS, financial organizations are able to provide their employees with seamless access to applications and desktops on any device. (parallels.com)
  • data
  • Parallels RAS reinforces data security, allowing finance and banking institutions to adhere to government regulations with enhanced security settings such as granular permission settings. (parallels.com)
  • Parallels RAS provides employees with quick, easy and secure access to line of business (LOB) financial applications, desktops, and data on nearly any device or operating system. (parallels.com)
  • Parallels RAS delivers employees instant and secure access to LOB applications and data on any device, including iPad®, Mac®, Android, and more. (parallels.com)
  • Parallels RAS simplifies banking and finance IT operations with centralized management for applications, server-hosted desktops, and data. (parallels.com)
  • Parallels RAS helps secure finance institutions' assets from data leakage and malicious activity with a highly granular access permission policy, combined with SSL encryption as well as two-factor and smart card authentication. (parallels.com)
  • input
  • M. H. Orme, S. Alrubaie, G. L. Bradley, C. D. Walker, S. J. Leevers, Input from Ras is required for maximal PI(3)K signalling in Drosophila . (sciencemag.org)
  • domain
  • identified mSos1, the Ras guanine nucleotide exchange factor, as another binding partner for the first SH3 domain of intersectin, SH3A. (sciencemag.org)
  • applications
  • Parallels RAS facilitates the deployment and maintenance of virtual infrastructure by providing auto-configuration wizards and pre-tested templates to manage virtual applications and server-based desktops. (parallels.com)
  • several
  • National Public Radio recently aired a story on cancers caused by RAS that featured the NCI RAS Initiative and several of its collaborators. (cancer.gov)
  • main
  • Approach to Ras Sidr is by way of the main Suez to Sharm el Sheikh Road through almost total desert terrain. (wikipedia.org)
  • Ras Sedr itself is made up of two residential areas, bisected by the main north/south road. (wikipedia.org)