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  • Oral
  • 2 Since about half of diclofenac is metabolised during its first passage through the liver ('first pass' effect), the area under the concentration curve (AUC) following oral or rectal administration is about half that following an equivalent parenteral dose. (healthdocbox.com)
  • The average percentage of the dose recovered in urine from 0 to 72 hours after a single oral dose of sulfamethoxazole and trimethoprim is 84.5% for total sulfonamide and 66.8% for free trimethoprim. (nih.gov)
  • The usual initial dose of oral LASIX in pediatric patients is 2 mg/kg body weight, given as a single dose. (rxlist.com)
  • Clinical
  • The clinical signs of an ADR are almost always non-specific and rarely if ever pathognomonic for an ADR. (vin.com)
  • Scattered reports exist of other manifestations of sulfite sensitivity including anaphylaxis but the role of sulfites in triggering these other adverse reactions is not well established by controlled clinical challenge trials. (unl.edu)
  • In uniretic┬« controlled clinical trials, the average change in serum potassium was near zero in subjects who received 3.75 mg / 6.25 mg or 7.5 mg / 12.5 mg, but subjects who received 15 mg / 12.5 mg or 15 mg / 25 mg experienced a mild decrease in serum potassium, similar to that experienced by subjects who received the same dose of hydrochlorothiazide monotherapy. (rxlist.com)
  • When doses exceeding 80 mg/day are given for prolonged periods, careful clinical observation and laboratory monitoring are particularly advisable. (rxlist.com)
  • NSAIDs
  • Nonsteroidal anti-inflammatory drugs ( NSAIDs ) are a drug class that reduce pain , decrease fever , prevent blood clots and, in higher doses, decrease inflammation . (wikipedia.org)
  • therapeutic
  • Therapy should be individualized according to patient response to gain maximal therapeutic response and to determine the minimal dose needed to maintain that response. (rxlist.com)
  • severe
  • Sulfites are capable of causing severe reactions in sensitive individuals. (unl.edu)
  • Also, the use of sulfite is banned from many fresh food products such as lettuce where high residual levels were associated with provocation of particularly severe reactions until this use was prohibited. (unl.edu)
  • regimens
  • Therapy with any combination of moexipril and hydrochlorothiazide will be associated with both sets of dose-independent side effects, but regimens in which moexipril is combined with low doses of hydrochlorothiazide produce minimal effects on serum potassium. (rxlist.com)
  • 12.5
  • The recommended dosage range of moexipril is 7.5 to 30 mg daily, administered in a single or two divided doses one hour before meals, while hydrochlorothiazide is effective in a dosage of 12.5 to 50 mg daily. (rxlist.com)
  • aspirin
  • Uricosuric effect of these agents may be decreased by large doses of aspirin, in addition, renal excretion of salicylate may be reduced. (drugs.com)
  • hydrochlorothiazide
  • those of hydrochlorothiazide are a mixture of dose-dependent phenomena (primarily hypokalemia ) and dose-independent phenomena (e.g., pancreatitis ), the former much more common than the latter. (rxlist.com)
  • serum
  • In high doses, mitoxantrone has been associated with a high rate of jaundice, but the degree of hyperbilirubinemia has been mild, transient and not associated with significant serum enzyme elevations or evidence of hepatitis. (nih.gov)
  • The product label recommends regular monitoring of serum aminotransferase levels before each monthly or every-three-month infusion of mitoxantrone therapy, but dose modifications or discontinuation are rarely necessary. (nih.gov)
  • initial dose
  • Children maybe given an initial dose of 250 ug per kg body-weight three times daily, adjusted according to response: treatment in children should be by a specialist. (proselpharma.com)
  • The usual initial dose of LASIX is 20 to 80 mg given as a single dose. (rxlist.com)
  • If the diuretic response is not satisfactory after the initial dose, dosage may be increased by 1 or 2 mg/kg no sooner than 6 to 8 hours after the previous dose. (rxlist.com)
  • The usual initial dose of LASIX for hypertension is 80 mg, usually divided into 40 mg twice a day. (rxlist.com)
  • Alternatively
  • Alternatively, the dose may be continued at the initial level in combination with supplement thyroxin as a clocking replacement regimen. (proselpharma.com)
  • type
  • This type of injury does not have a clear dose-response nor temporal relationship, and most often does not have predictive models. (wikipedia.org)
  • Two types of ADRs exist: Type 1 results from dosage mismatch and Type 2 from rare conditions often as a consequence of a small dose. (thefreedictionary.com)
  • Type B (bizarre) reactions are unexpected or aberrant responses that are unrelated to the drug's pharmacological effect. (vin.com)
  • liver
  • The dose toxic to the liver is quite variable from person to person and is often thought to be lower in chronic alcoholics. (wikipedia.org)
  • typical
  • NMS has a slow onset and progression (hours to days), non-predictably , and only rarely in association with neuroleptics: it also happens in the complete absence of neuroleptics, but not with typical 'serotonergic' drugs like SSRIs. (psychotropical.com)
  • Typical maintenance doses are 5 to 15 mg daily. (proselpharma.com)
  • formulation
  • If the optimal dose corresponds to the ratio contained in the combination formulation, this product can be used for convenient dosing. (pdr.net)
  • body weight
  • Underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack of calibration of the dosing device (if any). (viovet.co.uk)
  • Doses greater than 6 mg/kg body weight are not recommended. (rxlist.com)
  • signs
  • Occasionally at the recommended dose cattle may show signs of lip-licking and slight muscle tremor. (viovet.co.uk)
  • symptoms
  • That reaction, along with a collection of other symptoms, has come to be labeled as pine nut mouth or pine nut syndrome. (ift.org)
  • days
  • however, such effects appear to be limited to doses taken over a period longer than 7 days. (wikipedia.org)
  • Since headache appears to be a dose-related adverse effect and tends to disappear with continued treatment, it is recommended that ISMN treatment be initiated at low doses for several days before being increased to desired levels. (prescriptiondrugs.com)