[ 12 ] The bone is destroyed as the tumor advances, suggesting a malignant process. (medscape.com)
While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. (cytojournal.com)
Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
Serous1
Most tumors metastatic to the serous membranes are of epithelial origin. (cytojournal.com)
Benign3
Although MNTI is an aggressive benign tumor, malignant variants have been reported. (medscape.com)
Most melanotic neuroectodermal tumors of infancy (MNTIs) are benign and effectively managed by aggressive surgical excision. (medscape.com)
diagnosis of bilateral benign tumors of salivary origin was made. (9lib.co)
Surgical excision1
The treatment of choice for melanotic neuroectodermal tumor of infancy (MNTI) is surgical excision, and it is usually curative. (medscape.com)
MNTI7
Complete tumor removal of the melanotic neuroectodermal tumor of infancy (MNTI) may not be the goal when it may sacrifice vital structures such as the orbital or intracranial contents. (medscape.com)
Melanotic neuroectodermal tumor of infancy (MNTI) is a relatively uncommon osteolytic-pigmented neoplasm that primarily affects the jaws of newborn infants. (medscape.com)
Several patients with melanotic neuroectodermal tumor of infancy (MNTI) have demonstrated a high urinary excretion of VMA. (medscape.com)
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm and approximately 485 cases have been reported in the literature to date worldwide. (medscape.com)
Melanotic neuroectodermal tumor of infancy (MNTI) has a slight male predilection, with a male-to-female ratio of 1.3:1. (medscape.com)
[ 14 ] A few cases of melanotic neuroectodermal tumor of infancy (MNTI) have been reported in adults, notably, a 23-year-old man, a 39-year-old woman, and a 67-year-old woman. (medscape.com)
A comprehensive systematic review of 472 cases of MNTI found that age at diagnosis is an important prognostic indicator in these tumors. (medscape.com)
Recurrent2
Interestingly, Davis et al in 2015 reported a unique mixed response of an aggressive recurrent tumor to neoadjuvant chemotherapy using agents known to be effective for neuroblastomalike tumors (vincristine and cyclophosphamide). (medscape.com)
[ 13 ] Unfortunately, reports have shown that recurrent tumors tend to behave more aggressively and involve other anatomic structures such as the orbit and skull base. (medscape.com)
Oral1
Here we report a rare case of bilateral symmetric ectopic oral tonsillar tissue observed on the ventral surface of the tongue and two other solitary cases arising from floor of the mouth along with a review of the literature. (9lib.co)
Aggressive1
Neven et al in 2008 advocate for adjuvant chemotherapy in cases of multiple aggressive recurrences and/or inoperable tumors. (medscape.com)
Origin2
In 1966, Borello and Gorlin reported a case with high urinary excretion of vanillylmandelic acid (VMA), suggesting a neural crest origin, and they proposed the term melanotic neuroectodermal tumor of infancy. (medscape.com)
[ 6 ] Since then, numerous histochemical, immunohistochemical, electron microscopic, and tissue culture studies have supported the neural crest origin and confirmed the preferred term of melanotic neuroectodermal tumor of infancy. (medscape.com)