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Histiocytosis, Langerhans-CellHistiocytosisEosinophilic GranulomaHistiocytosis, SinusErdheim-Chester DiseaseHistiocytesHistiocytic SarcomaXanthogranuloma, JuvenileHistiocytosis, Non-Langerhans-CellLangerhans CellsBone DiseasesVulvar DiseasesOrbital DiseasesAntigens, CD1Lymphatic DiseasesMicrofluidic Analytical TechniquesDiabetes InsipidusMicrofluidicsPolydipsiaCell SeparationSea-Blue Histiocyte SyndromeAntibodies, ImmobilizedImage CytometryPenile DiseasesForeheadVinblastineSkin DiseasesHypoaldosteronismNeoplastic Cells, CirculatingRemission, SpontaneousFatal OutcomeImmunomagnetic SeparationOrbital NeoplasmsTomography, X-Ray ComputedCladribinePrednisoneSpinal DiseasesMannose-Binding LectinsLung Diseases, InterstitialBiopsyS100 ProteinsFlow CytometryLung DiseasesMagnetic Resonance ImagingMedlinePlus
Eosinophilic granulomaPLCHType of Langerhans cell histiocyOrgansErdheim-ChesterHistiocytesHemophagocytic lymphohistiocytosisLesionsLymphangioleiomyomatosisDiseasesSymptomsTumorsDisorderPulmonary histiocytosisMalignant histiocytosisHistiocyticLymph nodesDendriticMultifocalSystemicGroup of idiopathic disordersChemotherapyMyeloidMutationsLangerhans-CellCutaneousPediatricImmatureLarge-cell lymphomasProliferation of langerhans cellsLungsHistiocyteLymphocytesIncidenceTissuesAffectsBoneDana-Farber CaDiseaseInvolvementTreatmentMacrophagesFormHematopoieticInflammationMonoclonalBody's immune systemAbnormal
Eosinophilic granuloma4
PLCH14
  • Pulmonary Langerhans Cell Histiocytosis (PLCH) is a relatively uncommon lung disease that generally, but not invariably, occurs in cigarette smokers. (nih.gov)
  • The pathologic hallmark of PLCH is the accumulation of Langerhans and other inflammatory cells in small airways, resulting in the formation of nodular inflammatory lesions. (nih.gov)
  • Single-system Pulmonary Langerhans cell histiocytosis (PLCH) is an uncommon type of Langerhans cell histiocytosis that affects only the lung. (histio.org)
  • The exact prevalence of single-system Pulmonary Langerhans cell histiocytosis (PLCH) is unknown. (histio.org)
  • Pulmonary Langerhans cell histiocytosis (PLCH) is proliferation of monoclonal Langerhans cells in lung interstitium and airspaces. (msdmanuals.com)
  • Pulmonary Langerhans cell histiocytosis X (PLCH) is histologically characterized by parenchymal infiltration of the lungs by activated Langerhans cells. (medscape.com)
  • However, in contrast to pediatric histiocytoses, which involve multiple organs, PLCH usually manifests in a single organ - the lung. (medscape.com)
  • The granulomatous infiltrates seen in PLCH are composed of Langerhans cells, eosinophils, lymphocytes, macrophages, plasma cells, and fibroblasts, which form nodules centered on the terminal and respiratory bronchioles, causing destruction of the airway walls. (medscape.com)
  • Pulmonary Langerhans cell histiocytosis X (PLCH) is a rare disorder and the true prevalence is unknown. (medscape.com)
  • [ 5 ] A large Japanese study estimated the prevalence of pulmonary Langerhans cell histiocytosis X (PLCH) at 0.27 males and 0.07 females per 100,000 population based on hospital discharge diagnoses over a 1-year period. (medscape.com)
  • Because of the rarity of pulmonary Langerhans cell histiocytosis X (PLCH) , no definitive epidemiologic data related to racial background are available. (medscape.com)
  • No sex predilection is recognized for pulmonary Langerhans cell histiocytosis X (PLCH). (medscape.com)
  • The peak incidence of pulmonary Langerhans cell histiocytosis X (PLCH) occurs in the 20- to 40-year age bracket. (medscape.com)
  • The prognosis for pulmonary Langerhans cell histiocytosis X (PLCH) varies and is related to smoking cessation. (medscape.com)
Type of Langerhans cell histiocy1
  • Chronic multifocal Langerhans cell histiocytosis, previously known as Hand-Schüller-Christian disease, is a type of Langerhans cell histiocytosis (LCH), which can affect multiple organs. (wikipedia.org)
Organs10
  • Other signs and symptoms that may occur in Langerhans cell histiocytosis, depending on which organs and tissues have Langerhans cell deposits, include swollen lymph nodes, abdominal pain, yellowing of the skin and whites of the eyes (jaundice), delayed puberty, protruding eyes, dizziness, irritability, and seizures. (medlineplus.gov)
  • On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)
  • Langerhans cell histiocytosis can cause damage to tissues and organs all over the body if it's not treated. (chkd.org)
  • An inflammatory issue in which inflammatory cells can form clumps in various organs like the lungs. (healthline.com)
  • In HLH, infection-fighting cells attack and destroy organs. (childrensnational.org)
  • These cells are found in the skin, bone, and other organs, and play a key role in the immune system. (scitechdaily.com)
  • Elvira Mass's research has provided a completely new perspective on the role of cells of the innate immune system regulating embryonic development of tissues and organs," says Prof. Dr. Dr. h.c. (uni-bonn.de)
  • In a series of genetic labelling experiments, Mass has shown that these cells are mainly yolk sac-derived progenitor cells that migrate to the developing organs, where they immediately differentiate and self-maintain for a lifetime. (uni-bonn.de)
  • The treatment for Langerhans' cell histiocytosis will depend on the organs affected. (homeremedylifestyle.com)
  • Langerhans Cell Histiocytosis Langerhans cell histiocytosis (LCH) is a proliferation of dendritic mononuclear cells with infiltration into organs locally or diffusely. (msdmanuals.com)
Erdheim-Chester5
Histiocytes5
Hemophagocytic lymphohistiocytosis3
  • More recently, histiocytic diseases have been reclassified into five groups: (1) Langerhans-related, (2) cutaneous and mucocutaneous, (3) malignant histiocytosis, (4) Rosai-Dorfman disease, and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. (medscape.com)
  • Our doctors provide unparalleled expertise in the diagnosis and treatment of the major types of histiocytosis - Langerhans cell histiocytosis (LCH) and hemophagocytic lymphohistiocytosis (HLH) - and treat rare, related disorders, such as juvenile xanthogranuloma and Rosai-Dorfman disease. (childrenshospital.org)
  • Our expertise also includes treating non-malignant conditions such as Langerhans cell histiocytosis, histiocytic and hemophagocytic lymphohistiocytosis (HLH) disorders, fibromatosis and benign tumors that may require surgery and surveillance. (cookchildrens.org)
Lesions5
  • Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)
  • A 31 year old man was diagnosed in 1986 as having histiocytosis X because of pulmonary fibrosis and radiological maxillary lytic lesions. (bmj.com)
  • OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
  • Langerhans cell histiocytosis (LCH) is a rare disease of unknown etiology, lacking an animal model, that cumulates symptoms that are found separately in various IL-17A-related diseases, such as aggressive chronic granuloma formation, bone resorption and soft tissue lesions with occasional neurodegeneration(11,12). (dtu.dk)
  • We examined IL-17A in the context of LCH and found that there were high serum levels of IL-17A during active LCH and unexpected IL-17A synthesis by dendritic cells (DCs), the major cell type in LCH lesions. (dtu.dk)
Lymphangioleiomyomatosis1
  • and rare forms of ILD such as lymphangioleiomyomatosis (LAM) or Langerhans cell histiocytosis (LCH) account for the remaining subgroups. (springer.com)
Diseases10
  • The Rare Lung Disease Program's mission is to provide state of the art collaborative evaluation and treatment for patients with rare lung diseases. (uab.edu)
  • This program exists to better understand rare lung diseases, train physicians to more completely treat rare lung diseases, and to drive the creation of superior treatment options. (uab.edu)
  • As part of the Rare Lung Disease Clinic Network and member of the Rare Lung Disease Consortium, this program collaborates in the development of novel testing and treatments for rare lung diseases. (uab.edu)
  • Additionally, it is an aim of the program to provide information about rare lung diseases to patient, physicians and the pu blic. (uab.edu)
  • It's brimming with advice and resources for caregivers of patients with rare diseases. (histio.org)
  • This is a national registered charity in the U.K. that provides support and information to families of disabled children, as well as children with rare diseases. (histio.org)
  • For Elvira Mass, impaired function of these immune cells might cause many diseases. (uni-bonn.de)
  • Rare Disease PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other information that address the public health impact and translation of genomic and other precision health discoveries into improved health outcomes related to rare diseases. (cdc.gov)
  • Each of these infectious diseases is designated by the major target cell: human monocytic ehrlichiosis is caused by Ehrlichia chaffeensis, and human granulocytic ehrlichiosis by an E. equi -like organism. (cdc.gov)
  • Extreme difficulty in developing methods for cultivation of these ehrlichiae and, until recently, the lack of molecular approaches to the study of uncultivated organisms partly explain why these far from rare diseases were not detected sooner ( 3 - 5 ). (cdc.gov)
Symptoms8
Tumors7
  • In Langerhans cell histiocytosis, excess immature Langerhans cells usually form tumors called granulomas. (medlineplus.gov)
  • The cells build up and create tumors. (chkd.org)
  • In LCH, extra Langerhans cells spread through the blood and build up in certain parts of the body, where they can damage tissue or form tumors. (dana-farber.org)
  • In LCH, these cells become abnormal and form tumors in various parts of the body. (scitechdaily.com)
  • Tumors occur when cells multiply in an unregulated fashion. (petmd.com)
  • Genetic factors most likely cause these cells to overmultiply, rather than environmental factors associated with other tumors, like radiation or pet owners who smoke. (petmd.com)
  • The treatment of solid tumors may require a range of therapies, including surgery, radiation therapy, chemotherapy, stem cell therapy, biologic or targeted therapies, or a combination of these treatment modalities. (cookchildrens.org)
Disorder15
  • Langerhans cell histiocytosis is a disorder in which excess immune system cells called Langerhans cells build up in the body. (medlineplus.gov)
  • In many people with Langerhans cell histiocytosis, the disorder eventually goes away with appropriate treatment. (medlineplus.gov)
  • Langerhans cell histiocytosis is a rare disorder. (medlineplus.gov)
  • Langerhans cell histiocytosis of the vulva is a rare disorder with few options for treatment. (nih.gov)
  • Langerhans cell histiocytosis (LCH) is a rare disorder. (chkd.org)
  • Langerhans cell histiocytosis is a rare disorder that damages tissues all over the body. (chkd.org)
  • Langerhans cell histiocytosis (LCH) is a rare disorder that occurs when a child has too many of a certain type of cell called Langerhans cells. (dana-farber.org)
  • Rosai-Dorfman disease is a rare disorder characterized by overproduction (proliferation) and accumulation of a specific type of white blood cell (histiocyte) in the lymph nodes of the body (lymphadenopathy), most often those of the neck (cervical lymphadenopathy). (rarediseases.org)
  • We offer novel treatments and comprehensive care for all forms of this rare disorder. (childrensnational.org)
  • From infectious disease care to novel medications, we offer hope and healing for any histiocytosis disorder. (childrensnational.org)
  • Natal molars, in particular, have been linked to Pfieffer syndrome (a genetic disorder) and Langerhans cell histiocytosis (a white blood cell disorder). (thebump.com)
  • Pulmonary Langerhans cell histiocytosis (LCH) is the histiocytic disorder that most frequently manifests with thoracic involvement in adults and is associated with cigarette smoking. (elsevierpure.com)
  • In a normal physiological, "non-dangerous" situation, LCs coordinate a continuous state of immune tolerance Langerhans cell histiocytosis (LCH) is a rare disorder in which the body makes too many dendritic cells. (netlify.app)
  • This disorder is characterized by an abnormal increase in certain immune cells called histiocyte cells. (netlify.app)
  • Histiocyte cells are a form of white blood cells that help the immune system destroy Langerhans cell histiocytosis is a rare disorder that can look like some types of cancer. (netlify.app)
Pulmonary histiocytosis1
Malignant histiocytosis3
  • The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
  • Cases previously reported as malignant histiocytosis were shown to be lymphomas of T or B lineage, especially anaplastic large-cell lymphomas. (bmj.com)
  • This is the second reported case of malignant histiocytosis presenting with spontaneous splenic rupture. (bmj.com)
Histiocytic1
Lymph nodes3
Dendritic12
  • The origin is a dendritic cell, although previously thought to be a histiocyte, a term still used. (wikipedia.org)
  • The mutations causes white blood cells (lymphocytes, macrophages, and eosinophils) to move towards dendritic cells, resulting in damage in any organ except the heart and kidneys. (wikipedia.org)
  • In 1868, Paul Langerhans discovered the epidermal dendritic cells that now bear his name. (medscape.com)
  • Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)
  • Some researchers are convinced that LCH is derived from a certain type of immune cell called dendritic cells, while others believe that they come from related cells called monocytes," says Egle Kvedaraite, a doctor and researcher at the Department of Medical Biochemistry and Biophysics at Karolinska Institutet and first author of the new study. (scitechdaily.com)
  • They discovered that mutated LCH cells had properties similar to both monocytes and dendritic cells, as well as a relatively newly discovered type of dendritic cell, the so-called dendritic cell type 3 (DC3). (scitechdaily.com)
  • Today we know that DC3 has a separate pathway of development, separate from other dendritic cells and monocytes, and knowledge of this was crucial in our study," says Egle Kvedaraite. (scitechdaily.com)
  • Dendritic cells are a form of histiocyte, or white blood cell. (netlify.app)
  • Langerhans cells (LC) are members of the dendritic cells family, residing in the basal and suprabasal layers of the epidermis and in the epithelia of the respiratory, digestive and urogenital tracts. (netlify.app)
  • cellytsglykoproteinet uttryckt på kortikala tymocyter, Langerhans celler och interdigitala dendritiska (retikel) Fil:Dendritic cells.jpg. (netlify.app)
  • Storlek på BeskrivningDendritic cells.jpg, Section of skin showing large numbers of dendritic (Langerhans) cells in the epidermis. (netlify.app)
  • Langerhans cells are differentiated cells of the dendritic cell system and are closely related to the monocyte-macrophage line. (medscape.com)
Multifocal3
Systemic1
  • We report a rare case of adult Langerhans cell histiocytosis in the dorsal spine causing a spinal cord compression associated with a pulmonary process treated by surgery, radiotherapy and systemic therapy with good evolution. (scirp.org)
Group of idiopathic disorders1
  • Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
Chemotherapy4
  • It was considered to be specific bone involvement in histiocytosis X. Chemotherapy (six regimens of vinblastin and corticosteroids, then two regimens of methotrexate) was administered. (bmj.com)
  • The Dana-Farber/Boston Children's Cancer and Blood Disorders Center provides expert treatment for newly diagnosed or recurrent histiocytosis, which is a cancer-like condition and may involve treatment with chemotherapy . (childrenshospital.org)
  • Single-system Langerhans' cell histiocytosis responds well to chemotherapy. (homeremedylifestyle.com)
  • About a year later, doctors revealed another devastating diagnosis: Langerhans cell histiocytosis (LCH), a rare, cancer-like condition that required a year of chemotherapy. (gotowncrier.com)
Myeloid3
  • The biopsy specimen from the right maxillary sinus showed soft tissue infiltration with myeloid leukemic cells, consistent with a chloroma. (contemporarypediatrics.com)
  • These neoplastic cells are the result of sporadic activating mutations in genes of the mitogen-activated protein kinase (MAPK) signaling pathway expressed by multipotent hematopoietic stem/progenitor cells or committed myeloid precursors [ 1 ]. (biomedcentral.com)
  • Using a more sensitive technique for detection of mutant BRAF alleles (droplet digital PCR) [ 9 ], BRAF V600E was not detected in DNA extracted from myeloid or lymphoid cells isolated by flowcytometric sorting from a peripheral blood sample collected at the time of the fourth bone sample. (biomedcentral.com)
Mutations4
  • Somatic mutations in the BRAF gene have been identified in the Langerhans cells of about half of individuals with Langerhans cell histiocytosis. (medlineplus.gov)
  • Somatic gene mutations are acquired during a person's lifetime and are present only in certain cells. (medlineplus.gov)
  • LCH is a disease in which cancerous mutations occur in immune cells, which typically play a role in detecting and eliminating cancer cells. (scitechdaily.com)
  • Although the pathogenesis is not fully understood, it is now apparent that some of these disorders are associated with activating mutations in cell proliferative/regulatory pathways. (elsevierpure.com)
Langerhans-Cell64
Cutaneous2
  • This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)
  • PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
Pediatric1
  • If a child has HLH and needs a stem cell transplant (also called a bone marrow transplant), Dana-Farber/Boston Children's is one of the oldest, largest, and most experienced pediatric stem cell transplant centers in the country. (childrenshospital.org)
Immature2
  • A bone marrow transplant is a non-surgical procedure to replace damaged blood-forming cells with healthy, immature donor cells (stem cells). (childrensnational.org)
  • The marrow specimen showed extensive replacement of normal hematopoietic elements by immature monocytic cells. (contemporarypediatrics.com)
Large-cell lymphomas1
  • Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
Proliferation of langerhans cells1
  • Pathophysiology may involve recruitment and proliferation of Langerhans cells in response to cytokines and growth factors secreted by alveolar macrophages in response to cigarette smoke. (msdmanuals.com)
Lungs3
  • It is believed that cigarette smoke attracts specific immune cells in the lungs (Langerhans cells) which leads to a cascade of inflammation and injury to the air passages and lung tissue over time. (histio.org)
  • This is a rare but serious type of vasculitis , inflammation of the blood vessels in your nose, throat, lungs, and kidneys. (healthline.com)
  • The accumulation of Langerhans cells in the lungs is hypothesized to occur in response to exposure to cigarette smoke. (medscape.com)
Histiocyte2
  • Before the Histiocyte Society classified histiocytoses in the 1980s, the condition was also known as "Histiocytosis X", where "X" denoted the then unknown cause. (wikipedia.org)
  • The information on this page has been written and reviewed by the Histiocytosis Association Board of Trustees Scientific Committee and a member of the Histiocyte Society , and subsequently audited by patients and families to ensure enough information was captured. (histio.org)
Lymphocytes3
  • A surgical biopsy showed an infiltrate of eosinophilic cells with oval, grooved and convoluted nucleus, associated with eosinophils, lymphocytes and plasma cells ( Figure 2 ). (scirp.org)
  • It consists of Langerhans cells with oval, grooved and convoluted nucleus and slightly eosinophilic cytoplasm, associated with eosinophils, lymphocytes and plasma cells (H & E × 400). (scirp.org)
  • People with leukemia may develop lung granulomas due to lymphomatoid granulmatosis, a rare condition caused by the overproduction of lymphocytes, or white blood cells. (healthline.com)
Incidence1
  • Due to the rare incidence, wide spectrum of clinical manifestations, and high mortality rate, clinicians must maintain a high index of suspicion for LCH. (thieme-connect.de)
Tissues4
  • They all share histologically a significant infiltration of affected tissues by langerhans cells. (scirp.org)
  • A PET/CT scan can provide information about both the structure and function of cells and tissues in the body during one imaging session. (dana-farber.org)
  • X-rays and PET-CT scans may be performed to see if the affected tissues and cells are present. (homeremedylifestyle.com)
  • Same as with "The Dungeon" and Single-celled organisms are organized using specialized cell organelles, while several cells may organize into larger structures, such as tissues and organ Single-celled organisms are organized using specialized cell organelles, while sever B cells are immune cells that provide protection against specific pathogens and disease through the production of antibodies. (netlify.app)
Affects1
Bone2
  • Until a few years ago, it was believed that this task is performed by immune cells originating from the bone marrow. (uni-bonn.de)
  • While IAEMH is associated with severe anaemia due to intravascular haemolysis caused by red cell invasion, oxidative injury, auto-antibodies, and/or pathogen-haem interaction, IAIMH is associated with haemophagocytic tri-lineage destruction of haematopoietic precursors in the bone marrow. (bvsalud.org)
Dana-Farber Ca1
Disease14
  • The disease is rare. (wikipedia.org)
  • While the overwhelming majority of patients are smokers, mechanisms by which smoking induces this disease are not known, but likely involve a combination of events resulting in enhanced recruitment and activation of Langerhans cells in small airways. (nih.gov)
  • [ 3 ] Taken together, these findings have led some to speculate that LCH is not a specific disease of epidermal Langerhans cells, but rather one of mononuclear phagocyte dysregulation. (medscape.com)
  • After the appointment is scheduled, your patient will receive a package containing a schedule of tests and appointments, along with the "UAB Rare Lung Disease Patient Questionnaire," maps, and information on lodging in the Kirklin Clinic area. (uab.edu)
  • AILDR is an important clinical and research tool providing a platform for epidemiological data that will prove essential in promoting understanding of a rare cohort of lung disease and provide foundations for our aspiration to standardise investigation and treatment pathways of ILD across Australasia. (springer.com)
  • We regularly care for children with rare and life-threatening forms of this disease. (childrensnational.org)
  • 2021 rare disease resource guide for caregivers published by Global Genes. (histio.org)
  • IL-17A is a T cell-specific cytokine(1) that is involved in chronic inflammations, such as Mycobacterium infection(2), Crohn's disease(3), rheumatoid arthritis(4) and multiple sclerosis(5). (dtu.dk)
  • Some of the highlights include: unique pulmonary pathology in our world renowned Rare Lung Disease clinic, cutting edge interventional pulmonology, high-acuity medical ICU, comprehensive critical care exposure in specialty ICUs (neurosurgical, surgical and cardiovascular) and in depth pulmonary physiology training in the UCMC and the Cincinnati VA Medical Center PFT labs. (uc.edu)
  • The Foundation announced the distinguished citizen for 2015, which will be awarded on April 30 at Michigan Shores: Sydney Martin, a D39 alum who is a survivor of the rare blood disease Langerhan's Cell Histiocytosis (LCH), creator of Syd Rocks, a line of rock necklaces sold to raise funds for LCH research, and one of the founders of the non-profit Giving Rocks Foundation. (wilmette39.org)
  • In the most severe form of the disease, the cancer cells can spread to other parts of the body. (homeremedylifestyle.com)
  • Pulmonary LCH is a rare disease found almost exclusively in cigarette smokers. (radiogyan.com)
  • Global Genes is an advocacy platform committed to providing information, resources and connections to all communities affected by rare disease. (planotechmediahouse.com)
  • Sickle cell disease (SCD) is associated with chronic haemolysis, immuno-suppression and suscepti- bility to infections, which may trigger infection-associated haemolysis (IAH). (bvsalud.org)
Involvement2
  • Moreover, spinal involvement causing myelopathy is even rare and unusual. (scirp.org)
  • Intracranial manifestations are rare and the usual localisations are the retro-orbital space and hypothalamic involvement with neurogenic diabetes insipidus. (bmj.com)
Treatment2
  • Further rationale for this is highlighted by the lack of data to inform standardised diagnostic and treatment approaches, particularly for the rarer ILD subgroups. (springer.com)
  • The findings could lead to a treatment aimed at eliminating the pathological cells," says Egle Kvedaraite. (scitechdaily.com)
Macrophages3
  • These immune cells are referred to as tissue-resident macrophages and belong to our innate immune system. (uni-bonn.de)
  • Her attempt to manipulate microglia, as the brain-specific macrophages are called, were stimulated by the findings in patients suffering from a rare form of cancer called histiocytosis. (uni-bonn.de)
  • Mass introduced the mutation typical for histiocytosis specifically into yolk sac-derived tissue-resident macrophages of mice and followed the development of the animals. (uni-bonn.de)
Form2
  • There are two suspected root causes of natal teeth, Lee says: tooth germ cells (cells that eventually form a tooth) that are positioned close to the surface of the gum, and hereditary factors. (thebump.com)
  • The main mission is to share love, hope and joy with everyone affected by any form of Histiocytosis in the world. (planotechmediahouse.com)
Hematopoietic1
  • Children with leukemia who receive fractionated total body irradiation (fTBI) with 12 to 13.2 Gy as part of conditioning for hematopoietic stem cell transplant are frequently treated with an additional 4 Gy testicular boost to reduce the risk of testicular relapse. (stanfordchildrens.org)
Inflammation1
  • These cells determine the appropriate adaptive immune response (inflammation or tolerance) by interpreting the microenvironmental context in which they encounter foreign substances. (netlify.app)
Monoclonal2
  • The antibody is a new monoclonal antibody against a C-type lectin found on the surface of Langerhans cells. (homeremedylifestyle.com)
  • ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
Body's immune system1
  • These cells play a role in the body's immune system. (netlify.app)
Abnormal2
  • In extremely rare cases, affected individuals may experience abnormal enlargement of the liver and/or spleen (hepatosplenomegaly). (rarediseases.org)
  • This is because they have an abnormal increase in immune cells. (homeremedylifestyle.com)