This, in turn, inhibits the conversion of arachidonic acid to prostaglandin 12 (a potent vasodilator and inhibitor of platelet activation) and thromboxane A2 (a potent vasoconstrictor and platelet aggregate). (medscape.com)
Adenosine is a potent vasodilator in most vascular beds, except in renal afferent arterioles and hepatic veins where it produces vasoconstriction. (globalrph.com)
Nitric Oxide, or simply NO, is a colorless, odorless gas, which is known to be a potent and selective pulmonary vasodilator [1] -Vasodilators are the agents that aid in the dilation or widening of the blood vessels, which decreases blood pressure, due to the relaxation of smooth muscle cells within the vessel walls as shown in figure 1- [2]. (gov.sa)
There is recent data which indicates the ability of peroxynitrite (ONOO-) to modulate the expression of HO-1 and suggests that the heme oxygenase pathway contributes to protection against the cytotoxic action of ONOO- which is a potent oxidizing agent generated by the interaction of nitric oxide (NO) and the superoxide anion. (ihcworld.com)
Ubrogepant is a small molecule inhibitor of the calcitonin gene-related peptide (CGRP) receptor that blocks the action of CGRP, a potent vasodilator believed to play a role in migraine headaches. (nih.gov)
CGRP is a potent vasodilator and pain-signaling neurotransmitter that is found throughout the central and peripheral nervous system but is particularly common in trigeminal ganglia. (nih.gov)
Antihypertensive agents5
With the advent of antihypertensive agents, the incidence of hypertensive emergencies in the United States has declined from 7% to approximately 1% of patients with hypertension. (medscape.com)
Amlodipine and olmesartan medoxomil tablets are a combination of a dihydropyridine calcium channel blocker and an angiotensin II receptor blocker combination product indicated for the treatment of hypertension, alone or with other antihypertensive agents, to lower blood pressure. (nih.gov)
Amlodipine and olmesartan medoxomil tablets may also be used as initial therapy in patients likely to need multiple antihypertensive agents to achieve their blood pressure goals ( 1 ). (nih.gov)
Amlodipine and olmesartan medoxomil tablets are indicated for the treatment of hypertension, alone or with other antihypertensive agents, to lower blood pressure. (nih.gov)
Ischemic stroke1
Vasodilator - medicine for in ischemic stroke to really reached blood to the obstacle area of the brain. (illnesshacker.com)
Pulmonary7
NO is considered as an ideal pulmonary vasodilator for two reasons. (gov.sa)
Therefore, this feature enables NO to be a pulmonary-specific vasodilator. (gov.sa)
Abrupt discontinuation of vasodilators is reported by the US FDA to cause rebound pulmonary hypertension, [4] which reflect the necessity behind the suggestions of using delivery systems to administer the gas, in order to supply the patients with constant dosage, and to ensure the continuous delivery. (gov.sa)
5] However, these vasodilators are still not approved for the use with PPHN because they are supplied through nebulizers, and thus, lack the consistency in the drug delivery, which do not fulfill the requirement of preventing the rebound pulmonary hypertension. (gov.sa)
Chronic Daily House Dust Mite Exposure in Mice is an Effective Model to Quantify the Effect of Pharmacologic Agents on Discrete Stages of Artery Remodeling in Pulmonary Hypertension. (stanford.edu)
For this reason, the skin is often exposed to potentially hazardous agents, including chemicals, which may contribute to the onset of a spectrum of adverse health effects ranging from localized damage (e.g., irritant contact dermatitis and corrosion) to induction of immune-mediated responses (e.g., allergic contact dermatitis and pulmonary responses), or systemic toxicity (e.g., neurotoxicity and hepatoxicity). (cdc.gov)
Pharmacologic1
TTDE CFVR is free from ionizing radiation Catholic University of the Sacred and widely available, utilizing high-frequency transducers, pharmacologic vasodilator Heart, Italy stress, and pulsed-wave Doppler quantification of diastolic peak flow velocities. (readkong.com)
Hypotension2
Dopamine and dobutamine are the drugs of choice to improve cardiac contractility, with dopamine the preferred agent in patients with hypotension. (medscape.com)
Coadministration with blood pressure lowering agents may increase the risk and severity of hypotension associated with amifostine. (medscape.com)
Vascular smooth3
Vasodilators relax vascular smooth muscle and reduce the SVR, allowing for improved forward flow, which improves cardiac output. (medscape.com)
This agent causes relaxation of vascular smooth muscle by stimulating intracellular cyclic guanosine monophosphate production. (medscape.com)
Nifedipine is a peripheral arterial vasodilator which acts directly on vascular smooth muscle. (nih.gov)
Vasodilation1
As the blood concentration of a local anesthetic agent increases further, CVS depression occurs, resulting in a decrease in blood pressure secondary to myocardial depression, impaired cardiac conduction, and eventual peripheral vasodilation. (dieutridau.com)
Nifedipine1
Nifedipine is a drug belonging to a class of pharmacological agents known as the calcium channel blockers. (nih.gov)
Nitric oxide2
The present study was designed to examine whether donepezil induces acute cerebral arteriolar dilation and whether neuronal nitric oxide synthase contributes to this vasodilator response. (silverchair.com)
stimulates two key responses that are extremely beneficial for athletes who want to gain Clean and Lean MASS. It stimulates Nitric Oxide production (NO) which is a vasodilator, it helps blood vessel walls relax and expand to carry more blood to working muscles for higher performance and stronger muscle pump. (houseofsupplements.com.au)
Local anesthetic agents are relatively lipid-soluble, low-molecular-weight compounds that readily cross the blood-brain barrier. (dieutridau.com)
Effects2
Isosorbide dinitrate (ISDN), an organic nitrate, is a vasodilator with effects on both arteries and veins. (prescriptiondrugs.com)
Because the effects of controlled-release oral isosorbide dinitrate are so difficult to terminate rapidly, this formulation is not recommended in these settings. (prescriptiondrugs.com)
Acute2
According to American Heart Association guidelines , clear evidence suggests that cocaine can precipitate acute coronary syndrome, and that trying agents that show efficacy in the management of acute coronary syndrome may be reasonable in patients with severe cardiovascular toxicity. (emergencymedicineexpert.com)
To reduce the chances of heart attack, stroke, or death in patients with acute coronary syndrome (incomplete heart attack or rapidly worsening angina-type chest pain) who are going to be treated with medicines or heart surgery. (ventln.com)
Inhibit2
Agents that irreversibly inhibit platelet aggregation may improve morbidity. (medscape.com)
It is metabolized in the liver largely by CYP 3A4 and is susceptible to drug-drug interactions with agents that induced or inhibit this microsomal enzyme. (nih.gov)
Secondly, NO has high affinity for heme protein, and as a result of this, any excess inhaled NO in the lung would rapidly binds to hemoglobin, eliminating the potential for systemic vasodilatation. (gov.sa)
To minimize systemic reactions to local anesthetic agents, intravascular injection (the most common cause of seizures) should be avoided. (dieutridau.com)
Excessive1
Lipid-lowering agent - to remove the excessive fat & plaque that are accumulated in the blood vessel in the body. (illnesshacker.com)
Therapy3
Details of antihypertensive drug therapy and compliance, intake of over-the-counter (OTC) preparations such as sympathomimetic agents, and use of illicit drugs such as cocaine are important elements of the medication history. (medscape.com)
In the large majority of these trials, active agents were no more effective than placebo after 24 hours (or less) of continuous therapy. (prescriptiondrugs.com)
In contrast, telcagepant, the initial oral CGRP receptor antagonist evaluated as therapy for migraine headaches, was abandoned during development because of several instances of clinically apparent liver injury in recipients that was characterized by marked elevations in serum aminotransferase levels and symptoms of fatigue, nausea and abdominal discomfort arising within 2 to 4 weeks of starting therapy which rapidly resolved with prompt stopping of therapy. (nih.gov)
Clinical2
Clinical pharmacology of local anesthetic agents. (dieutridau.com)
Stroke is defined by the World Health Organization 7 as 'a clinical syndrome consisting of rapidly developing clinical signs of focal (or global in case of coma) disturbance of cerebral function lasting more than 24 hours or leading to death with no apparent cause other than a vascular origin. (illnesshacker.com)
Heart1
Aortic dissection: Rapidly lower SBP to 100-120 mmHg and heart rate less than 60-80 with IV beta blocker ± vasodilator to reduce shear stress. (pharmacy-acutecareuniversity.com)
Cerebral1
These agents augment coronary and cerebral blood flow during the low-flow state associated with cardiogenic shock. (medscape.com)
Oral1
Theophylline is rapidly and completely absorbed after oral administration in solution or immediate-release solid oral dosage form. (pharmacycode.com)
Directly1
This agent may be capable of enhancing this enzymatic activity directly or via acetylcholinesterase existing on the arteriolar wall. (silverchair.com)
Free1
is the most abundant free amino acid in human muscle and plasma and is needed at high levels by rapidly dividing cells during protein synthesis. (houseofsupplements.com.au)
Active2
They should be stored in the dark because the active ingredients rapidly degrade in the light[238]. (pfaf.org)