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  • axon initial segments
  • βIV-spectrin expression is mostly restricted to neurons, where it colocalizes with and binds to ankyrin-G at axon initial segments (AISs) and nodes of Ranvier (NR). In βIV-spectrin -null neurons, neither ankyrin-G nor voltage-gated sodium channels (VGSC) are correctly clustered at these sites, suggesting that impaired action potential caused by mislocalization of VGSC leads to the phenotype. (rupress.org)
  • paranodes
  • However, because K + channels in these mutants are mislocalized to the paranodes, immediately adjacent to Na + channels at the node, the transverse bands are essential for localization of K + channels to the juxtaparanodes. (jneurosci.org)
  • voltage-gated c
  • These findings indicate that interactions of the paranodal loops with the axon promote the transition in sodium channel subtypes at CNS nodes and provide a lateral diffusion barrier that, even in the absence of transverse bands, maintains a high concentration of components at the node and the integrity of voltage-gated channel domains. (jneurosci.org)
  • proteins
  • The node of Ranvier is a complex macromolecular assembly of ion channels and other proteins that is specialized for the rapid propagation of the action potential. (jneurosci.org)
  • A full understanding of the processes responsible for the assembly and maintenance of the node requires first the identification and characterization of the proteins found there. (jneurosci.org)
  • axolemma
  • They flank the node on either side and physically separate it from the juxtaparanodal axolemma, which is enriched in K v 1.1 and K v 1.2 channels. (jneurosci.org)
  • Caspr
  • To investigate these roles, we characterized node development in mice deficient in contactin-associated protein (Caspr), an integral junctional component. (jneurosci.org)
  • molecular
  • Here we show that NG2, a structurally unique chondroitin sulfate proteoglycan, is a molecular component of the node of Ranvier in the peripheral nervous system. (jneurosci.org)
  • Given the functional importance of the node of Ranvier and the disastrous consequences of demyelinating diseases that disrupt nodal structure, it is important to identify molecular components of the node and to understand their functions there. (jneurosci.org)
  • mechanisms
  • Interactions with myelinating glia are essential for node formation and maintenance, although the precise mechanisms involved have remained elusive ( Peles and Salzer, 2000 ). (jneurosci.org)
  • neurofascin
  • Disintegration of the nodes occurred in an orderly manner, starting with the disappearance of neurofascin 186, followed by the loss of Na + channels and ankyrin G, and then βIV spectrin, a sequence that reflects the assembly of nodes during development. (jneurosci.org)
  • regeneration
  • His observations on fiber nodes and the degeneration and regeneration of cut fibers had a great influence on Parisian neurology at the Salpêtrière. (bionity.com)