• A better-ranked biotech stock is Ligand Pharmaceuticals Incorporated LGND with a Zacks Rank #2 (Buy). (yahoo.com)
  • Why Is Ligand (LGND) Up 5.3% Since Last Earnings Report? (benzinga.com)
  • Ligand Pharmaceuticals Incorporated (NASDAQ:LGND) (the Company or Ligand) today announced that the United States Patent and Trademark Office issued U.S. Patent No. 7,314,887, titled "Thrombopoietin Activity Modulating Compounds and Methods," to Ligand for LGD-4665, the Company's lead thrombopoietin (TPO) receptor agonist and a family of related compounds. (ligand.com)
  • Ligand Pharmaceuticals Incorporated LGND reported third-quarter 2018 adjusted earnings of $1.32 per share, significantly up from the year-ago figure of 69 cents. (nasdaq.com)
  • We report that mice lacking OPGL or its receptor RANK fail to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. (nih.gov)
  • Transplantation and OPGL-rescue experiments in opgl-/- and rank-/- pregnant females showed that OPGL acts directly on RANK-expressing mammary epithelial cells. (nih.gov)
  • Recombinant OPGL binds specifically to RANK expressed by transfected cell lines and purified osteoclast progenitors. (duke.edu)
  • Recombinant RANK-Fc binds with high affinity to OPGL in vitro and blocks osteoclast differentiation and activation in vitro and in vivo. (duke.edu)
  • Furthermore, polyclonal Ab against the RANK extracellular domain promotes osteoclastogenesis in bone marrow cultures suggesting that RANK activation mediates the effects of OPGL on the osteoclast pathway. (duke.edu)
  • These data indicate that OPGL-induced osteoclastogenesis is directly mediated through RANK on osteoclast precursor cells. (duke.edu)
  • The Patent Scorecard--Quarterly Leader Board report, issued on 11/30/2007, listed Ligand Pharmaceuticals Incorporated as one of the top innovators in the industry with the highest score for the Industry Impact metric ( www.patentboard.com/scorecard ). (ligand.com)
  • GRIM aligns protein-ligand interaction patterns of docked poses to those of available PDB templates for the target protein, and rescore poses by a graph matching method. (chemaxon.com)
  • VM2 can provide accurate protein-ligand binding affinities, and recent advances, such as parallel processor implementations for CPU and GPU clusters, as well as ports to Cloud platforms, now allow routine use of VM2 for rank-ordering of ligand series in pharmaceutical industry drug development settings. (verachem.com)
  • Accurate predictions of protein-ligand binding affinities, therefore, provide the potential for tremendous savings with respect to cost and time in the drug development process. (verachem.com)
  • VeraChem's state of the art computational chemistry software is capable of protein-ligand and host-guest binding affinity prediction, fast calculation of accurate partial atomic charges for drug-like compounds, computation of energies and forces with empirical force fields, automatic generation of alternate resonance forms of drug-like compounds, conformational search with the powerful Tork distort-minimize algorithm, and automatic detection of topological and 3D molecular symmetries. (verachem.com)
  • Inhibition of RANK Ligand is a novel way of improving the rheumatoid arthritis patient. (healthcentral.com)
  • Ligand discovers and develops new drugs that address critical unmet medical needs of patients in the areas of thrombocytopenia, hepatitis C, cancer, hormone-related diseases, osteoporosis and inflammatory diseases. (ligand.com)
  • RANK-Ligand stands for receptor activator of NF-κB ligand, also termed TNSFSF11 or TRANCE. (miltenyibiotec.com)
  • The TRANCE-RANK interaction regulates the expression of the anti-apoptotic molecule Bcl-xL.Applications Reported: The MIH24 antibody has been reported for use in flow cytometric analysis, and ELISA.Applications Tested: The MIH24 antibody has been tested by flow cytometric analysis of human RANKL transfected cells. (fishersci.co.uk)
  • A novel docking challenge has been set by the Drug Design Data Resource (D3R) in order to predict the pose and affinity ranking of a set of Farnesoid X receptor (FXR) agonists, prior to the public release of their bound X-ray structures and potencies. (chemaxon.com)
  • In the second phase, 102 FXR agonists were ranked by decreasing affinity according to the Gibbs free energy of the corresponding GRIMselected poses, computed by the HYDE scoring function. (chemaxon.com)
  • We have investigated the effect of these flanking sequences on binding and the reasons for the differences and established a computational method to rank ligand affinity against varying DNA sequences. (strath.ac.uk)
  • Ligands in a complex dictate the reactivity of the central atom, including ligand substitution rates, the reactivity of the ligands themselves, and redox. (phys.org)
  • Binding of the metal with the ligands results in a set of molecular orbitals, where the metal can be identified with a new HOMO and LUMO (the orbitals defining the properties and reactivity of the resulting complex) and a certain ordering of the 5 d-orbitals (which may be filled, or partially filled with electrons). (wikipedia.org)
  • This year so far, Ligand has entered into a worldwide OmniAb platform license agreement with Glenmark Pharmaceuticals per which the latter will be able to use the its full OmniAb platform to discover fully human mono- and multispecific antibodies. (yahoo.com)
  • Ligand also entered into a worldwide OmniAb platform license agreement with Ferring Pharmaceuticals and venBio Partners this year. (yahoo.com)
  • During the quarter, Ligand also entered into a license agreement with Fred Hutchinson Cancer Research Center, granting the latter rights to use the OmniAb rodent platform technologies to develop new products. (nasdaq.com)
  • The pocket here is predefined as a 10 Å sphere, and the center of the pocket is either defined as the center of the supplied ligand molecule or explicitly given by the user. (silcsbio.com)
  • The patent describes LGD-4665 and other small-molecule TPO mimetic compounds discovered at Ligand, formulations involving these compounds, as well as methods of making and using the compounds and formulations. (ligand.com)
  • Receipt of this patent reflects our continued focus on innovation while strengthening our intellectual property portfolio, and covers a platform molecule that we believe has significant market potential," said John L. Higgins, President and Chief Executive Officer of Ligand Pharmaceuticals. (ligand.com)
  • The immunogen for anti-sRANK Ligand antibody: antibody was raised against a 14 amino acid peptide from near the center of human sRANK-L. (avivasysbio.com)
  • However, more work needs to be done before inhibiting RANK ligand becomes an established method of prevention-drugs that work well in mice don't necessarily work well for humans. (facingourrisk.org)