Rank ligand. Medical search. FAQ

As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis. (fishersci.com)
Description: The MIH24 monoclonal antibody reacts with human TRANCE (TNF-related activation-induced cytokine receptor) also known as RANKL (receptor activator of NF-kappaB ligand) and OPGL (Osteoprotegerin Ligand). (fishersci.co.uk)
Osteoprotegerin-ligand (OPGL) is a key osteoclast differentiation/activation factor essential for bone remodeling. (nih.gov)
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. (duke.edu)
A receptor that mediates osteoprotegerin ligand (OPGL)-induced osteoclast differentiation and activation has been identified via genomic analysis of a primary osteoclast precursor cell cDNA library and is identical to the tumor necrosis factor receptor (TNFR) family member RANK. (duke.edu)
Receptor activator of nuclear factor kappa-Β ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 gene. (wikipedia.org)

Denosumab injection (Xgeva) is used Denosumab injection is in a class of medications called RANK ligand inhibitors. (medlineplus.gov)
The effect of radiotherapy, and radiotherapy combined with bisphosphonates or RANK ligand inhibitors on bone quality in bone metastases. (ru.nl)
This systematic review assessed the effects of (1) radiotherapy, (2) radiotherapy combined with bisphosphonates, and (3) radiotherapy combined with RANK ligand (RANKL) inhibitors on bone quality and bone strength in bone metastases originating from solid tumors. (ru.nl)
As such, the researchers decided to investigate how one of these drugs - known as RANK ligand inhibitors - would affect the progression of pre-cancerous breast cells. (medicalnewstoday.com)

Genetic experiments have shown that mice lacking either rankl or rank suffer from severe osteoporosis and defective tooth eruption due to complete lack of osteoclasts. (wikipathways.org)
Binding of RANKL to RANK triggers downstream signaling events that leads to the activation of osteoclasts and controlling of lineage commitment. (wikipathways.org)
The RANK mRNA was highly expressed by isolated bone marrow-derived osteoclast progenitors and by mature osteoclasts in vivo. (duke.edu)
Transgenic mice expressing a soluble RANK-Fc fusion protein have severe osteopetrosis because of a reduction in osteoclasts, similar to OPG transgenic mice. (duke.edu)
Osteoclast precursors which express receptor activator of NF-kappaB (RANK) recognize RANKL through cell-to-cell interaction with osteoblasts/stromal cells, and differentiate into osteoclasts in the presence of macrophage-colony stimulating factor (M-CSF). (nih.gov)
RANK Ligand-driven osteoclast activity osteoclasts being those cells which erode the bones has been implicated in the destructive bone erosions which are characteristic of rheumatoid arthritis and other forms of erosive arthritis such as psoriatic arthritis. (healthcentral.com)
The generation of osteoclasts depends on RANK Ligand. (healthcentral.com)
The significance of RANK-RANKL pathway is supported by studies that show that disruption in either rank or rankl in mice produced severe osteopetrosis and defective tooth eruption resulting from a complete lack of osteoclasts ( 6 ). (aacrjournals.org)
Pre-osteoclasts have membrane receptors called RANK, related to the TNF family. (washington.edu)
When RANK-L activates these receptors the cells fuse and differentiate into mature multinucleared osteoclasts which develop a ruffled border and resorb bone. (washington.edu)
The first part of the review will focus on targeting the bone resorbing function of osteoclasts by means of bisphosphonates or drugs blocking the pro-resorbing cytokine receptor activator of NF-kappa B ligand. (frontiersin.org)
RANKL binds to RANK expressed by osteoclasts and osteoclast precursors to promote osteoclast differentiation. (medscape.com)
Osteoclasts are regulated by the RANK ligand pathway. (aacrjournals.org)
It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B. (curehunter.com)
Pre-osteoclasts are activated by RANK-ligand (RANKL) and then differentiate into mature osteoclasts which develop a ruffled border and resorb bone. (dentalcare.com)
Osteoclasts are more effective at resorbing bone when RANK-ligand's effect is reduced. (dentalcare.com)
The RANK Ligand is the essential mediator of osteoclast formation, function, and survival and thereby plays a key role in rheumatoid arthritis (RA) associated bone erosions (osteoclasts are the cells responsible for the break down of bone material). (news-medical.net)
Prolia is the first approved therapy that specifically targets RANK Ligand, an essential regulator of bone-removing cells (osteoclasts). (prnewswire.com)
Osteoclastic activity is triggered via the osteoblasts' surface-bound RANKL activating the osteoclasts' surface-bound receptor activator of nuclear factor kappa-B (RANK). (wikipedia.org)

Traditional treatment strategies include analgesics, external beam radiation therapy (EBRT), and bone acting agents such as bisphosphonates or the receptor activator of nuclear factor kappa-B ligand (RANKL) monoclonal antibody denosumab. (hindawi.com)
Denosumab targets a protein called RANK ligand (RANKL). (breastcancer.org)
Denosumab is a monoclonal antibody which targets RANK Ligand, a cell mediator that break down bone. (healthcentral.com)
Denosumab is a fully human monoclonal antibody which binds to and inhibits the RANK Ligand. (news-medical.net)
Update added 11/24/19: The RANK ligand inhibitor, denosumab is currently being studied as a possible breast and ovarian cancer preventive agent in human clinical trials. (facingourrisk.org)

A better-ranked biotech stock is Ligand Pharmaceuticals Incorporated LGND with a Zacks Rank #2 (Buy). (yahoo.com)
Why Is Ligand (LGND) Up 5.3% Since Last Earnings Report? (benzinga.com)
Ligand Pharmaceuticals Incorporated (NASDAQ:LGND) (the Company or Ligand) today announced that the United States Patent and Trademark Office issued U.S. Patent No. 7,314,887, titled "Thrombopoietin Activity Modulating Compounds and Methods," to Ligand for LGD-4665, the Company's lead thrombopoietin (TPO) receptor agonist and a family of related compounds. (ligand.com)
Ligand Pharmaceuticals Incorporated LGND reported third-quarter 2018 adjusted earnings of $1.32 per share, significantly up from the year-ago figure of 69 cents. (nasdaq.com)

Very recently, osteoprotegerin (OPG), a key factor in bone remodeling, 5 a member of the tumor necrosis factor (TNF) receptor family, and a decoy receptor for the receptor activator of nuclear factor-κB ligand (RANKL) and TNF-related apoptosis-inducing ligand (TRAIL), 6 was implicated in human atherogenesis. (ahajournals.org)
Among these genes, osteoprotegerin ( OPG ) is known to be associated with aggressiveness in several cancers through inhibition of apoptosis via neutralization of the function of TNF-related apoptosis-inducing ligand. (aacrjournals.org)

Publications] Kitazawa S: 'Epigenetic control of mouse receptor activator of NFkB ligand gene expression'BBRC. (nii.ac.jp)

Receptor activator of nuclear factor kappa-B (RANK) ligand, also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), together with RANK, is a member of the TNF superfamily of ligands and receptors involved in activation of immune response and in bone regeneration. (miltenyibiotec.com)
RANKL is specifically categorized under the TNFSF11, the TNF ligand superfamily member. (wikipedia.org)

Receptor Activator of NF-κB Ligand (RANKL) is a cell-bound marker (CD254) related to the TNF family of proteins. (cellsciences.com)

We report that mice lacking OPGL or its receptor RANK fail to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. (nih.gov)
Transplantation and OPGL-rescue experiments in opgl-/- and rank-/- pregnant females showed that OPGL acts directly on RANK-expressing mammary epithelial cells. (nih.gov)
Recombinant OPGL binds specifically to RANK expressed by transfected cell lines and purified osteoclast progenitors. (duke.edu)
Recombinant RANK-Fc binds with high affinity to OPGL in vitro and blocks osteoclast differentiation and activation in vitro and in vivo. (duke.edu)
Furthermore, polyclonal Ab against the RANK extracellular domain promotes osteoclastogenesis in bone marrow cultures suggesting that RANK activation mediates the effects of OPGL on the osteoclast pathway. (duke.edu)
These data indicate that OPGL-induced osteoclastogenesis is directly mediated through RANK on osteoclast precursor cells. (duke.edu)

These plots are of VM2 calculated binding free energy predictions versus experimental binding affinities for the protein receptors P38A kinase, HIV-1 protease, PDE10A, and BRCA1, and corresponding inhibitor series ranging between 16 and 38 ligands. (verachem.com)
In contrast, genetic deletion of osteoprotegerin, a decoy receptor for RANKL and an inhibitor of RANK, produced osteoporosis resulting from an increased number of osteoclast ( 7 ). (aacrjournals.org)
Osteoprotegerin (OPG), The Endogenous Inhibitor of Receptor Activator of NF-κB Ligand (RANKL), is Dysregulated in BRCA Mutation Carriers. (nih.gov)
This research study identified a type of drug, called a "RANK ligand inhibitor," that may prevent breast cancer. (facingourrisk.org)
Mice that were genetically engineered to have no BRCA1 genes and were given a drug known as a RANK ligand inhibitor developed fewer breast tumors compared to mice that were not given the drug. (facingourrisk.org)
RANKL may also bind to osteoprotegerin, a protein secreted mainly by cells of the osteoblast lineage which is a potent inhibitor of osteoclast formation by preventing binding of RANKL to RANK. (wikipedia.org)

RANKL/RANK signaling is essential for skeletal homoeostasis and its interference leads to inhibition of bone resorption resulting in bone diseases including osteoporosis osteopetrosis and rheumatoid arthritis. (wikipathways.org)
Receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL) has emerged as a major mediator of bone resorption, commonly associated with cancer and other chronic inflammatory diseases. (aacrjournals.org)
The receptor activator of nuclear factor-kappa B ligand (RANKL)/receptor activator of nuclear factor-kappa B (RANK)/osteoprotegerin (OPG) system is the final common pathway for bone resorption. (medscape.com)
a ) the RANK ligand/osteoprotegerin pathway, which regulates osteoclast formation and bone resorption, ( b ) the Runx2 transcription factor, which controls osteoblast differentiation, and ( c ) the Wnt signaling pathway, which regulates osteoblasts and bone formation. (aacrjournals.org)
The investigators' data suggests that PSA may contribute to the high bone resorption seen in prostate cancer by increasing the ratio of RANK ligand (increased by PSA) to osteoprotegerin (decreased 95× by PSA). (aacrjournals.org)
1 ⇓ - 3 The interaction of malignant plasma cells with the surrounding stromal microenvironment mediated by increased receptor activator of nuclear factor-kappa B ligand (RANKL) production and reduced osteoprotegrin secretion plays a critical role in accelerating osteoclast (OC)-mediated bone resorption and destruction. (bloodjournal.org)

Mouse RANK-Ligand shares with human 85% amino acid identity. (miltenyibiotec.com)
Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution. (ebi.ac.uk)

Binding of RANKL to RANK leads to the activation of signaling modules such as NF-kappa B, mitogen activated protein kinases (MAPK's), protein kinase C (PKC), Ca2+/Calcineurin/nuclear factor of activated T cells (NFAT) and phosphatidyl 3-kinase (PI3K). (wikipathways.org)

A comprehensive manually curated reaction map of RANKL/RANK signaling pathway. (wikipathways.org)

The bonding between metal and ligand generally involves formal donation of one or more of the ligand's electron pairs. (phys.org)
This is because the ligand and central metal are bonded to one another, and the ligand is providing both electrons to the bond (lone pair of electrons) instead of the metal and ligand each providing one electron. (wikipedia.org)

Osteoclast formation requires the presence of RANKL (receptor activator of nuclear factor κβ ligand) and M-CSF (Macrophage colony-stimulating factor) . (wikipedia.org)

Receptor activator of nuclear factor-kappa B ligand (RANKL) is a member of tumor necrosis factor (TNF) superfamily. (wikipathways.org)
Receptor activator of nuclear factor kappa-B (RANK)-signaling is involved in tumor growth and spread in experimental models. (biomedcentral.com)
RANK ligand and osteoprotegerin are members of the tumor necrosis factor ligand and receptor superfamilies with opposing actions to stimulate osteoclast formation, activity, and survival ( 8 ). (aacrjournals.org)
Background- Osteoprotegerin is a novel member of the tumor necrosis factor receptor superfamily and a soluble decoy receptor of the receptor activator of nuclear factor-κB ligand. (ahajournals.org)
TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. (avivasysbio.com)
RANKL is a member of the tumor necrosis factor (TNF) cytokine family, it binds to RANK on cells of the myeloid lineage and functions as a key factor for osteoclast differentiation and activation. (wikipedia.org)

The RANKL-RANK signaling system is negatively regulated by a decoy receptor known as Osteoprotegerin. (wikipathways.org)
RANKL (Receptor activator of nuclear factor-kappa B ligand), RANK (Receptor activator of nuclear factor-kappa B) and the natural decoy receptor of RANKL, OPG (Osteoprotegerin) are three important molecules identified to play a major role in osteoclastogenesis and bone remodelling. (wikipathways.org)
OPG is the decoy receptor for RANKL and can downregulate RANK-signaling. (biomedcentral.com)
Meanwhile, OPG is a free-floating decoy receptor, made by mature osteoblasts, which can bind the RANK-L. (washington.edu)
OPG is a soluble decoy receptor that inhibits RANK-RANKL by binding and sequestering RANKL. (medscape.com)

The Patent Scorecard--Quarterly Leader Board report, issued on 11/30/2007, listed Ligand Pharmaceuticals Incorporated as one of the top innovators in the industry with the highest score for the Industry Impact metric ( www.patentboard.com/scorecard ). (ligand.com)

RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. (fishersci.com)
It binds to Receptor activator of NF-kB (RANK) and plays a major role in the regulation of osteoclast function. (wikipathways.org)
Osteoclast differentiation is inhibited by osteoprotegerin (OPG), which is produced by osteoblasts and binds to RANKL thereby preventing interaction with RANK. (wikipedia.org)
In coordination chemistry, a ligand is an ion or molecule (see also: functional group) that binds to a central metal atom to form a coordination complex. (phys.org)

Binding of osteoprotegerin (OPG) by RANK-Ligand inhibits osteoclastogenesis and leads to accumulation of bone and cartilage. (miltenyibiotec.com)

Catalytic subunits, IκB kinase α and IκB kinase β and the non-catalytic subunit IKKγ (also called NEMO) are also essential for RANKL-RANK signaling and osteoclastogenesis. (wikipathways.org)

Receptor activator of nuclear factor-κB ligand is an osteoclast differentiation and activation factor which also augments the ability of dendritic cells to cause T-cell proliferation. (ganfyd.org)

TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells. (fishersci.com)
The objective of the study was to evaluate synovial tissue receptor activator of nuclear factor-κβ ligand (RANKL) and osteoprotegerin (OPG) as biomarkers of disease activity, progressive joint damage, and therapeutic response, during cytokine blockade in rheumatoid arthritis (RA). (springer.com)

GRIM aligns protein-ligand interaction patterns of docked poses to those of available PDB templates for the target protein, and rescore poses by a graph matching method. (chemaxon.com)
VM2 can provide accurate protein-ligand binding affinities, and recent advances, such as parallel processor implementations for CPU and GPU clusters, as well as ports to Cloud platforms, now allow routine use of VM2 for rank-ordering of ligand series in pharmaceutical industry drug development settings. (verachem.com)
Accurate predictions of protein-ligand binding affinities, therefore, provide the potential for tremendous savings with respect to cost and time in the drug development process. (verachem.com)
VeraChem's state of the art computational chemistry software is capable of protein-ligand and host-guest binding affinity prediction, fast calculation of accurate partial atomic charges for drug-like compounds, computation of energies and forces with empirical force fields, automatic generation of alternate resonance forms of drug-like compounds, conformational search with the powerful Tork distort-minimize algorithm, and automatic detection of topological and 3D molecular symmetries. (verachem.com)

Integrins are cell-surface receptors that bind ligands and reduce their bone-building effect. (dentalcare.com)

Objective: Receptor activator of nuclear factor-kappa B ligand (RANKL) appears to be an osteoclast-activating factor, bearing an important role in the pathogenesis of multiple myeloma. (sid.ir)
The receptor activator of nuclear factor-κB (RANK) pathway plays essential roles in breast development. (aacrjournals.org)
RANKL activates NF-κβ (nuclear factor-κβ) and NFATc1 (nuclear factor of activated t cells, cytoplasmic, calcineurin-dependent 1) through RANK . (wikipedia.org)
receptor activator of nuclear factor kappa-B (RANK), its ligand (RANKL), and osteoprotegerin (OPG). (biomedcentral.com)
What is the role of receptor activator of nuclear factor-kappa B ligand (RANKL) and receptor activator of nuclear factor-kappa B (RANK) in the pathogenesis of osteoporosis? (medscape.com)
Osteoprotegerin-receptor activator of nuclear factor-[kappa]B ligand ratio: a new approach to osteoporosis treatment? (thefreedictionary.com)
Evidence that receptor activator of the nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism. (avivasysbio.com)

Binding of RANK ligand (RANKL) to RANK activates signaling, which is inhibited by osteoprotegerin (OPG). (biomedcentral.com)

Inhibition of RANK Ligand is a novel way of improving the rheumatoid arthritis patient. (healthcentral.com)

Ligand discovers and develops new drugs that address critical unmet medical needs of patients in the areas of thrombocytopenia, hepatitis C, cancer, hormone-related diseases, osteoporosis and inflammatory diseases. (ligand.com)

RANKL is an apoptosis regulator gene, a binding partner of osteoprotegerin (OPG), a ligand for the receptor RANK and controls cell proliferation by modifying protein levels of Id4, Id2 and cyclin D1. (wikipedia.org)

RANK-Ligand stands for receptor activator of NF-κB ligand, also termed TNSFSF11 or TRANCE. (miltenyibiotec.com)
The TRANCE-RANK interaction regulates the expression of the anti-apoptotic molecule Bcl-xL.Applications Reported: The MIH24 antibody has been reported for use in flow cytometric analysis, and ELISA.Applications Tested: The MIH24 antibody has been tested by flow cytometric analysis of human RANKL transfected cells. (fishersci.co.uk)

A novel docking challenge has been set by the Drug Design Data Resource (D3R) in order to predict the pose and affinity ranking of a set of Farnesoid X receptor (FXR) agonists, prior to the public release of their bound X-ray structures and potencies. (chemaxon.com)
In the second phase, 102 FXR agonists were ranked by decreasing affinity according to the Gibbs free energy of the corresponding GRIMselected poses, computed by the HYDE scoring function. (chemaxon.com)
We have investigated the effect of these flanking sequences on binding and the reasons for the differences and established a computational method to rank ligand affinity against varying DNA sequences. (strath.ac.uk)

RANK-Ligand is expressed in several tissues and cell types, including fibroblasts, T cells, and osteoblasts, and functions by binding its cell surface signaling receptor RANK. (miltenyibiotec.com)
Recent studies have established that osteoblasts/stromal cells express receptor activator of NF-kappaB ligand (RANKL) in response to several bone-resorbing factors including 1alpha,25(OH)(2)D(3) to support osteoclast differentiation from their precursors. (nih.gov)
The stromal cells also divide to produce pre-osteoblasts, which express RANK-ligand (RANK-L) on their cell surfaces. (washington.edu)
Osteoblasts also secreted the RANK ligand binding protein, osteoprotegerin (data not shown), which decreases osteoclast formation. (aacrjournals.org)

Ligands in a complex dictate the reactivity of the central atom, including ligand substitution rates, the reactivity of the ligands themselves, and redox. (phys.org)
Binding of the metal with the ligands results in a set of molecular orbitals, where the metal can be identified with a new HOMO and LUMO (the orbitals defining the properties and reactivity of the resulting complex) and a certain ordering of the 5 d-orbitals (which may be filled, or partially filled with electrons). (wikipedia.org)

nhances the expression of stromal RANK ligand, both of which increase osteolytic bone degradation . (psu.edu)

This study also attempted to show the molecular mechanism of RANK and RANKL on differentiation capability of human cord blood HSC to osteoclast, as well as expression of calcitonin receptor (CTR) on cord blood HSC surface. (sid.ir)

This year so far, Ligand has entered into a worldwide OmniAb platform license agreement with Glenmark Pharmaceuticals per which the latter will be able to use the its full OmniAb platform to discover fully human mono- and multispecific antibodies. (yahoo.com)
Ligand also entered into a worldwide OmniAb platform license agreement with Ferring Pharmaceuticals and venBio Partners this year. (yahoo.com)
During the quarter, Ligand also entered into a license agreement with Fred Hutchinson Cancer Research Center, granting the latter rights to use the OmniAb rodent platform technologies to develop new products. (nasdaq.com)

Publications] Srivastava S: 'Receptor Activator of NF-kB Ligand (RANKL) Induction via Jak2 and Stat 5a in Mammary Epithelial Cells'J Biol Chem. (nii.ac.jp)

Targeting RANK Ligand directly affects the mechanism responsible for the loss of cartilage and bone in long-term rheumatoid arthritis. (healthcentral.com)
Evaluation of bone mineral density, bone metabolism, osteoprotegerin and receptor activator of the NFkappaB ligand serum levels during treatment with infliximab in patients with rheumatoid arthritis. (thefreedictionary.com)

In addition, RANK Ligand is expressed by some T cells is a dendritic cell survival factor and is involved in the regulation of T cell-dependent immune response. (cellsciences.com)
Some studies demonstrated that U-266 myeloma cell line and primary myeloma cells expressed RANK and RANKL. (sid.ir)
Results: Hematopoietic stem cells expressed RANK before and after differentiation into osteoclast. (sid.ir)
RANK-Ligand is expressed by T helper cells and is involved in dendritic cell maturation. (miltenyibiotec.com)
Human RANK-Ligand shares with mouse 85% amino acid identity and is reactive on murine cells. (miltenyibiotec.com)
Using the enzyme fragment complementation technology, simply infect your target cells with the PathHunter β-Arrestin Retroparticles, transfect the cells with a GPCR plasmid, and perform a PathHunter GPCR β-arrestin assay with your ligand of interest. (discoverx.com)
Cells expressing CHRM2-PK fusion proteins were infected with PathHunter β-Arrestin2 Retroparticles and tested using 3 ligands: acetylcholine, carbachol and oxotremorine-M (oxo-M). Both pathway assays showed agonist pharmacology for all 3 ligands. (discoverx.com)
The lining cells that were activated during Origination secrete RANK-ligand, which may remain bound to the cell surface. (dentalcare.com)
What is more, the researchers found that a protein called RANK acted as a marker for these pre-cancerous cells - a finding that excited the team, given that there are already drugs in clinical use that target and block the RANK pathways. (medicalnewstoday.com)

The pocket here is predefined as a 10 Å sphere, and the center of the pocket is either defined as the center of the supplied ligand molecule or explicitly given by the user. (silcsbio.com)
The patent describes LGD-4665 and other small-molecule TPO mimetic compounds discovered at Ligand, formulations involving these compounds, as well as methods of making and using the compounds and formulations. (ligand.com)
Receipt of this patent reflects our continued focus on innovation while strengthening our intellectual property portfolio, and covers a platform molecule that we believe has significant market potential," said John L. Higgins, President and Chief Executive Officer of Ligand Pharmaceuticals. (ligand.com)

Ligands are viewed as Lewis bases, although rare cases are known involving Lewis acidic "ligands. (phys.org)

Differences in Volumetric Percent Density by Tertiles of Circulating RANK and sRANKL. (aacrjournals.org)
Least Square Means of Non-Dense Volume by Tertiles of Circulating RANK and sRANKL. (aacrjournals.org)
We, therefore, investigated the associations of circulating RANK and soluble RANK ligand (sRANKL) with mammographic density in premenopausal women. (aacrjournals.org)
We used linear regression models adjusted for confounders, to compare the least-square means of volumetric percent density across tertiles of circulating RANK and sRANKL. (aacrjournals.org)
Circulating RANK was positively associated with volumetric percent density, while circulating sRANKL was positively associated with volumetric percent density among women with higher progesterone levels. (aacrjournals.org)

The immunogen for anti-sRANK Ligand antibody: antibody was raised against a 14 amino acid peptide from near the center of human sRANK-L. (avivasysbio.com)

High expression of RANK-Ligand is observed during degenerative bone diseases and in tumors. (miltenyibiotec.com)

Does Accurate Scoring of Ligands against Protein Targets Mean Accurate Ranking? (bl.uk)

Osteoprotegerin (OPG) can act to bind the RANK-ligand which reduces its effect. (dentalcare.com)
Due to the chelate effect , ligands with two phosphine groups bind more tightly to metal centers than do two monodentate phosphines. (wikipedia.org)
Metal ions preferentially bind certain ligands. (wikipedia.org)

Human RANK-Ligand - soluble is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays. (miltenyibiotec.com)

However, more work needs to be done before inhibiting RANK ligand becomes an established method of prevention-drugs that work well in mice don't necessarily work well for humans. (facingourrisk.org)

Anatomy 12

Diseases 7

Chemicals and Drugs 14

Analytical, Diagnostic and Therapeutic Techniques and Equipment 6

Phenomena and Processes 11

Information Science 7

Geographicals 1