Controlled TrialsMethodsTrialEfficacyDouble-blindClinical trialsColorectal cancer patientsCliniciansOutcomesPhaseSingle-blindedPlaceboParticipantsInterventionChemotherapyProspective StudyCervical cancerStudy ProtocolPostoperativeRespiratoryObjectiveEvaluateOsteoarthritisProspectivelyOutcome measuresTreatmentVersusRegimenType 2 diabetChronicTherapiesSurgicalT2DMEligiblePediatric patientsCatheterMorbidity and mortaUndergoneSevereInvestigateAdherenceThoracicInfluenzaResultsHospitalTumorsOutpatientTherapySignificantly higherCONCLUSIONSStandard
Controlled Trials5
- This NIH Funding Opportunity Announcement (FOA) invites applications to plan and conduct low-cost, pragmatic randomized controlled trials (RCTs). (nih.gov)
- OBJECTIVES: Patient-reported outcome measures (PROMs) are evaluated in randomized controlled trials (RCTs) in patients with systemic lupus erythematosus (SLE), but not widely used in clinical practice. (aau.dk)
- A meta-analysis of randomized controlled trials (RCTs) for treating depression in diabetes showed that psychotherapeutic treatments are moderately effective for depression and that cognitive behavior therapy (CBT) in particular had a small effect on glycemic control ( 6 ). (diabetesjournals.org)
- Not all RCTs are randomized controlled trials (and some of them could never be, as in cases where controls would be impractical or unethical to use). (wikipedia.org)
- Treatment with neuraminidase inhibitors has been shown to have clinical and public health benefit in reducing illness and severe outcomes of influenza based on evidence from randomized controlled trials, meta-analyses of randomized controlled trials, and observational studies during past influenza seasons and during the 2009 H1N1 pandemic. (cdc.gov)
Methods7
- Methods: Seventy-five patients with primary unilateral hip osteoarthritis operated with an uncemented anatomical stem were randomized for either standard or modular stems. (lu.se)
- METHODS: After the completion of the phase 1 component, the phase 2 trial (ClinicalTrials.gov identifier NCT00892177) randomized patients with recurrent GBM 2:1 to receive 100 mg of oral dasatinib twice daily (arm A) or placebo (arm B) on days 1 to 14 of each 14-day cycle combined with 10 mg/kg of intravenous bevacizumab on day 1 of each 14-day cycle. (healthpartners.com)
- Methods/design: The study is a 6-weeks single site trial with a controlled, randomized, single-blinded, parallel-group design including patients with a diagnosis of AUD. (uni-muenchen.de)
- Methods We examined the effect of omalizumab on sleep-related outcomes during 3-6 months omalizumab or placebo treatment and a 16-week follow-up period within three Phase III double-blind randomized placebo-controlled pivotal trials in CIU/CSU: ASTERIA I, ASTERIA II, and GLACIAL. (figshare.com)
- METHODS Histologically determined NASH patients with elevated alanine aminotransferase (ALT) and decreased 25-OH vitamin D level at baseline received vitamin D3 or placebo orally over a 48-week period. (uzh.ch)
- Methods Patients with a PS 0-1, HLA-A2+ and CEA-expressing, previously-treated PC were randomized to receive 10 μg (arm A), 100 μg (arm B) or 1000 μg (arm C) of CEA peptide emulsified in Montanide and GM-CSF, given every 2 weeks until disease progression. (bmj.com)
- A multitude of randomized clinical trials and other treatment studies have demonstrated that currently available therapeutic methods are 22%-94% effective in clearing external exophytic genital warts, and that recurrence rates are high (usually at least 25% within 3 months) with all modalities. (cdc.gov)
Trial41
- Understanding and preventing wrong-patient electronic orders: a randomized controlled trial. (ahrq.gov)
- In this study, investigators at an academic medical center first developed a measurement tool within their electronic medical record to identify wrong-patient orders (and found that they were surprisingly common), then conducted a randomized trial investigating the efficacy of two different strategies to prevent wrong-patient orders. (ahrq.gov)
- Effect of restriction of the number of concurrently open records in an electronic health record on wrong-patient order errors: a randomized clinical trial. (ahrq.gov)
- Evaluation of a patient-centered fall-prevention tool kit to reduce falls and injuries: a nonrandomized controlled trial. (ahrq.gov)
- In a 12-month follow-up randomized clinical trial, we aimed to measure the efficacy of a brief family psychoeducation program in terms of reducing relapse risk and improving medication adherence in patients, as well as reducing caregiver burden, depression and increasing knowledge of the illness. (frontiersin.org)
- Two hundred ten patients with extensive stage small cell lung cancer (SCLCa) were enrolled onto this prospective trial, which was partially randomized. (oncolink.org)
- A large intergroup trial has demonstrated that AHFRT over standard fractionation TRT seems to further benefit patients with limited disease SCLCa.4 Most of the literature to date has not demonstrated an advantage in treating extensive disease with TRT in regards to response or survival. (oncolink.org)
- The results of this trial suggest that a certain subset of extensive stage patients may benefit from TRT in regards to survival, as is the case in limited stage SCLCa. (oncolink.org)
- Effects of a proactive interdisciplinary self-management program on patient self-efficacy and participation during practice nurse consultations: a randomized controlled trial in type 2 diabetes. (nivel.nl)
- Within a randomized controlled trial, patients were followed for 6 months. (nivel.nl)
- The Lymphoma Intervention (LIVE) trial is conducted to examine the impact of return of individual patient-reported outcome (PRO) results and a web-based self-management intervention on psychological distress, self-management, satisfaction with information, and health care use in a population-based setting. (jmir.org)
- Kobeissy AA, Hashash JG, Jamali FR, Skoury AM, Haddad R, El-Samad S, Ladki R, Aswad R, Soweid AM. A randomized open-label trial of on-demand rabeprazole vs ranitidine for patients with non-erosive reflux disease. (wjgnet.com)
- This is a single center, prospective, randomized, open-label trial of on-demand therapy with rabeprazole (group A) vs ranitidine (group B) for 4 wk. (wjgnet.com)
- Among the 83 patients who were enrolled in the study, 76 patients (40 in the rabeprazole group and 36 in the ranitidine group) completed the 4-wk trial. (wjgnet.com)
- Cluster-randomized controlled trial comparingan individualized intervention with a general guideline implementationin geographically diverse primary care clinics of a university-affiliated Department of Veterans Affairs healthcare system. (ajmc.com)
- Design A randomized, double-blind, placebo-controlled clinical trial. (medrxiv.org)
- It's the first randomized trial that I'm aware of in urine markers looking at standard of care versus a marker-based approach,' says Yair Lotan, MD. (urologytimes.com)
- In this video, Yair Lotan, MD , University of Texas Southwestern Harold C. Simmons Comprehensive Cancer Center, discusses the randomized STRATA trial (NCT03988309), which is comparing the genomic urine test Cxbladder with standard of care in patients with hematuria who are being evaluated for urothelial carcinoma. (urologytimes.com)
- The randomized [STRATA] trial is on ClinicalTrials.gov (NCT03988309) and I think it's 80% to 90% enrolled. (urologytimes.com)
- Noninvasive ventilation and weaning in patients with chronic hypercapnic respiratory failure: a randomized multicenter trial. (insa-lyon.fr)
- Adenoma detection by Endocuff-assisted versus standard colonoscopy in an organized screening program: the "ITAVISION" randomized controlled trial. (asge.org)
- Discussion: This study is a randomized controlled trial to investigate the efficacy of a personalized circadian Zeitgeber therapy as an adjunctive treatment for alcohol use disorder patients. (uni-muenchen.de)
- To prove advanced gastric cancer patients after neoadjuvant chemotherapy should have better disease-free survival than adjuvant chemotherapy patients, RESONANCE trial was designed and registered. (omicsonline.org)
- From March 1, 2012 to January 14, 2013, eighty- one gastric cancer patients were enrolled in RESONANCE trial as neoadjuvant chemotherapy arm. (omicsonline.org)
- Sixty patients with RA aged 25-70 years were assigned into two groups to receive either probiotic capsules (n = 30) or placebo (n = 30) in this randomized, double-blind, placebo-controlled trial. (eurekamag.com)
- We describe a multi-centre randomized controlled trial to test whether these patients can be followed up by their general practitioner (GP) without altering quality of life, cost effectiveness and/or the incidence of serious clinical events. (biomedcentral.com)
- Thus, the purpose of this randomized controlled trial (RCT) was to evaluate the effects of self-compassion training on mood and metabolic outcomes among patients with diabetes. (diabetesjournals.org)
- We conducted a pilot randomized phase I trial in PC patients to determine the peptide dose required to induce an optimal CD8 + T cell response. (bmj.com)
- T cell responses developed or increased in 20%/60%/100% of pts in Arms A/B/C. Seven of the 19 patients remain alive at a minimum 32 months from trial initiation, including three with unresectable disease. (bmj.com)
- Conclusions The T cell response in this randomized phase I trial was dose-dependent with the 1 mg CEA peptide dose eliciting the most robust T cell responses. (bmj.com)
- This was a randomized clinical trial study. (jpalliativecare.com)
- We conducted a multicenter randomized controlled trial to compare the effects of morning radiotherapy (900-1100 AM) with evening radiotherapy (700-900 PM) in cervical cancer patients receiving radiotherapy . (bvsalud.org)
- Knoller N, Levi L, Shoshan I, Reichenthal E, Razon N, Rappaport ZH, Biegon A. "Dexanabinol (HU-211) in the treatment of severe closed head injury: a randomized, placebo-controlled, phase II clinical trial" Crit Care Med . (erowid.org)
- however no randomized control trial (RCT) has evaluated this treatment approach among patients with comorbid PTSD and respiratory illness. (cdc.gov)
- however, no randomized clinical trial (RCT) has evaluated this treatment approach among patients with these comorbidities. (cdc.gov)
- A randomized controlled trial can provide compelling evidence that the study treatment causes an effect on human health. (wikipedia.org)
- The terms "RCT" and "randomized trial" are sometimes used synonymously, but the latter term omits mention of controls and can therefore describe studies that compare multiple treatment groups with each other in the absence of a control group. (wikipedia.org)
- Similarly, the initialism is sometimes expanded as "randomized clinical trial" or "randomized comparative trial", leading to ambiguity in the scientific literature. (wikipedia.org)
- The first published Randomized Controlled Trial in medicine appeared in the 1948 paper entitled "Streptomycin treatment of pulmonary tuberculosis", which described a Medical Research Council investigation. (wikipedia.org)
- One randomized trial of laser therapy indicated efficacy of 43%, with recurrence among 95% of patients. (cdc.gov)
- A randomized trial of surgical excision demonstrated efficacy of 93%, with recurrences among 29% of patients. (cdc.gov)
Efficacy13
- A three-arm prospective, double-blind, randomized, controlled study was performed to evaluate the efficacy of the oral and topical CA extract in 159 T2DM patients with dry skin. (hindawi.com)
- The Src family kinase inhibitor dasatinib has been found to effectively block bevacizumab-induced glioma invasion in preclinical models, which led to the hypothesis that combining bevacizumab with dasatinib could increase bevacizumab efficacy in patients with recurrent GBM. (healthpartners.com)
- This study aimed to investigate the effects of the Proactive Interdisciplinary Self-Management (PRISMA) training program on participation during consultations with practice nurses and self-efficacy of patients with T2DM in general practice. (nivel.nl)
- Self-efficacy was assessed using the 5-item Perceived Efficacy in Patient-Physician Interactions (PEPPI-5) scale. (nivel.nl)
- Efficacy was assessed by patient evaluation of global symptom relief, scores of the SF-36 quality of life (QoL) questionnaires, total number of pills used, and number of medication-free days. (wjgnet.com)
- In patients with anti-panitumumab antibodies, there was no impact on efficacy, safety and pharmacokinetics. (amgen.com)
- Objective To evaluate the efficacy of hydroxychloroquine to reduce time in quarantine for symptomatic ≥40 years-old COVID-19 patients. (medrxiv.org)
- Limitation Since this study was terminated early due to a lack of feasibility, no conclusion can be made about the efficacy of hydroxychloroquine as a treatment for COVID-19 patients 40 years of age or older quarantined at home. (medrxiv.org)
- To compare efficacy and safety of these regimens, we performed a network meta-analysis (NMA) of 27 phase 2/3 randomized trials including a total of 12935 patients and 23 different schedules. (cun.es)
- We investigated the efficacy and safety of a 48-week treatment with vitamin D3 in NASH patients. (uzh.ch)
- To investigate the short-term efficacy and radiotoxicity 3.543of chronoradiotherapy in patients with cervical cancer . (bvsalud.org)
- The short-term efficacy of radiotherapy on cervical cancer patients at different time points and the occurrence of radiotoxicity were explored after patients had undergone radiotherapy . (bvsalud.org)
- Efficacy of interferon injected directly into genital warts (intralesional therapy) during two randomized trials was 44%-61%, with recurrences among none to 67% of patients. (cdc.gov)
Double-blind2
- Prospective, randomized, double-blind, placebo- (vehicle) controlled, multicenter, escalating dose study of a single administration of drug (48 or 150 mg) or vehicle (1 or 3 mL). (erowid.org)
- Sixty euthymic subjects with DSM-IV bipolar disorder were enrolled in an 8-week, double-blind, placebo-controlled, randomized study of WSE (500 mg/d) as a procognitive agent added adjunctively to the medications being used as maintenance treatment for bipolar disorder. (psychiatrist.com)
Clinical trials3
- Trials proposed under this FOA should answer questions that are high impact to patients or health care providers, and must leverage existing clinical practice settings and/or existing electronic resources such as registries for the conduct of clinical trials. (nih.gov)
- Patients and physicians can access www.amgentrials.com for more information about ongoing panitumumab clinical trials. (amgen.com)
- Objective: to realize a systematic review about cognitive and psycho-social intervention strategies in patients with colorectal cancer in randomized clinical trials. (bvsalud.org)
Colorectal cancer patients1
- THOUSAND OAKS, Calif.--(BUSINESS WIRE)--April 3, 2006--Amgen (Nasdaq:AMGN), the world's largest biotechnology company, today announced pivotal Phase 3 results demonstrating that panitumumab significantly improved progression-free survival and disease control (response rate and stable disease) compared to best supportive care (BSC) in metastatic colorectal cancer patients who had failed standard chemotherapy. (amgen.com)
Clinicians4
- Critical care clinicians' experiences of patient safety during the COVID-19 pandemic. (ahrq.gov)
- Telehealth monitoring of patients' vital signs allows clinicians to prioritise their workload and enables patients to take more responsibility for their health. (bepress.com)
- 1-4 Provision of educationand feedback to clinicians based on drugprofiling of panels of patients effectively changes practicein various settings, 5 including hypertension management. (ajmc.com)
- Advise clinicians that all hospitalized patients and all high-risk patients (either hospitalized or outpatient) with suspected influenza should be treated as soon as possible with a neuraminidase inhibitor antiviral. (cdc.gov)
Outcomes9
- As confirmed by previous studies, the brief multifamily program (consisting of six sessions over a period of 1.5 months) was found to be effective in improving outcomes for caregivers (e.g., burden, depression, knowledge) and patients (e.g., preventing relapse) in the context of routine care. (frontiersin.org)
- For patients, family psychoeducation has been effective in improving outcomes in schizophrenia with a better level of global functioning, medication adherence, and a reduction in the use of healthcare resources and the frequency of relapse ( 6 - 8 ). (frontiersin.org)
- CONCLUSIONS: Despite upregulation of Src signaling in patients with GBM, the combination of bevacizumab with dasatinib did not appear to significantly improve the outcomes of patients with recurrent GBM compared with bevacizumab alone. (healthpartners.com)
- Return of PRO results included comparison with age- and sex-matched peers and was built into the Patient-Reported Outcomes Following Initial Treatment and Long-Term Evaluation of Survivorship registry. (jmir.org)
- According to our hypothesis, the primary outcomes of this study are improvements of regularity, alcohol consumption, and relapse rate in AUD patients compared to AUD patients receiving control treatment. (uni-muenchen.de)
- Of note, given the scale and impact of mood disturbance among patients with diabetes, evidence for psychological interventions that successfully treat depression and distress and, ideally, concurrently improve metabolic outcomes is limited. (diabetesjournals.org)
- Several reasons exist to continue the search for psychotherapeutic interventions to improve mental and physical health outcomes among patients with diabetes. (diabetesjournals.org)
- Patients with HPS have significant exercise limitations, impacting their quality of life and associated with poor liver transplant outcomes. (biomedcentral.com)
- We will randomly assign 154 patients with comorbid WTC-related PTSD and respiratory illness to the two adjunctive treatments and assess outcomes immediately post-intervention and at 3 and 6 month follow-ups. (cdc.gov)
Phase4
- Despite the rapid pace of discovery in health care, only a small part of routine medical therapy provided to individual patients is based on the highest level of evidence, the phase 3 patient-centered RCT. (nih.gov)
- In this multi-national, open-label Phase 3 study, 463 patients with metastatic colorectal cancer who had failed standard chemotherapy, including oxaliplatin and irinotecan, were randomized to receive 6 mg/kg panitumumab plus BSC (n=231) every two weeks or BSC alone (n=232). (amgen.com)
- Following the induction phase of treatment for 2 weeks, patients were assessed for early response, defined as ≥ 20% reduction in YBOCS score after 4 weeks of reaching the minimum therapeutic dose of each drug. (psychiatrist.com)
- In contrast to placebo, patients in the vitamin D group had markedly decreased ALT levels after the end-of-treatment phase. (uzh.ch)
Single-blinded1
- We will conduct a multicentre, intra-patient, single-blinded, randomised controlled longitudinal pilot study with parallel assignments to achieve this objective. (canfieldsci.com)
Placebo3
- Patients are randomly assigned to either an intervention group (DAILY) or a sham control group (placebo treatment). (uni-muenchen.de)
- In placebo-controlled studies, genital warts have cleared spontaneously without treatment in 20%-30% of patients within 3 months. (cdc.gov)
- Two randomized trials established systemic interferon alpha to be no more effective than placebo. (cdc.gov)
Participants7
- Nowadays, patients with chronic conditions such as type 2 diabetes mellitus (T2DM) need and want to be more active participants in their health care. (nivel.nl)
- Of all invited patients, 51.1% (456/892) responded and web-based participants (n=227) were randomly assigned to care as usual (n=76), return of PRO results (n=74), or return of PRO results and access to Living with lymphoma (n=77). (jmir.org)
- Participants were 36 attending physicians and nursepractitioners (16 in the general group and 20 in the individualizedgroup), with findings based on 4500 hypertensive patients. (ajmc.com)
- Participants Out of 5511 SARS-CoV-2 positive patients, 1072 met initial eligibility criteria for telephone-based recruitment, but only 34 subjects were able to be randomized. (medrxiv.org)
- To analyze the therapeutic effects of tunnel thread-drawing therapy in treatment of horseshoe-shaped low-position perianal abscess.Design, setting, participants and interventions: A total of 68 patients with horseshoe-shaped low-position perianal abscess were from Department of Anorectal Surgery, Shanghai Tianshan Traditional Chinese Medicine Hospital, and were randomly divided into treatment group and control group. (jcimjournal.com)
- Participants will be randomized to cycle ergometry in either the supine or upright position. (biomedcentral.com)
- Little is known about the proportion of eligible VA patients ("candidates") who participate in the program, the characteristics of participants, or the program's effectiveness. (cdc.gov)
Intervention9
- After we assessed the functional status of 439 patients with osteoarthritis, we randomly assigned them to 1 of 3 intervention groups or to a control group. (nih.gov)
- We conclude that telephone contact is a useful intervention that can enhance the functional status of patients with osteoarthritis. (nih.gov)
- For patients, the family psychoeducation intervention significantly reduced the risk of relapse with a significant effect found at 12 months follow-up ( p = 0.014). (frontiersin.org)
- Therefore, family intervention should be developed to reduce the burden of caregivers and enhance patients' prognosis. (frontiersin.org)
- Patients with lymphoma who completed the web-based questionnaire were equally randomized to care as usual, return of PRO results, and return of PRO results plus self-management intervention. (jmir.org)
- We hypothesized that an intervention with informationindividualized to particular patients would increaseclinician adherence to drug-therapy guidelines in primarycare clinics of a large healthcare system. (ajmc.com)
- They will be randomized after surgery to follow-up at the surgical outpatient clinic (control group) or follow-up by the district GP (intervention group). (biomedcentral.com)
- 45 were randomized into the intervention group and 39 into the control group. (cdc.gov)
- In the intervention group, 301 patient encounters met the inclusion criteria for acute LBP. (cdc.gov)
Chemotherapy6
- PE chemotherapy x 4 more cycles alone.Only 109 patients met criteria to be randomized. (oncolink.org)
- The 5 year survival rates are under 5% in most reported series.1,2 The standard of care continues to be chemotherapy with a duration of 4 - 6 cycles.3 The benefits of thoracic radiation therapy (TRT) have been demonstrated in numerous randomized trials for limited stage disease. (oncolink.org)
- Neoadjuvant chemotherapy has some advantages over postoperative chemotherapy in advanced cancer patients, represented by primary tumor downstaging, testing chemotherapy sensitivity and controlling distant micrometastasis. (omicsonline.org)
- All these patients were in AJCC II-III stages, evaluated by CT, EUS, and laparoscopic exploration and were administered preoperative 2 to 4 cycles SOX regimen chemotherapy. (omicsonline.org)
- This small sample data showed most of AJCC II-III stage gastric cancer patients could benefit from preoperative SOX regimen chemotherapy and long-term survival needed to be expected. (omicsonline.org)
- Patients with metastatic disease (~40%) had a historical median OS of approximately 6 months, although recently substantial progress has been made in chemotherapy options for these patients [ 3 ]. (bmj.com)
Prospective Study2
- Comparison of Platelet-Rich Plasma Treatment and Partial Plantar Fasciotomy Surgery in Patients with Chronic Plantar Fasciitis: A Randomized, Prospective Study. (iasp-pain.org)
- This was a randomized, open-label prospective study of 50 drug-naive patients with OCD (per DSM-5 criteria) conducted from January 2019 to November 2020 in the outpatient department of a tertiary care teaching hospital in North India. (psychiatrist.com)
Cervical cancer1
- The effect of chronoradiotherapy on cervical cancer patients: A multicenter randomized controlled study. (bvsalud.org)
Study Protocol1
- Here we present a study protocol for our newly developed therapy approach for AUD patients, in which we take advantage of this mutual influence and stabilize and strengthen their circadian system by creating strict daily schedules for daily Zeitgeber activities. (uni-muenchen.de)
Postoperative5
- Lung protective mechanical ventilation significantly improved intraoperative pulmonary oxygenation function and pulmonary compliance in patients experiencing various abdominal laparoscopic surgeries, but it could not ameliorate early postoperative atelectasis and oxygenation function on the first day after surgery. (springer.com)
- We hypothesize that postoperative follow-up of colon cancer patients (according to national guidelines) by GPs will not have any impact on patients' quality of life. (biomedcentral.com)
- The patients in the treatment group received thread-drawing therapy and the patients in the control group received multiple incisions and drainage.Main outcome measures: Lasting time of postoperative pain, healing time of incision, average area of the wound scar, anal function and postoperative recurrence were observed in the two groups. (jcimjournal.com)
- In the postoperative period patient -controlled analgesic pumps were used to deliver similar types of mixtures via the epidural catheter . (bvsalud.org)
- Patients were evaluated for rescue analgesic requirements, haemodynamic stability, postoperative pain , sedation and any adverse events. (bvsalud.org)
Respiratory2
- Background Older patients are at risk of increased morbidity and mortality from COVID-19 disease due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). (medrxiv.org)
- None of the patients had bradycardia , hypotension , excessive sedation or respiratory depression . (bvsalud.org)
Objective3
- The objective response rate was 15.7% in arm A and 26.3% in arm B (P = .52), but with a significantly longer duration in patients treated on arm A (16.3 months vs 2 months). (healthpartners.com)
- Furthermore, the difference in objective response rates and the proportion of patients with disease stabilization between panitumumab and best supportive care alone demonstrated the significant activity of this agent. (amgen.com)
- The objective was to assess agreement in PROMs answered using a web app versus an outpatient touchscreen among patients with SLE. (aau.dk)
Evaluate2
- Using a logic model to design and evaluate quality and patient safety improvement programs. (ahrq.gov)
- This randomized clinical study aimed to evaluate the proper timing of a VR tour of an OR (a few days before vs. immediately before anesthesia) to reduce the anxiety in a pediatric patient undergoing elective surgery. (frontiersin.org)
Osteoarthritis1
- Can the provision of information to patients with osteoarthritis improve functional status? (nih.gov)
Prospectively1
- The placement of central venous catheters was studied prospectively in 138 selected adult patients with hypovolemic shock or in whom rapid volume replacement was needed. (nih.gov)
Outcome measures2
- A recent systematic review including 11 studies demonstrates consistent improvement in many outcome measures of patients, such as relapse rates and medication adherence, but heterogeneity in symptoms reliefs ( 9 ). (frontiersin.org)
- The co-primary outcome measures were the proportion of COPD patients readmitted to hospital and changes in patients' self-reported quality of life. (bepress.com)
Treatment16
- Although skin problems are often found in T2DM patients, the awareness and choice of treatment are commonly lacking. (hindawi.com)
- As such, we compared PRP treatment to PPF surgery in patients with CPF. (iasp-pain.org)
- Between January 2015 and January 2017, patients were randomly divided into two groups, a PRP treatment group, and a PPF group. (iasp-pain.org)
- Patients treated with PRP injection reported a significant increase in their activity scores, shorter recovery time, and lower complication rates compared to PPF treatment. (iasp-pain.org)
- Most patients with extensive disease respond well to treatment, yet the median survivals remain around 10 - 12 months. (oncolink.org)
- Panitumumab treatment also showed a clinical benefit in the patients crossing over from the BSC arm, despite their disease progression. (amgen.com)
- In these patients, panitumumab treatment resulted in a nine percent partial response and 32 percent stable disease, as well as one complete response. (amgen.com)
- The treatment scenario for newly-diagnosed transplant-ineligible multiple myeloma patients (NEMM) is quickly evolving. (cun.es)
- Patients receiving omalizumab 300 mg achieved greater improvement in sleep than those in other treatment arms. (figshare.com)
- CONCLUSIONS Treatment with 2100 IE vitamin D q.d. over 48 weeks was well tolerated and led to a significant improvement of serum ALT levels in patients with hypovitaminosis D and histology-proven NASH as the primary endpoint together with a trend toward reduction of hepatic steatosis, which was not significant due to a small number of available biopsy specimens. (uzh.ch)
- Its treatment leads to a surgery with biopsychosocial impact on the life of the patient. (bvsalud.org)
- Sixty-seven patients, aged 16-65 yrs, Glasgow Coma Scale score of 4-8, injured within 6 hrs of treatment. (erowid.org)
- Regimens - Treatment of genital warts should be guided by the preference of the patient. (cdc.gov)
- and 4) background information for patients about influenza treatment. (cdc.gov)
- Evidence from previous influenza seasons suggests that NAI antivirals are underutilized in outpatients and hospitalized patients with influenza who are recommended for treatment. (cdc.gov)
- Conclusion: Expression of ERh is an independent marker for favorable prognosis after adjuvant tamoxifen treatment in ERa-negative breast cancer patients and involves a gene expression program distinct from ERa. (lu.se)
Versus3
- Patients who received panitumumab every two weeks showed a 46 percent decrease in tumor progression rate versus those who received best supportive care alone (p less than 0.000 000 001). (amgen.com)
- For example, after six months (week 24) approximately four times as many panitumumab-treated patients were alive and progression-free (18 percent versus five percent with BSC alone). (amgen.com)
- Twice as many panitumumab-treated patients were alive and progression-free at week 32 (10 percent versus four percent with BSC alone). (amgen.com)
Regimen2
- There is an ongoing debate on the best follow-up regimen for patients with CRC [ 5 - 7 ]. (biomedcentral.com)
- If our study is positive, a supine exercise regimen could become a routine prescription for patients with HPS and orthodeoxia, enabling them to exercise more effectively. (biomedcentral.com)
Type 2 diabet1
- This RCT tested the effects of a standardized 8-week mindful self-compassion (MSC) program ( n = 32) relative to a wait-list control condition ( n = 31) among patients with type 1 and type 2 diabetes. (diabetesjournals.org)
Chronic4
- Schizophrenia is a chronic and severe mental disorder which has serious consequences for both the patient and caregivers. (frontiersin.org)
- Platelet-Rich Plasma (PRP) injection has become a desirable alternative to Partial Plantar Fasciotomy (PPF) surgery and steroid injection for patients with chronic plantar fasciitis (CPF) due to its potential for shorter recovery times, reduced complications, and similar activity scores. (iasp-pain.org)
- Abstract Background Patients with chronic idiopathic/spontaneous urticaria (CIU/CSU) report difficulty with sleep. (figshare.com)
- Major depression is estimated to affect at least 12% of patients with diabetes ( 1 ), with subclinical mood symptoms and distress apparent in nearly one-third (31%) of those living with this chronic condition ( 2 ). (diabetesjournals.org)
Therapies1
- Purpose: Endocrine therapies, such as tamoxifen, are commonly given to most patients with estrogen receptor (ERa) ^ positive breast carcinoma but are not indicated for persons with ERa-negative cancer. (lu.se)
Surgical1
- Currently, the only possibility of cure is through surgical resection, but only approximately 15%-20% of patients are eligible candidates at diagnosis and even with surgery the 5-year overall survival in multiple series is 10%-30% [ 2 ]. (bmj.com)
T2DM3
- Combination of oral and topical Centella asiatica (CA) is expected to treat dry skin in T2DM patients more effectively through decreasing N(6)-carboxymethyl-lysine (CML) and interleukin-1 α (IL-1 α ) and increasing superoxide dismutase (SOD) activity. (hindawi.com)
- CAo and CAt combination can be used to significantly improve dry skin condition through increasing SOD activity in T2DM patients with controlled blood glucose. (hindawi.com)
- 3 ] found that 74% of T2DM patients had one or more skin problems, with the highest amount being dry skin (47%), followed by infection (10%), diabetic foot (5%), hair loss, and diabetic dermopathy (4%), respectively. (hindawi.com)
Eligible3
- Eighty-three patients who presented to the American University of Beirut Medical Center with persistent gastroesophageal reflux disease (GERD) symptoms and a normal upper gastrointestinal endoscopy were eligible for the study. (wjgnet.com)
- Patients undergoing surgery for colon cancer with histological grade Dukes's Stage A, B or C and below 75 years of age are eligible for inclusion. (biomedcentral.com)
- Few eligible patients participated in the program during the study period, and overall estimates of effectiveness were low. (cdc.gov)
Pediatric patients7
- The virtual reality (VR) experience of an operation room (OR) prior to anesthesia and surgery has been known to reduce the anxiety and distress of pediatric patients. (frontiersin.org)
- Surgery and anesthesia are extremely stressful events for pediatric patients and their parents. (frontiersin.org)
- The incidence of preoperative anxiety has been reported to be nearly 60% for pediatric patients, which may be due to fear of pain, unfamiliarity, and even death ( 1 ). (frontiersin.org)
- One of the clinical applications of VR technology is to educate pediatric patients and address their preoperative anxiety before anesthesia and surgery ( 5 ). (frontiersin.org)
- VR enables pediatric patients to immerse themselves in this virtual environment through visual, auditory, tactile, and olfactory sensations, thus focusing their attention away from the unknown and fearful hospital situation ( 5 ). (frontiersin.org)
- Additionally, preoperative anxiety of pediatric patients may arise from the unfamiliarity or strangeness about the unknown event or space and they can learn from VR experience of hospital environment. (frontiersin.org)
- Since 1947, Dana-Farber's sole focus has been to provide expert cancer care and groundbreaking treatments for adult and pediatric patients. (dana-farber.org)
Catheter1
- The patients were randomized into two groups to receive a central vein catheter: one by basilic vein cutdown and the other by percutaneous subclavian vein placement. (nih.gov)
Morbidity and morta2
- For many years before the development of effective antiretroviral therapy (ART), these infections inflicted significant morbidity and mortality on patients living with AIDS. (medscape.com)
- Prevention of opportunistic infections (OI) in patients with HIV has since significantly reduced morbidity and mortality in these patients. (medscape.com)
Undergone2
- At the time of diagnosis, about two thirds of patients had undergone resection, but 30-50% of them relapsed and died of the disease [ 4 ]. (biomedcentral.com)
- [ 4 ] Once patients had undergone extraction of their sixth needle-core biopsy, many of them reported pain. (medscape.com)
Severe1
- Schizophrenia is recognized for its severe impact on both patients and caregivers. (frontiersin.org)
Investigate1
- The purpose of this study was to investigate the effect of positive psychotherapy on understanding the meaning of life in patients with cancer. (jpalliativecare.com)
Adherence1
- Sociodemographic, symptom severity (PANSS) and medication adherence (MARS) from patients were assessed at baseline and relapse rates was recorded during the 12 months follow-up period. (frontiersin.org)
Thoracic1
- Forty adult patients of American Society of Anesthesiologists grade I-II undergoing upper abdominal surgery were randomly allocated into two groups to receive 50 µg fentanyl or 50 µg dexmedetomidine as an adjunct to 10 ml 0.125% bupivacaine via thoracic epidural. (bvsalud.org)
Influenza1
- 3) Any patient who is at higher risk for influenza complications but not hospitalized. (cdc.gov)
Results5
- Patient misidentification errors -such as laboratory results or notes being entered into the wrong patient chart-have been shown to occur in the emergency department and inpatient settings. (ahrq.gov)
- There has been a cultural shift toward patient engagement in health, with a growing demand from patients to access their results. (jmir.org)
- Return of individual PRO results seems to meet patients' wishes but had no beneficial effects on patient outcome. (jmir.org)
- RESULTS: Thirty-four patients with SLE were included. (aau.dk)
- Results Sixty-six patients were screened and 19 enrolled of whom 14 received at least 3 doses of the vaccine and thus evaluated for the primary immunologic endpoint. (bmj.com)
Hospital4
- Descriptive analyses showed that the standard service group had a lower proportion of patients with hospital readmissions and a greater increase in self-reported quality of life compared to the Telehealth-supported group. (bepress.com)
- Panitumumab reduced the rate of disease progression by approximately half compared to best supportive care alone in these heavily pre-treated patients," said Marc Peeters, M.D., Ph.D., coordinator of Digestive Oncology Unit, University Hospital Ghent, and one of the study's lead investigators. (amgen.com)
- In Norway, most of these patients are followed up in a hospital setting. (biomedcentral.com)
- Most studies on follow-up of CRC patients have been performed in a hospital outpatient setting. (biomedcentral.com)
Tumors4
- Correlative tissue analysis demonstrated an association between pSRC/LYN signaling in patient tumors and outcome. (healthpartners.com)
- The factors responsible for response to tamoxifen in 5% to 10% of patients with ERa-negative tumors are not clear. (lu.se)
- ExperimentalDesign: We investigated ERh by immunohistochemistry in 353 stage II primary breast tumors from patients treated with 2 years adjuvant tamoxifen, and generated gene expres- sion profiles for a representative subset of 88 tumors. (lu.se)
- Patients with tumors lacking ERa in general do not charges. (lu.se)
Outpatient1
- A total of 25 days of patients with schizophrenia (DSM-IV-TR) and family primary caregivers were recruited in a single regional psychiatric outpatient facility located in Bordeaux. (frontiersin.org)
Therapy5
- Our hypothesis is that a regular exposure to Zeitgebers stabilizes behavioral and physiological circadian rhythms and thereby reduces the risk of alcohol relapses and depressive symptoms and facilitates physical recovery in AUD patients during the 1st weeks of their addiction therapy. (uni-muenchen.de)
- The overall goal of this and more extended future studies is the development of an adjunctive therapy for AUD patients that is uncomplicated in its use and easy to implement in the clinical and everyday routine. (uni-muenchen.de)
- Accodrding to Japanese Gastric Cancer Association histological evaluation criteria of tumor response after preoperative therapy, 7 patients achieved Grade 3 response (complete response), 20 patients Grade 2 response, 9 patients Grade 1 response, 1 patient Grade 0 response. (omicsonline.org)
- The most common acute side effect of patients receiving radiation therapy to the breast/chest wall is radiation induced dermatitis. (lancs.ac.uk)
- Patients may apply podofilox with a cotton swab to warts twice daily for 3 days, followed by 4 days of no therapy. (cdc.gov)
Significantly higher3
- Concentration of AGEs in diabetes patients is significantly higher due to the hyperglycemic state and oxidative stress. (hindawi.com)
- A significantly higher proportion of patients were alive and free of disease progression on panitumumab at all of the scheduled time points through week 32. (amgen.com)
- The patients in the MG had significantly higher Anderson symptom scores than patients in the EG (21.64 ± 7.916 vs. 18.53 ± 4.098, p (bvsalud.org)
CONCLUSIONS1
- Due to a wide range of follow-up programmes and paucity of randomized trials, it is impossible to draw conclusions about the best combination and frequency of clinic (or family practice) visits, blood tests, endoscopic procedures and radiological examinations that maximize the clinical outcome, quality of life and costs. (biomedcentral.com)
Standard1
- So, you could argue that maybe there's a double standard compared to prostate markers, which also haven't necessarily done any randomized trials, but the reality is that when people sit down-and I'm on the hematuria guidelines-and look at the evidence, they [have been saying], "For us, we don't feel like it's enough to make recommendations. (urologytimes.com)