Evolution, MolecularMutagenesisMutationPoint MutationDirected Molecular EvolutionMolecular Sequence DataMutation, MissenseBase SequenceAmino Acid SequenceSelection, GeneticEscherichia coliAmino Acid SubstitutionPolymerase Chain ReactionModels, GeneticSequence Analysis, DNAMutagenesis, Site-DirectedFrameshift MutationModels, MolecularPhenotypeSequence Homology, Amino AcidBiological EvolutionPhylogenyGerm-Line MutationBacterial ProteinsPedigreeMutation RateExonsHeterozygoteAllelesSequence AlignmentDNA Mutational AnalysisGenetic VariationGenotypeProtein Structure, TertiaryPolymorphism, Single-Stranded ConformationalSpecies SpecificityBinding SitesHomozygoteCodon, NonsenseChromosome MappingDNA PrimersCodonDNASequence DeletionGenes, RecessiveCloning, MolecularCell LineProtein BindingAdaptation, BiologicalConserved SequenceModels, BiologicalCultural EvolutionModels, ChemicalGenes, DominantTranscription FactorsGenetic TestingDNA-Binding ProteinsGene DeletionProtein ConformationRecombination, GeneticSaccharomyces cerevisiaeIntronsSuppression, GeneticProteinsMultigene FamilyKineticsDNA, MitochondrialStructure-Activity RelationshipClonal EvolutionPolymorphism, GeneticGenetic Complementation TestPlasmidsMembrane ProteinsGenetic LinkageFounder EffectGenes, BacterialTranscription, GeneticTemperatureMutant ProteinsGenes, p53Time FactorsSyndromeGenomeRNA, MessengerSequence Homology, Nucleic AcidGenesDrosophila melanogasterEvolution, ChemicalChemical PhenomenaSignal TransductionMutagenesis, InsertionalRecombinant ProteinsGenetic Predisposition to DiseaseMutagensPromoter Regions, GeneticMagnetic Resonance SpectroscopyPrimatesTransfectionProtein Structure, SecondaryGene Frequency