Loading...
  • eukaryotic cells
  • The principal attention is paid to Rop mG-proteins, unique small GTPases of eukaryotic cells functioning during various developmental stages of plants, from pollen tube and root hair growth to plant responses to biotic and abiotic stresses. (deepdyve.com)
  • Activated in response to upstream signals, small GTPases act as molecular switches (ON when GTP-bound, otherwise OFF) and control a variety of essential cellular processes in eukaryotic cells. (biologists.org)
  • Calcium
  • That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. (genecards.org)
  • Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. (princeton.edu)
  • membrane proteins
  • Here we use immunoelectron microscopy and nanospray liquid chromatography-tandem MS (LC-MS/MS) analysis of urinary membrane proteins to show that AQP2 and other apical plasma-membrane proteins are excreted through the process of exosome formation in agreement with the predictions above. (pnas.org)
  • downstream
  • Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. (genecards.org)
  • Active, GTP-bound Ras proteins interact with specific downstream effectors, that is, signalling or structural proteins that are ultimately responsible for mediating their cellular effects. (biologists.org)
  • whereas
  • A commonly accepted working hypothesis is that whereas fully conserved positions are related to functional features common to all the members of the family, these other residues are related to functional specificity (e.g., binding of different cofactors). (pnas.org)
  • gene
  • Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. (cancerindex.org)
  • In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • The structure of protein families is shaped by the sequence divergence accumulated as a consequence of speciation, gene duplication, and deletion events, as well as by the evolutionary selective pressure exerted on each protein in accordance with the corresponding 3D structure and the specific function performed ( 1 , 2 ). (pnas.org)
  • GO annotations related to this gene include GTP binding and GDP binding . (genecards.org)
  • cytoskeletal
  • Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. (cancerindex.org)
  • ligand
  • Previous studies have limited their analysis to the study of the relationship between these positions and ligand-binding specificity, demonstrating significant yet limited predictive capacity. (pnas.org)
  • The combined analysis of SDPs in interfaces and ligand-binding sites provides a more complete picture of the organization of protein families, constituting the necessary framework for a large scale analysis of the evolution of protein function. (pnas.org)
  • Similarly, they can take into account the associated conservation at the molecular signatures level (SDPs) in fundamental regions corresponding to ligand-binding sites and protein interaction sites. (pnas.org)
  • apical
  • However, it remains a mystery how aquaporin-2 (an integral membrane protein) and other apical transporters are delivered to the urine. (pnas.org)
  • Immunoblotting of urinary membrane fractions has revealed that, in addition to AQP2, the kidneys excrete membranes containing apical plasma-membrane transporter proteins from each renal tubule segment ( 5 ), suggesting that analysis of urinary membrane fractions could provide noninvasive information about the pathophysiological state of the entire renal tubule. (pnas.org)
  • signal transduction
  • Moshkov, I. 2007-11-07 00:00:00 The control of plant growth, differentiation, and development is considered in relation to the involvement of monomeric GTP-binding proteins (mG-proteins) in the extra-and intracellular signal transduction. (deepdyve.com)
  • The network for 'regulation of ras protein signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. (princeton.edu)
  • Any process that modulates the frequency, rate or extent of Ras protein signal transduction. (princeton.edu)
  • differing involvement
  • While the above functions appear to be shared between the two Ral isoforms, their differential subcellular localizations result in their differing involvement in certain biological processes. (wikipedia.org)
  • catalytic
  • These may include the global conservation of catalytic mechanisms (in the case of enzymes), specific binding to substrates and cofactors, as well as the interaction with other proteins in processes such as cell signaling, the regulation of reactions and the formation of macromolecular complexes. (pnas.org)
  • subfamilies
  • The divergence accumulated during the evolution of protein families translates into their internal organization as subfamilies, and it is directly reflected in the characteristic patterns of differentially conserved residues. (pnas.org)
  • These specifically conserved positions in protein subfamilies are known as "specificity determining positions" (SDPs). (pnas.org)
  • We have systematically extended this observation to include the role of differential protein interactions in the segregation of protein subfamilies and explored in detail the structural distribution of SDPs at protein interfaces. (pnas.org)
  • Interestingly, even though specific protein interactions certainly are an important part of protein function, the organization of protein families in relation to the specific interactions of different subfamilies remains a poorly studied aspect of functional specificity. (pnas.org)