Radiotherapy xerostomia. Medical search. Frequent questions

Since its introduction in the previous decade, intensity-modulated radiotherapy has been widely applied in head and neck squamous cell carcinoma (HNSCC). (snmjournals.org)
In the head and neck region, where malignant growth often lies near critical normal tissues, intensity-modulated radiotherapy has the potential to ensure sufficient target coverage while significantly reducing toxicity. (snmjournals.org)
As intensity-modulated radiotherapy permits lowering the dose to the organs at risk outside the target volume, the maximum dose becomes restricted by the presence of dose-limiting structures within the target volume, such as cartilage, connective tissue, nerves, and bone. (snmjournals.org)
The present study was aimed at analyzing the impact of enteral nutrition on the maintenance of body weight and on the necessity of replanning and/or interruption of treatment of head and neck cancer patients undergoing intensity-modulated radiotherapy (IMRT). (rb.org.br)
Intensity-modulated radiotherapy (IMRT) has been demonstrating to be advantageous over traditional techniques such as conventional (2D) RT and conformational (3D) RT, as it provides a more homogeneous dose coverage of the target volume, while reducing the dose to adjacent tissues(4,5). (rb.org.br)

Acute confluent mucositis occurred with significant higher frequency with accelerated radiotherapy. (biomedcentral.com)
The indicators used were DMFT (decayed, missing, and filled teeth) for dental caries, SOHI (simplified oral hygiene index) for oral hygiene, and the presence of mucositis, xerostomia, and candidiasis. (bvsalud.org)
The results showed the presence of 61.9% of mucositis in patients and 28.6% of xerostomia. (bvsalud.org)
It is concluded that the main oral complications in children during antineoplastic treatment were mucositis and xerostomia. (bvsalud.org)
The presence of xerostomia, mucositis and other side effects of RT were also evaluated. (bvsalud.org)
After completion of radiotherapy, 68% of patients had level III or IV mucositis. (bvsalud.org)
Dose AM. The symptom experience of mucositis, stomatitis, and xerostomia. (ac.ir)
La mucositis oral (MO) representa una afección inflamatoria frequente em pacientes oncológicos e uma higiene oral insatisfatória tem frecuente en pacientes con cáncer, y la mala higiene bucal se ha relacionado sido relacionada como fator predisponente para o seu surgimento. (bvsalud.org)
Malnutrition is a frequent outcome in head and neck cancer patients, not only by the tumor itself, but also as a result of the treatment which can commonly cause side effects such as dysgeusia, dysphagia, xerostomia and mucositis(7,8). (rb.org.br)

The aim of the study is to compare the palliative efficacy of two saliva substitutes (Sinspeek and Xerostom) in patients during radiotherapy for cancer of the head and neck. (uwc.ac.za)
the disruption is both temporary and reversible.To indicate the effect of chemotherapy and radiotherapy treatments on the electrolyte and pH of saliva. (edu.iq)
Saliva electrolyte analysis and xerostomia-related quality of life in nasopharyngeal carcinoma patients following intensity-modulated radiation therapy. (edu.iq)
Unstimulated saliva production in patients was measured using the spitting method at three stages: two weeks before the commencement of radiotherapy, two weeks after, and four weeks after the completion of radiotherapy. (ac.ir)
Researcher Hal Clark and his team looked into saliva loss resulting in a condition called xerostomia, more commonly known as dry mouth. (ubc.ca)
Radiotherapy that's used to treat oral cancer kills saliva-producing cells as the beam passes through the salivary glands. (bottomlineinc.com)
Xerostomia, commonly known as dry mouth, is an excessive dryness of mouth due a lack of saliva production (hyposialia) or decreased saliva production (asialia). (booboone.com)
abstract = "{\textcopyright} 2021, The Author(s).Objectives: The study aimed to quantify the lubricating properties of chewing stimulated whole saliva from healthy controls (n = 22), from patients suffering from primary Sj{\"o}gren{\textquoteright}s syndrome (n = 37) and from patients undergoing head-and-neck radiotherapy (n = 34). (vu.nl)
MUC5b and total protein output were significantly lower in patients subjected to radiotherapy compared to saliva from healthy controls and pre-irradiation patients. (vu.nl)
These can limit the flow of saliva which can lead to 'Dry Mouth' (Xerostomia). (ibuypharmacy.co.nz)

Cancer treatment - chemotherapy and radiotherapy can cause damage to the salivary glands and cause a serious xerostomia. (booboone.com)

Patients at high risk for tumor recurrence may benefit from more aggressive altered fractionation schedules in order to reduce the overall time from surgery to completion of radiotherapy. (biomedcentral.com)

other drugs, and dry mouth (xerostomia). (ahflatamycaribe.org)
Mouth dryness, known as xerostomia , is commonly thought of as a normal part of aging. (bottomlineinc.com)
In moderate forms of xerostomia, you can use a mouthwash to partially clean your mouth and keep it moist. (booboone.com)
This is because more than 1,100 medications can cause dry mouth, also known as xerostomia. (aquoralspray.com)
Materials and methods: All participants had to complete the Xerostomia Inventory questionnaire to score dry mouth sensation. (vu.nl)
The update of a 2007 Cochrane review of parasympathomimetic drugs for dry mouth after radiotherapy did not identify an new studies. (nationalelfservice.net)
Dry mouth, or xerostomia, is a group of incurable conditions caused by aging, radiation/chemical exposure, or aberrant inflammation in the salivary glands. (lu.se)

Hyposalivation and xerostomia in dentate older adults. (edu.iq)
Radiation-induced hyposalivation is a common complication of radiotherapy for head and neck cancers. (ac.ir)
Villa A, Connell CL, Abati S. Diagnosis and management of xerostomia and hyposalivation. (ac.ir)
In addition, Vissink et al conducted case studies that helped to further identify how radiotherapy causes hyposalivation of the salivary glands [4]. (asu.edu)

The rationale of concurrent chemotherapy with IMRT in the management of NPC was largely derived from experience with conventional radiotherapy. (biomedcentral.com)
xerostomia compared with conventional radiotherapy. (9lib.net)

Parotid-sparing radiotherapy: does it really reduce xerostomia? (wikipedia.org)

Daily adaptive radiotherapy can improve salivary gland sparing and lead to fewer acute toxicities for patients with squamous cell head and neck cancer, according to results from a randomized trial presented at the American Society for Radiation Oncology (ASTRO) 2023 Annual Meeting. (medscape.com)
Overall, daily adaptive radiotherapy with 1-mm planning tumor volumes reduced radiation exposure and was associated with less dermatitis and improved salivary outcomes, said lead investigator David Sher, MD , chief of head and neck radiation oncology at the University of Texas Southwestern Medical Center, Dallas. (medscape.com)
Adaptive radiotherapy, a concept introduced in the 1990s, updates radiation plans to adjust for anatomic changes in patients and their disease. (medscape.com)
Daily adaptive radiotherapy (DART) makes the adjustment before each fraction, allowing for tighter planning of tumor volume margins and less collateral damage to nearby healthy tissue. (medscape.com)
Introduced in 2020 , Ethos is a cone beam CT-based system that uses artificial intelligence and machine learning to perform adaptive radiotherapy. (medscape.com)

Investigators assessed the presence of xerostomia prior to and after the study using a 10-question survey developed by Fox et al, where the participant answers yes or no, and a linear VAS from 0 to 100. (naturalmedicinejournal.com)

Therapy should be discontinued if no improvement in xerostomia is noted after 2 to 3 months of therapy. (medscape.co.uk)

Clinical use of a combination of radiotherapy and chemotherapy continues to increase, while the development of immunotherapy, such as checkpoint inhibitors, offers hope in improving treatment outcome. (hkmj.org)
An improvement in patient survival can be achieved also with the combination of radiotherapy and concurrent chemotherapy in patients with advanced tumours, at expenses of an increased morbidity. (biomedcentral.com)

in parotid gland function after radiotherapy in the head-and-neck region. (9lib.net)
During this PhD thesis, we aimed to evaluate whether cell-derived strategies (e.g., extracellular vesicles, EVs) could be a potential new therapy to ameliorate salivary gland injury and restore function after radiotherapy or in autoimmune diseases. (lu.se)

The planning tumor volume margin in the DART arm was 1 mm, vs 5 mm in the standard radiotherapy arm. (medscape.com)

1. Brizel, D.M., The Role of Combined Radiotherapy and Chemotherapy in the Management of Locally Advanced Squamous Carcinoma of the Head and Neck, in Principles and practice of radiation oncology, P.C. Halperin EC, Brady LW, Editor 2008, Lippincott Williams & Wilkins: Philadelphia. (9lib.net)
Radiotherapy and Oncology. (wustl.edu)

For example, if the hyposialia/asialia is caused by taking certain medications, your health care provider will adjust the dose or substitute them by other drugs that do not cause xerostomia. (booboone.com)
Certain medications and healthcare treatments have been proven to cause xerostomia. (asu.edu)

Does fluorodeoxyglucose PET add to the management of the neck following curative radiotherapy in head and neck cancer compared with computed tomography? (wikipedia.org)
This was a prospective study carried out on people newly diagnosed with HNC requiring curative radiotherapy of more than 60 Gy. (ac.ir)
The results suggested that the evaluation of salivary amylase on day 22 could be a useful predictive marker to understand the development of radiation-induced dysfunction in patients with curative radiotherapy for their head and neck cancer. (ac.ir)

Accelerated radiotherapy did not improve the loco-regional control ( n = 988, HR = 0.740, CI = 0.48-1.13, p = 0.162), progression-free survival (HR = 0.89, CI = 0.76-1.04, p = 0.132) or overall survival (HR = 0.88, CI = 0.75-1.04, p = 0.148) significantly. (biomedcentral.com)
Ginger, aloe vera, and saline significantly improved symptoms in xerostomia patients. (naturalmedicinejournal.com)

In this study, xerostomia is assessed through a subjective salivary gland function questionnaire. (houstonmethodist.org)
The study assessed improvement in the subjective feeling of xerostomia, reflected in a lower total score from the Fox questionnaire and in a linear decrease in the VAS. (naturalmedicinejournal.com)
Difference in the pre-intervention and post-intervention total score from the Fox questionnaire, validated with changes in the VAS, with a decrease indicating improvement in the subjective feeling of xerostomia. (naturalmedicinejournal.com)

secretion in nasopharyngeal carcinoma patients treated with radiotherapy. (9lib.net)

Porceddu was awarded a doctorate of medicine for his research into improving the integration of radiotherapy in the management of head and neck cancer and received the American Head and Neck Society/ANZ Head and Neck Cancer Society Christopher O'Brien Traveling Scholarship. (wikipedia.org)
Radiotherapy -induced xerostomia (RIX) is one of the most common adverse effects of radiotherapy (RT) in head and neck cancer patients (HNC) and a major determinant of survivors ' quality of life . (bvsalud.org)
Adjuvant radiotherapy in advanced head and neck squamous cell cancer (HNSCC) reduces the risk of local-regional failure and most likely increases the survival rate. (biomedcentral.com)
This article examines the use of intensity modulated radiation therapy in the treatment of head and neck cancer to decrease xerostomia. (houstonmethodist.org)
Pinto VL, Fustinoni SM, Nazário ACP, Facina G, Elias S. Prevalence of xerostomia in women during breast cancer chemotherapy. (edu.iq)
In this recent study , patients underwent radiotherapy treatment for head-and-neck cancers at the BC Cancer Agency. (ubc.ca)
This study evaluated the oral conditions of 50 cancer patients undergoing head and neck radiotherapy (RT). (bvsalud.org)
Clinical features and preventive therapies of radiation-induced xerostomia in head and neck cancer patient: a literature review. (ac.ir)
Principe S, Dikova V, Bagan J. Salivary cytokines in patients with head and neck cancer (HNC) treated with radiotherapy. (ac.ir)
The treatment for head and neck cancer consists of surgery, followed or not by radiotherapy (RT) or radical RT, concomitantly or not with chemotherapy. (rb.org.br)
Specifically patients that have been diagnosed with oral cancer, and are treated by radiotherapy, have been diagnosed with xerostomia. (asu.edu)
Shortening the overall treatment time without increasing acute reactions is one of the major aims in radiotherapy for head and neck cancer (HNC). (biomedcentral.com)

During my thesis, we evaluated whether cell-derived strategies, in this case, extracellular vesicles (EVs) could be a potential new therapy to repair salivary gland injury and restore function following radiotherapy or in autoimmune diseases. (lu.se)

This study aimed to evaluate the impact of 1% Pilocarpine mouthwash on salivary flow in patients with radiation-induced xerostomia. (ac.ir)
1% Pilocarpine mouthwash is recommended for managing radiation-induced xerostomia. (ac.ir)
Haddad P, Karimi M. A randomized, double-blind, placebo-controlled trial of concomitant pilocarpine with head and neck irradiation for prevention of radiation-induced xerostomia. (ac.ir)
The 3 RCTs identified in the previous version provide limited evidence to support the use of pilocarpine hydrochloride in the treatment of radiation-induced xerostomia. (nationalelfservice.net)

By decreasing xerostomia through conformal avoidance of the parotid glands, we can improve patient satisfaction and quality of life. (houstonmethodist.org)

The addition of clinical signs certainly aids in the diagnosis of xerostomia. (naturalmedicinejournal.com)

Sodium-hyaluronate mouthwash on radiotherapy-induced xerostomia: a randomised clinical trial. (bvsalud.org)
The primary objective was to evaluate the reduction of patients ' xerostomia symptoms after the utilisation of a sodium -hyaluronate mouthwash compared to a placebo solution . (bvsalud.org)

All patients received chemotherapy as treatment of choice and 38.1% received radiotherapy as part of the treatment. (bvsalud.org)
However, it is important for your doctor to know the cause of your xerostomia to recommend an appropriate treatment. (booboone.com)
The first one aims to reduce the proliferation of the tumour by shortening the total duration of the radiotherapy treatment, increasing the number of fractions/week, and/or the fractions/day. (biomedcentral.com)

The next 31 patients received carboplatin at the same dose on days 1 to 5, 15 to 19, 29 to 33, and 43 to 47 of radiotherapy. (cancernetwork.com)
The purpose of this work was to evaluate the potential of functional imaging with 18 F-FDG PET, 18 F-fluoromisonidazole PET, diffusion-weighted MRI, and dynamic contrast-enhanced MRI to provide an appropriate and reliable biologic target for dose painting in radiotherapy for head and neck squamous cell carcinoma (HNSCC). (snmjournals.org)
These results confirm the added value of 18 F-FDG PET and 18 F-fluoromisonidazole PET for radiotherapy planning of HNSCC and suggest the potential of diffusion-weighted and dynamic enhanced MRI for dose painting and early response assessment. (snmjournals.org)
To conclude his study, Hal suggested a minimum radiation dose to the main salivary gland to greatly reduce the chances of xerostomia. (ubc.ca)

Xerostomia is known to cause a decrease in patient's quality of life, such as discomfort in speaking and swallowing, pain and possibly anxiety and sleep disturbance . (ubc.ca)

One of the main causes of xerostomia is linked to radiation therapy for patients with head-and-neck cancers. (ubc.ca)

The authors elucidate the possible sequelae from xerostomia including infections of the oral cavity, accumulating bacteria that can become systemic, fungal infections, respiratory pathology, and cardiovascular implications. (naturalmedicinejournal.com)
Due to the decreased salivary output, caused by xerostomia, increased parasitic bacteria build up within the oral cavity thus causing dental disease. (asu.edu)
The purpose of the thesis is to research what is known about xerostomia and its effects on the complex microbiome of the oral cavity. (asu.edu)

In the six trials of interest, a total of 988 patients with locally advanced HNSCC were randomly assigned to receive either accelerated or conventionally fractionated adjuvant radiotherapy. (biomedcentral.com)

The time interval between amifostine administration and the end of daily irradiation was less than 60 minutes, and no cytoprotectant was given on days of radiotherapy alone. (cancernetwork.com)
This is particularly evident with head and neck irradiation, where a common side effect is xerostomia. (houstonmethodist.org)
In conclusion, hDPSCs-EVs reduced senescence of salivary gland epithelial cells in both murine irradiation and Sjögren's syndrome models and may become a promising future for xerostomia patients. (lu.se)

Pinna R, Campus G, Cumbo E, Mura I, Milia E. Xerostomia induced by radiotherapy: an overview of the physiopathology, clinical evidence, and management of the oral damage. (ac.ir)

This study aimed to assess the prevalence of the main oral complications and the oral hygiene index in children and adolescents aged 5 to 12 years, who received chemotherapy and/or radiotherapy. (bvsalud.org)
5% was observed in 58 patients (70%), with a higher prevalence in the group of patients who had not received pre-radiotherapy enteral nutrition. (rb.org.br)

This double-blind, randomized clinical trial involved 63 patients with radiation-induced xerostomia. (ac.ir)
Comparison of the effect of ginger and aloe vera mouthwashes on xerostomia in patients with type 2 diabetes: a clinical trial, triple-blind. (naturalmedicinejournal.com)

Medications - xerostomia is often the side effect of certain medications. (booboone.com)

This is probably due to a better understanding of the risk factors associated with the disease, its genomic landscape, advances in radiotherapy technology, and development of effective systemic agents. (hkmj.org)

Possible complications associated with xerostomia are difficulty in speaking, swallowing, or tasting food, as well as the inability to retain dental prosthesis. (naturalmedicinejournal.com)

Anatomy6

Diseases23

Chemicals and Drugs10

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Psychiatry and Psychology1

Phenomena and Processes4

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Humanities1

Information Science5

Health Care9

Intensity-modulated radiotherapy5

Mucositis9

Saliva10

Chemotherapy and radiotherapy1

Completion of radiotherapy1

Mouth7

Hyposalivation4

Conventional radiotherapy2

Reduce xerostomia1

Adaptive radiotherapy5

Presence of xerostomia1

Improvement in xerostomia1

Combination of radiotherapy2

Function after radiotherapy2

Standard radiotherapy1

Oncology2

Cause xerostomia2

Curative radiotherapy3

Significantly2

Questionnaire3

Nasopharyngeal carcinoma patients1

Cancer12

Autoimmune diseases1

Pilocarpine4

Parotid1

Diagnosis1

Mouthwash2

Treatment3

Dose4

Decrease1

Radiation therapy1

Oral cavity3

HNSCC1

Irradiation3

Physiopathology1

Prevalence2

Clinical trial2

Medications1

Systemic1

Complications1