• 42 Adjuvant chemotherapy is given after a local treatment (radiotherapy or surgery). (wikipedia.org)
  • These micrometastases can be treated with adjuvant chemotherapy and can reduce relapse rates caused by these disseminated cells. (wikipedia.org)
  • 3. Temozolomide (TMZ) - Concomitant TMZ chemotherapy during RT and adjuvant (maintenance) TMZ for 6 cycles has been shown to significantly improve survival (HR 0.63)3. (orlandohealth.com)
  • Following R0 resection of T2-4 disease in N1 gallbladder cancer, patients should be considered for adjuvant systemic chemotherapy and/or chemoradiotherapy. (medscape.com)
  • The role of radiotherapy is controversial in both the adjuvant (post-operative) and definitive (unresectable localized disease) settings. (ku.edu)
  • Chemotherapy and radiotherapy are commonly used adjuvant therapies in GBM patients who have undergone surgery. (biomedcentral.com)
  • To determine if surgical secondary cytoreduction in addition to adjuvant chemotherapy increases the duration of overall survival in patients with recurrent platinum sensitive epithelial ovarian cancer , peritoneal primary or fallopian tube cancer. (ucsf.edu)
  • To determine if surgical secondary cytoreduction in addition to adjuvant chemotherapy increases quality of life (QOL) in patients with recurrent platinum-sensitive epithelial ovarian cancer, peritoneal primary or fallopian tube cancer, as measured by the Functional Assessment of Cancer Therapy-Ovarian (FACT-O) trial outcome index and Rand Short Form (SF)-36 physical functioning scale. (ucsf.edu)
  • Biocon Biologics Ltd), BT-ON013 - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)
  • 2 cm in diameter, as adjuvant therapy following neoadjuvant chemotherapy and surgery (see sections 4.4 and 5.1). (who.int)
  • In order to achieve a more effec- were recommended postoperative radiation and adjuvant tive and individualised chemotherapeutic treatment of breast chemotherapy. (lu.se)
  • 55-59 : 17-18 Neoadjuvant chemotherapy is given prior to a local treatment such as surgery, and is designed to shrink the primary tumor. (wikipedia.org)
  • Patients with preoperatively staged T3 or T4 N1 disease should be considered for clinical trials of neoadjuvant chemotherapy. (medscape.com)
  • The decision to use neoadjuvant chemotherapy needs to be individualized, with close consultation of a multidisciplinary team. (medscape.com)
  • NCCN guidelines recommend consideration of a course of neoadjuvant chemotherapy for patients with jaundice. (medscape.com)
  • For highly selected patients with early stage (≤3 cm), unresectable hilar cholangiocarcinoma or cholangiocarcinoma arising in the setting of primary sclerosing cholangitis, the sequential combination of high-dose neoadjuvant radiotherapy with chemosensitization, brachytherapy, maintenance chemotherapy, and orthotopic liver transplantation achieves excellent outcomes, with a 65% rate of recurrence-free survival after 5 years. (medscape.com)
  • Purpose: Following neoadjuvant chemotherapy for breast cancer, postoperative systemic therapy, also called post-neoadjuvant treatment, has been established in defined risk settings. (uni-luebeck.de)
  • Conclusion: Regarding oncologic outcome, the influence of sequencing radiation therapy with maintenance capecitabine chemotherapy in the post-neoadjuvant setting is unclear. (uni-luebeck.de)
  • DNA repair gene and MTHFR gene polymorphisms as prognostic markers in locally advanced adenocarcinoma of the esophagus or stomach treated with cisplatin and 5-fluorouracil-based neoadjuvant chemotherapy. (cdc.gov)
  • Today, treatment consists of maximal surgical removal plus craniospinal radiotherapy and maintenance chemotherapy. (news-medical.net)
  • With regards to treatment, the role of surgical resection, radiotherapy, chemotherapy, and tumor-treating fields will be presented. (cancernetwork.com)
  • 2. Radiotherapy (RT) - Post-surgical RT improves survival, though even with maximal treatment, survival after RT alone is still limited to about one year3. (orlandohealth.com)
  • Surgical resection includes cholecystectomy, en bloc hepatic resection (typically of segments IVb and V), and lymphadenectomy with or without bile duct excision, depending on the location of the tumor. (medscape.com)
  • Localized forms of neuroblastoma are treated by surgical resection, sometimes preceded by chemotherapy. (orpha.net)
  • Standard therapies for these cancers are mainly based on surgical resection, radiotherapy, and chemotherapy. (cancerindex.org)
  • To define molecular and biochemical profiles associated with the duration of progression-free survival in platinum-sensitive recurrent ovarian, peritoneal primary or fallopian tube carcinoma treated with combination chemotherapy with or without bevacizumab followed with or without maintenance bevacizumab therapy in the presence or absence of secondary surgical cytoreduction. (ucsf.edu)
  • Most patients with rhabdomyosarcoma require radiation therapy to achieve adequate local control, though this treatment is not usually performed until after initial surgical resection and the start of chemotherapy. (medscape.com)
  • Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. (wikipedia.org)
  • Chemotherapy is the main treatment for ALL and is given according to a treatment plan (often called a protocol or regimen). (nhsinform.scot)
  • We reviewed the evidence for sequencing of postoperative radiation and chemotherapy, with a focus on a capecitabine and trastuzumab emtansine (T-DM1)-based regimen. (uni-luebeck.de)
  • Platinum-based chemotherapy is considered the standard treatment for advanced or recurrent cervical cancer, and a combination regimen of paclitaxel, platinum, and bevacizumab (Avastin and its FDA-approved biosimilar Mvasi, is widely recognized as the standard treatment. (centerforbiosimilars.com)
  • One patient continued the regimen as maintenance chemotherapy for more than 13 months after radiotherapy for metastases in the pubic region and surrounding soft tissues. (centerforbiosimilars.com)
  • These cases demonstrate the use of CFA-BEV with minimal toxicity and expected anti-cancer activity and indicate that this regimen should be considered for second-line chemotherapy in advanced recurrent cervical cancer," they noted. (centerforbiosimilars.com)
  • At 6 months, event-free survival in these patients, whose prognosis was unfavorable, was 65% with temsirolimus versus 50% with bevacizumab, when these agents were added to a chemotherapy regimen of vinorelbine and cyclophosphamide. (medscape.com)
  • The most commonly used chemotherapy regimen was the BFM-95 protocol. (bvsalud.org)
  • 55-59 Combined modality chemotherapy is the use of drugs with other cancer treatments, such as surgery, radiation therapy, or hyperthermia therapy. (wikipedia.org)
  • 1 Early clinical studies of the EGFR monoclonal antibody in combination with radiotherapy primarily included head and neck squamous cell carcinoma, and the study of its combination with radiation therapy for NSCLC was performed relatively late. (dovepress.com)
  • In the United States, Optune with temozolomide is indicated for the treatment of adult patients with newly diagnosed, supratentorial GBM following maximal debulking surgery and completion of radiation therapy together with concomitant standard of care chemotherapy. (novocure.com)
  • 8. Subjects are allowed to receive palliative radiation therapy (including brain radiotherapy for symptomatic brain metastases and radiotherapy for bone metastases), but the radiotherapy must be completed at least 1 week before enrollment, and the toxicity related to radiotherapy should be restored to less than or equal to 1 degree (CTCAE 5.0, excluding hair loss). (who.int)
  • In patients with localized disease, overall 5-year survival rates have improved to more than 80% with the combined use of surgery, radiation therapy, and chemotherapy. (medscape.com)
  • Treatment for patients with rhabdomyosarcoma involves a combination of surgery, chemotherapy, and radiation therapy. (medscape.com)
  • The first-line treatment typically includes chemotherapy combined with immunotherapy, which is a combination of medications that destroy the cancer cells. (rarediseases.org)
  • it means you have a longer period between platinum-based chemotherapy treatments (carboplatin and cisplatin). (targetovariancancer.org.uk)
  • This depends on how long it has been since you last had chemotherapy containing a platinum-based chemotherapy (carboplatin or cisplatin). (targetovariancancer.org.uk)
  • If it's been six months or more since your last treatment with carboplatin or cisplatin chemotherapy, the cancer is called platinum-sensitive. (targetovariancancer.org.uk)
  • Drugs used in chemotherapy, such as carboplatin, paclitaxel and gemcitabine hydrochloride work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (ucsf.edu)
  • To determine if the addition of bevacizumab to the second-line and maintenance phases of treatment increases the duration of overall survival relative to second-line paclitaxel and carboplatin alone in patients with recurrent platinum sensitive epithelial ovarian cancer, peritoneal primary or fallopian tube cancer. (ucsf.edu)
  • To identify molecular determinants that predict sensitivity or resistance to carboplatin and paclitaxel with or without bevacizumab followed with or without maintenance bevacizumab therapy. (ucsf.edu)
  • This multicenter, randomized, phase 2 study compared continuation maintenance therapy with pemetrexed (500 mg/m 2 every 21 days) and best supportive care (BSC) versus BSC alone in patients with advanced, non-squamous NSCLC who had not progressed after 4 cycles of induction chemotherapy with pemetrexed (500 mg/m 2 ) and cisplatin (75 mg/m 2 ). (biomedcentral.com)
  • Pemetrexed received approval of the U.S. Food and Drug Administration (FDA) as initial therapy in combination with cisplatin, as monotherapy after prior chemotherapy, and as maintenance monotherapy in patients with locally advanced or metastatic non-squamous NSCLC whose disease has not progressed after four cycles of platinum-based first-line chemotherapy [ 3 ]. (biomedcentral.com)
  • This is when the cancer comes back between six and 12 months after your last treatment with platinum-based chemotherapy. (targetovariancancer.org.uk)
  • Some cervical cancer patients with advanced or recurrent disease suffer from anaphylaxis after taxane- or platinum-based therapy, and there is no standard treatment for progressive disease that develops during or shortly after platinum-based chemotherapy. (centerforbiosimilars.com)
  • 4. It is recommended that idarubicin hydrochloride be administered only under the supervision of a physician who is experienced in leukemia chemotherapy and in facilities with laboratory and supportive resources adequate to monitor drug tolerance and protect and maintain a patient compromised by drug toxicity. (nih.gov)
  • In advanced NSCLC, maintenance therapy is typically initiated after 4-6 cycles of induction chemotherapy with an active doublet and is continued until disease progresses or unacceptable toxicity is reached. (biomedcentral.com)
  • The researchers therefore considered metronomic chemotherapy with bevacizumab because it could potentially prolong tumor stabilization with mild toxicity rather than the rapid and short-term regression responses caused by standard MTD therapy. (centerforbiosimilars.com)
  • Induction chemotherapy is the first line treatment of cancer with a chemotherapeutic drug. (wikipedia.org)
  • Maintenance chemotherapy is a repeated low-dose treatment to prolong remission. (wikipedia.org)
  • The study will prospectively investigate molecular subtypes in an adult population, addressing the area of better characterization of cancers through biomarkers, and will implement a dose reduction of radio-chemotherapy in its experimental arms, focusing on treatment de-escalation. (news-medical.net)
  • The standard treatment is to give one treatment of high dose chemotherapy and a stem cell transplant. (cancerresearchuk.org)
  • Researchers think that giving an extra treatment of high dose chemotherapy with 2 stem cell transplants might be better. (cancerresearchuk.org)
  • The other half have an extra treatment of high dose chemotherapy and 2 stem cell transplants. (cancerresearchuk.org)
  • Researchers are also looking at adding an extra treatment of radiotherapy to the standard treatment. (cancerresearchuk.org)
  • Radiotherapy has been the mainstay in the treatment of diffuse gliomas for several decades. (smw.ch)
  • Tumour-treating fields (TTFields) have emerged as an additional treatment option in combination with maintenance temozolomide treatment for patients with newly diagnosed glioblastoma. (smw.ch)
  • To determine if TTFields treatment at 200 kHz to the brain concomitantly with RT and TMZ in the treatment of GBM patients prolongs the overall survival of patients, compared to RT and TMZ treatments followed by TTFields and maintenance TMZ. (orlandohealth.com)
  • Mycelex ® Troches are also indicated prophylactically to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions that include chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation. (nih.gov)
  • Treatment of metastatic forms in children of more than one year and forms with amplification of MYCN is by: conventional chemotherapy, surgery of the initial tumor, high dose chemotherapy with hematopoietic stem cell transplantation, local radiotherapy and maintenance therapy with retinoic acid. (orpha.net)
  • Chemotherapy is recommended for patients able to tolerate treatment, but response rates for gross disease are poor. (ku.edu)
  • Glioblastoma remains to be a highly destructive type of tumor despite availability of treatment strategies like surgery, chemotherapy, and radiation. (biomedcentral.com)
  • Multiagent chemotherapy in combination with rituximab is the most common first-line treatment strategy for follicular lymphoma. (medscape.com)
  • In triple-negative breast cancer, the usual systemic treatment is chemotherapy. (karger.com)
  • That's because research has shown that starting chemotherapy when your CA125 levels starts rising (but before you have any symptoms) doesn't have an effect on how successful the treatment is. (targetovariancancer.org.uk)
  • In the United States, for the treatment of recurrent GBM, Optune is indicated following histologically-or radiologically-confirmed recurrence in the supratentorial region of the brain after receiving chemotherapy. (novocure.com)
  • In secondary glioblastomas after chemotherapy, GABPB1 and GABPB1-L are expressed on a lower level than without treatment. (oncotarget.com)
  • The current treatment, chemotherapy and radiotherapy, has been around for decades. (bemoreruby.com)
  • A recent Japanese case report of 4 women with recurrent cervical cancer, published in Gynecologic Oncology Reports , suggests that bevacizumab with metronomic chemotherapy (treatment in which low doses of anticancer drugs are given on a continuous or frequent, regular schedule such as daily or weekly, usually over a long period of time) of low-dose oral cyclophosphamide (CFA) should be considered for second-line chemotherapy. (centerforbiosimilars.com)
  • Among the 3 patients who received salvage chemotherapy, 1 had a progression-free survival (PFS) of 4.2 months and the other 2 continued treatment for more than 13 months without disease progression. (centerforbiosimilars.com)
  • as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)
  • BT-ON013 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)
  • According to treatment guidelines in the regional care pro- recur in spite of chemotherapy. (lu.se)
  • Treatment that combines chemotherapy with radiotherapy. (bvsalud.org)
  • Radiotherapy combined with targeted therapy has considerably furthered the study of non-small-cell lung carcinoma (NSCLC) under the joint efforts of the two disciplines, yielding both exciting results and worrisome reports. (dovepress.com)
  • Maintenance therapy for non-small cell lung cancer (NSCLC) aims to extend disease control after first-line chemotherapy with active and well-tolerated agents. (biomedcentral.com)
  • Continuation pemetrexed maintenance therapy resulted in promising PFS with an acceptable safety profile in a Middle Eastern population with advanced non-squamous NSCLC and is worthy of further investigation. (biomedcentral.com)
  • In patients with advanced non-small cell lung cancer (NSCLC), there is generally a brief period of disease control after response to first-line chemotherapy. (biomedcentral.com)
  • 55-59 Combination chemotherapy involves treating a person with a number of different drugs simultaneously. (wikipedia.org)
  • In view of novel combination therapies, it will use a targeted therapy in combination with radio-chemotherapy in a randomized setting, based on evaluation of the genetic subtype of medulloblastoma, and will therefore be personalized. (news-medical.net)
  • Researchers think that another combination of chemotherapy called GOPH might be better. (cancerresearchuk.org)
  • Combination Systemic Chemotherapy plus 3-Drug Combination Intrathecal Chemotherapy. (knowcancer.com)
  • 4-Drug Combination Systemic Chemotherapy plus Single-Agent Intrathecal Chemotherapy. (knowcancer.com)
  • TRANSPLANTATION: 2-Drug Combination Myeloablative Chemotherapy followed by Radiotherapy followed by Hematopoietic Rescue plus GVHD Prophylaxis. (knowcancer.com)
  • The combination of radiotherapy and targeted therapy is an important approach in the application of targeted therapy in clinical practice, and represents an important opportunity for the development of radiotherapy itself. (dovepress.com)
  • Targeted therapy in combination with radiotherapy has a bright future. (dovepress.com)
  • Giving monoclonal antibody therapy in combination chemotherapy may kill cancer cells more effectively. (stanford.edu)
  • It is not yet known whether combination chemotherapy is more effective when given with or without bevacizumab after surgery in treating patients with ovarian, epithelial, primary peritoneal, or fallopian tube cancer. (ucsf.edu)
  • Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (wikipedia.org)
  • A number of studies of radiotherapy combined with targeted therapy in non-small-cell lung carcinoma have been completed or are ongoing. (dovepress.com)
  • Differences in the experimental results prompted this summary for a more comprehensive and rational understanding of radiotherapy combined with targeted therapy. (dovepress.com)
  • This retrospective review of the literature indicates that numerous drugs have been used for targeted therapy and that the studies of radiotherapy combined with targeted therapy are diverse and complicated by their variable quality. (dovepress.com)
  • 6. Lomustine-TMZ as maintenance therapy might improve survival in newly diagnosed patients compared to maintenance TMZ alone, as suggested by an open-label phase 3 trial in 141 patients, which demonstrated a HR of 0.6 (95% CI 0.35-1.03, p=0.0492) for the combined treatment9. (orlandohealth.com)
  • After completing a course of maintenance therapy, Elliot now 13, has MRI scans every three months to check that the residual tumour is still stable. (make-a-wish.org.uk)
  • The utility of continuation maintenance therapy requires further research. (biomedcentral.com)
  • A total of 106 patients commenced induction therapy, of whom 55 patients were randomized to maintenance pemetrexed/BSC (n = 28) or BSC (n = 27). (biomedcentral.com)
  • A key consideration for maintenance therapy is to utilize a well-tolerated agent with a relatively low risk of serious, cumulative toxicities. (biomedcentral.com)
  • Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)
  • The other half have the standard radiotherapy and a booster dose. (cancerresearchuk.org)
  • Twenty-eight patients were identified who received SBRT after a median prior external beam radiotherapy dose of 50.4 Gy. (ku.edu)
  • Dose reduction of capecitabine should be considered, especially if normofractionated radiotherapy is used. (uni-luebeck.de)
  • Isono-Nakata R, Tsubamoto H, Ueda T, Inoue K, Shibahara H. Bevacizumab with metronomic chemotherapy of low-dose oral cyclophosphamide in recurrent cervical cancer: four cases. (centerforbiosimilars.com)
  • The recommended maintenance dose is 6 mg/kg body weight every three weeks, beginning three weeks after the loading dose. (who.int)
  • Consolidation chemotherapy is given after remission in order to prolong the overall disease-free time and improve overall survival. (wikipedia.org)
  • Similar PFS results were observed for the overall study period (induction plus maintenance) and when the PFS analysis was adjusted for sex, baseline disease stage, and the ECOG PS prior to randomization. (biomedcentral.com)
  • 55-59 Salvage chemotherapy or palliative chemotherapy is given without curative intent, but simply to decrease tumor load and increase life expectancy. (wikipedia.org)
  • Furthermore, several randomised trials have shown that the addition of alkylating chemotherapy, either temozolomide or nitrosourea-based regimens, to radiotherapy results in prolonged survival. (smw.ch)
  • 55-59 Intensification chemotherapy is identical to consolidation chemotherapy but a different drug than the induction chemotherapy is used. (wikipedia.org)
  • Results: We first show that scoring captures differential induction of damage or inflammatory pathways in a series of public datasets involving radiotherapy of colon adenocarcinoma, chemotherapy of breast cancer cells, replicative senescence of mesenchymal stem cells, and progression of melanoma. (gla.ac.uk)
  • Oral lesions were associated with the induction phase of chemotherapy. (bvsalud.org)
  • 759P) PANOVA: A phase II study of TTFields (150 kHz) with concomitant standard chemotherapy for front-line advanced pancreatic adenocarcinoma - Updated efficacy results. (novocure.com)
  • Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (wikipedia.org)
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (wikipedia.org)
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (wikipedia.org)
  • Chemotherapy drugs work in different ways to stop the growth of cancer cells, either by killing them or by stopping them from dividing. (stanford.edu)
  • Conclusions: Oral abnormalities were common in children receiving chemotherapy and mucositis was the most prevalent manifestation. (bvsalud.org)
  • Chemotherapy and targeted therapies are the most common treatments offered for those with recurrent ovarian cancer. (targetovariancancer.org.uk)
  • It was assessed prospectively women with breast cancer in a cohort of patients undergoing chemotherapy. (isciii.es)
  • This Phase II trial is studying how well giving epratuzumab together with an established chemotherapy platform works in treating young patients with relapsed acute lymphoblastic leukemia. (stanford.edu)
  • Prior chemotherapy must have included at least an anthracycline and a taxane unless patients are unsuitable for these treatments. (who.int)
  • Progression-free survival (PFS) for first-line chemotherapy was 7 months. (karger.com)
  • The one-year survival probabilities were similar for both arms for the maintenance phase and the overall study period. (biomedcentral.com)
  • The stress caused by chronic, life-threatening chemotherapy, radiotherapy, surgery, and in some illness in a child interferes with parents' cases, bone marrow transplants2. (bvsalud.org)
  • This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (wikipedia.org)
  • Senescence involves convergence of multiple pathways and requires ongoing dynamic signalling throughout its establishment and maintenance. (gla.ac.uk)
  • Total body irradiation is a form of radiotherapy that involves irradiating the patient's entire body in an attempt to suppress the immune system, prevent rejection of the transplanted bone marrow and/or stem cells and to wipe out any remaining cancer cells. (survivornet.com)
  • Due to the lack of drug-targetable receptors, the primary method for systemic management of both early-stage and metastatic settings is chemotherapy, which improves outcomes in TNBC [2]. (karger.com)
  • Chemotherapy may be given with a curative intent or it may aim to prolong life or to palliate symptoms. (wikipedia.org)
  • This type of chemotherapy is used for curative intent. (wikipedia.org)
  • To assess the role of body composition on quality of life and the impact of chemotherapy on both, in women with breast cancer. (isciii.es)
  • To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (wikipedia.org)
  • Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called medical oncology. (wikipedia.org)
  • To give me the best chance of beating the cancer, I immediately underwent six bouts of chemotherapy - one cycle every two weeks, followed by radiotherapy twice a day for five weeks and then a year of maintenance chemo. (plymouth.ac.uk)
  • The median OS for the maintenance phase was 12.2 months (95%CI: 5.6 to 20.6) for the pemetrexed/BSC arm and 11.8 months (95% CI: 6.3 to 25.6) for BSC arm. (biomedcentral.com)