Radiotherapy dose cardiac radiation cause cancer. Medical search. Frequent questions

An early dose-finding study by the Radiation Therapy Oncology Group (RTOG) 7301 study was conducted from 1973 to 1978 and studied four different doses and schedules: 40 Gy split course, 40 Gy continuously, 50 Gy, and 60 Gy. (frontiersin.org)
Each patient will be seen at Radiation Oncology and undergo a CT scan for planning of their radiation therapy. (uclahealth.org)
Each subject will receive a 30 minute session of SABR, and will be asked to return to both their cardiologist and UCLA Radiation Oncology on a regular, routine basis for check-up visits for up to five years. (uclahealth.org)
Physics and imaging in radiation oncology. (lu.se)
Technical Innovations and Patient Support in Radiation Oncology. (lu.se)
Nowadays, the FLASH effect has the potential to revolutionize the field of radiation oncology and is investigated worldwide by various companies and academic institutions. (unil.ch)
Cardio-oncology, or onco-cardiology, is the discipline that focuses on the intersection of cardiovascular disease and cancer. (ajmc.com)
The MGH Cardio-Oncology Program introduced in 2011 is a joint initiative between the Heart and Cancer Centers at Massachusetts General Hospital that provides comprehensive cardiovascular care to cancer patients, with the goal of improving short- and long-term outcomes ( Figure ). (ajmc.com)
1 Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Republic of Korea. (rmwebzine.re.kr)
2 Department of Radiation Oncology, Ajou University Hospital, Ajou University School of Medicine, Republic of Korea. (rmwebzine.re.kr)
Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, Republic of Korea. (rmwebzine.re.kr)
Alpha-emitter RPT (αRPT), in vivo RBE evaluation in collaboration with Radiation Oncology SARRP facility. (hopkinsmedicine.org)
Radiotherapy and Oncology. (uib.no)
Advances in Radiation Oncology. (uib.no)
International Journal of Radiation Oncology, Biology, Physics. (uib.no)
Radiation oncology is the medical specialty concerned with prescribing radiation, and is distinct from radiology, the use of radiation in medical imaging and diagnosis). (medicalmarijuana.com)
Since March 2017, clinicians in the Department of Oncology and Radiation Therapy at Turku University Hospital (Turku, Finland) have been using Philips MR-only simulation for simulating and planning radiation therapy for their patients with prostate cancer. (philips.com)
Professor and Head of TYKS's Department of Oncology and Radiotherapy, where he started in 1985. (philips.com)
Medical physicist at TYKS's Departments of Medical Physics and of Oncology and Radiotherapy. (philips.com)
Our on-site pharmacy offers expert oncology-trained pharmacists and the most-up-to-date cancer protocols. (genesishcs.org)
My clinical training as a pediatric hematology oncology fellow at Memorial Sloan Kettering Cancer Center highlighted the desperate need for novel therapeutic options for a subtype of aggressive pediatric leukemia, Acute Myeloid Leukemia (AML). (stanford.edu)
These opportunities are a great way to contribute to the literature while reinforcing our ever-present, all-important goal: strengthening patient outcomes in radiation oncology. (appliedradiationoncology.com)
Their current application in oncology has revolutionized cancer treatment by improving the antitumor activity of several chemotherapeutic agents. (mdpi.com)
Radiation does cause a type of injury, but it's different from catheter ablation," said co-author and radiation oncologist Julie K. Schwarz, MD, PhD , professor of radiation oncology and director of the Cancer Biology Division in the Department of Radiation Oncology . (wustl.edu)
Scientific council on ionizing radiation within oncology (2016). (lu.se)
The American Society for Clinical Oncology (ASCO) recommends considering the combination of palliative care with standard oncology care early in the course of treatment for patients with metastatic cancer and/or a high symptom burden. (medscape.com)

The current standard of care for locally advanced non-small cell lung cancer (NSCLC) includes radiation, chemotherapy, and surgery in certain individualized cases. (frontiersin.org)
However, for patients with more locally advanced NSCLC, 5-year OS after treatment with definitive radiation therapy and concurrent chemotherapy remains modest, at approximately 15-20% ( 4 ). (frontiersin.org)
Prior to the advent of cytotoxic chemotherapy, lung cancer at all stages was treated surgically or by radiation alone ( 5 , 6 ). (frontiersin.org)
Presently, stage III lung cancer is managed with a combination of chemotherapy, radiation therapy, and sometimes surgery but the two major challenges in improving outcomes of the treatment of this disease remain local control and metastatic spread. (frontiersin.org)
1,2 Similarly, there are increased risks of congestive heart failure in adults treated with anthracycline-based chemotherapy regimens, which in current practice includes patients with breast cancer, leukemia, lymphoma, sarcoma, and other cancer types. (ajmc.com)
Along with the traditional approaches of chemotherapy, a revolution in the understanding of the molecular mechanisms that underlie many common cancers has led to the development of targeted pathway inhibitors, many of which inhibit tyrosine kinases. (ajmc.com)
There are data suggesting that early recognition of chemotherapy-induced cardiomyopathy and prompt initiation of medical therapy can promote recovery of cardiac function. (ajmc.com)
In patients with localized disease, overall 5-year survival rates have improved to more than 80% with the combined use of surgery, radiation therapy, and chemotherapy. (medscape.com)
Treatment for patients with rhabdomyosarcoma involves a combination of surgery, chemotherapy, and radiation therapy. (medscape.com)
Most patients with rhabdomyosarcoma require radiation therapy to achieve adequate local control, though this treatment is not usually performed until after initial surgical resection and the start of chemotherapy. (medscape.com)
It is not yet known whether high-dose radiation therapy is more effective than standard-dose radiation therapy when given together with combination chemotherapy with or without cetuximab in treating patients with non-small cell lung cancer. (stanfordhealthcare.org)
PURPOSE: This randomized phase III trial is studying high-dose or standard-dose radiation therapy given together with chemotherapy with or without cetuximab to see how well they work in treating patients with newly diagnosed stage III non-small cell lung cancer that cannot be removed by surgery. (stanfordhealthcare.org)
note that prior chemotherapy for a different cancer is allowable. (stanfordhealthcare.org)
Further, cancer treatment often involves radiotherapy and chemotherapy, which not only kills cancer cells but also affects healthy cells. (aspetjournals.org)
The majority of patients with small-cell lung cancer (SCLC) receive radiotherapy in combination with chemotherapy. (iiarjournals.org)
Study Population: 15 recurrent glioblastoma patients previously treated by surgery, conventional radiotherapy and chemotherapy with temozolomide (TMZ. (knowcancer.com)
It is also common to combine radiation therapy with surgery, chemotherapy, hormone therapy, Immuno-therapy or some mixture of the four. (medicalmarijuana.com)
Any other chemotherapy, immunotherapy, immunosuppressant medication (other than corticosteroids) or anti-cancer agents within 3 weeks of the first dose of study treatment, except hormonal therapy with luteinising hormone-releasing hormone (LHRH) analogues for medical castration in patients with prostate cancer, which are permitted. (astrazenecaclinicaltrials.com)
Depending on the type of biotherapy used, you may receive this treatment at the Genesis Cancer Care Center in the chemotherapy and infusion suite or in your home. (genesishcs.org)
Chemotherapy uses medications to kill cells that grow quickly, including cancer. (genesishcs.org)
The Cancer Care Center has a chemotherapy and infusion suite. (genesishcs.org)
Women treated with radiotherapy without chemotherapy for a unilateral breast cancer and aged 40-75 years meet the inclusion criteria. (rug.nl)
This phase I trial studies the best dose and side effects of CD19/CD22 chimeric antigen receptor (CAR) T cells when given together with chemotherapy, and to see how well they work in treating children or young adults with CD19 positive B acute lymphoblastic leukemia that has come back or does not respond to treatment. (stanford.edu)
Drugs used in chemotherapy, such as fludarabine phosphate and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (stanford.edu)

This paper provides an updated review of the recent progress achieved in ultra-high dose rate radiobiology experiments employing laser-driven protons, including a brief discussion of the relevant methodology and dosimetry approaches. (frontiersin.org)
His current interests are MRI in radiotherapy, small-field dosimetry and dose calculation, quality assurance, and stereotactic and adaptive treatments. (philips.com)
Objective: The MEDIRAD EARLY HEART study aims to identify and validate new cardiac imaging and circulating biomarkers of radiation-induced cardiovascular changes arising within first 2 years of breast cancer radiotherapy and to develop risk models integrating these biomarkers combined with precise dose metrics of cardiac structures based on three-dimensional dosimetry. (rug.nl)
Radiation protection dosimetry 2023 9 199 (14): 1533-1538. (cdc.gov)
As complex radiotherapy techniques become more readily-practiced, comprehensive 3D dosimetry is a growing necessity for advanced quality assurance. (duke.edu)
Development of three-dimensional dosimetry for radiotherapy. (sbcrowe.net)

The exposition of cardiac conduction system during breast radiation therapy has never been studied, despite the increasing use of intensity-modulated radiation therapy, which exposes larger volume to low-dose bath. (allenpress.com)
Atrioventricular (AVN) and sinoatrial (SAN) nodes were retrospectively delineated according to published guidelines on the simulation computed tomography scans of 12 breast cancer patients having undergone conserving surgery and adjuvant locoregional volumetric modulated arc therapy. (allenpress.com)
Intensity-modulated proton therapy treatment was replanned on the simulation computed tomography scans for all breast cancer patients. (allenpress.com)
Intensity-modulated proton therapy significantly reduced mean and maximum doses to the SAN and AVN. (allenpress.com)
Cardiotoxicity studies evaluating conduction node exposure might define dose constraints and criteria for additional cardiac-sparing techniques, such as respiratory techniques or proton therapy, which could benefit patients with underlying rhythmic or conduction disorders. (allenpress.com)
Adjuvant breast radiation therapy is associated with increased locoregional control and patient-specific survival [ 1 ]. (allenpress.com)
Such techniques include rotational intensity-modulated radiation therapy (IMRT) or proton therapy. (allenpress.com)
She also leads studies on the risk of second cancer after proton therapy and other emerging radiotherapy techniques. (wikipedia.org)
She is also developing methods to project risks from high-doses of radiation exposure and conducting a pilot study to assess the feasibility of performing the first multi-center study of the second cancer risks from proton therapy and IMRT. (wikipedia.org)
Given the widespread use of radiation therapy in the treatment of breast cancer, and the continually expanding arsenal of novel therapies, the current study calls for greater collaboration between oncologists and cardiologists. (cardiobrief.org)
An important lesson for the oncologist may be that the time to address concerns about cardiovascular "survivorship" is at the time of cancer diagnosis and before treatment rather than after completion of therapy. (cardiobrief.org)
Similarly, cardiologists need to assess prior exposure to radiation therapy as a significant cardiovascular risk factor in survivors of breast cancer. (cardiobrief.org)
Over the last 17 years, stereotactic body radiation therapy (SBRT) has shown a high degree of safety and local control for stage I lung cancers and other localized malignancies. (frontiersin.org)
Subjects who enroll will receive stereotactic ablative radiotherapy (SABR), a therapy routinely used in cancer patients with minimal side effects. (uclahealth.org)
BACKGROUND: Volumetric Modulated Arc Therapy (VMAT) offers better conformity, homogeneity and sparing of the heart and ipsilateral lung for locoregional radiotherapy in left-sided breast cancer compared to three-dimensional conformal radiotherapy (3D-CRT). (bvsalud.org)
For each patient, treatment plans were generated with the following three techniques: 3D-CRT, tangential intensity-modulated radiotherapy (tIMRT) and volumetric modulated arc therapy with partial arcs (pVMAT). (bvsalud.org)
My group has been the first to develop FLASH-Radiotherapy, a novel modality of radiation therapy at ultra high dose rate that minimizes normal tissue toxicity but eradicates tumors. (unil.ch)
Next, using a lung adenocarcinoma model (KP), we demonstrated that modulation of neutrophil phenotype was able to enhance the tumor response to radiation therapy without any stimulation of fibrosis. (unil.ch)
With recent technological advances, modalities such as Intensity Modulated Radiotherapy (IMRT), Stereotactic Body Radiotherapy (SBRT) or Volumetric Modulated Arc Therapy (VMAT) can conform doses to tumours more precisely than possible a few decades ago sparing the normal tissue to a larger extent. (frontiersin.org)
Working closely with the cancer care team, we provide a comprehensive cardiovascular evaluation and treatment plan prior to cancer therapy to minimize cardiovascular complications. (ajmc.com)
We analyzed 67 patients with esophageal crab who received outer beam radiation therapy with a full dose of >or=50 gy and were followed for >or=6 months. (eu.org)
The purpose of this study was aiming to investigate change of myocardial [18F]FDG uptake before and after radiotherapy, and relationship between this change and radiation dose on myocardium during therapy. (aapm.org)
Regional lymph nodes that appear to be clinically or radiographically involved should be sampled to determine the tumor's surgicopathologic clinical group and the need for later radiation therapy. (medscape.com)
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. (stanfordhealthcare.org)
Hence, a major goal in cancer drug development and therapy is to increase tumor-specific drug uptake while reducing uptake into normal tissues to minimize toxicities. (aspetjournals.org)
The FLUKA Monte Carlo code coupled with an OER model for biologically weighted dose calculations in proton therapy of hypoxic tumors. (uib.no)
Spatial agreement of brainstem dose distributions depending on biological model in proton therapy for pediatric brain tumors. (uib.no)
Plan selection in proton therapy of locally advanced prostate cancer with simultaneous treatment of multiple targets. (uib.no)
The FLUKA Monte Carlo code coupled with the NIRS approach for clinical dose calculations in carbon ion therapy. (uib.no)
Linear energy transfer distributions in the brainstem depending on tumour location in intensity-modulated proton therapy of paediatric cancer. (uib.no)
Biological dose and complication probabilities for the rectum and bladder based on linear energy transfer distributions in spot scanning proton therapy of prostate cancer. (uib.no)
A phenomenological biological dose model for proton therapy based on linear energy transfer spectra. (uib.no)
Modelling of organ-specific radiation-induced secondary cancer risks following particle therapy. (uib.no)
Therefore, this study was performed aiming to identify the prevalence of pneumonitis and potential risk factors for this complication in patients with locally advanced lung cancer irradiated with volume-modulated arc therapy (VMAT). (iiarjournals.org)
This phase I trial studies the side effects and the best dose of wild-type reovirus (viral therapy) when given with sargramostim in treating younger patients with high grade brain tumors that have come back or that have not responded to standard therapy. (mayo.edu)
Radiation therapy is commonly applied to the cancerous tumor because of its ability to control cell growth. (medicalmarijuana.com)
Radiation may be prescribed by a radiation oncologist with intent to cure ("curative") or for adjuvant therapy. (medicalmarijuana.com)
Most common cancer types can be treated with radiation therapy in some way. (medicalmarijuana.com)
Total body irradiation (TBI) is a radiation therapy technique used to prepare the body to receive a bone marrow transplant. (medicalmarijuana.com)
Brachytherapy, in which a radiation source is placed inside or next to the area requiring treatment, is another form of radiation therapy that minimizes exposure to healthy tissue during procedures to treat cancers of the breast, prostate and other organs. (medicalmarijuana.com)
Radiation therapy has several applications in non-malignant conditions, such as the treatment of trigeminal neuralgia, severe thyroid eye disease, pterygium, pigmented villonodular synovitis, and prevention of keloid scar growth, vascular restenosis , and heterotopic ossification. (medicalmarijuana.com)
The use of radiation therapy in non-malignant conditions is limited partly by worries about the risk of radiation-induced cancers. (medicalmarijuana.com)
Radiation therapy works by damaging the DNA of cancerous cells. (medicalmarijuana.com)
In the older, most common form of radiation therapy, Intensity-modulated radiation therapy (IMRT) (photons), most of the radiation effect is through free radicals. (medicalmarijuana.com)
One of the major limitations of photon radiation therapy is that the cells of solid tumors become deficient in oxygen. (medicalmarijuana.com)
SCOPE 1 [ 3 ] was a phase 2/3 multi-centre trial of CRT for patients with non-metastatic oesophageal cancer, incorporating the use of biological therapy. (biomedcentral.com)
The trial is looking at the role of dose intensification and adaptive therapy. (biomedcentral.com)
The radiation therapy department at Turku University Hospital (TYKS) has been home to a Philips Ingenia MR-RT 1.5T since January 2016. (philips.com)
Immunotherapy is a type of biological therapy that helps your immune system fight cancer. (genesishcs.org)
Radiation therapy uses high-energy waves that you can't feel to kill cancer cells. (genesishcs.org)
Using advanced external radiation therapy equipment, we can precisely target radiation to destroy tumors in your body. (genesishcs.org)
Urinary Continence Recovery after Retzius-Sparing Robot Assisted Radical Prostatectomy and Adjuvant Radiation Therapy. (cdc.gov)
Contralateral breast cancer risk with radiation therapy in BRCA mutation carriers: what do we tell patients? (cdc.gov)
Neurotransmitter Gene Polymorphisms Are Associated with Symptom Clusters in Patients Undergoing Radiation Therapy. (cdc.gov)
We identify details including the computed tomography (CT) scanning considerations, the radiobiological basis of IR anti-inflammatory effects, the supportive evidence for low dose radiation therapy (LDRT), and the risks of radiation-induced cancer and cardiac disease associated with LDRT. (bvsalud.org)
METHOD: Four different radiotherapy techniques, including 3D-conformal with anterior and posterior fields (3D-CRT AP-PA), 3D-conformal with 8 coplanar fields (3D-CRT 8 fields), eight fields intensity-modulated radiotherapy (IMRT), and volumetric modulated arc therapy using 2 full arcs (VMAT) were planned on the CT images of 32 COVID-19 patients with the prescribed dose of 1 Gy to the lungs. (bvsalud.org)
As a prelude to Breast Cancer Awareness Month coming up in October, we are pleased to focus this issue on several evolving areas of breast radiation therapy. (appliedradiationoncology.com)
The cover article, Cardiac-sparing radiation therapy for breast cancer, examines the wide variety of methods for adjuvant breast or chest wall RT that can help minimize radiation dose to the heart-a key contributor to coronary stenosis and other cardiac diseases. (appliedradiationoncology.com)
University of Pennsylvania authors provide an enlightened review of techniques to help individualize and, in turn, maximize cardiac-sparing radiation treatments, from a minimum standard of forward planning, to more advanced methods of prone positioning, deep-inspiration breath hold, intensity-modulated radiation therapy, and proton therapy. (appliedradiationoncology.com)
This definitive review assesses applicator-based brachytherapy and its toxicity-related concerns, external-beam approaches, proton therapy, intraoperative radiation therapy, and the future outlook of APBI. (appliedradiationoncology.com)
Finally in our breast cancer lineup, we present Soft tissue sarcoma of the breast following breast-conserving therapy, a helpful case report describing the challenge of re-irradiating the left chest while managing heart and lung dose. (appliedradiationoncology.com)
Available interventions to control vaginal bleeding include vaginal packing, radiation therapy, embolization of the uterine arteries, surgical resection, and arterial ligation. (medscape.com)
Regional collaboration to improve quality of radiation therapy in Asia. (fmu.ac.jp)
Plan-Optimization Method for Central-shielding Pelvic Volumetric-modulated Arc Therapy for Cervical Cancer. (fmu.ac.jp)
Radiation therapy for ventricular tachycardia - a life-threatening irregular heart rhythm - appears to work by reverting heart muscle cells to a younger state, reducing the irregular rhythms, according to a new study from Washington University School of Medicine in St. Louis. (wustl.edu)
New research from Washington University School of Medicine in St. Louis suggests that radiation therapy can reprogram heart muscle cells to what appears to be a younger state, fixing electrical problems that cause a life-threatening arrhythmia without the need for a long-used, invasive procedure. (wustl.edu)
The new study, however, shows that noninvasive radiation therapy normally used to treat cancer can reprogram the heart muscle cells to a younger and perhaps healthier state, fixing the electrical problem in the cells themselves without needing scar tissue to block the overactive circuits. (wustl.edu)
The study also suggests that the same cellular reprogramming effect could be achieved with lower doses of radiation, opening the door to the possibility of wider uses for radiation therapy in different types of cardiac arrhythmias. (wustl.edu)
Physician-scientists at Washington University showed in 2017 that radiation therapy typically reserved for cancer treatment could be directed at the heart to treat ventricular tachycardia. (wustl.edu)
In theory, radiation therapy could reproduce the scar tissue usually created through catheter ablation but with a much shorter and totally noninvasive procedure, making the treatment available to more severely ill patients. (wustl.edu)
Surprisingly, the doctors found that patients experienced large improvements in their arrhythmias a few days to weeks after radiation therapy, much quicker than the months it can take scar tissue to form after radiation therapy, suggesting that a single dose of radiation reduces the arrhythmia without forming scar tissue. (wustl.edu)
To help us understand whether the same thing was happening with radiation therapy, some of the first patients to have this new treatment gave us permission to study their heart tissue - following heart transplantation or if they had passed away for another reason, for example. (wustl.edu)
Radiation therapy seems to kick up the speed faster by activating early developmental pathways that revert the heart tissue back into a healthier state. (wustl.edu)
Out-of-field dose in contemporary radiation therapy. (sbcrowe.net)
Ionizing radiation is emitted by radioactive elements and by equipment such as x-ray and radiation therapy machines. (msdmanuals.com)
As breast cancer treatment is multimodality approach Radiation therapy has significant impact on prevention of local recurrence. (who.int)
Conclusion: Local recurrence after treatment of breast cancer with mastectomy+radiotherapy+/-systemic therapy is associated with a significantly higher risk of distant metastasis and death. (who.int)

Neurocognitive and cardiac toxicity are severely impacting cancer survivors' quality of life. (unil.ch)
In parallel, g rowing evidence suggests that the long-term neurocognitive changes as well as cardiac toxicity induced by anti-cancer treatments might differ between the sexes in both human cancer patients and in rodent models. (unil.ch)
increased long-term survival in esophageal cancer patients with radiotherapy, radiation-induced cardiac toxicity happens more frequently. (aapm.org)
Since without clinical data, it is not possible to correlate the FDG PET uptake pattern with cardiac toxicity in current study. (aapm.org)
This mini-review focuses on the clinical applications of mIBG in neuroendocrine cancers and the differential roles of NET, OCT, and MATE transporters in mIBG disposition, response and toxicity. (aspetjournals.org)
Understanding the molecular mechanisms governing mIBG transport in cancer and normal cells is a critical step for developing strategies to optimize the efficacy of 131 I-mIBG while minimizing toxicity in normal tissues. (aspetjournals.org)
Treatment-related toxicity is frequently a dose-limiting factor and represents a major challenge in clinical management of cancer. (aspetjournals.org)
Single Nucleotide Polymorphisms in DNA Repair Genes (XRCC1, XRCC2, XRCC3) and Their Association with Radiotherapy Toxicity among Head and Neck Cancer Patients:A Study from South-Western Maharashtra. (cdc.gov)

Berrington de González has conducted a series of risk projection studies to estimate the potential cancer risks from both diagnostic and screening examinations, including: cardiac stress tests, CT colonography and lung CT screening. (wikipedia.org)
One hundred years ago, lung cancer was a rare malignancy ( 1 ). (frontiersin.org)
Lung cancer today is the leading cause of cancer death in the United States, with over 158,000 estimated deaths in 2016 ( 2 ). (frontiersin.org)
Approximately 80-90% of newly diagnosed lung cancers are classified as NSCLC, primarily consisting of adenocarcinoma, squamous cell carcinoma, or large cell carcinoma histologies. (frontiersin.org)
TNM staging was introduced in 1974 and it helped shape the way lung cancer was managed. (frontiersin.org)
Stage III lung cancer, though heterogeneous in its classification, includes non-metastatic but locally advanced disease with involvement of N1-N3 nodal stations and/or T3 and T4 primaries. (frontiersin.org)
Doses to the heart and ipsilateral lung were significantly lower with ncVMAT compared to both cVMAT and 3D-CRT. (bvsalud.org)
ncVMAT reduced doses to both the contralateral breast and lung compared to cVMAT and achieved levels similar to 3D-CRT for the contralateral breast and moderately higher doses for the contralateral lung. (bvsalud.org)
Doses to the heart, left anterior descending (LAD) coronary artery, ipsilateral and contralateral lung as well as the contralateral breast (CB) were assessed. (bvsalud.org)
The mean doses to the ipsi- and contralateral lung and CB were similar with tIMRT and 3D-CRT but significantly higher with pVMAT. (bvsalud.org)
A dose planning study for cardiac and lung dose sparing techniques in left breast cancer radiotherapy: Can free breathing helical tomotherapy be considered as an alternative for deep inspiration breath hold? (lu.se)
We mainly focused our investigation on radiation impact on innate immunity and found a role of interstitial macrophages in radiation-induced lung fibrogenesis. (unil.ch)
RhoB had a causative role in the development of these radiation-induced complications in various organs (including the heart, lung and gut). (unil.ch)
Background/Aim: Radiotherapy of locally advanced lung cancer often requires high doses potentially leading to pneumonitis. (iiarjournals.org)
Patients and Methods: This study included 278 patients irradiated for locally advanced lung cancer between 2016 and 2019. (iiarjournals.org)
Frequent characteristics included high mean lung doses, systemic treatment, cardiovascular disease (and risk factors), heavy smoking, older age, chronic inflammatory disease and history of a previous tumor. (iiarjournals.org)
Lung cancer is the second most common solid cancer in Europe and Northern America ( 1 ). (iiarjournals.org)
Also, many patients with locally advanced non-small-cell lung cancer (NSCLC) receive radiotherapy, if they are not candidates for surgery. (iiarjournals.org)
Moreover, in the literature, the prevalence of symptomatic pneumonitis after irradiation of lung cancer varies considerably ( 4 - 7 ). (iiarjournals.org)
In this retrospective study, which was approved by the ethics committee of the University of Lübeck, 278 patients irradiated for locally advanced lung cancer between 2016 and 2019 were evaluated with respect to the development of symptomatic (grade ≥2) pneumonitis. (iiarjournals.org)
Treatment characteristics included mean dose to the ipsilateral lung and type of systemic treatment. (iiarjournals.org)
Should Prophylactic Cranial Irradiation Be Used in Patients with Stage III Non-Small Cell Lung Cancer? (libsyn.com)
This is an evaluation of PCI in stage III Non-Small-Cell Lung Cancer. (libsyn.com)
8. Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease. (astrazenecaclinicaltrials.com)
Comparing Fractionated and Single-Fraction Gamma Knife Radiosurgery for Brain Metastases From Non-Small-Cell Lung Cancer With a Focus on Driver Alterations. (cdc.gov)
This study aimed to estimate cancer risks induced by lung LDRT for different radiotherapy delivery techniques. (bvsalud.org)
Lung cancer is the leading cause of cancer-related death in the US. (uspreventiveservicestaskforce.org)
To review the evidence on screening for lung cancer with low-dose computed tomography (LDCT) to inform the US Preventive Services Task Force (USPSTF). (uspreventiveservicestaskforce.org)
English-language studies of screening with LDCT, accuracy of LDCT, risk prediction models, or treatment for early-stage lung cancer. (uspreventiveservicestaskforce.org)
number needed to screen [NNS] to prevent 1 lung cancer death, 323 over 6.5 years of follow-up) with 3 rounds of annual LDCT screening compared with chest radiograph for high-risk current and former smokers aged 55 to 74 years. (uspreventiveservicestaskforce.org)
NNS to prevent 1 lung cancer death of 130 over 10 years of follow-up) with 4 rounds of LDCT screening with increasing intervals compared with no screening for high-risk current and former smokers aged 50 to 74 years. (uspreventiveservicestaskforce.org)
Overdiagnosis estimates varied greatly (0%-67% chance that a lung cancer was overdiagnosed). (uspreventiveservicestaskforce.org)
Screening high-risk persons with LDCT can reduce lung cancer mortality but also causes false-positive results leading to unnecessary tests and invasive procedures, overdiagnosis, incidental findings, increases in distress, and, rarely, radiation-induced cancers. (uspreventiveservicestaskforce.org)
In 2020, lung cancer was the second most common cancer and the leading cause of cancer-related death in both men and women in the US. (uspreventiveservicestaskforce.org)
For example, Temel et al reported that in patients with metastatic non-small cell lung cancer, early palliative care led to significant improvements in both quality of life and mood. (medscape.com)

Average mean doses delivered to the SAN and AVN were 2.8 and 2.3 Gy, respectively, for left-sided irradiation and 9.6 and 3.6 Gy, respectively, for right-sided irradiation. (allenpress.com)
Average maximum doses to the SAN and AVN were 3.5 Gy and 2.8 Gy, respectively, for left-sided irradiation and 13.1 and 4.6 Gy, respectively, for right-sided irradiation. (allenpress.com)
CONCLUSION: tIMRT and 3D-CRT with DIBH are better techniques for sparing heart tissue and other organs at risk without compromising target coverage in early-stage breast cancer irradiation compared to VMAT. (bvsalud.org)
In the hope of generalizing the efficacy of radio-immunotherapy to all cancer paptients, we are developing preclinical strategies to better understand the modulation induced by irradiation on the microenvironment. (unil.ch)
However, breast cancer radiotherapy can lead to incidental irradiation of the heart, resulting in an increased risk for a variety of heart diseases arising many years after radiotherapy. (rug.nl)
Radiotherapy, including internal mammary nodal irradiation, and heart failure in patients receiving concurrent treatment with trastuzumab further explores the critical challenge of RT-induced cardiotoxicity. (appliedradiationoncology.com)
In Accelerated partial-breast irradiation (APBI): An emerging standard of care, Cleveland Clinic authors evaluate data supporting this underused, yet proven, technique for women with early stage breast cancer who have undergone breast-conserving surgery. (appliedradiationoncology.com)
This study aims to explore the role and potential mechanism of microRNA-223-3p (miR-223-3p) in RIHD.Methods: Mice were injected with miR-223-3p mimic, inhibitor, or their respective controls in the tail vein and received a single dose of 20 Gy whole-heart irradiation (WHI) for 16 weeks after 3 days to construct a RIHD mouse model. (sciencegate.app)

Baseline and follow-up data include cardiac measurements based on two-dimensional speckle-tracking echocardiography, computed tomography coronary angiography, cardiac magnetic resonance imaging, and a wide panel of circulating biomarkers of cardiac injury. (rug.nl)

However, conventional coplanar VMAT (cVMAT) can result in higher doses to the normal tissue on the contralateral side. (bvsalud.org)
RESULTS: In IMRT and VMAT techniques, heart (mean and max), breast (mean, and max), and stomach (mean) doses and also maximum dose in the body were significantly lower than the 3D-CRT techniques. (bvsalud.org)
However, the overall estimated risks induced by IMRT and VMAT radiotherapy techniques were lower than the 3D-CRT techniques and can be used clinically in younger patients or patients having greater concerns about radiation induced cancers. (bvsalud.org)
Developing new methods of dose evaluation for VMAT patient specific plans. (sbcrowe.net)

patients with thoracic esophageal cancer with radiotherapy were enrolled in Shangdong Tumor Hospital, Jinan, China during 2016-2018. (aapm.org)

Arrhythmias and conduction disorders are described as radiation-induced complications of thoracic irradiations [ 5 ]. (allenpress.com)
Radiotherapy is mostly well tolerated but can result in some short term skin changes as well as longer term changes in the breast such as increased sensitivity/ tenderness, late complications from radiotherapy such as cardiac disease or second cancer are very rare. (lakesidespecialists.com.au)
Therefore, identifying breast cancer patients at the highest risk for radiation-induced cardiac complications is crucial for developing strategies for primary and secondary prevention, which may contribute to healthy aging. (rug.nl)
There is still a need for precise knowledge on the relationship between radiation dose to specific cardiac structures and early subclinical cardiac changes and their occurrence over time that could finally lead to cardiac complications. (rug.nl)
Objectives: Radiotherapy improves the survival rate of cancer patients, yet it also involves some inevitable complications. (sciencegate.app)
Radiation-induced heart disease (RIHD) is one of the most serious complications, especially the radiotherapy of thoracic tumors, which is characterized by cardiac oxidative stress disorder and programmed cell death. (sciencegate.app)

The data indicated that radiation treatment worked just as well, if not better, than catheter ablation for certain patients with ventricular tachycardia but in a different and unknown way. (wustl.edu)

Starting 5 years after radiotherapy, and with no sign of a threshold, the risk for major coronary events increased by 7.4% per gray. (cardiobrief.org)
Methods: The EARLY HEART study is a multicenter, prospective cohort study in which 250 women treated for breast cancer and followed for 2 years after radiotherapy will be included. (rug.nl)

Further, this increased risk may just be the tip of the iceberg of more radiation-related problems, warns a cardio-oncologist in an accompanying editorial . (cardiobrief.org)
Dr Tim Wang is an experienced radiation oncologist working in the team at Lakeside specialist breast clinic, who will be able to talk to you in more detail about what to expect from your radiation treatment, advise you on any risks associated with RT and how to manage any side effects. (lakesidespecialists.com.au)
In its traditional CT-MRI simulation and planning workflow, Ingenia has been invaluable for its superb, tunable soft-tissue contrast, particularly for planning prostate cancer cases, according to Prof. Heikki Minn, MD, Radiation Oncologist at TYKS. (philips.com)
Optimal palliative care is provided by a treatment team that may include a gynecologic oncologist, a radiation oncologist, a radiologist, a pain specialist from hospice services, and/or a palliative care physician when available. (medscape.com)

With the development of cardiac conduction system delineation atlases [ 6 ], evaluating the relationship between conduction disorders or arrhythmias and conduction substructure exposure has become possible. (allenpress.com)
The overarching goal of Berrington de González's research is to quantify the potential cancer risks from this important source of radiation exposure in order to provide information for public health and clinical purposes. (wikipedia.org)
Previous results showed some unexpected and potentially concerning effects of cosmic radiation exposure on the brain and investigating the impact of cosmic rays on cognitive function of animals is required to determine whether travel to Mars will be possible for Astronauts. (unil.ch)
However, the risk of exposure of the surrounding normal tissues remains a concern for patient outcomes [ 2 ], with the potential for late tissue damage and escalating the risk of initiating secondary cancers in a patient's lifetime, especially for paediatric patients [ 3 ]. (frontiersin.org)
We investigated prognostic impact of CAC on ACE development with cardiac exposure to radiation. (rmwebzine.re.kr)
The majority of exposure to radiation comes from natural sources. (cdc.gov)
With the exception of indoor radon exposure (and to some extent exposure from terrestrial sources), exposure to natural radiation is only moderately controllable. (cdc.gov)
To spare normal tissues (such as skin or organs which radiation must pass through in order to treat the tumor), shaped radiation beams are aimed from several angles of exposure to intersect at the tumor, providing a much larger absorbed dose there than in the surrounding, healthy tissue. (medicalmarijuana.com)
Purpose: Current Monte Carlo simulations modeling space radiation exposure typically use simplistic human phantoms with low anatomical detail and minimal variability in physical characteristics. (duke.edu)
Ionizing radiation injures tissues variably, depending on factors such as radiation dose, rate of exposure, type of radiation, and part of the body exposed. (msdmanuals.com)
Diagnosis is by history of exposure, symptoms and signs, and sometimes use of radiation detection equipment to localize and identify radionuclide contamination. (msdmanuals.com)

Tim has multiple publications on advanced radiotherapy technique to minimize the risk of heart disease after radiotherapy, such as deep inspiration breath hold technique and volumetric arc radiotherapy. (lakesidespecialists.com.au)

Radiation may also cause increases in pericardial disease, peripheral vascular disease, cardiomyopathy, valvular dysfunction, and arrhythmias, according to Moslehi, and other breast cancer therapies, such as anthracyclines and hormonal therapies, may have "additional cardiotoxic effects. (cardiobrief.org)
Seminal studies demonstrated the increased risk of left ventricular (LV) dysfunction or cardiomyopathy in survivors of childhood cancer who had been treated with anthracyclines and chest radiation. (ajmc.com)
miR-223-3p mimic significantly relieved, while miR-223-3p inhibitor aggravated apoptosis, oxidative damage, and cardiac dysfunction in RIHD mice. (sciencegate.app)

The cardiovascular risks of radiotherapy include coronary artery disease, valvular heart disease, pericardial disease, conduction system abnormalities, and myocardial fibrosis. (ajmc.com)
Management of preexisting conditions such as hypertension, coronary artery disease, congestive heart failure, heart valve disease, and arrhythmias in cancer patients requires an approach customized to their overall care. (ajmc.com)

Despite its selective uptake by neuroendocrine tumors, mIBG accumulates in several normal tissues and leads to tissue-specific radiation toxicities. (aspetjournals.org)
His current interests are head-and-neck and prostate cancer, CNS neoplasms and neuroendocrine tumors. (philips.com)

We evaluated breast cancer patients with (n = 511) or without (n = 600) adjuvant radiotherapy (RT) between 2005 and 2013. (rmwebzine.re.kr)

But the researchers found that a single dose of radiation temporarily activates Notch signaling, leading to a long-term increase in sodium ion channels in the heart muscle, a key physiologic change that can reduce arrhythmias. (wustl.edu)

patients with esophageal cancer with radiotherapy, accumulation of FDG is complicated with increased, decreased or no-change modes related to radiation dose. (aapm.org)

Conventional three-dimensional conformal radiotherapy (3D-CRT) in deep inspiration breath-hold (DIBH) has demonstrated substantial reduction in cardiac doses as compared to treatment in free breathing. (bvsalud.org)

Delivery of high doses (>30 Gy) to the contralateral side was completely avoided with ncVMAT, contrary to the results for cVMAT and 3D-CRT. (bvsalud.org)

MATERIAL AND METHODS: CT series of 20 left sided breast cancer patients were included for planning of locoregional breast radiotherapy including internal mammary nodes (IMN). (bvsalud.org)

purpose: To measure the incidence and hazard factors of enlargement of cardiac silhouette connected thorax radiographs aft radiotherapy for esophageal cancer. (eu.org)

Transporter-mediated uptake has been exploited successfully in nuclear medicine to deliver several radiopharmaceuticals for cancer imaging and treatment ( Zhang and Wang, 2020 ). (aspetjournals.org)

6 Trials are being conducted to validate this approach and define the appropriate method of screening for cardiotoxicity, including the use of cardiac imaging and biomarkers. (ajmc.com)

Berrington de González has conducted a number of studies using the SEER cancer registries to evaluate patterns of second cancers and the second cancer risks related to radiotherapy treatment. (wikipedia.org)
In the accompanying editorial, Javid Moslehi writes that results of the study suggest that "cardiac risk factors should be assessed and aggressively managed - starting at the time of radiation treatment (or even before) and continuing throughout survivorship. (cardiobrief.org)
Multiple studies have examined the issue of the optimal dose of radiotherapy in NSCLC but are complicated by the heterogeneity of the disease itself in terms of size and location of the primary tumor, number and size of involved lymph nodes, and the patient's comorbidities, all of which limit the treatment tolerability and risks. (frontiersin.org)
Delivery of tumoricidal doses to the primary tumor and involved lymph nodes is balanced by treatment-related toxicities, namely esophagitis, pneumonitis, and cardiac injury. (frontiersin.org)
Radiation oncologists use a patient-centered approach and individualized treatment plans. (uclahealth.org)
The purpose of this treatment planning study is to investigate if dynamic techniques in combination with DIBH could improve the quality of the treatment plans and further reduce the doses to the heart and other organs at risk for early-stage breast cancer patients. (bvsalud.org)
For many cancers, including breast cancer and lymphoma, chest radiation remains an important component of the treatment regimen. (ajmc.com)
The development of cardiotoxicity may also increase the risk of morbidity and mortality, as evidenced in an analysis of Medicare patients undergoing treatment for breast cancer. (ajmc.com)
The clinical use of mIBG as a radiopharmaceutical in cancer diagnosis and treatment can be further improved by taking a holistic approach considering mIBG transporters in both cancer and normal tissues. (aspetjournals.org)
Radiotherapy or radiation treatment (RT) is an integral part of breast cancer management. (lakesidespecialists.com.au)
More recently the treatment time can be reduced in many patients following BCS to 3-4 weeks by using so called hypofractionated radiotherapy. (lakesidespecialists.com.au)
He offers treatment in the private sector via Macquarie university hospital and at Westmead public hospital, advanced cardiac sparing radiotherapy techniques including deep inspiratory breath hold technique are available in both hospitals. (lakesidespecialists.com.au)
Therefore, it would be desirable to identify patients, who are at high risk of developing radiation pneumonitis, prior to the start of treatment. (iiarjournals.org)
These patients would require a closer monitoring during the course of radiotherapy and several months following treatment. (iiarjournals.org)
In these patients developing pneumonitis following radiotherapy, clinical and treatment characteristics were analyzed to detect potential risk factors for this treatment-related complication. (iiarjournals.org)
Recurrence or progression after treatment with radiotherapy and temozolomide. (knowcancer.com)
Nitrosourea or mitomycin C within 6 weeks of the first dose of study treatment. (astrazenecaclinicaltrials.com)
Any investigational agents or study drugs from a previous clinical study within 30 days of the first dose of study treatment. (astrazenecaclinicaltrials.com)
Potent inhibitors or inducers or substrates of CYP3A4 within 2 weeks before the first dose of study treatment (3 weeks for St. John's wort) or sensitive substrates of CYP3A4, CYP2C9 and/or CYP2D6 with a narrow therapeutic window within 1 week prior to the first dose of study treatment. (astrazenecaclinicaltrials.com)
4. Major surgery (excluding placement of vascular access) within 4 weeks of the first dose of study treatment. (astrazenecaclinicaltrials.com)
5. Radiotherapy with a wide field of radiation within 4 weeks of the first dose of study treatment. (astrazenecaclinicaltrials.com)
Biotherapy is a treatment that uses substances made from living organisms to treat diseases like cancer. (genesishcs.org)
Imaging procedures are used to diagnose cancer and evaluate if treatment is working, and to see if the cancer has spread or has been contained. (genesishcs.org)
Our pharmacists provide education regarding your cancer treatment and side effect management. (genesishcs.org)
Your doctor will recommend the type of radiation treatment that's right for you and your condition. (genesishcs.org)
Background: Breast cancer is the most common cancer among women, and radiotherapy plays a major role in its treatment. (rug.nl)
Translational cancer research has been around for many years and has resultedin many advancements in cancer treatment. (duke.edu)
As with most incurable cancers, pain is a dominant issue and can require multiple treatment modalities to adequately control. (medscape.com)
In the presence of distant metastasis, cervical cancer is generally not curable, and treatment is of palliative intent. (medscape.com)
Type and length of radiation treatment should depend on the patient's performance status. (medscape.com)
The scientists found that radiation treatment triggered heart muscle cells to begin expressing different genes. (wustl.edu)
[ 1 ] There is growing recognition of palliative care as an integral aspect of cancer treatment, with the ability to improve quality of life and prevent unnecessary hospital admissions and the use of health services, especially when instituted early in the course of disease. (medscape.com)
Inpatients and outpatients with advanced cancer should receive dedicated palliative care services early in the disease course, concurrent with active treatment. (medscape.com)
5 Years Local Recurrencce Rates Following Post- Operative 2D Radiotherapy Treatment Planning Patients - An Institutional Experience. (who.int)
So, purpose of the study is to assess 5 year rates of local recurrence following post-operative 2D Radiotherapy treatment planning. (who.int)
Methods and Materials: We have selected 198 patients treated for post-operative 2D Radiotherapy treatment planning from September 2009-September 2010. (who.int)
All patients had been treated with 2D conventional Radiotherapy treatment plan with tangential fields and supraclavicular and axillary fields according to histopathology report. (who.int)
Radiotherapy treatment dose was - 45Gy/20#, 2.25Gy/#, 5 days/week, total 4 weeks of treatment. (who.int)

Her 2001 dissertation was titled Epidemiological evidence for the risk of cancer from diagnostic X-rays. (wikipedia.org)
The studies vary across the dose-spectrum from low-dose diagnostic and screening procedures to high-dose radiotherapy, with distinct opportunities and challenges in each area. (wikipedia.org)
Radioiodine-labeled meta -iodobenzylguanidine (mIBG) is used as a diagnostic agent ( 123 I-mIBG) and a targeted radiotherapy ( 131 I-mIBG) for neuroendocrine cancers. (aspetjournals.org)
SIGNIFICANCE STATEMENT Radiolabeled meta -iodobenzylguanidine (mIBG) has been used as a diagnostic tool and as radiotherapy for neuroendocrine cancers and other diseases. (aspetjournals.org)
This Ingenia is a workhorse for the department, as about 60% of the MRI scans performed are to aid in planning the hospital's 1,600 radiotherapy patients per year, with cardiac and emergency diagnostic scans making up the balance. (philips.com)

Radiotherapy is delivered to over 50% of cancer patients with curative intent for solid localized tumours [ 1 ]. (frontiersin.org)

This absolute risk can be weighed against the probable absolute reduction in her risk of recurrence or death from breast cancer that would be achieved with radiotherapy. (cardiobrief.org)
For some patients who have undergone a mastectomy who are at higher risk of cancer recurrence, there will be a recommendation for RT to the chest wall and/or the surrounding lymph node basins. (lakesidespecialists.com.au)

The heart is a complex organ at risk, and the multiplicity of its substructures explains the vast range of described radiation-induced cardiotoxicity types [ 4 ]. (allenpress.com)
Cardiotoxicity After Breast Cancer Radiotherapy: Which Part of the Heart Matters Most? (libsyn.com)

JAK1 inhibitor) Primary Objective Phase 1: - Characterize the dose-limiting toxicities (DLTs) of each novel oral targeted agent in combination with oral ASTX727 in order to determine the recommended phase 2 dose (RP2D) and schedule. (mycancergenome.org)
The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)

Findings from the study, according to the authors, "make it possible to estimate" a patient's risk for heart disease related to radiation. (cardiobrief.org)

To perform these studies she and other collaborators developed the NCI Radiation Risk Assessment Tool (RadRAT), which is interactive computer software that uses state of the art risk projection models to estimate lifetime cancer risks and incorporates Monte Carlo simulation methods to assess the impact of uncertainties in the assumptions and data. (wikipedia.org)
Women exposed to larger doses of radiation would be exposed to even greater risks. (cardiobrief.org)
With the prognosis for many cancers improving, we are seeing an appropriate sharpening of focus on the cardiovascular risks of patients who have survived cancer or are being treated for cancer, as well as a growing recognition of the impact this competing morbidity has on both short- and long-term health outcomes. (ajmc.com)
7 The interplay and balance between the competing morbidity and mortality of cardiovascular disease and cancer is particularly important in an older population, whose risks are inherently higher. (ajmc.com)
For many patients, determining if there are cardiovascular risks that need to be addressed before they undergo medical or surgical treatments for cancer is necessary in order to ensure optimal outcomes. (ajmc.com)
Develop strategies that better communicate radiation doses and risks with patients and staff. (hopkinsmedicine.org)
The radiation-induced cancer incidence and cancer-specific mortality, and cardiac heart disease risks were estimated for the assessed techniques. (bvsalud.org)
CONCLUSION: All the radiotherapy techniques had low cancer risks. (bvsalud.org)
Alleviating the consequences of nuclear disasters on views on radiation risks among physicians and patients: Fukushima experience. (fmu.ac.jp)

T. Kairn, S. B. Crowe, "Application of data mining to clinical protocol design: Are breath-hold techniques beneficial for prone breast radiotherapy patients? (tanyakairn.net)

More recently, phase I/II studies using SBRT for dose escalation after conventional chemoradiation in locally advanced NSCLC have been promising with good apparent safety. (frontiersin.org)
By building on the proven concept of conventional chemoradiation for patients with locally advanced NSCLC with a subsequent radiation dose intensification to residual disease with SBRT concurrent with immunotherapy, we hope address the issues of metastatic and local failures. (frontiersin.org)

Berrington de González is co-PI of the UK Pediatric CT scans cohort, which was the first epidemiological study to suggest a direct link between CT scans and subsequent cancer risk. (wikipedia.org)
Since 1947, Dana-Farber's sole focus has been to provide expert cancer care and groundbreaking treatments for adult and pediatric patients. (dana-farber.org)
Search clinical trials for adult and pediatric cancers and blood disorders offered through Dana-Farber and our clinical partners. (dana-farber.org)

Finally, the relationship between change of FDG PET uptake and radiation dose for left ventricular myocardium was calculated. (aapm.org)

Local and distant failure remains high in this group of patients, so dose escalation has been studied in both single institution and national clinical trials. (frontiersin.org)
Clinical trials with domestic animals (cats with spontaneous cancer), in col with Zurich Vet School, Pr C Rohrer. (unil.ch)

She is currently developing a cohort of breast cancer survivors using the electronic medical records from Kaiser Permanente Health Plans to study the late effects of various breast cancer treatments. (wikipedia.org)

4 A recent analysis by Darby et al suggested a linear increase in the incidence of ischemic heart disease with higher estimated radiation doses to the heart. (ajmc.com)
This podcast includes commentary upon a large case control series that examined the incidence of cardiac injury in association with radiation dose to distinct segments of the left ventricle and coronary arteries. (libsyn.com)

Other potentially helpful approaches include external beam radiation or brachytherapy. (medscape.com)
T. Kairn, H. Stephens, C. Deans, "Accuracy of optically stimulated luminescence dosimeter measurements of skin dose from high dose rate brachytherapy", Engineering and Physical Sciences in Medicine, Perth, Australia, 2019. (tanyakairn.net)

They may also help lessen some side effects caused by some cancer treatments. (genesishcs.org)
Our two linear accelerators enable us to offer the latest radiation treatments with little or no wait time. (genesishcs.org)
These treatments include high-dose hypo-fractionated radiation, which compresses your treatments into just a few visits rather than several days in a row. (genesishcs.org)

A new study published in the New England Journal of Medicine offers the best look yet at the increased risk for heart disease produced by radiotherapy for breast cancer. (cardiobrief.org)
The new study, based on data from Sweden and Denmark of women treated with radiotherapy for invasive breast cancer, found a linear increase in the rate of heart disease associated with the dose of radiation received by the heart. (cardiobrief.org)
BACKGROUND: For breast cancer patients, radiotherapy increases the risk of cardiac disease. (bvsalud.org)
PURPOSE: The purpose of this study was to establish a feasible and convenient method for selection of the subset of patients with left-sided breast cancer for whom respiratory-gated radiotherapy (RT) would be necessary to meet the national recommendation regarding radiation dose to the heart. (bvsalud.org)
Validation of coronary artery calcium (CAC) scores as prognostic factors of acute coronary events (ACE) development in breast cancer patients are demanded. (rmwebzine.re.kr)
The CAC score was a significant predictor of ACE in patients with breast cancer. (rmwebzine.re.kr)
RT uses megavoltage X-ray to kill any remaining cancer cells that are left over following your breast cancer surgery. (lakesidespecialists.com.au)
Recent studies have shown that RT not only reduces the chance of cancer relapsing locally, it also reduces the risk of cancer coming back elsewhere, leading to increased chance of cure for breast cancer. (lakesidespecialists.com.au)
Ex Vivo Chromosomal Radiosensitivity Testing in Patients with Pathological Germline Variants in Breast Cancer High-Susceptibility Genes BReast CAncer 1 and BReast CAncer 2. (cdc.gov)
Introduction: In India, almost 150,000 women are diagnosed with breast cancer every year and almost half of patients expected to die of the disease. (who.int)
In India most of patients with breast cancer diagnosed with advanced stage of the disease. (who.int)

Ideally, these drugs would target only cancer cells, but the potential for cardiovascular effects exists due to the presence of identical molecular pathways in cardiovascular cells. (ajmc.com)

APLIUT( Les), research 2001, Radiotherapy XXI application? (silverkingtractors.com)

Quantitative imaging and image quality optimization to assess therapeutic response in prostate cancer patients with skeletal metastases. (hopkinsmedicine.org)
Approximately one in five of the radiotherapy cases are prostate cancer patients and for those, MRI simulation is part of the standard clinical care. (philips.com)
Using MR-only simulation and planning would give us a 'onestop- shop' workflow for imaging, contouring and planning of radical radiotherapy for patients with prostate cancer," he says. (philips.com)

For instance, the use of 131 I radiotherapy to treat thyroid cancer is highly dependent on the selective expression of the sodium/iodine symporter on these cells ( Kogai and Brent, 2012 ). (aspetjournals.org)

Asian Pacific journal of cancer prevention : APJCP 2023 9 24 (9): 3049-3057. (cdc.gov)

In addition, the ability of radiotherapy to stimulate both innate and adaptive immune cells' function has been shown to enhance the therapeutic benefit of immunotherapy in some cases. (unil.ch)
The use of particle accelerators in radiotherapy has significantly changed the therapeutic outcomes for many types of solid tumours. (frontiersin.org)

Each Arm of AM-001 will test an active myeloid target compound in combination with ASTX727, an oral drug combining fixed doses of the DNA methyltransferase inhibitor (DNMTi) decitabine and the cytidine deaminase inhibitor E7727, also known as cedazuridine in a single tablet. (mycancergenome.org)

For patients with newly diagnosed advanced cancer, the Expert Panel suggests early palliative care involvement within 8 weeks after diagnosis. (medscape.com)
All cancer patients should be repeatedly screened for palliative care needs, beginning with their initial diagnosis and thereafter at intervals as clinically indicated. (medscape.com)

Correlation coefficients were calculated between doses to the SAN or the AVN and the whole heart. (allenpress.com)
Although the relative risk was consistent throughout the study, the increase in absolute risk was greatest in women with cardiac risk factors or established heart disease. (cardiobrief.org)
Part 1 is designed to determine the highest safely tolerated dose of radiation to the heart. (uclahealth.org)
The mean heart dose was similar for 3D-CRT and tIMRT, 1.3 and 1.1 Gy, respectively, but significantly higher for pVMAT, 1.6 Gy. (bvsalud.org)
Individual mean heart dose (MHD) was calculated, and no RT was categorized as 0 Gy. (rmwebzine.re.kr)
The absorbed dose will be evaluated globally for the heart and different substructures. (rug.nl)
Conclusions: The MEDIRAD EARLY HEART study will allow identifying the main cardiac imaging and blood-based determinants of radiation-induced cardiac injuries to better propose primary and secondary preventive measures in order to contribute to enhanced patient care and quality of life. (rug.nl)
In the human heart samples, the researchers found that these changes in heart muscle cells were only present in areas of the heart that received the targeted radiation dose. (wustl.edu)

Therefore, high radiation doses are often required that may lead to pneumonitis. (iiarjournals.org)
Pneumonitis can occur up to 21 weeks following radiotherapy ( 3 ). (iiarjournals.org)
Radiation pneumonitis must be considered a serious complication that was reported to be fatal in approximately 2% of the patients ( 2 ). (iiarjournals.org)
Thus, more studies are required to properly identify the rate of symptomatic pneumonitis, particularly studies using modern precision radiotherapy techniques. (iiarjournals.org)
In addition, time to progression (local and/or distant failure) was evaluated in the patients developing pneumonitis, which was calculated from the end of radiotherapy. (iiarjournals.org)

Mean and maximum doses delivered to the SAN and the AVN were retrieved and compared. (allenpress.com)
Organ average and maximum doses, and PTV dose distribution indexes were compared between different techniques. (bvsalud.org)

Anatomy10

Organisms4

Diseases64

Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment93

Phenomena and Processes36

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science10

Named Groups1

Health Care44

Geographicals2

Oncology26

Chemotherapy24

Dosimetry6

Therapy77

Toxicity8

Lung35

Irradiation8

Computed tomography1

VMAT4

20161

Complications6

Ventricular Tachycardia1

Years after radiotherapy2

Oncologist4

Exposure11

Volumetric1

Dysfunction3

Coronary artery2

Tumors2

Adjuvant radiotherapy1

Arrhythmias1

Patients with esophageal1

Deep inspiration breath-hold1

High-doses1

Internal mammary1

Esophageal1

20201

Imaging and biomarkers1

Treatment38

Diagnostic5

Curative1

Recurrence2

Cardiotoxicity2

Toxicities2

Patient's1

Risks9

Breath-hold1

Conventional2

Pediatric3

Left ventricular1

Clinical trials2

Cohort1

Incidence2

Brachytherapy2

Treatments3

Breast cancer11

Cardiovascular1

20011

Prostate cancer3

Thyroid cancer1

20231

Therapeutic2

Combination1

Diagnosis2

Heart8

Pneumonitis5

Maximum doses2