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  • SPECT
  • 2014. "U-SPECT-BioFluo: an integrated radionuclide, bioluminescence, and fluorescence imaging platform. (harvard.edu)
  • Background: In vivo bioluminescence, fluorescence, and single-photon emission computed tomography (SPECT) imaging provide complementary information about biological processes. (harvard.edu)
  • A combination of a fluorescent dye and radioactive moiety was used to directly relate the optical images of the module to the SPECT findings. (harvard.edu)
  • The SPECT and bioluminescence images could be used to place the fluorescence findings in perspective, e.g. by showing tracer accumulation in non-target organs such as the liver and kidneys (SPECT) and giving a semi-quantitative read-out for tumor spread (bioluminescence). (harvard.edu)
  • Conclusions: We developed a fully integrated multimodal platform that provides complementary registered imaging of bioluminescent, fluorescent, and SPECT signatures in a single scanning session with a single dose of anesthesia. (harvard.edu)
  • All entry ECGs, SPECT images and cardiac events were reviewed in blinded manner and were not available to the admitting physicians. (onlinejacc.org)
  • Multiple logistic regression analysis demonstrated abnormal SPECT imaging to be the best predictor of MI and significantly better than clinical data. (onlinejacc.org)
  • Using a normal SPECT image as a criterion not to admit patients would result in a 57% reduction in hospital admissions, with a mean cost savings per patient of $4,258. (onlinejacc.org)
  • Abnormal rest Tc-99m tetrofosmin SPECT imaging accurately predicts acute MI in patients with symptoms and a nondiagnostic ECG, whereas a normal study is associated with a very low cardiac event rate. (onlinejacc.org)
  • The use of acute rest SPECT imaging in the ED can substantially and safely reduce the number of unnecessary hospital admissions. (onlinejacc.org)
  • Methods Twenty-one ACE-1 over-expressing transgenic (Tg) and 18 wild-type control rats were imaged using in vivo micro single-positron emission computed tomography (SPECT)-computed tomography (CT) at 10, 30, 60, and 120 min after Tc-Lis injection. (onlinejacc.org)
  • Milabs B.V., manufacturer of the world's only fully integrated SPECT/PET/Optical/CT-scanner, today announces that the core molecular imaging facility at Queen Mary University of London's Barts Cancer Institute has boosted its radionuclide imaging capabilities with a MILabs VECTor PET/SPECT/CT omni-tomography system. (news-medical.net)
  • conventional
  • Imaging is by a conventional gamma camera focused on the principal 159 keV 123 I-emission using a low energy collimator, although there are reports suggesting that use of a medium energy collimator to block corrupting higher energy emissions may be better. (acc.org)
  • Readers will also find explanation of the relation of the clinical and pathological background to imaging and the value of PET/CT compared with conventional radiological imaging. (tenlong.com.tw)
  • necrosis
  • Although patients are initially asymptomatic, avascular necrosis of the femoral head usually progresses to joint destruction, requiring total hip replacement (THR), usually before the fifth decade (see the images below). (medscape.com)
  • See the images of vascular necrosis below. (medscape.com)
  • assessment
  • Termaat MF, Raijmakers PG, Scholten HJ et al (2005) The accuracy of diagnostic imaging for the assessment of chronic osteomyelitis: a systematic review and meta-analysis. (springer.com)
  • We believe this PET/MRI imaging technology can be of value in the assessment and development of targeted therapeutics," Ms. Sullivan said, "and we are collaborating in this area of research with two major pharmaceutical companies, in addition to evaluating this with our own antibody-based therapeutics. (cnbc.com)
  • These findings provide a basis for further assessment of the role of phase imaging in the evaluation of patients with spontaneous ventricular ectopy. (ahajournals.org)
  • 4 Iodine-123- meta -iodobenzylguanidine ( 123 I- m IBG) is a radiolabeled analogue of the false NE transmitter guanethidine that, when injected intravenously, diffuses into synaptic spaces and is taken up into presynaptic terminals by the NET1 transporter but not metabolized, thereby accumulating and allowing imaging for assessment of the functional state of adrenergic innervation. (acc.org)
  • The specific subproject in the SFB 824 is focussed on therapy assessment in prostate cancer using novel probes for PET-imaging and radionuclide therapy. (academics.de)
  • An imaging technique capable of localizing and quantifying apoptosis in vivo would permit assessment of disease progression or regression and similarly define the efficacy of therapy designed to inhibit or induce cell death ( 5 - 6 ). (pnas.org)
  • After imaging, the rat myocardium was explanted, ex vivo images were acquired, and percent injected dose per gram gamma-well was counted, followed by an assessment of enzyme-linked immunosorbent assay-verified ACE activity and messenger ribonucleic acid expression. (onlinejacc.org)
  • Infection
  • Palestro CJ, Kim CK, Swyer AJ et al (1990) Total-hip arthroplasty: periprosthetic indium-111-labeled leukocyte activity and complementary technetium-99m-sulfur colloid imaging in suspected infection. (springer.com)
  • Love C, Marwin SE, Tomas MB et al (2004) Diagnosing infection in the failed joint replacement: a comparison of coincidence detection 18F-FDG and 111 In-labeled leukocyte/ 99mTc-sulfur colloid marrow imaging. (springer.com)
  • Stumpe KD, Dazzi H, Schaffner A, von Schulthess GK (2000) Infection imaging using whole-body FDG-PET. (springer.com)
  • Nuclear
  • Cynthia L. Sullivan, President and CEO, explained: "PET with F-18 is already one of the most prevalent nuclear tracer methods used in oncology and neurology, so our scientists, as part of developing companion imaging agents for our therapeutics, strived to invent rapid and simple methods to label peptides and other proteins, including antibodies, for convenient and accurate imaging. (cnbc.com)
  • The first clinical validation of this new F-18 labeling kit was just published in The Journal of Nuclear Medicine ( http://jnm.snmjournals.org/content/54/5/691.full.pdf+html ), where National Institute of Health scientists, collaborating with Chinese physicians, successfully imaged all sites of lung cancer in 9 patients, using a peptide labeled by the method patented by Immunomedics. (cnbc.com)
  • The book is published within the Springer series Clinicians' Guides to Radionuclide Hybrid Imaging (compiled under the auspices of the British Nuclear Medicine Society) and will be an excellent asset for referring clinicians, nuclear medicine/radiology physicians, radiographers/technologists, and nurses who routinely work in nuclear medicine and participate in multidisciplinary meetings. (tenlong.com.tw)
  • Synthesis, 68Ga labeling and preliminary evaluation of DOTA peptide binding vascular adhesion protein-1: a potential PET imaging agent for diagnosing osteomyelitis," Nuclear Medicine and Biology , vol. 36, no. 6, pp. 631-641, 2009. (hindawi.com)
  • 68Ga-siderophores for PET imaging of invasive pulmonary aspergillosis: Proof of principle," Journal of Nuclear Medicine , vol. 51, no. 4, pp. 639-645, 2010. (hindawi.com)
  • leukocyte
  • Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer," Blood , vol. 118, no. 13, pp. 3725-3733, 2011. (hindawi.com)
  • Diseases
  • Further," she remarked, "this patent shows how to use this new technology for imaging of cancer, autoimmune, and infectious diseases, particularly with antibody-based targeting agents, which is an area of our strength. (cnbc.com)
  • preclinical
  • Practical experience in cell culture, flow cytometry and animal research including preclinical imaging is required (e.g. (academics.de)
  • Jagiellonian University in Kraków recently became the first institute in Poland to install MILabs' Adaptive U-CT for in-vivo preclinical imaging. (news-medical.net)
  • Patients
  • Sympathetic innervation imaging can provide insights into the prognosis of patients with HF and, in the future, may evolve into a prognostic tool to help risk stratify patients who will benefit from particular interventions including device therapy. (acc.org)
  • Integrating artificial intelligence to analyze imaging data allows early recognition of heart disease, saving patients' time, money and, most importantly, lives. (news-medical.net)
  • These findings suggest that ERNA may serve as a valuable imaging tool in the diagnostic evaluation of patients with suspected ARVC. (nih.gov)
  • Proteins
  • Syngene, a world-leading manufacturer of image analysis solutions, today announced its G:BOX Chemi XX6 multi-application imager is being utilized by scientists at a major London university to speed up analysis of proteins, DNA and cells associated with breast and a range of other cancer types. (news-medical.net)
  • Severity
  • Radionuclide imaging has traditionally been used to evaluate the etiology of HF, whether ischemic or non-ischemic and to determine the extent and severity of ischemia. (acc.org)
  • Conclusions
  • Conclusions The Tc-Lis binds specifically to ACE, and the activity can be localized in Tg rat hearts that over-express human ACE-1 with a signal intensity that is sufficiently high to allow external imaging. (onlinejacc.org)
  • musculoskeletal
  • In addition, the patent now covers the same labeling with F-19, which can be used for MRI, another major imaging modality for depicting, in particular, musculoskeletal and neurological structures. (cnbc.com)
  • cancers
  • The authors reported that they could label their peptide in about 20 minutes and image the cancers within 1 hour of injecting the radiodiagnostic. (cnbc.com)