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  • Medulloblastoma
  • Medulloblastoma (MB) is the most common malignant brain tumor of pediatric age and is characterized by cells expressing stem, astroglial, and neuronal markers. (readbyqxmd.com)
  • Brain tumors are the most common solid malignancies in children, and among these medulloblastoma is the most frequent ( 1 ). (frontiersin.org)
  • Medulloblastoma was classified clinically by Chang in 1969 based on the size and invasiveness of the tumor as determined intra-operatively and on the presence of metastases ( 10 ). (frontiersin.org)
  • Incidence
  • Available registry data from the Surveillance, Epidemiology, and End Results (SEER) database for 1996 to 2000 indicate that the combined incidence of primary invasive CNS tumors in the United States is 6.6 per 100,000 persons per year with an estimated mortality of 4.7 per 100,000 persons per year. (uchile.cl)
  • classification
  • The WHO classification of CNS tumors is the most widely accepted system for classifying CNS tumors and was based on the histological characteristics of the tumor. (radiopaedia.org)
  • The most recent update (2016) has significantly changed the classification of a number of tumor families, introducing a greater reliance on molecular markers. (radiopaedia.org)
  • metastasis
  • Conceptually, CUP represents a tumor that has a greater propensity for early dissemination than the more common presentation in which the primary tumor is apparent with or without metastasis. (uchile.cl)
  • Differentiation
  • Pineal Parenchymal Tumor of Intermediate Differentiation, 49. (springerpub.com)
  • An important gene associated with Bednar Tumor is PDGFB (Platelet Derived Growth Factor Subunit B), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers . (malacards.org)
  • pituitary
  • Hormonal deficiencies may result as the tumor interrupts the pituitary stalk or destroys the hypothalamus. (thedoctorsdoctor.com)
  • INTERVENTION: The patient underwent a right frontotemporal craniotomy with total resection of the suprasellar tumor, which was dissected from the pituitary stalk. (thedoctorsdoctor.com)
  • carcinoma
  • The familial tumor syndromes (and respective chromosomal abnormalities that are associated with CNS neoplasms) include neurofibromatosis type I (17q11), neurofibromatosis type II (22q12), von Hippel-Lindau disease (3p25-26), tuberous sclerosis (9q34, 16p13), Li-Fraumeni syndrome (17p13), Turcot syndrome type 1 (3p21, 7p22), Turcot syndrome type 2 (5q21), and nevoid basal cell carcinoma syndrome (9q22.3). (uchile.cl)
  • primary
  • When these results do not reveal signs of a potential primary lesion and the biopsy is not consistent with a primary tumor at the biopsy site, a CUP must be assumed. (uchile.cl)
  • Other less common primary spinal tumors include sarcomas, astrocytomas, vascular tumors, and chordomas, in decreasing order of frequency. (uchile.cl)
  • Few definitive observations on environmental or occupational causes of primary CNS tumors have been made. (uchile.cl)
  • prognostic
  • Descriptive Comparisons of Additional Secondary Endpoints - To perform descriptive comparisons of additional secondary outcome endpoints, including overall survival, objective tumor response, prognostic factor analysis and quality of life. (clinicaltrials.gov)
  • Tissue
  • Tumors are also called neoplasms , which means that they are composed of new and actively growing tissue. (thefreedictionary.com)
  • Banking of Biospecimens and Neuroimaging Studies - To store blood products (i.e., plasma, DNA and buffy coat), tumor tissue and MRI/CT images for future scientific investigations. (clinicaltrials.gov)
  • diagnosis
  • In all cases, the clinical features must be correlated with the distinctive microscopic appearance of the tumor to confirm or exclude the diagnosis on the basis of physical examination. (doctorlib.info)