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  • Necrosis
  • We investigated the usefulness of magnetization transfer imaging (MTI) and proton magnetic resonance spectroscopy (Proton-MRS) for the early detection of cerebral radiation necrosis in the normal brain of cats. (nii.ac.jp)
  • We speculate that, just before radiation necrosis, cell membrane kinetics was changed as membrane synthesis was disturbed and/or membrane degradation was accelerated. (nii.ac.jp)
  • There is no satisfactory treatment of radiation necrosis using conventional therapy. (statpearls.com)
  • Analysis of the soft tissues and mandible within the radiation field revealed severe unilateral alopecia and dermatitis of the skin, extensive inflammation of the submandibular gland with loss of serous secretory cells, hyperkeratinization and dense connective fiber bundles of the gingival tissue, and disturbed tooth development with necrosis of the pulp. (biomedcentral.com)
  • mice
  • This article reviews studies in which CD2F1 mice were irradiated with sufficiently high doses to cause acute radiation syndrome symptoms and then administered (iv) progenitor-enriched whole blood or peripheral blood mononuclear cells from tocol- and AMD3100-injected donor mice (AMD3100 is a chemokine receptor antagonist used to improve the yield of mobilised progenitors). (sigmaaldrich.com)
  • Mice exposed to two radiation doses, one lethal and one survivable, showed no outward differences for three to four weeks. (dana-farber.org)
  • In addition, when the researchers gave the mice a radiation protection drug that "rescued" many of the human cells, the miRNA test results confirmed this protective effect. (dana-farber.org)
  • Scientists at Washington University School of Medicine in St. Louis have shown that taking a probiotic before radiation therapy can protect the intestine from damage - at least in mice. (wustl.edu)
  • This study showed that the probiotic bacteria Lactobacillus rhamnosus GG (LGG), among other Lactobacillus probiotic strains, protected the lining of the small intestine in mice receiving radiation. (wustl.edu)
  • The researchers found that the probiotic was effective only if given to mice before radiation exposure. (wustl.edu)
  • In mutant mice unable to manufacture COX-2, the radiation destroyed epithelial cells in the intestine, just as it did in mice that didn't receive the probiotic. (wustl.edu)
  • Methods 8-week-old C57BL/6 wild-type or knockout mice were administered probiotic by gavage for 3 days before 12 Gy whole body radiation. (bmj.com)
  • misc{etde_5915766, title = {Radiation genetic injury and metabolic difference of tritiated thymidine in testis of young and adult mice} author = {Mingyue, Lun, and Shoupeng, Zhu} abstractNote = {The radiogenetoxicological effects on the adult testis and the metabolic difference of tritiated thymidine between the testis of young and adult BALB/C mice were studied. (osti.gov)
  • This possibility was evaluated in conventional and decontaminated normal mice and in those exposed to 850 rads x radiation or undergoing graft versus host disease (GVHD). (dtic.mil)
  • For this purpose, one group of male Swiss albino mice was exposed to 7.5 Gy gamma radiation to serve as the irradiated control, while the other group received TCE (75 mg/kg b. wt. (hindawi.com)
  • Ghrelin accelerates wound healing in combined radiation and wound injury in mice. (sigmaaldrich.com)
  • After isolation and analysis of granulation tissues in combined radiation and wound injury (CRWI) mice treated with and without ghrelin, a phenomenon of increased DNA, hexosamine, nitrate and nitrite synthesis, elevated collagen content and enhanced neovascularization was observed after ghrelin treatment. (sigmaaldrich.com)
  • Results showed that RE-CE treatment markedly improved survival, ameliorated organ injuries and myelosuppression, elevated HSPCs frequency, and promoted differentiation and proliferation of HSPCs in irradiated mice. (mdpi.com)
  • TESTES
  • The primary objective of this investigation is to determine the deleterious effects of sub lethal gamma radiation on testes and their possible inhibition by Tinospora cordifolia extract (TCE). (hindawi.com)
  • With the increasing incidences of radiation-induced reproductive disorders, there is an urgent need to identify a radio-protector that is effective in multidirectional manner and can supplement the tissue's own antioxidant strategies to rescue the testes from the deleterious consequences of ROS attack. (pubmedcentralcanada.ca)
  • RATS
  • Healthy male Sprague‑Dawley rats were used in the present study to examine the radioprotective effect of a type of pan-caspase inhibitor, z-VAD-fmk, following radiation, to investigate the effects of caspase blockade in a model of the nucleus of the abducens nerve. (sigmaaldrich.com)
  • Earlier studies in our laboratory (23) showed evidence of dose-related acute injury to the myocardium after exposure of rats to ionizing radiation. (springer.com)
  • The above drugs were administered to male albino rats weighing 150 to 200 g 30 min before exposure to 6000-rad single-dose γ radiation over the precordial area. (springer.com)
  • Abstract
  • Radiation Dose Reduction in the Pediatric Interventional Cardiovascular Laboratory: A Quality Improvement Study [abstract 878, Thurs., Feb. 12. (eurekalert.org)
  • oxidative
  • The first postulates direct damage to small vessel endothelium, being a tissue that exhibits rapid turnover, through interaction with the radiation-induced reactive oxidative species. (statpearls.com)
  • Collectively, these findings demonstrate that RE-CE is able to ameliorate IR-induced hematopoietic injury partly by reducing IR-induced oxidative stress. (mdpi.com)
  • Ionizing radiation inflicts its adverse effects through the generation of oxidative stress that unleash large-scale destruction or damage of various biomolecules. (pubmedcentralcanada.ca)
  • mechanisms
  • A discussion of the mechanisms of injury and the threshold doses for their occurrence can be found in Koenig et al. (springer.com)
  • It reviews the mechanisms of radiation injury, the clinical problem, the preclinical and clinical development of candidate agents, and the design and conduct of clinical trials. (aacrjournals.org)
  • The mechanisms of radiation injury, the clinical challenges, and the design and conduct of clinical trials are reviewed. (aacrjournals.org)
  • Two mechanisms of injury have been proposed and supported by animal and in vitro studies. (statpearls.com)
  • Impaired wound healing caused by radiation happens frequently in clinical practice, and the exact mechanisms remain partly unclear. (sigmaaldrich.com)
  • complications
  • Tissue complications caused by radiation-induced stem cell depletion may result in structural and functional alterations of the gastrointestinal (GI) tract. (irsn.fr)
  • cutaneous
  • This Cutaneous Radiation Injury Treatment market study offers a comprehensive analysis of the business models, key strategies, and respective market shares of some of the most prominent players in this landscape. (futuremarketinsights.com)
  • This study is one of the most comprehensive documentation that captures all the facets of the evolving Cutaneous Radiation Injury Treatment market. (futuremarketinsights.com)
  • Emergence of new technology and development of new treatment option available will further drive the growth of cutaneous radiation therapy treatment market. (futuremarketinsights.com)
  • Growing prevalence of cancer among population, growing number of cardiovascular surgeries, and growing adoption of radiation therapy particularly in the middle and low income economies further spur the cutaneous radiation injury treatment market. (futuremarketinsights.com)
  • Favorable reimbursement scenarios and government initiative towards the treatment for disease which are growing rapidly such as cancer will further lead to the growth of cutaneous radiation injury treatment market. (futuremarketinsights.com)
  • Advances in the technology and development of new therapeutic regimens for the cutaneous radiation injury treatment creates huge opportunity for the cutaneous radiation injury treatment market to grow in the forecast period. (futuremarketinsights.com)
  • Advancements with targeted therapies for reducing the underlying inflammatory cascade, such as superoxide dismutase/catalase mimetic to decrease reactive oxygen species and interleukin inhibitors will further drive the cutaneous radiation injury treatment market. (futuremarketinsights.com)
  • The North America is expected to contribute to a major share in the global cutaneous radiation injury treatment, owing to increasing incidence of cancer, growing demand of radiation therapy. (futuremarketinsights.com)
  • Healthy reimbursement policies and well developed healthcare facilities further drive the market for cutaneous radiation injury treatment. (futuremarketinsights.com)
  • Europe contributes for the second largest share with significant growth in the global cutaneous radiation injury treatment market owing to technological advancement in the treatment for cancer coupled with growing adoption of new treatment regimen and undergoing clinical trial for the development of new drug for cutaneous radiation injury treatment. (futuremarketinsights.com)
  • In its most severe form late radiation injuries of the head and neck can progress to cutaneous fistulas, trismus, pathologic fractures and osteoradionecrosis [ 8 ]. (biomedcentral.com)
  • epithelium
  • If the epithelium breaks down as the result of radiation, the bacteria that normally reside in the intestine can be released, travel through the body and cause serious problems such as sepsis. (wustl.edu)
  • significantly
  • The mean cumulative skin dose per minute of radiation decreased significantly, from 91.30 (plus or minus 166.23) cGy-cm2/min. (eurekalert.org)
  • Platelet number is diminished by radiation, a further reduction of the thrombocyte adhesion and aggregation would increase significantly the risk of acute bleeding. (dtic.mil)
  • In addition, the aggregation time reflecting the speed of the platelet aggregation is decreased after 2 hours, but significantly increased after 24 hours following combined injuries. (dtic.mil)
  • reactive
  • Since the cells of spermatogenic lineage are especially vulnerable to radiation-induced reactive oxygen species (ROS) because they are constantly under mitosis or meiosis. (pubmedcentralcanada.ca)
  • time of radiation
  • The other model describes a delayed process initiated at the time of radiation with the release of bioactive, fibrogenic cytokines inhibiting parenchymal and stem cells and causing the extensive fibrosis seen in several damaged irradiated tissue. (statpearls.com)
  • Cells exhibit different levels of radiosensitivity depending on their stage in the cell cycle at the time of radiation [ 4 ]. (biomedcentral.com)
  • cancer
  • A novel blood test could greatly improve triage of victims of radiation accidents by rapidly predicting who will survive, who will die, and who should receive immediate medical countermeasures, according to scientists at Dana-Farber Cancer Institute. (dana-farber.org)
  • It is known that children and fetuses are at risk of cancer from medical radiation. (springer.com)
  • It is reasonable to expect that these agents will be less likely to also protect cancer cells than a radiation "protector," which, by definition, is administered before or during radiation. (aacrjournals.org)
  • Unfortunately, ionizing radiation when used to treat cancer is a double-edged sword. (statpearls.com)
  • Thus the patient is fortunate to be cured of cancer, but may be faced with delayed radiation injury months or even decades after the treatment is complete. (statpearls.com)
  • What Marilyn Skinner kisses repaired n't deals have that full Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation of account you generally relatively Fill to give just every 2019t results. (onsitepr.com)
  • There have much and exclusive seconds which effectively 're the links of Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, to serving its Accused offers. (onsitepr.com)
  • moderate Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, can delete from the formal. (onsitepr.com)
  • neoplasm
  • Some fluoroscopists have been injured from their use of fluoroscopy, and they are known to be at risk of radiation-induced neoplasm when radiation is not well-controlled. (springer.com)
  • Ionizing
  • Radiation injury , tissue damage or changes caused by exposure to ionizing radiation -namely, gamma rays , X-rays , and such high-energy particles as neutrons, electrons, and positrons. (britannica.com)
  • Sources of ionizing radiation may be natural (e.g., radioactive substances such as the element radium or the radioisotopes potassium-40 and carbon-14) or man-made (X-ray machines, nuclear reactors, particle accelerators, nuclear weapons, etc. (britannica.com)
  • The incidence of mental retardation and reduced head size in such children increased substantially when exposure occurred between the 8th and 15th weeks of gestation, which has been determined to be the age of greatest susceptibility to ionizing radiation. (britannica.com)
  • However, it is indiscriminate, and despite best efforts and intentions, there is no way to protect nonmalignant tissues from being irreparably damaged by the ionizing radiation. (statpearls.com)
  • This study analyzed practice changes in the pediatric cardiac catheterization laboratory at Children's Mercy Hospital, aimed at reducing patient and provider exposure to ionizing radiation. (eurekalert.org)
  • The ionizing radiation interrupts the growth of cancerous cells by causing direct damage to the DNA and other cell components, or through the formation of free radicals. (biomedcentral.com)
  • Ionizing radiation (IR)-induced myelosuppression is largely attributed to the injury of hematopoietic stem and progenitor cells (HSPCs). (mdpi.com)
  • Han X, Xue X, Zhao Y, Li Y, Liu W, Zhang J, Fan S. Rutin-Enriched Extract from Coriandrum s ativum L. Ameliorates Ionizing Radiation-Induced Hematopoietic Injury. (mdpi.com)
  • Chernobyl
  • Knizhnikov VA, Shandala NK, Komleva VA (1992) Study of anticarcinogenic properties of selenium microelement in Chernobyl-type radiation model. (springer.com)
  • The need for faster, more definitive predictive tests was highlighted by radiation accidents such as the 2011 reactor meltdown at the Fukushima Daiichi plant in Japan, radiation releases from Chernobyl and Three Mile Island, as well as the potential for terrorist radiologic weapons. (dana-farber.org)
  • lethal
  • Any living organism can be killed by radiation if exposed to a large enough dose, but the lethal dose varies greatly from species to species. (britannica.com)
  • After a radiation release, there is currently no way to tell who was exposed and who wasn't, and if someone was exposed, is it lethal or not? (dana-farber.org)
  • intestine
  • In the large intestine, or colon, cells that make COX-2 migrate to sites of injury and assist in repair," Ciorba says. (wustl.edu)