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  • lymphocytes
  • Lymphocytes are white blood cells that recognize and destroy disease-causing organisms. (encyclopedia.com)
  • To determine if blunting of apoptotic response (with two or more consecutive apoptotic fractions) following treatment using annexin V staining of peripheral blood CD5+ and CD19+ lymphocytes by flow cytometry is predictive of outcome (i.e. lack of clinical response). (knowcancer.com)
  • Lymphomas are cancer of white blood cells (lymphocytes) and can be divided depending on the type of cells, B-lymphocytes (B-cells) or T-lymphocytes (T-cells), AITL is a T-cell lymphoma. (rarediseases.org)
  • Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes. (rarediseases.org)
  • In addition to the lymph nodes, the lymphatic system includes the spleen, which filters worn-out red blood cells and produces lymphocytes, and bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. (rarediseases.org)
  • There are two main types of lymphocytes: B-lymphocytes (B-cells), which may produce specific antibodies to "neutralize" certain invading microorganisms, and T-lymphocytes (T-cells), which may directly destroy microorganisms or assist in the activities of other lymphocytes. (rarediseases.org)
  • myeloma
  • It is important to consider the possibility of a future ASCT at the time of diagnosis because stem cells have to be collected and frozen early in the disease course even if the initial treatment plan involves ASCT for treatment after a myeloma recurrence. (radiationoncologyassociates.co)
  • monoclonal
  • Since there is no single diagnostic test for the diagnosis of POEMS syndrome, the diagnosis is typically based on the presence of polyneuropathy associated with monoclonal plasma cell disorders presenting with the distinct symptoms described above. (biomedcentral.com)
  • Patients were diagnosed with POEMS syndrome if they met the two mandatory major criteria (polyneuropathy and monoclonal plasma cell-proliferative disorder), at least one of the other major criteria (CD, sclerotic bone lesion, and VEGF elevation), and at least one of the minor criteria (organomegaly, extravascular volume overload, endocrinopathy, skin changes, papilledema, and thrombocytosis/polycythemia). (biomedcentral.com)
  • Nearly all patients with POEMS have a lambda light chain monoclonal plasma cell proliferative disorder, although rare cases with heavy chain disease have been reported. (renalandurologynews.com)
  • Some may present with known history of a specific monoclonal gammopathy, while in others, boney lesions of osteomyeloma or other evidence of a plasma cell dyscrasia are detected during workup for POEMS in patients with neuropathy. (renalandurologynews.com)