• Cordyceps cicadae mushroom treatment prevented testicular damage and tumors caused by the chemotherapy drug cisplatin via inhibition of oxidative stress and inflammation in rats. (greenmedinfo.com)
  • Acetyl-L-carnitine in the amount of 1,000 mg three times per day for eight weeks has been shown to improve nerve damage (neuropathy) caused by the chemotherapy drug cisplatin. (peacehealth.org)
  • The study's results confirmed previous findings that a treatment protocol of cisplatin and radiation was superior to radiation alone and confirmed the feasibility of using primary tumor cells for spheroid formation, which could yield MCTS that more closely mimic in vivo tumor behavior. (corning.com)
  • Spheroids have also been used to study transcoelomic metastasis in ovarian cancer, in which primary tumor cells seep into the abdominal cavity, where they form spheroids and then travel through fluids to secondary sites. (corning.com)
  • It works by binding to and blocking the action of a protein called ABL, which signals tumor cells to multiply. (policylab.us)
  • This helps slow or stop the proliferation of tumor cells. (policylab.us)
  • Here we show that nutrient deprivation can consistently enhance the sensitivity of tumor cells to cell death induction by CDDP, also of those malignancies particularly resistant to any treatment, such as oncogenic BRAF melanomas. (unisalento.it)
  • This study investigated the role of TIGAR in DNA damage response (DDR) induced by genotoxic drugs and hypoxia in tumor cells. (nature.com)
  • In the early 1920s, German biochemist and physiologist Otto Warburg conducted groundbreaking research and proposed the famous "Warburg effect": Tumor cells prefer to use glycolysis for glucose metabolism even in oxygen-rich conditions, rather than more efficient mitochondrial oxidative phosphorylation for ATP production [ 3 ]. (biomedcentral.com)
  • Metabolic reprogramming refers to the redefinition of the flow and flux of nutrient in tumor cells in the metabolic network to meet the needs of tumor cells for energy and anabolism [ 8 ]. (biomedcentral.com)
  • Weinberg characterized "aberrant metabolic phenotype" with "autologous proliferation signaling, apoptosis resistance, evasion of proliferation inhibition, continuous angiogenesis, infiltration and migration, unlimited replication capacity, immune escape" in tumor cells. (biomedcentral.com)
  • In PTT, nanoparticles are delivered to the tumor cells and subsequently exposed to light at the NPs resonant energy, causing synchronized oscillation of the NPs conduction-band electrons, what results in heat production [ 6 ]. (biomedcentral.com)
  • Autophagy also protects tumor cells attacked by chemotherapy drugs or radiotherapy radiation to prevent apoptosis [ 9 ]. (biomedcentral.com)
  • Therefore, it is reasonable to hypothesize that increased chemotherapy sensitivity of tumor cells may be achieved by inhibiting autophagy. (biomedcentral.com)
  • Typically, rapidly proliferating tumor cells have glycolytic rates up to 200 times higher than those of their normal tissue of origin, even in the presence of oxygen [ 3 ]. (hindawi.com)
  • Lymphoma arises mainly from the uncontrolled proliferation of T-cells and can become cancerous. (wikipedia.org)
  • The ECM a researcher chooses has a significant effect on cancer cell proliferation, initiation, invasion, and metastasis, and it alters how the tumor model responds to drug therapy. (corning.com)
  • The aberrant glucose metabolism is associated with dramatically increased bioenergetics, biosynthetic, and redox demands, which is vital to maintain rapid cell proliferation, tumor progression, and resistance to chemotherapy and radiation. (biomedcentral.com)
  • Most cancer cells undergo metabolic reprogramming that support their survival and proliferation. (degruyter.com)
  • H2 has been shown to reduce the excessive expressions of MMP genes (MMP proteins are involved in multiple functions in cells, including cell proliferation, cartilage synthesis, apoptosis, angiogenesis, etc). (h2hubb.com)
  • Cell proliferation involves the replication of all cellular contents with the required energy for this to happen. (hindawi.com)
  • To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)
  • This activation is necessary for both cell proliferation as well as glucose uptake and use. (hindawi.com)
  • Also known as adenocarcinoma or Squamous cell carcinoma, they account for 80% of Lung Cancer cases. (zuviuslifesciences.in)
  • They can also start in flat, thin cells called squamous cells. (zuviuslifesciences.in)
  • It derives from the epithelium of the inner prepuce and glans which turn cancerous and form squamous cell carcinoma of the penis. (medthical.com)
  • It is associated with squamous cell carcinoma. (medthical.com)
  • Malignant (cancer) lesions are squamous cell carcinoma . (medthical.com)
  • Bowen disease is a subset of squamous cell carcinoma commonly appear in the genitalia area. (medthical.com)
  • At present, advanced stage human Papillomavirus (HPV) negative and positive head and neck squamous cell carcinoma (HNSCC) are treated by intense multimodal therapy that includes radiochemotherapy, which are associated with relevant side effects. (oncotarget.com)
  • Two main etiologies of head and neck squamous cell carcinoma (HNSCC) are recognized that reveal distinct biological characteristics. (oncotarget.com)
  • Excretory stem cells give rise to squamous cell and mucoepidermoid carcinomas, while intercalated stem cells give rise to pleomorphic adenomas, oncocytomas, adenoid cystic carcinomas, adenocarcinomas, and acinic cell carcinomas. (medscape.com)
  • Squamous cell carcinomas arise from excretory duct cells, pleomorphic adenomas arise from the intercalated duct cells, oncocytomas arise from the striated duct cells, and acinic cell carcinomas arise from acinar cells. (medscape.com)
  • After therapy, the incidence of pleomorphic adenomas, mucoepidermoid carcinomas, and squamous cell carcinomas is increased. (medscape.com)
  • Tobacco and alcohol, which are highly associated with head and neck squamous cell carcinoma, have not been shown to play a role in the development of malignancies of the salivary glands. (medscape.com)
  • HNSCC is the sixth oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)
  • Patients usually do not increased incidence of oropharyngeal squamous cell carci- seek counseling until the tumors are large because small noma (OSCC), the head and neck cancer in which HPV is tumors cause little distress and may not be noticed by the most commonly found ( 4 ). (cdc.gov)
  • the goal is to cause as little functional squamous cell carcinoma type (HNSCC) and includes and cosmetic damage as possible ( 6 , 9 ). (cdc.gov)
  • A growing body of research shows that human papillomavirus (HPV) is a common and increasing cause of oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)
  • We focus on the role of HPV in the increased incidence of oropharyngeal squamous cell carcinoma (OSCC), the head and neck cancer in which HPV is most commonly found ( 4 ). (cdc.gov)
  • Head and neck cancer most commonly is of the squamous cell carcinoma type (HNSCC) and includes cancers of the oral cavity, oropharynx, hypopharynx, larynx, sinonasal tract, and nasopharynx. (cdc.gov)
  • risk of esophageal squamous cell carcinoma. (who.int)
  • PMID:18786442 mutations and the risk of esophageal squamous cell carcinoma. (who.int)
  • Arbyn M, Bergeron C, Klinkhamer P, Martin-Hirsch squamous cell carcinoma in a high-risk region in Iran. (who.int)
  • MCTS can mimic metastatic microtumors, which form when cancer cells spread from the site of the primary tumor via intravasation into the blood circulation and via extravasation into the parenchyma of an organ. (corning.com)
  • Thus MCT models are particularly useful, according to Science Advances, for developing therapies that target metastatic cells. (corning.com)
  • Participant must have histologically confirmed, locally advanced (i.e., not amenable to curative surgery and/or radiation therapy) or metastatic cancer that has progressed during or after at least 1 prior therapeutic regimen. (uclahealth.org)
  • Treatment of patients with advanced and metastatic LC presents a significant challenge as malignant cells use different mechanisms to resist chemotherapy. (preprints.org)
  • Has received prior systemic anticancer therapy for metastatic NSCLC. (who.int)
  • SETD8 was a promising therapeutic target to ameliorate cisplatin resistance and improve the efficacy of chemotherapy. (biomedcentral.com)
  • Primary cutaneous anaplastic large cell lymphoma: a less aggressive ALCL that commonly presents as skin tumors. (wikipedia.org)
  • MCTS mimic many of the features that tumors exhibit in the human body, including extracellular matrix (ECM) deposition between cells, gradients in nutrient concentration, and strong cell-cell junctions. (corning.com)
  • They have complementary mechanisms to hinder the carcinogenic process by searching free radicals, inhibiting survival and multiplication of malignant cells, as well as reducing invasiveness and angiogenesis of tumors. (researchsquare.com)
  • Radiation is used to destroy mesothelioma tumors that persist after surgery or chemotherapy. (preschoolcurriculum.in)
  • Children most at risk for chemotherapy-caused hearing loss are those treated for brain tumors, germ cell tumors, osteosarcoma, and neuroblastoma. (alexslemonade.org)
  • Survivors who had head and neck tumors treated with higher doses of radiation and/or older radiation techniques (from the 1950s and 1960s) often develop hearing loss. (alexslemonade.org)
  • Here we investigated the effect Cisplatin (CDDP), one of the most potent chemotherapeutic agent used to treat tumors, in association with fasting in wild type and mutated BRAF(V600E) melanoma cell lines. (unisalento.it)
  • Their job is to keep abnormal cells from growing and forming tumors. (healthywomen.org)
  • A research study published in the journal Science Translational Medicine in July, 2017 suggests that chemotherapy may increase the chance of cancer cells spreading to other parts of the body, and also lead to more aggressive tumors . (diagnose-me.com)
  • Because these tumors are rare it is not known which is the best combination of drugs, but chemotherapy can often control the tumor for long periods. (diagnose-me.com)
  • Clinically, although chemotherapy is one of the most commonly used methods of treating tumors, chemotherapeutic drugs can induce autophagic flux and increase tumor cell resistance, leading to drug tolerance. (biomedcentral.com)
  • Although autophagy is an important life process involved in the maintenance of normal cell homeostasis and can actively remove excess, damaged, senescent proteins and organelles to achieve self-renewal [ 5 ], it is a double-edged sword for tumors. (biomedcentral.com)
  • This theory holds that tumors arise from 1 of 2 undifferentiated stem cells: the excretory duct reserve cell or the intercalated duct reserve cell. (medscape.com)
  • This theory more logically explains neoplasms that contain multiple discrete cell types, such as pleomorphic adenomas and Warthin tumors. (medscape.com)
  • Has a diagnosis of small cell lung cancer or, for mixed tumors, presence of small cell elements. (who.int)
  • Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program. (cancercentrum.se)
  • Chemotherapy uses anticancer (cytotoxic) drugs to destroy cancer cells. (cancer.ca)
  • It is most often used to treat cancer, by means of cytotoxic and other drugs. (diagnose-me.com)
  • There are a lot of studies, which showed non-toxicity of NPs, as well as high number of publications showing a cytotoxic effect of nanoparticles on the cells. (biomedcentral.com)
  • 1] Until recently, treatment paradigms in gynecologic oncology have mainly included a combination of radical surgery, cytotoxic chemotherapy (CT), and radiation therapy. (cancernetwork.com)
  • however these treatments have limited efficacy and induce significant toxic effects on healthy cells. (unisalento.it)
  • However, Hsp90 interferes with a number of molecules that up-regulate the intracellular level of survivin, raising the question that clinical use of Hsp90 inhibitors may indirectly induce survivin expression and subsequently enhance cancer anti-drug responses. (biomedcentral.com)
  • Instead, targeting Hsp90 with small molecule inhibitors will induce the over-expression of survivin in certain cancer cell lines and subsequently enhances the ability of cell survival in drug-treated situations. (biomedcentral.com)
  • For example, over-expression of survivin has been shown to induce drug resistance against anti-mitotic compounds by stabilizing microtubule network in vincristine/colchicine-resistant oral cancer cells and down-regulation of it restores drug sensitivity to those compounds in the same cell line [ 9 ]. (biomedcentral.com)
  • Epirubicin, a DNA damaging anticancer agent and CoCl 2 , which was used to imitate hypoxia condition, was applied to induce DNA damage in TIGAR knockdown HepG2 cells. (nature.com)
  • Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
  • On the other hand, clinically, acquired chemo-resistant cell against an anticancer drug after therapy will be a critical problem to be solved, urgently. (aacrjournals.org)
  • A study published in Anticancer Research on head and neck cancers charted the development of a method for generating MCTS from tumor biopsies, the first step toward creating a method of assessing individual susceptibility to chemotherapy drugs and radiation therapy. (corning.com)
  • As a direct result of this work, in 2014, the PARP inhibitor olaparib became the first targeted therapy for the treatment of patients with ovarian cancer with germline BRCA1 / 2 mutations to be approved by the European Medicines Agency (EMA) and US Food and Drug Administration (FDA). (nature.com)
  • Recent studies indicate that Pt NPs can be used as a therapy for cancer showing a limited toxicity to healthy cells. (aiche.org)
  • Combination chemotherapy is often utilized in conjunction with other treatments, such as radiation therapy and immune therapy. (preschoolcurriculum.in)
  • Gene therapy is another experimental treatment that alters the body's cells to fight mesothelioma tumours. (preschoolcurriculum.in)
  • External beam radiation therapy is the most popular method of treatment, but it can also be administered via brachytherapy and intraoperative radiation. (preschoolcurriculum.in)
  • Limited-stage disease is typically treated with systemic therapy, with or without radiation therapy. (medscape.com)
  • chemotherapy is given first, followed by radiation therapy because of the high rate of responsiveness to chemotherapy for SCLC. (medscape.com)
  • Patients found to have pN1 or pN2 disease should receive systemic therapy with or without mediastinal radiation therapy. (medscape.com)
  • Thoracic radiation therapy should be considered for patients with extensive stage disease after they complete systemic therapy. (medscape.com)
  • One of most promising novel therapeutic approach to cancer therapy is the combination of anti-cancer drugs with calorie restriction. (unisalento.it)
  • Mechanistic studies revealed that the combined therapy induced cell death is characterized by ROS accumulation and ATF4 in the absence of ER-stress. (unisalento.it)
  • Chemotherapy is sometimes combined with radiation therapy to treat stomach cancer. (cancer.ca)
  • The chemotherapy drugs help make the cancer cells more sensitive to radiation therapy. (cancer.ca)
  • How often and how long chemotherapy is given depends on the type of drug or drug combination used and if radiation therapy is used at the same time. (cancer.ca)
  • Side effects of chemotherapy will depend mainly on the type of drug or combination, the dose, how it's given, if radiation therapy is given at the same time and your overall health. (cancer.ca)
  • 3 Although there have been no randomised controlled trials to compare surgery with radiation therapy or chemotherapy, observational studies have suggested that surgery is the most curative treatment for lung cancer. (bmj.com)
  • The treatment modalities available include topical treatment, surgery (main treatment), radiation therapy and chemotherapy. (medthical.com)
  • BACKGROUND: Currently, radiation therapy treatment planning system intends biological optimization that relies heavily upon plan metrics from tumor control probability (TCP) and normal tissue complication probability (NTCP) modeling. (bvsalud.org)
  • Treatment usually involves radiation therapy or chemotherapy . (diagnose-me.com)
  • It is hard to limit the effects of therapy so that only cancer cells are destroyed. (diagnose-me.com)
  • Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures. (peacehealth.org)
  • PtAu NRs could be applied as effective light-absorbers in the PTT anticancer therapy. (biomedcentral.com)
  • Classical Hodgkin lymphoma (cHL) is a highly curable disease (70-80%), even though long-term toxicities, drug resistance, and predicting clinical responses to therapy are major challenges in cHL treatment. (preprints.org)
  • Some patients with extensive small cell lung cancer also receive radiation therapy. (yourcancercare.com)
  • Radiation therapy can reduce symptoms from cancer that has spread outside of the lungs, and also helps to manage cancer that has spread to the brain (brain metastases). (yourcancercare.com)
  • Radiation therapy to the head may also be used preventively to reduce the likelihood of brain metastases. (yourcancercare.com)
  • In conclusion, this review sheds light on the emerging insights into nutraceuticals' anticancer properties and their potential as valuable components of integrative cancer therapy. (ijpbp.com)
  • Radiation therapy in low doses has been associated with the development of parotid neoplasms 15-20 years after treatment. (medscape.com)
  • A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)
  • Has received radiation therapy to the lung (>30 Gray) within 6 months of start of study intervention. (who.int)
  • In HRSdx cells, less sensitive to DNA damage and oxidative stress, the efflux drug transporters MDR1 and MRP1 were not up-regulated, and doxorubicin accumulated in cytoplasm rather than in nucleus. (preprints.org)
  • There are many factors and variables that contribute to the pathogenesis of cancers such as oxidative stress, DNA damage and mutation, ionizing radiations, carcinogenic chemicals, and so much more. (h2hubb.com)
  • Radiation will overcome acquired chemo-resistance with cisplatin in gastric cancer cell. (aacrjournals.org)
  • We established CDDP-resistant gastric cancer cell lines using TMK-1 and MKN-74 with long-term exposure (several months) with low concentration of CDDP (TMK-1/D and MKN-74/D). Evaluation of each cell resistance was performed with MTT method. (aacrjournals.org)
  • Radiation might have potent possibilities to re-control and overcome acquired resistance to CDDP after exposure with CDDP in gastric cancer cell lines. (aacrjournals.org)
  • Sensitization of cancer cells to conventional drugs using multi-target agents that block survival and oncogenic pathways, alone or in combination, is an emerging strategy to overcome drug resistance. (researchsquare.com)
  • Potential of nanomedicines to overcome resistance, ameliorate solubility, improve pharmacological profile, and reduce adverse effects of chemotherapeutical drugs is thus highly regarded. (oaepublish.com)
  • Here, we provide a closer review of clinical prospects and mechanisms of action of nanomedicines to overcome drug resistance. (oaepublish.com)
  • Consequent drug resistance allows the tumour to grow and spread even with the treatment [ 3 ] . (oaepublish.com)
  • In addition, heterogeneity among patients and tumours make drug resistance a highly challenging event [ 5 ] . (oaepublish.com)
  • Closer understanding of the mechanisms involved in drug resistance is needed in order to achieve better outcomes in cancer treatment. (oaepublish.com)
  • Cisplatin is commonly used to treat cervical cancer while drug resistance limits its effectiveness. (biomedcentral.com)
  • In addition, SETD8 expression was positively correlated with resistance to cisplatin and negatively associated with the prognosis of cervical cancer patients. (biomedcentral.com)
  • These observations indicate the need to investigate mechanisms of drug resistance. (biomedcentral.com)
  • Various mechanisms are possible for the development of resistance to platinum-based drugs. (biomedcentral.com)
  • Among them, increased rate of DNA repair is considered as a key factor for cisplatin resistance. (biomedcentral.com)
  • Due to various factors including socioeconomic factors, compliance is poor to anti-tuberculosis drugs, leading to resistance. (preprints.org)
  • Conclusion Multi-drug resistance tuberculosis is very prevalent in Pakistan, which may increase burden on health care system and may lead to various complications of tuberculosis. (preprints.org)
  • Drug resistance (DR) is a complex process that occurs due to a variety of genetic and acquired factors. (preprints.org)
  • These attributes enhance the delivery of multiple therapeutic agents directly to the tumor microenvironment (TME), resulting in reversal of LC resistance to anticancer treatment. (preprints.org)
  • To solve these problems, we characterized two cHL cell lines with acquired resistance to doxorubicin, KM-H2dx and HDLM-2dx (HRSdx), generated from KM-H2 and HDLM-2 cells, respectively. (preprints.org)
  • Both HDLM-2 and HDLM-2dx cells had an intrinsic resistance to BV but not to the drug MMAE. (preprints.org)
  • Although first-line clinical chemotherapy drugs can prolong the survival of NSCLC Patients to a certain extent, long-term drug use is prone to drug resistance with a greatly reduced chemotherapy effect. (biomedcentral.com)
  • In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
  • In a synthetic-lethality screen, BRAF inhibition in colorectal cancer cells exposed a sensitivity to the concomitant loss or inhibition of the receptor tyrosine kinase EGFR, both in vitro and in vivo. (nature.com)
  • Interestingly, real-time PCR and translation inhibition studies revealed that survivin was over-expressed partially through the up-regulation of protein translation instead of gene transcription in A549 cancer cells. (biomedcentral.com)
  • In addition, 17-AAG-treated A549, HONE-1 and HT-29 cells showed reduced proteasomal activity while inhibition of 26S proteasome activity further increased the amount of survivin protein in cells. (biomedcentral.com)
  • In all five HPV negative and HPV positive cell lines tested, roscovitine caused inhibition of CDK1 and 2. (oncotarget.com)
  • Scientific Methods: In vitro growth inhibition assays were completed with AHCC alone and in combination with PLD in panel of human cancer cell lines and findings confirmed in vivo in an ovarian cancer xenograft mouse model. (researchgate.net)
  • First, molecular hydrogen caused growth inhibition of human tongue carcinoma cells HSC-4 (cancerous) and human fibrosarcoma cells HT-1080 (cancerous) but did not compromise growth of normal human tongue epithelial-like cells DOK [ 14 ]. (h2hubb.com)
  • See: Synthesis of combretastatin A-4 prodrugs: Pettit et al , Anticancer drug Design , 10 ,(1995a) 299 and more recently via a new method ). (bris.ac.uk)
  • Consequently, ROS-modulation has emerged as an anticancer strategy with synthesis of various ROS-inducing or responsive agents that target cancer cells. (degruyter.com)
  • It works by blocking the synthesis of genetic material (DNA and RNA) and certain essential proteins and enzymes which are required for the cells to grow and multiply. (netmeds.com)
  • Conventionally, Hodgkin's disease is treated by a team of specialists that may include a medical oncologist , oncology nurse, and/or radiation oncologist. (diagnose-me.com)
  • And, radiation may be modifying some acquired resistant mechanism to CDDP in gastric cancer cells. (aacrjournals.org)
  • New Therapeutic Procedure To Eliminate Cancer Cells Infiltrated In Brain. (usherbrooke.ca)
  • Collagen type I hydrogels have been used to grow MCTS from osteosarcomas, breast cancer cells, human colorectal cancer cells, prostate cancer cell lines, and primary cancer cells from colorectal cancer patients, according to the Science Advances study. (corning.com)
  • Radiotherapy may also be given after surgery to help to get rid of any cancer cells that may have been left behind. (healthlibrary.com)
  • Malignant tumour is a group of cancer cells that can invade and destroy nearby tissue. (zuviuslifesciences.in)
  • Rapidly dividing cells had long been known to be susceptible to drug-induced DNA damage, suggesting that DNA-repair inhibitors might selectively kill cancer cells. (nature.com)
  • By the 1980s, inhibitors of the DNA-repair poly(ADP)-ribose polymerase (PARP) enzymes had been shown to kill cancer cells more efficiently in concert with DNA-damaging agents than as single agents. (nature.com)
  • Building on these findings, two landmark studies in 2005 by Alan Ashworth's group in collaboration with KuDOS Pharmaceuticals Ltd. and the groups of Thomas Helleday and Nicola Curtin demonstrated that human cancer cells with mutations in the DNA-repair tumour-suppressor genes BRCA1 and BRCA2 are selectively sensitive to PARP inhibitors. (nature.com)
  • In 2012, René Bernards and colleagues studied why melanoma cells with the activating V600E alteration in the kinase BRAF are sensitive to BRAF inhibitors, but colorectal cancer cells with the same mutation are not. (nature.com)
  • It does this by killing cancer cells or preventing them from dividing. (preschoolcurriculum.in)
  • They could also inject cancerous tissue with a medication that targets the genetics of mesothelioma cancer cells, and increases their likelihood of dying. (preschoolcurriculum.in)
  • Chemotherapy uses anti-cancer drugs that circulate through the bloodstream to kill cancer cells. (preschoolcurriculum.in)
  • This means that the drugs travel through the blood to reach and destroy cancer cells all over the body, including those that may have broken away from the primary tumour in the stomach. (cancer.ca)
  • Chemotherapy may cause side effects because it can damage healthy cells as it kills cancer cells. (cancer.ca)
  • Because cancer cells are abnormal, this lack of cell death adds to the accumulation of cells and tumor formation. (healthywomen.org)
  • For intra-epithelial cancers like Bowen disease or erythroplasia of Queyrat which had not invaded the basement membrane can be treated with topical 5-fluorouracil which causes denudation of the cancer cells. (medthical.com)
  • It inhibits the apoptosis of cancer cells by inhibiting caspases, and also promotes cancer cell growth by stabilizing microtubules during mitosis. (biomedcentral.com)
  • Increased survivin mRNA transcripts were observed in 17-AAG and geldanamycin-treated HT-29 and HONE-1 cancer cells. (biomedcentral.com)
  • Interestingly, a recent report suggests that over-expression of survivin may also enhance DNA double-strand breaks (DBD) repair capability in radiation-treated oral cancer cells by up-regulating the molecular sensor of DNA damage, Ku70 [ 11 ]. (biomedcentral.com)
  • The significance of specific targeting towards cancer cells is debated as well. (oaepublish.com)
  • In addition, many classical chemotherapeutic anti-cancer agents kill cancer cells by directly damaging their DNA, which produces high toxicity due to its non-specificity [ 3 ] . (oaepublish.com)
  • Cancer cells are masters in finding a way to resist the treatment designed to kill them. (oaepublish.com)
  • Results showed that TIGAR was increased and relocated to the nucleus after epirubicin or hypoxia treatment in cancer cells. (nature.com)
  • We have previously reported that TIGAR plays a pro-survival role in cancer cells through increase PPP flux 19 . (nature.com)
  • In a lung cancer-induced study of mice, treatment with reishi mushrooms inhibited cell viability and mobility of lung cancer cells in vitro. (greenmedinfo.com)
  • [vii] In a cell study of reishi mushroom extract, the treatment offered high antitumor and liver protection with low toxicity on human liver cancer cells. (greenmedinfo.com)
  • In addition to cancer cells, these include blood cells which fight infection, help the blood to clot, and carry oxygen to all parts of the body. (diagnose-me.com)
  • Knockdown of SETD8 increased the responsiveness of cervical cancer cells to cisplatin treatment. (biomedcentral.com)
  • Vitamin C appears to increase the effectiveness of chemotherapy in animals and with human breast cancer cells in test tube research. (peacehealth.org)
  • The first-line treatment typically includes chemotherapy combined with immunotherapy, which is a combination of medications that destroy the cancer cells. (rarediseases.org)
  • The energy metabolism of cancer cells. (biomedcentral.com)
  • The MTS assay showed ~ 25% mortality of cancer cells due to the addition of PtAu NRs to the cell culture, while for laser irradiation combined with nanoparticles, the mortality of cancer cells increased to 65% for the 650 nm laser and to 60% for the 808 nm laser. (biomedcentral.com)
  • Cancer cells often maintain high basal level of ROS and are vulnerable to any further increase in ROS levels beyond a certain protective threshold. (degruyter.com)
  • This mini review highlights the development of compounds that target cancer cells by taking advantage of redox or metabolic alteration in cancer cells. (degruyter.com)
  • Cancer cells also enhance glucose-uptake to fuel these enhanced metabolic activities [ 2 ]. (degruyter.com)
  • Redirection of glutamine to cellular energetics destabilizes glutathione homeostasis in glioblastoma cells and other cancer cells [ 9 ]. (degruyter.com)
  • This indicates the intricate control of metabolism and redox balance for survival of cancer cells that can be targeted by therapeutic agents. (degruyter.com)
  • This is because cancer cells maintain high basal level of ROS, thus they are vulnerable to any further increase in ROS (Fig. 1 ). (degruyter.com)
  • H2 appears to shorten telomeres in cancer cells. (h2hubb.com)
  • ERW [hydrogen water] causes telomere shortening in cancer cells and suppresses tumor angiogenesis by scavenging intracellular ROS and suppressing the gene expression and secretion of vascular endothelial growth factor. (h2hubb.com)
  • As a result, it prevents abnormal cell division within the body, slows down the growth of cancer cells and eventually kills them. (netmeds.com)
  • Growing evidence suggests that the interaction between the genomic/epigenomic aberrations in cancer cells and the surrounding microenvironment, composed of immune and stromal cells, contributes to the development of tumor invasion via mechanisms such as the so-called "angiogenic switch,"[3-5] creating multiple opportunities for therapeutic intervention. (cancernetwork.com)
  • Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. (ijpbp.com)
  • However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
  • In contrast to normal cells, most cancer cells predominantly produce energy by a high rate of glycolysis followed by lactate fermentation, even in the presence of oxygen, a less efficient metabolism compared to a low rate of glycolysis followed by mitochondrial oxidation of pyruvate [ 2 ]. (hindawi.com)
  • In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)
  • Metabolic adaptations of cancer cells. (hindawi.com)
  • Glucose and glutamine are the 2 major substrates used by cancer cells. (hindawi.com)
  • citation needed] Anaplastic large cell lymphoma (ALCL): ALCL has four distinct types:[citation needed] ALK-positive anaplastic large cell lymphoma: an aggressive, systemic ALCL that strongly expresses anaplastic lymphoma kinase, i.e. (wikipedia.org)
  • ALK-negative anaplastic large cell lymphoma: an aggressive, systemic ALCL that does not express ALK. (wikipedia.org)
  • It is used to treat various types of cancer such as breast cancer, ovarian cancer, gastric cancer (stomach cancer), small cell lung cancer, head and neck cancer, liver cancer, blood cancer (leukemia), lymph cancer (lymphoma), pancreatic cancer and colorectal cancer (cancers of colon or rectam). (netmeds.com)
  • These macrotumors remained viable for days - sometimes weeks - allowing the researchers to test therapeutic drugs. (corning.com)
  • Moreover, a majority of chemotherapeutic drugs are highly hydrophobic and need to be diluted in organic solvents, which cause high toxicity, in order to reach effective therapeutic dose. (oaepublish.com)
  • The Cdk5-AMT signal pathway involved in regulation of DDR by TIGAR defines a new role of TIGAR in cancer cell survival and it suggests that TIGAR may be a therapeutic target for cancers. (nature.com)
  • this therapeutic class of drugs appears promising. (cancernetwork.com)
  • Due to their nutritional value and therapeutic potential against malignant cells, several nutraceuticals have recently attracted a lot of fascination. (ijpbp.com)
  • Recently, combination chemotherapy with cisplatin (CDDP) becomes one of effective treatment against gastric cancer, clinically. (aacrjournals.org)
  • The prognosis and treatment of T-cell lymphoma can vary drastically based on the specific type of lymphoma and its growth patterns. (wikipedia.org)
  • The treatment of T-cell lymphoma is often similar to other Non-Hodgkin lymphomas with early-stage treatments consisting of chemotherapy and/or radiotherapy. (wikipedia.org)
  • The purpose of the study is to evaluate how safe and effective an investigational study drug is compared to a placebo (both groups will receive injections, but the placebo contains no active medication) in the treatment of liver disease. (policylab.us)
  • Numerous phytochemicals and their determined analogs have been recognized as possible contender for anticancer treatment and the present review article sheds light on few of these phytocompounds. (researchsquare.com)
  • Indeed, cells with deletion of B RCA1 or BRCA2 (or other HR genes) were viable but died after PARP-inhibitor treatment. (nature.com)
  • Beyond associations with specific genetic mutations, drugs may synergize, such that treatment with one cancer drug exposes a vulnerability to a second drug. (nature.com)
  • In addition, chemotherapy, surgery, or radiation are often combined to increase the effectivity of the treatment. (aiche.org)
  • Therefore, new treatment options need to be developed for TNBC with low toxicity to healthy cells. (aiche.org)
  • In summary this work provides a new treatment for TNBC based on Pt NPs with no apparent toxicity for healthy cells, overcoming one of the major drawbacks of current treatments. (aiche.org)
  • Ethan's treatment for medulloblastoma, which included cisplatin, caused high-end hearing loss, which means that in rooms with a lot of people he can't hear at all. (alexslemonade.org)
  • While, the exposure to 2-DG further enhanced the apoptotic rate observed in SK Mel 28 cells upon treatment with both CDDP and EBSS. (unisalento.it)
  • Introduction In patients with non-small cell lung cancer, surgical treatment with postoperative adjuvant chemotherapy is performed. (bmj.com)
  • Considering the relationships among surgical treatments, inflammation and carcinogenesis, non-steroidal anti-inflammatory drugs (NSAIDs) are a candidate postoperative treatment for preventing recurrence and maintaining QOL. (bmj.com)
  • In line with this, for HPV negative but not for HPV positive cell lines, treatment with roscovitine resulted in a pronounced enhancement of the radiation-induced G2 arrest as well as a significant increase in radiosensitivity. (oncotarget.com)
  • DNA damage in HepG2 cells after TIGAR knockdown with or without treatment of epirubicin or CoCl 2 was detected by Comet assay. (nature.com)
  • In a clinical study of 105 cancer patients undergoing chemotherapy or radiation treatments, a combination of reishi mushroom extract and geraniums improved immunity and fought the cancer and secondary infections that could have compromised treatment and health. (greenmedinfo.com)
  • In a clinical study of asymptomatic children from 3 to 5 years old, treatment with beta glucans from reishi mushrooms showed increased immune system cells in the peripheral blood -- signaling a strong defense against childhood infections. (greenmedinfo.com)
  • Chemotherapy is a drug treatment that uses powerful chemical substances to kill fast-growing cells in the body. (diagnose-me.com)
  • Because such treatment also damages healthy cells and tissues, it often causes side-effects. (diagnose-me.com)
  • The following is a general overview of the treatment of extensive small cell lung cancer. (yourcancercare.com)
  • Clinical trials are studies that evaluate the effectiveness of new drugs or treatment strategies. (yourcancercare.com)
  • Patients with extensive disease small cell lung cancer are rarely curable with currently available standard treatment strategies although many patients experience a response to treatment. (yourcancercare.com)
  • While some progress has been made in the treatment of small cell lung cancer, better treatment strategies are clearly needed, as the majority of patients still experience disease recurrence. (yourcancercare.com)
  • The progress that has been made in the treatment of small cell lung cancer has resulted from the development of multi-modality treatments, new anti-cancer agents and participation in clinical trials. (yourcancercare.com)
  • Future progress in the treatment of small cell lung cancer will result from continued participation in appropriate clinical trials. (yourcancercare.com)
  • There are several areas of active exploration aimed at improving the treatment of small cell lung cancer. (yourcancercare.com)
  • Clinical trials continue to evaluate new drugs and new combinations of drugs in an effort to improve upon the treatment results achieved with standard chemotherapy regimens. (yourcancercare.com)
  • Treatment with both H2 waters (HHW and NHW) increased the expression of p-AMPK, AIF and Caspase 3 (cell apoptosis pathways) in colon 26 cells. (h2hubb.com)
  • In August 2014, the US Food and Drug Administration (FDA) approved bevacizumab for the treatment of advanced cervical cancer, the first gynecologic cancer for which an anti-angiogenic agent has demonstrated an advantage in overall survival (OS). (cancernetwork.com)
  • There have been few treatment advances for patients with malignant pleural mesothelioma, which can be challenging to treat through surgery and radiation alone," said Dr. Quincy Chu, CCTG's study chair of the IND.227 trial/KEYNOTE-483 trial. (merck.com)
  • Prior treatment with cisplatin is excluded, unless prior cisplatin treatment was given in the neo/adjuvant setting. (mycancergenome.org)
  • Therefore, there remains an urgent need to identify effective and safe drugs for the prevention and treatment of NSCLC. (biomedcentral.com)
  • Ears and hearing can be damaged by chemotherapy, high-dose radiation, and some antibiotics. (alexslemonade.org)
  • Cells that line the digestive tract also divide rapidly, and are often damaged by chemotherapy. (diagnose-me.com)
  • Has received prior radiotherapy within 2 weeks of start of study intervention or has radiation-related toxicity requiring corticosteroids. (who.int)
  • Heat shock protein 90 (Hsp90) is a molecular chaperone that assists the correct folding and stabilization of various proteins in cells. (biomedcentral.com)
  • Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes. (rarediseases.org)
  • Sulforaphane suppresses the growth of triple-negative breast cancer stem-like cells in vitro and in vivo. (ijpbp.com)
  • If stomach cancer does not respond to drugs used in earlier treatments or if it comes back, different drugs or combinations may be used. (cancer.ca)
  • Reviewing in vivo and in vitro studies on mice and human cell lines using lion's mane (Hericium erinaceus) and tiger tail (Trametes versicolor) mushrooms, treatments showed immunomodulatory, anticancer, anti-inflammatory and neuroregenerative effects. (greenmedinfo.com)
  • Synthetic lethality, a term coined by Theodosius Dobzhansky in 1946, arises when co-occurring mutations in two genes kill cells, whereas mutation of either gene alone does not and may elicit a milder phenotype. (nature.com)
  • These genes contribute to carcinogenesis when they are inactivated by mutation and can no longer provide a brake on cell division. (pvpharma.com)
  • Indeed, some chemotherapeutic drugs selectively killed cells with specific genetic mutations. (nature.com)
  • Also, many effective chemotherapeutic drugs are hydrophobic and need to be diluted in an organic solvent (DMSO, Cremophor EL, ethanol etc .) that causes toxicity when injected. (oaepublish.com)
  • Laboratory trials have found that the drug, may kill up to 95% of solid tumour cells when combined with radiation or chemotherapy. (bris.ac.uk)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Targeted therapies are anticancer drugs that interfere with specific pathways involved in cancer cell growth or survival. (yourcancercare.com)
  • High abundance of glucose in the cytoplasm of a cancer cell also increases flux into other metabolic pathways such as hexosamine biosynthetic pathway (HBP) [ 7 ]. (degruyter.com)
  • Molecular hydrogen appears to stimulate cellular death pathways in cancerous cells. (h2hubb.com)
  • The levels of pAkt and pGSK3β (cell survival pathways), mainly expressed in neurons, were markedly up-regulated. (h2hubb.com)
  • In the last 8 decades, theories regarding carcinogenesis have progressed to include numerous pathways by which cells achieve immortality. (cancernetwork.com)
  • Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)
  • FARMORUBICIN RTU 50MG INJECTION contains Epirubicin which belongs to the group of medicines called Anticancer agents. (netmeds.com)
  • 1 2 In Japan, non-small cell lung cancer (NSCLC) accounts for 75%-85% of all lung cancers. (bmj.com)
  • We observed the changes of autophagy level in NSCLC cells under the effect of FJHQ, and verified the level of the autophagy marker protein and cathepsin. (biomedcentral.com)
  • We observed that FJHQ induced autophagosomes in NSCLC cells and increased the levels of P62 and LC3-II protein expression in a concentration- and time-gradient-dependent manner, indicating that autophagic flux was inhibited. (biomedcentral.com)
  • Non-small Cell Lung Cancer (NSCLC). (who.int)
  • T-cell lymphoma is a rare form of cancerous lymphoma affecting T-cells. (wikipedia.org)
  • Cancerous growth is characterized as the uncontrolled multiplication and spread of the body's particular cells causing infection and addresses one of the greatest medical care issues for humanity and requests a proactive procedure for fix. (researchsquare.com)
  • It has been accounted that unusual symmetric cell division is the central point for causing cancerous growth. (researchsquare.com)
  • Mesothelioma is treated by medical professionals using chemotherapy, radiation and surgery to destroy cancerous cells or prevent them from growing. (preschoolcurriculum.in)
  • The procedure involves taking a small amount of mesothelioma taken from the lung to test for cancerous cells. (preschoolcurriculum.in)
  • Some are injected directly in the pleura or peritoneum in order to kill cancerous cells. (preschoolcurriculum.in)
  • 6.Chronic inflammatory conditions/trauma of the penis: balanoposthitis, lichen sclerosus , and atrophicus (balanitis Xerotica obliterans) may result in cell changes of the penis and increases risk of cancerous change. (medthical.com)
  • The cancerous cells then will spread to the lymph nodes in the groin area and further spread to distant organs in very advance stage. (medthical.com)
  • The groin lymph nodes will also be examined as it is the first place the cancerous cells will spread to. (medthical.com)
  • The suspicious penile lesion will be biopsied and the tissue cells are sent to the laboratory to confirm presence of any cancerous cells. (medthical.com)
  • It has been shown that cancerous cells have a higher expression of MMP genes leading to tumor invasion and tumor angiogenesis. (h2hubb.com)
  • These bioactive compounds are capable of killing cancerous cells without damaging normal cells. (ijpbp.com)
  • Pt NPs anticancer activity was tested performing cell viability experiments with TNBC and comparing with a common chemotherapeutic drug (cisplatin). (aiche.org)
  • 2)Interestingly, radiation sensitivity (in 8 Gy alone without chemotherapy) will be decreasing in each resistant cell, as each survival ratio of TMK-1 and TMK-1/D with 8Gy radiation is 44.6%, 55.5%,respectively, and that of MKN-74 and MKN-74/D is 33.5 and 59.6%, respectively. (aacrjournals.org)
  • There are many types and variations of T-cell lymphoma, each with vastly different symptoms, survival, and prognosis. (wikipedia.org)
  • Previous study revealed that the protective effect of TIGAR in cell survival is mediated through the increase in PPP (pentose phosphate pathway) flux. (nature.com)
  • Cell functional assays, in vivo xenografts tumor growth experiments, and survival analysis were used to investigate the functional significance and mechanism of chemosensitization after SETD8 downregulation. (biomedcentral.com)
  • A rapidly growing cancer, large-cell undifferentiated carcinomas form near the outer edges or surface of the lungs. (zuviuslifesciences.in)
  • Phytochemicals are viewed as appropriate possibility for anticancer medication advancements due to their pleiotropic activities on track occasions with numerous habits. (researchsquare.com)
  • Unlike other IAPs, survivin is a bifunctional protein that functions as a key regulator of mitosis and inhibitor of programmed cell death. (biomedcentral.com)
  • Here we tested whether roscovitine, an inhibitor of cyclin-dependent kinases (CDKs), which hereby also blocks homologous recombination (HR), can be used to enhance the radiation sensitivity of HNSCC cell lines. (oncotarget.com)
  • Due to a defect in HR, all HPV positive cell lines were efficiently radiosensitized by the PARP-1 inhibitor olaparib. (oncotarget.com)
  • Further, UNC0379 as a small molecule inhibitor of SETD8 was found to enhance cisplatin sensitivity both in vitro and in vivo. (biomedcentral.com)
  • Hemophagocytic syndrome has been associated with most T-cell lymphoma subtypes, and is commonly characterized by fevers, reduction of lymphocytes numbers, enlarged liver or spleen, and liver dysfunction. (wikipedia.org)
  • T-cell lymphoma which develops from the lymph nodes commonly causes symptoms as such swollen lymph nodes. (wikipedia.org)
  • Cancer starts when any change in the gene forces the cell to grow and multiply uncontrollably. (zuviuslifesciences.in)
  • Nanotechnology-based drug delivery systems are able to incorporate drugs or gene products with active anti-cancer activity but poor solubility, low bioavailability, or inadequate toxicological profile. (oaepublish.com)
  • Cisplatin acts to destroy the template function of the DNA double helix by forming intra-chain and inter-chain adducts, leading to DNA damage [ 3 ]. (biomedcentral.com)
  • A peptide from the shiitake mushroom showed promising results in growth arrest, cell death and cleaning out damaged cells in a breast cancer in vitro study. (greenmedinfo.com)
  • The focus of this review is on illuminating the anticancer attributes found in a variety of nutraceuticals, such as polyphenols, flavonoids, carotenoids, and other bioactive compounds. (ijpbp.com)
  • Anticancer effect of antimalarial artemisinin compounds. (ijpbp.com)
  • These cancers usually start in cells that line the bronchi in the centre of the lungs. (zuviuslifesciences.in)
  • Lymphomas are cancers that involve white blood cells, and can be divided depending on the type of cell involved, either B-lymphocytes or T-lymphocytes. (rarediseases.org)
  • Mantle cell lymphoma belongs to a group of diseases known as non-Hodgkin's lymphomas, which are related malignancies (cancers) that affect the lymphatic system. (rarediseases.org)
  • At the functional level, down-regulation of survivin by siRNA further increased the drug sensitivity to 17-AAG in the tested cancer cell lines. (biomedcentral.com)
  • To define a role of TIGAR in DNA damage, TIGAR expression was knocked down with siRNA in HepG2 cells. (nature.com)
  • We tested our hypothesis by examining the effects of silencing C/EBPβ, DDIT4, Trib3 or α-syn with small interfering ribonucleic acid (siRNA) on METH-induced autophagy and apoptosis in the human neuroblastoma SH-SY5Y cells. (cancerindex.org)
  • In the present study, we attempt to establish a resistant gastric cancer cell to CDDP, and to overcome the resistant mechanism by radiation, which will be one of potent therapies for gastric cancer. (aacrjournals.org)
  • Breast cancer-associated anaplastic large cell lymphoma: a less aggressive ALCL that occurs around and is caused by breast implants. (wikipedia.org)
  • There is an urgent need to identify strategies that increase cisplatin sensitivity and improve the outcomes of chemotherapy. (biomedcentral.com)
  • The results showed no apparent toxicity of Pt NPs for healthy cells in contrast to cisplatin. (aiche.org)
  • Surprisingly, all HPV positive cell lines were found to be defective in HR. In contrast, HPV negative strains demonstrated efficient HR, which was completely suppressed by roscovitine. (oncotarget.com)
  • In contrast, in HPV negative cell lines a significant radiosensitization by olaparib was only achieved when combined with roscovitine. (oncotarget.com)
  • These spheroids will be used as a drug screening platform with enhanced in vivo characteristics that better mimic how cancer forms and spreads in the human body. (corning.com)
  • In this study, we investigate the effects of the perioperative administration of flurbiprofen axetil on postoperative recurrence in patients with non-small cell lung cancer. (bmj.com)
  • Patients clinically suspected of non-small cell lung cancer are randomly assigned to the flurbiprofen axetil group or the no-NSAIDs group. (bmj.com)
  • Patients with inoperable head and neck cancer were treated with a spleen peptide preparation (Polyerga) in a double-blind trial during chemotherapy with cisplatin and 5-FU. (peacehealth.org)
  • Following that, patients may be eligible for a stem cell transplant, and/or an extended course of immunotherapy that is meant to prolong cancer remission. (rarediseases.org)