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  • Mutation
  • Failure of the spindle checkpoint caused by mutation of the responsible genes may be one of the important factors for the development of aneuploidy. (bmj.com)
  • Evidence such as tumour specific aneuploidy, presence of aneuploidy in various preneoplastic conditions, increased frequency of genetic instability in aneuploid cell lines compared with diploid cells, and mutation of mitotic checkpoint genes suggests that aneuploidy possibly plays an active role in carcinogenesis. (bmj.com)
  • It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. (cancerindex.org)
  • We recently reported that a synthetic genetic array (SGA) analysis identified genes required for viability when rereplication controls were partially compromised by combining the ORC6-rxl mutation blocking Clb5 binding to Orc6, and the CDC6 Δ NT mutation, an N-terminal truncation resulting in abrogation of Cdk control of Cdc6 activity (see above). (genetics.org)
  • To do this, they deleted each gene one at a time, in combination with another mutation. (technologynetworks.com)
  • The researchers ended up with 172 drug-gene mutation combinations that successfully killed both yeast and human cancer cells. (technologynetworks.com)
  • rereplication
  • When programmed DNA double-strand breaks are generated but not repaired due to absence of DMC1 , a pathway involving the checkpoint gene RAD17 prevents this DNA rereplication. (g3journal.org)
  • Rereplication of the genome, or even a segment of it, could initiate gene amplification and cause chromosomal translocation and loss, contributing to the tumorigenesis process. (rupress.org)
  • plays
  • That is, if one gene plays a role that buffers the phenotypic expression of variation in another, then loss of the first reveals the phenotypic consequences of variation in the second. (washington.edu)
  • RAD17 plays a central role in cell cycle checkpoint control. (qedbio.com)
  • There is an increasing understanding that the interrelationship between BRCA gene cluster and Fanconi anemia (FA), mismatch repair (MMR) and DNA repair gene status plays a key role in the pathogenesis of cancer predisposition syndromes. (spandidos-publications.com)
  • chromatin
  • Rad17 participates in the recruitment of the 9-1-1 complex onto chromatin. (ebi.ac.uk)
  • For representative genes, we illustrate relationships between DNA methylation, the local chromatin state, DNaseI hypersensitivity, and gene expression. (mdpi.com)
  • These studies have demonstrated that relationships between DNA methylation and gene expression are much more complex than previously assumed and often highly dependent on the context of the gene region, the surrounding chromatin epigenetics, and the cell type [ 8 , 9 , 10 ]. (mdpi.com)
  • cancers
  • Overexpression of Rad17 has been associated with human breast and colon cancers [ PMID: 10232579 , PMID: 11555598 ]. (ebi.ac.uk)
  • Furthermore
  • Furthermore, exclusive association between biological subclasses and restricted LOH events provides rationale to search for targeted genes. (aacrjournals.org)
  • recombination
  • Besides checkpoint activation, Rad17 may also serve as a sensor of DNA replication progression, and may be involved in homologous recombination [ PMID: 15297881 ]. (ebi.ac.uk)