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  • Transfection
  • 9-20 Reconstitution of the oxidase by transfection into cell lines deficient in the oxidase proteins or recombination of the components in vitro shows that efficient superoxide generation by the NADPH oxidase complex is absolutely dependent on these components. (bloodjournal.org)
  • tyrosine
  • The immunoreceptor tyrosine-based inhibitory motif of FcγRIIB1 represents a docking site for the SH2 domains of at least two proteins, the tyrosine phosphatase SHP1 (( 16 )) and the inositide phosphatase SHIP (( 17 )), either of which may mediate inhibitory effects. (rupress.org)
  • metabolism
  • With GWAS-based pathway analysis, we found that VEGF signaling pathway, glutathione metabolism, and Rac-1 pathway were significantly enriched biological pathways involved with OBS on MetS. (hindawi.com)
  • focal
  • Conversely, when contact targeting at the cell front was prevented by freezing microtubule growth with 20 nM taxol and protrusion stimulated by the injection of constitutively active Rac, peripheral focal complexes became abnormally enlarged. (nih.gov)
  • cellular
  • Promoter activity and transcript levels of p40 phox increased in HL-60 cells during dimethyl sulfoxide-induced differentiation toward the granulocyte phenotype, and this was associated with increased cellular levels of PU.1 protein. (bloodjournal.org)
  • actin
  • A subset of effectors contains eukaryotic-like motifs that mimic host proteins to exploit signaling and modify specific cytoskeletal components such as actin and microtubules. (frontiersin.org)
  • whereas
  • The NG2-bound form of plasminogen exhibits an increased rate of conversion to plasmin, whereas binding of NG2 to angiostatin appears to neutralize the inhibitory effect of angiostatin on endothelial cell proliferation. (biologists.org)
  • integrin
  • This involves a conformational change in the extracellular domain of the integrin platelet glycoprotein (GP)IIb-IIIa facilitating the binding of soluble fibrinogen and enabling the formation of cross bridges between platelets essential for platelet aggregation. (ahajournals.org)
  • Essential
  • Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organization. (nih.gov)
  • ligands
  • On the cell surface, NG2 interacts with a variety of diverse ligands, including extracellular matrix (ECM) components, growth factors and kringle domain proteins. (biologists.org)
  • receptor
  • When Wnt acts on its cell surface receptor consisting of Frizzled and lipoprotein receptor-related protein 5/6, β-catenin escapes from degradation in the Axin complex ( 8 ). (aacrjournals.org)
  • intracellular
  • The intracellular signaling pathway activated by Wnt proteins was originally identified as a β-catenin-dependent signaling pathway that is highly conserved among species ( 1 ). (aacrjournals.org)
  • amino acid
  • For this purpose we used mbcF12.7, since the protein is truncated at amino acid 492, and analyzed embryos that were genetically mbcF12.7/Df(3R)mbc-30. (nih.gov)
  • vesicle
  • Both PS and anti-PSR antibodies stimulated membrane ruffling, vesicle formation, and "bystander" uptake of cells bound to the surface of the phagocyte. (rupress.org)
  • activate
  • It is thought that the Wnt proteins showing the high transforming activity in C57MG cells activate the β-catenin pathway. (aacrjournals.org)
  • Some Wnt proteins activate a β-catenin-independent pathway that primarily modulates cell movement and polarity ( 3 , 10 ). (aacrjournals.org)
  • It is generally believed that the intermediately transforming and nontransforming Wnt proteins activate the β-catenin-independent pathway ( 3 ). (aacrjournals.org)
  • Wnt-5a is a representative of Wnt proteins that activate the β-catenin-independent pathway. (aacrjournals.org)
  • found
  • genes encoding mG-proteins were found. (deepdyve.com)
  • We have tested several growth factors, and among these NG2 was found to selectively bind to platelet-derived growth factor AA (PDGF-AA) and basic fibroblast growth factor (bFGF). (biologists.org)
  • genes
  • The accumulated β-catenin is translocated to the nucleus, where it binds to the transcription factor T-cell factor (Tcf)/lymphoid enhancer factor (Lef) and thereby stimulates the expression of various genes ( 9 ). (aacrjournals.org)