TriglyceridesIncreases low density lipVLDLModulating lipoprotein metabolismLipidsAntibodyEndothelial cellsMetabolismPolyclonalApolipoproteinsInhibitsAtherogenicGeneDensityLigandsConcentrationsAtherosclerosisLIPGCholesterylProteinHypercholesterolemiaPlasmaRegulatorsSpeciesRoleCyclesMiceSequenceGenesIschemiaTypeClinicalResultsCurrentStudiesEffect
Triglycerides8
- Lipoprotein lipase (LPL), the rate-limiting enzyme for hydrolysis of plasma lipoprotein triglycerides, is a normal constituent of the arterial wall. (jci.org)
- Hyperlipidemia comprises a heterogeneous group of disorders, characterized by high levels in one or more lipids and/or lipoproteins [atherogenic free fatty acids (FA), triglycerides (TG) (hypertriglyceridemia), small dense low-density lipoprotein cholesterol (LDL-C) (hypercholesterolemia), and apolipoprotein (apo) B], and/or low level in antiatherogenic high density lipoprotein cholesterol (HDL-C), in the circulation [ 1 - 3 ]. (hindawi.com)
- Diabetic dyslipidemia is usually constituted by three concomitant plasma lipid alterations: elevation in the levels of triglycerides, a reduction in high-density lipoprotein (HDL) concentrations, and the predominance of atherogenic small dense low-density lipoproteins (LDL) [Krauss 2004]. (diabetologie-online.de)
- Indeed, the function of lipoprotein lipase is to hydrolyze triglycerides from chylomicrons (CM) and very low-density lipoproteins (VLDL) to produce fatty acids and glycerol, which subsequently enter the cells and can be resynthesized into triglycerides in the adipose tissue [Barylski 2014]. (diabetologie-online.de)
- The other enzyme is hepatic lipase, which complements the action of lipoprotein lipase, since it hydrolyzes triglycerides in intermediate-density lipoproteins (IDL) and LDL [Rizzo 2004], thus promoting the formation of smaller more dense LDL particles [Vekic 2022]. (diabetologie-online.de)
- LIPG is a carboxyl esterase that hydrolyzes high density lipoproteins, emulsifies triglycerides, is essential for the efficient digestion of dietary fats and can bind to heparin. (thermofisher.com)
- Although EL, LPL, and hepatic lipase (HL) hydrolyze both triglycerides (TG) and phospholipids (PL) in the lipoproteins, they show different substrate selectivity. (biomedcentral.com)
- Evinacumab inhibits ANGPTL3 and results in increased lipid metabolism, leading to decreased low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL_C), and triglycerides. (medscape.com)
Increases low density lip2
- Lipoprotein lipase increases low density lipoprotein retention by subendothelial cell matrix. (jci.org)
- This increases low-density lipoprotein (LDL-C) receptor recycling and expression on the hepatocyte cell surface, which increases LDL-C uptake and lowers LDL-C levels in the circulation. (medscape.com)
VLDL7
- Apo-CIII is a component of very low density lipoprotein (VLDL). (nsjbio.com)
- Follicular fluid - which surrounds oocytes in a developing follicle - contains all relevant lipoprotein subclasses that reach the follicular fluid either by diffusion, in the case of high-density lipoproteins (HDL), or by local production within the granulosa cells, in the case of very low-density lipoproteins (VLDL). (bvsalud.org)
- We suppose that very low density lipoprotein (VLDL) may have a similar role to ox-LDL in autoimmune response of atherosclerosis. (bvsalud.org)
- OBJECTIVE: To purify human VLDL apolipoproteins by middle-pressure liquid chromatography. (bvsalud.org)
- Delipided human VLDL was separated by Sephacryl S-200 molecular sieve chromatography. (bvsalud.org)
- Apo B-450 is associated with chylomicrons and their remnants, and apo B-100 is associated with low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), VLDL remnants, and intermediate-density lipoprotein. (medscape.com)
- Criteria for the definition of familial HAs are (1) a low HDL cholesterol level in the presence of normal VLDL cholesterol and LDL cholesterol levels, (2) an absence of diseases or factors to which HA may be secondary, and (3) the presence of a similar lipoprotein pattern in a first-degree relative. (medscape.com)
Modulating lipoprotein metabolism1
- LIPG most likely plays a physiological role in modulating lipoprotein metabolism. (thermofisher.com)
Lipids4
- To examine this hypothesis, we compared the effects of orchiectomy and ovariectomy on plasma lipids and diet-induced atherosclerosis in both Tg and non-Tg rabbits. (biomedcentral.com)
- We compared plasma lipids, lipoproteins, and apolipoproteins of rabbits before and after surgery in each group fed either a chow diet or cholesterol-rich diet. (biomedcentral.com)
- On a chow diet, both male and female Tg rabbits showed lower plasma lipids than non-Tg counterparts and this lipid-lowering effect of EL was not affected by either orchiectomy in male or ovariectomy in female Tg rabbits. (biomedcentral.com)
- Plasma lipoproteins are macromolecular complexes of lipids and proteins that are classified by density and electrophoretic mobility. (medscape.com)
Antibody3
- Amino acids S21-A99 from the human protein were used as the immunogen for the APOC3 antibody. (nsjbio.com)
- Evinacumab is a recombinant human monoclonal antibody that binds to and inhibits angiopoietin-like 3 (ANGPTL3). (medscape.com)
- Polyvinylidine fluoride Dynasore (PVDF) goat anti-rabbit IgG secondary antibody conjugated to HRP and goat anti-mouse IgG secondary antibody conjugated to HRP were purchased from Bio-Rad (Hercules CA). 6-N-biotinylaminohexyl isopropyl phosphorofluoridate hemihydrate (FP-biotin) was purchased from Toronto Research Chemicals (North York Ontario Canada). (ecologicalsgardens.com)
Endothelial cells1
- We explored whether LPL affects (a) lipoprotein transport across bovine aortic endothelial cells or (b) lipoprotein binding to subendothelial cell matrix (retention). (jci.org)
Metabolism10
- Reduction of total cholesterols (TC) and LDL-C by dietary alterations and medications that affect lipid metabolism [ 14 ] is found to reduce the occurrence of atherosclerosis in animals and clinical cardiovascular events in human [ 15 ]. (hindawi.com)
- In the present article we will discuss hypertriglyceridemia determined by the deficiency of lipoprotein lipase, which is one of the two lipase enzymes with a key role in serum lipid metabolism. (diabetologie-online.de)
- LIPG has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. (thermofisher.com)
- Here, we summarize current knowledge on lipoprotein metabolism in the ovary in the context of fertility, and hypothesize that lipoproteins within follicular fluid are relevant to the development of the early embryo and thereby putatively also to the programming of metabolic disease later in life. (bvsalud.org)
- Endothelial lipase (EL) plays an important role in lipoprotein metabolism and atherosclerosis. (biomedcentral.com)
- This gender difference suggests that sex hormones may mediate EL functions thereby influencing lipoprotein metabolism. (biomedcentral.com)
- This finding prompted us to envision that there is an interaction between EL and sex hormones thereby influencing lipoprotein metabolism and atherosclerosis. (biomedcentral.com)
- ANGPTL3 inhibits lipoprotein lipase and endothelial lipase, thereby reducing lipid metabolism. (medscape.com)
- The proteins, termed apolipoproteins, play an important role in lipoprotein metabolism. (medscape.com)
- The beta lipoproteins are structural, are never complexed with HDL, and remain throughout the metabolism of the lipoproteins with which they are associated. (medscape.com)
Polyclonal2
- Can be paired for ELISA with Rabbit polyclonal to Apolipoprotein CIII (ab21032) . (abcam.co.jp)
- Until lately, Rabbit Polyclonal to HNRPLL cholesterol has mainly been accepted with an impact on immunity during pathological circumstances such as for example in atherosclerosis (Fessler, 2016). (cancercurehere.com)
Apolipoproteins1
- The major apolipoproteins of high-density lipoprotein (HDL) are alpha lipoproteins (ie, apolipoprotein A-I [apo A-I], apo A-II, apo A-IV), which are soluble and can move between different classes of lipoproteins. (medscape.com)
Inhibits1
- Interestingly, increased hepatic expression of EL inhibits cholesterol diet-induced hypercholesterolemia and protects against atherosclerosis in male Tg rabbits but not in female Tg rabbits. (biomedcentral.com)
Atherogenic1
- This form of dyslipidemia is known as lipid triad or as atherogenic lipoprotein phenotype [Rizzo 2005]. (diabetologie-online.de)
Gene3
- Familial Chylomicronemia Syndrome (FCS) is a rare autosomal recessive monogenic disease, with one to two individuals in every million, most often caused by mutations in the lipoprotein lipase gene. (diabetologie-online.de)
- Apolipoprotein C-III, also known as apo-CIII, is a protein that in humans is encoded by the APOC3 gene. (nsjbio.com)
- LIPG (Lipase G, Endohelial type) is an endothelial lipase which is a novel member of the lipoprotein lipase gene family. (thermofisher.com)
Density6
- Omega-3-acid ethyl esters may increase levels of low-density lipoprotein (LDL). (nih.gov)
- Upon TLR4 stimulation, low- and high-density lipoproteins (LDL and HDL) strongly inhibited the ability of DC to induce a Th1 response of T cells, characterized by high levels of IFNγ secretion, whereas the effect of very low-density lipoprotein was subject to variations. (bvsalud.org)
- METHODS: Human VLDLs were isolated by one step density ultracentrifugation. (bvsalud.org)
- ABCA1 regulates the formation of nascent high-density lipoprotein (HDL) via cholesterol efflux to lipid free apolipoprotein A-1, whereas ABCG1 mediates cholesterol transport to the HDL fraction [ 13 ]. (biomedcentral.com)
- Degrees of cholesterol in the cell are preserved through de synthesis in the ER novo, and uptake of low-density lipoproteins (LDLs) produced from eating cholesterol. (cancercurehere.com)
- Low levels of high-density lipoprotein cholesterol (HDL), or hypoalphalipoproteinemia (HA), includes a variety of conditions, ranging from mild to severe, in which concentrations of alpha lipoproteins or high-density lipoprotein (HDL) are reduced. (medscape.com)
Ligands2
- It can bind other ligands such as lipoprotein lipase proneurotrophins protein RAP (receptor-associated protein) or protein SAP (sphingolipid activator protein) (Nielsen et al. (cancer8.info)
- Here the immune function of non-pathological lipoproteins is addressed by analysing their impact on human DC maturation triggered by TLR ligands. (bvsalud.org)
Concentrations1
- Conjugated linoleic acid is unique because it is present in food from animal sources, and its anticancer efficacy is expressed at concentrations close to human consumption levels. (integratedhealthblog.com)
Atherosclerosis4
- however, male Tg rabbits but not female Tg rabbits showed significant resistance to diet-induced hypercholesterolemia and atherosclerosis. (biomedcentral.com)
- Female Tg rabbits showed similar levels of total cholesterol and lesion size of atherosclerosis compared with non-Tg rabbits and ovariectomy did not affect diet-induced hypercholesterolemia or atherosclerosis. (biomedcentral.com)
- Recent findings suggest that DNA methylation changes are related to the development and progression of a group of human diseases including atherosclerosis. (biomedcentral.com)
- A low HDL cholesterol level is thought to accelerate the development of atherosclerosis because of impaired reverse cholesterol transport and possibly because of the absence of other protective effects of HDL, such as decreased oxidation of other lipoproteins. (medscape.com)
LIPG2
- Full length human recombinant protein of human LIPG produced in HEK293T cell. (thermofisher.com)
- Also, LIPG is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. (thermofisher.com)
Cholesteryl1
- Moreover we show that treatment of cholesterol-loaded THP-1 macrophages with a specific reversible inhibitor of CES1 (benzil) GPSA or a bioactive metabolite of an OP insecticide (paraoxon) that broadly targets multiple serine hydrolases including CES1 causes significant retention of cholesteryl esters in cultured macrophages under conditions which promote lipoprotein-dependent cholesterol efflux. (ecologicalsgardens.com)
Protein3
- SDS-Page: Recombinant Human Lipase A Protein [H00003988-P01] - 12.5% SDS-PAGE Stained with Coomassie Blue. (novusbio.com)
- The poultry sector is noted to make a considerable contribution to global nutrition and food security, which helps in the provision of cheap protein, essential micronutrients, and energy to humans ( 1 ). (frontiersin.org)
- Saboori and Newcombe [19] previously showed that a carboxylesterase protein which was purified from human monocytes could be inhibited by oxon treatment. (ecologicalsgardens.com)
Hypercholesterolemia1
- To study the functional roles of EL, we recently generated transgenic (Tg) rabbits and reported that increased hepatic expression of EL in male Tg rabbits significantly reduced diet-induced hypercholesterolemia compared with non-Tg controls. (biomedcentral.com)
Plasma3
- 1977. Inhibition of human plasma cholinesterase by ingested dichlorvos: effect of formulation vehicle. (cdc.gov)
- Finally, a organized investigation from the plasma proteome of GEMMs of NSCLC and SCLC [80] demonstrated significant amounts of similarity towards the human being disease, suggesting which they may be used to find early recognition markers and therapy response monitoring. (biopaqc.com)
- Exogenously attained LDL destined to LDL receptor is certainly internalized on the plasma membrane (PM) and it is carried through the endocytic pathway towards the past due endosomesClysosomes, where cholesterol esters inside the LDL primary are hydrolyzed by acidity lipases. (cancercurehere.com)
Regulators1
- Lipoproteins are both lipid carriers in the blood and regulators of essential biological processes. (bvsalud.org)
Species1
- Hier sind Liver Arginase Antikörper für eine Vielzahl von Species wie anti-Human Liver Arginase, anti-Rat Liver Arginase, anti-Mouse Liver Arginase zu finden. (antikoerper-online.de)
Role1
- 2011 ) have reviewed the vital role of SP from seaweeds in human health. (springer.com)
Cycles1
- Poultry, owing to their short production cycles and having the potential of converting wide ranges of agricultural food waste and by-products into eggs and meat edible for humans. (frontiersin.org)
Mice2
- e.g. in higher order primates, including humans, and also in rabbits, guinea pigs, mice, and rats) During pregnancy, placentation is the formation and growth of the placenta inside the uterus. (wikipedia.org)
- Propagation of human being tumours in mice is usually demanding with regards to work and costs. (biopaqc.com)
Sequence1
- CES1 and carboxylesterase 2 (CES2) are the two major human carboxylesterase isoforms and share 48% sequence homology. (ecologicalsgardens.com)
Genes1
- The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. (nsjbio.com)
Ischemia1
- 9. Sasayama S, Nonogi H , Fujita M, Sakurai T, Wakabayashi A, Kawai C, Eiho S, Kuwahara M: Changes in diastolic properties of the regional myocardium during pacing-induced ischemia in human subjects. (fiercecert.com)
Type1
- The replicative cycle of the Human being Immunodeficiency Virus type-1 begins after fusion of the viral and target-cell membranes. (cancerrealitycheck.com)
Clinical1
- This product is for research use only and is not approved for use in humans or in clinical diagnosis. (novusbio.com)
Results2
- Future trials should display whether these 668270-12-0 supplier results could be translated to human being lung malignancy. (biopaqc.com)
- Pratte, M. A. et al: An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). (natur-wiki.de)
Current1
- Our current aim was to assess the mechanism underlying tile receptors-specificity of apoE-carrying lipoproteins. (zhangqiaokeyan.com)
Studies1
- Several studies demonstrated that lipoproteins modified during pathological conditions could alter dendritic cell (DC) maturation. (bvsalud.org)
Effect2
- Pingali, U., Pilli, R. und Fatima, N.: Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants. (natur-wiki.de)
- The EL-mediated atheroprotective effect was eliminated after orchiectomy in male Tg rabbits. (biomedcentral.com)