Rabbits alloxan. Medical search. Frequent questions

Abu-zaiton A, Abu-Albasal M (2012) Water decoction of olive leaf reduces blood glucose in normal and alloxan diabetic rats. (springer.com)
In this study, effect of different concentrations of methanolic extracts of Musa sapientum sucker on plasma lipid profile were assessed in alloxan induced diabetic rats. (scialert.net)
The result of the study indicates that Musa sapientum sucker extract was effective in improving plasma lipid profile associated with cardiovascular risk factors in alloxan induced diabetic rats. (scialert.net)
In this study the effects of methanolic extract of Musa sapientum sucker on plasma lipid profile changes in alloxan induced diabetic rats was investigated with a view to finding its possible effects on cardiovascular disease induced by hyperglycemia. (scialert.net)
Daily feeding of Nelumbo nucifera leaf powder for 21 days resulted significant decrease in the blood glucose levels of alloxan-induced diabetic rats. (scirp.org)
Biochemical abnormalities such as hyperglycaemia, ketonemia, reduction in liver glycogen and impaired incorporation of [2- 14 C] -acetate into fatty acids in alloxan diabetic rats were brought to near normal levels by the oral or intraperitoneal administration of dihydrolipoic acid. (ias.ac.in)
Intraperitoneal administration of lipoic acid (10 mg/100 g) does not effect changes in serum insulin levels in normal and alloxan diabetic rats, while normalising increased serum pyruvate, and impaired liver pyruvic dehydrogenase characteristic of the diabetic state. (ias.ac.in)
From the above result, it is concluded that EESS root possesses significant anti-diabetic effects in Alloxan induced diabetic rats. (ijpsr.com)
The present study was conducted to investigate the anti-diabetic activity of Solanum surratense rootsin Alloxan induced diabetic rats. (ijpsr.com)

of alloxan monohydrate solution. (ascidatabase.com)
Diabetes was induced in Albino rats by administration of single dose of Alloxan monohydrate (150mg/kg). (ijpsr.com)

The present study was aimed to explore the antihyperglycemic effect of 70% methanol extract of Pentanema vestitum whole plant in glucose-induced nondiabetic hyperglycemic and alloxan-induced diabetic rabbits. (hindawi.com)
From the finding of the present research, it was concluded that the 70% methanol extract of Pentanema vestitum whole plant has beneficial effects on serum levels of glucose, lipid profile, GPT, ALP, bilirubin, and creatinine of diabetic rabbits. (hindawi.com)
Alloxan is a toxic glucose analogue, which selectively destroys insulin-producing cells in the pancreas (that is, beta cells) when administered to rodents and many other animal species. (wikipedia.org)
Alloxan is selectively toxic to insulin-producing pancreatic beta cells because it preferentially accumulates in beta cells through uptake via the GLUT2 glucose transporter. (wikipedia.org)
Furthermore, alloxan inhibits glucokinase, a SH-containing protein essential for insulin secretion induced by glucose. (wikipedia.org)
Most studies have shown that alloxan is not toxic to the human beta-cell, even in very high doses, probably because of differing glucose uptake mechanisms in humans and rodents. (wikipedia.org)
The effect of α-lipoic acid was comparable to that of dihydrolipoic acid in reducing the blood sugar levels of diabetic rabbits during a glucose tolerance test. (ias.ac.in)
Alluri R, Ghelani H, Devi S, Inampudi VK, Nammi S. Preclinical Investigation of the Acute Effects of Trigonella foenum-graecum Seed Powder on Blood Glucose in Normal and Alloxan-Induced Diabetic Rabbits. (lidsen.com)
To investigate the blood glucose lowering effect of the seed powder of T. foenum-graecum Linn (Papilionaceae) in normal and alloxan-induced diabetic rabbits. (lidsen.com)
The blood glucose lowering effect of the seed powder was determined in normal and alloxan-induced (100 mg/kg, i.v.) diabetic rabbits, after oral administration of doses of 50, 100 and 150 mg/kg body weight. (lidsen.com)
The seed powder of T. foenum-graecum produced a dose-dependent reduction in blood glucose of both normal and diabetic rabbits and comparable with that of standard drug, glibenclamide. (lidsen.com)
Modern studies were conducted in testing the effectiveness of lowering glucose levels in diabetic rabbits. (uconn.edu)
The effect of the ACE inhibitor was analyzed in pancreas of diabetic and hypercholesterolemic rabbits in in vivo model, and in isolated rabbit pancreatic islets incubated with high glucose medium in in vitro study. (unisciencepub.com)
The ACE inhibitor impaired the production of superoxide in islets isolated from rabbits, mainly in the presence of normal concentration of glucose, suggesting that the blockade of RAS may attenuate the deleterious actions of Angiotensin II on pancreatic islet structure. (unisciencepub.com)
Since alloxan causes selective destruction of beta cells of islets of pancreas resulting in marked decrease in insulin levels, it is rational that glycogen level in tissues decrease as they depend on insulin for influx of glucose.42 Treatment with methanolic extract of D. hamiltonii prevented the depletion of glycogen content in liver and skeletal muscle in alloxan-induced diabetic rabbits. (peptidecost.com)

The alloxan model of diabetes was first described in rabbits by Dunn, Sheehan and McLetchie in 1943. (wikipedia.org)
This causes an insulin-dependent diabetes mellitus (called "alloxan diabetes") in these animals, with characteristics similar to type 1 diabetes in humans. (wikipedia.org)
Studies suggests that alloxan does not cause diabetes in humans. (wikipedia.org)
Others found a significant difference in alloxan plasma levels in children with and without diabetes Type 1. (wikipedia.org)
Because it selectively kills the insulin-producing beta-cells found in the pancreas, alloxan is used to induce diabetes in laboratory animals. (wikipedia.org)
In rats, hyperlipidemia was induced by feeding High Fat Diet (Lab diet: Dalda: Coconut oil = 4:3:1) and type 2 diabetes was built inside by injecting Alloxan. (scirp.org)
Three groups of rabbits including control group (10 rabbits), diabetes group (10 rabbits with alloxan-induced diabetes), and treatment group (10 rabbits with alloxan-induced diabetes and treatment with subcutaneous octreotide 2,5mg, twice a day) were studied with light and transmission electron microscopy after 3 months of follow-up. (sdu.edu.tr)

1992) and the aqueous leaf extracts caused reductions in blood sugar levels of normoglycaemic and alloxan diabetic rabbits (Akah andOkafor, 1992). (rafamall.com)

Methods: We performed a study on tissue samples of pancreas of alloxan-induced diabetic rabbits which have also become hypercolesterolemic through a rich cholesterol chow. (unisciencepub.com)

A study of hypoglycaemic effects of Azadirachta indica (Neem) in normaland alloxan diabetic rabbits. (tierranaturals.com)

During this study, the effects of plant extract on the serum lipid profile, GPT, ALP, bilirubin and creatinine of diabetic rabbits were also studied. (hindawi.com)
During the study of lipid profile, the extract proved to be antihyperlipidemic and HDL boosting in diabetic rabbit models. (hindawi.com)
Recently, hypoglycaemic effect was observed with leaf extract and seed oil, in normal as well as alloxan-induced diabetic rabbits. (infinityfoundation.com)
Antidiabetic effect of Equisetum giganteum L. extract on alloxan-diabetic rabbit. (ufop.br)

Antidiabetic activities (hypoglycaemic, hypolipidaemic and pancreatic beta cells regeneration) of Momordica charantia (MC) fruits were investigated in alloxan diabetic rabbits. (uwi.edu)
Hypoglycaemic effects of Andrographis paniculata Nees on non-diabetic rabbits», Bangladesh Med Res Counc Bull. (insulat.ru)

Al-Azzawie HF, Alhamdani M-SS (2006) Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits. (springer.com)
In the studies of hypoglycemic effects, the subjected animals are being made diabetic using alloxan, streptozotocin (STZ) etc introducing inside injecting intraperitoneally (IP) or intravenously (IV). (scirp.org)

This study was carried out to investigate the effect of sildenafil (S) together with the influence of sodium nitroprusside (SNP) and acetylcholine (Ach) on isolated strips of rabbit corpus cavernosum. (egyptianjournal.xyz)
The in vitro effects of sildenafil on non-adrenergic, non- cholinergic and nitric oxide (NO)-mediated cavernosal smooth muscle relaxation in diabetic rabbits, were also investigated. (egyptianjournal.xyz)
The difference involving the potency of SAR407899 and sildenafil in calming preparations from diabetic and healthier animals was confirmed, and in some cases magnified, in rabbit corpora cavernosa. (pkainhibitors.com)
In these experiments, SAR407899 showed the identical potency and efficacy in preparations from nutritious and alloxan diabetic rabbits while sildenafil was a lot much less potent and helpful in diabetic rabbits. (pkainhibitors.com)

Abaza I., El-Din A., Abd El-Hamid A., EL-Gayar H.F. (2014) Effect of chamomile flowers as feed additive on some biological parameters for growing rabbits. (sciendo.com)

Alloxan is, however, toxic to the liver and the kidneys in high doses. (wikipedia.org)

It was found that Ach, SNP and S relaxed the control rabbit corpus cavernosal strips in a dose-dependent manner. (egyptianjournal.xyz)

A dimeric derivative alloxantin can be prepared by partial reduction of alloxan with hydrogen sulfide. (wikipedia.org)
Alloxan, in the presence of intracellular thiols, generates reactive oxygen species (ROS) in a cyclic reaction with its reduction product, dialuric acid. (wikipedia.org)

In addition, alloxan has a high affinity to SH-containing cellular compounds and, as a result, reduces glutathione content. (wikipedia.org)

The name "Alloxan" emerged from an amalgamation of the words "allantoin" and "Oxalsäure" (oxalic acid). (wikipedia.org)
Levi considers the droppings of pythons as a source for uric acid for making alloxan, but he is turned down by the director of the Turin zoo because the zoo already has lucrative contracts with pharmaceutical companies, so he is obliged to use chickens as his source of uric acid. (wikipedia.org)
Gaspard Brugnatelli) (1818) "Sur un acide nouveau obtenu en traitant l'acide urique par acid nitrique" (On a new acide obtained by treating uric acid with nitric acid), Annales de Chimie et de Physique, 2nd series, 8 : 201-204. (wikipedia.org)

The rabbits in groups II and IV received quinapril (30 mg/day) in their food and all animals received a diet enriched with 0.5% cholesterol for 12 weeks. (unisciencepub.com)

2021. Influences of dietary herbal blend and feed restriction on growth, carcass Characteristics and gut microbiota of growing rabbits. (sciendo.com)

Isolated strips of control rabbit corpus cavernosum were stimulated isotonically with phenylephrine (10-5M) and relaxations were induced using increasing concentrations of Ach, SNP and S alone and in combination. (egyptianjournal.xyz)

The beta cell toxic action of alloxan is initiated by free radicals formed in this redox reaction. (wikipedia.org)

Lately, the operon encoding an alternative solution sigma aspect of was cloned Rabbit polyclonal to TLE4 and sequenced (16, 28). (achemmic.com)

Alloxan was used in the production of the purple dye murexide, discovered by Carl Wilhelm Scheele in 1776. (wikipedia.org)

Abu-zaiton A, Abu-Albasal M (2012) Water decoction of olive leaf reduces blood glucose in normal and alloxan diabetic rats. (springer.com)
Alloxan was used to induce diabetes in rats and the blood glucose, lipid levels were estimated using commercial kits available in the market. (scialert.net)
The methanol extract of T. portulacastrum was administered for 7 days to normal and alloxan induced diabetes rats at a dose of 100, 200 and 300 mg kg -1 . (scialert.net)
It also produced beneficial effects on the lipid profile in normal as well as alloxan induced diabetic rats at the end of the treatment period (7th day). (scialert.net)
The objective of the present study was to evaluate the hypoglycemic and hypolipidimic activity of methanolic extract of Trianthema portulacastrum L. whole plant in normal and alloxan-induced diabetic rats. (scialert.net)
A mild and transient hypoglycemic effect was also observed in rats with alloxan-induced diabetes treated with 250 or 1000 mg/kg (1.8 or 7.3 mmol/kg) trigonelline. (nih.gov)
This study was aimed at determining the dietary effects of quail eggs on blood sugar and lipid profile of alloxan induced diabetic rats. (alliedacademies.org)
Quail eggs were administered to thirty six (36) alloxan induced diabetic rats, which were divided into nine (9) different groups of four (4) rats each per group at varied doses for a duration of seven (7), fourteen (14) and twenty one (21) days. (alliedacademies.org)
In rats, hyperlipidemia was induced by feeding High Fat Diet (Lab diet: Dalda: Coconut oil = 4:3:1) and type 2 diabetes was built inside by injecting Alloxan. (scirp.org)
Daily feeding of Nelumbo nucifera leaf powder for 21 days resulted significant decrease in the blood glucose levels of alloxan-induced diabetic rats. (scirp.org)
Animal experimentation is conducted under the guidance of the Institutional Animal Ethics Committee (IAEC) of Patanjali Research Foundation with a license to work on small experimental animals such as mice, rats, rabbits, hamsters and guinea pigs. (patanjali.res.in)
in alloxan induced rats. (innspub.net)
Dr Augusti continued his research on the benefits of leucocyanidin, pelargonidin and onion and garlic cysteine sulfoxides and allium oils to alloxan diabetic rats 8-11 and published the results. (org.in)
Dr. Augusti further studied on the mechanism of action of garlic, onion and cabbage oils with respect to their ameliorative effects in alcohol fed rats or alloxan diabetic rats as the case may be. (org.in)

In the studies of hypoglycemic effects, the subjected animals are being made diabetic using alloxan, streptozotocin (STZ) etc introducing inside injecting intraperitoneally (IP) or intravenously (IV). (scirp.org)
In modern experimental diabetology streptozotocin, alloxan and dithizone induced diabetic rat models are the most preferable. (ijpsr.com)
According to statistical data during the period from 1996 to 2006 streptozotocin and alloxan were used as chemical factors to investigate metabolic aspects in the development of disease in 69% and 31% of cases respectively 6, 7, 8, 9 . (ijpsr.com)

This causes an insulin-dependent diabetes mellitus (called "alloxan diabetes") in these animals, with characteristics similar to type 1 diabetes in humans. (wikipedia.org)
Alloxan diabetes mellitus (DM) simulates acute metabolic stress in a different direction, whose starting point is primary lysis of β-cells in the pancreas. (ijpsr.com)

The antidiabetic effects of the crude flavonoid (FV) and alkaloid (AK) of Abrus precatorius seed were studied in alloxan diabetic rabbits. (rjpponline.org)
Monago Comfort C., Nwodo O. Fred C. Antidiabetic Effects of Crude Flavanoid and Alkaloid of Abrus precatorius Linn Seed in Alloxan Diabetic Rabbits. (rjpponline.org)

Afterward, the animals had free access to regular rabbit chow and drinking water enriched with glucose to face alloxan-induced acute hypoglycemia. (medscape.com)

In 1949 it was discovered (Duff & McMillan " The effect of alloxan diabetes on experimental cholesterol atherosclerosis in the rabbit " ) that Rabbits exposed to the chemical alloxan became rapidly diabetic, but they appeared to be protected against the progression of atherosclerosis when fed cholesterol. (2keto.com)
In rodent experimental diabetes models, changes in these parameters were reported, but only limited relevant information is available in other species, having cardiac electrophysiological properties more resembling the human, including the rabbit. (unideb.hu)
The present study was designed to analyse the effects of experimental type 1 diabetes on ventricular repolarization and the underlying transmembrane potassium currents in rabbit hearts. (unideb.hu)

Alloxan is selectively toxic to insulin-producing pancreatic beta cells because it preferentially accumulates in beta cells through uptake via the GLUT2 glucose transporter. (wikipedia.org)
In our animal model, critical illness was induced by the combination of placing intravascular catheters, selectively destroying pancreatic β-cells by alloxan, followed by burn injury, which has previously shown to reveal the dynamic endocrine and metabolic changes characteristic of critical illness, including hyperglycemia and endogenous insulin deficiency. (medscape.com)

[ 10 ] Without exerting intrinsic effects on survival, [ 10 ] alloxan limits endogenous insulin release and thus minimizes interindividual differences in insulin levels upon glucose load. (medscape.com)
10. Anti-diabetic and hypolipidemic effects of extract from the seed of Gossypium herbaceum L. in Alloxan-induced diabetic rabbits. (nih.gov)
1997 Antidiabetic and anti-hyperlipaemic effects of neem seed kernel powder on alloxan diabetic rabbits. (innspub.net)
The effects were compared to that of chlorpropamide (CP) a known antidiabetic drug and a diabetic control group (CO). Blood glucose level drawn before the alloxan injection was 1.11+ 0.04, 1.33+0.06, 1.14 + 0.04, and 1.24+0.02 x 102 mg/dl for FV, AK, CP and CO groups respectively. (rjpponline.org)
PMID- 5157721 TI - Effects of the muscarinic agonist McN-A-343 on responses to sympathetic nerve stimulation in the rabbit ear artery. (nih.gov)
invaluable EnvironmentByPaul G. Properties of Synthetic Organic DyesByDavid G. LynchView Contact A infinite pdf Is Online Addiction Proof 1982 domain of Chemical Property Estimation Methods( away made as' Lyman's Handbook'), the Dream of Property Estimation Methods for Chemicals: Environmental and Health Sciences is and is quick Effects for doing not alloxan bestsellers of minor minds. (berlin-antik01.de)

Furthermore, alloxan inhibits glucokinase, a SH-containing protein essential for insulin secretion induced by glucose. (wikipedia.org)
METHODS AND RESULTS: Diabetes was induced by a single injection of alloxan, a subgroup of dogs received insulin substitution. (unideb.hu)

METHODS: Diabetes was induced by a single injection of alloxan (145 mg kg(-1) i.v.). After the development of diabetes (3 weeks), electrophysiological studies were performed using whole cell voltage clamp and ECG measurements. (unideb.hu)

The alloxan-diabetic rabbits consumed significantly higher quantities of cholesterol and food and had serum cholesterol and lipoprotein concentrations significantly increased over the control levels. (2keto.com)

Abaza I., El-Din A., Abd El-Hamid A., EL-Gayar H.F. (2014) Effect of chamomile flowers as feed additive on some biological parameters for growing rabbits. (sciendo.com)

How does a maternal diabetic hyperadiponectineamia affect signal transduction and lipid metabolism in rabbit preimplantation blastocysts? (nih.gov)

Responses of growing rabbits to supplementing diet with a mixture of black and red pepper oils as a natural growth promoter. (sciendo.com)

In a diabetic pregnancy in rabbits, maternal adiponectin levels are elevated fourfold and are accompanied by an increase in intracellular lipid droplets in blastocysts, implying consequences for the embryonic hormonal and metabolic environment. (nih.gov)

Trigonelline counteracted the hyperglycemic effect of cortisone when administered concomitantly, but not when administered 2 hours after cortisone administration, to non-diabetic rabbits. (nih.gov)

The alloxan model of diabetes was first described in rabbits by Dunn, Sheehan and McLetchie in 1943. (wikipedia.org)
Under conditions of alloxan-induced diabetic rat model intensification of oxidative stress processes occur provoking changes, which are typical for chronic hepatitis. (ijpsr.com)
Numerous publications of recent years show a consistently high interest of these models concerning the issue of forming different complications on the background of DM type 1 and 2, such as macrovascular disease, neuropathy, retinopathy, nephropathy, except this alloxan model provokes oxidative stress. (ijpsr.com)
However, the extract was found insignificant in the reversal of alloxan-induced diabetes in the rabbit model at test doses. (bvsalud.org)

The beta cell toxic action of alloxan is initiated by free radicals formed in this redox reaction. (wikipedia.org)
Later along with P.T. Mathew he worked with respect to the action of allicin in diabetic rabbits 14 . (org.in)

Others found a significant difference in alloxan plasma levels in children with and without diabetes Type 1. (wikipedia.org)

citation needed] Murexide results from the condensation of the unisolated intermediate uramil with alloxan, liberated during the course of the reaction. (wikipedia.org)

Most studies have shown that alloxan is not toxic to the human beta-cell, even in very high doses, probably because of differing glucose uptake mechanisms in humans and rodents. (wikipedia.org)

Adult male New Zealand White rabbits, weighing ±3 kg, were purchased from a local rabbitry, were housed individually with free access to water and regular rabbit chow, and were exposed to artificial light for 14 h per day. (medscape.com)
Alloxan diabetes serves as a classic example of free radical pathology. (ijpsr.com)

We've known, since the work of Russian scientist Nikolay Anichkov in 1913, that rabbits fed cholesterol rapidly become atherosclerotic and develop cardiovascular disease in a linear relationship - the more cholesterol they ate the faster they became atherosclerotic (unlike humans). (2keto.com)

Studies suggests that alloxan does not cause diabetes in humans. (wikipedia.org)

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