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rab GTP-Binding ProteinsGTP-Binding ProteinsGuanosine Triphosphaterab5 GTP-Binding Proteinsrab3 GTP-Binding Proteinsrab4 GTP-Binding Proteinsrab1 GTP-Binding ProteinsGTP Phosphohydrolasesrab3A GTP-Binding ProteinGuanosine DiphosphateMolecular Sequence DataMonomeric GTP-Binding ProteinsAmino Acid SequenceGuanosine 5'-O-(3-Thiotriphosphate)rab2 GTP-Binding ProteinADP-Ribosylation FactorsProtein BindingPertussis ToxinVirulence Factors, BordetellaGTPase-Activating Proteinsrho GTP-Binding ProteinsGuanine Nucleotide Exchange FactorsADP Ribose TransferasesBase SequenceAdenosine Diphosphate RiboseBotulinum ToxinsSequence Homology, Amino AcidThionucleotidesCloning, MolecularMutationras ProteinsrhoA GTP-Binding ProteinSignal TransductionKineticsCell MembraneCarrier ProteinsPoly(A)-Binding ProteinsSaccharomyces cerevisiaeCattleBinding SitesEndosomesGTP CyclohydrolaseProtein Structure, TertiaryProtein TransportGuanine Nucleotide Dissociation InhibitorsCell LineGuanine NucleotidesTacrolimus Binding ProteinsHydrolysisRecombinant ProteinsProtein PrenylationPoly(A)-Binding Protein IDNA-Binding ProteinsEndocytosisRecombinant Fusion ProteinsVesicular Transport ProteinsGuanylyl ImidodiphosphateMembrane ProteinsHeLa CellsInsulin-Like Growth Factor Binding ProteinsTwo-Hybrid System TechniquesModels, MolecularEscherichia coliRNA, MessengerRNA-Binding ProteinsTransfectionSequence AlignmentNuclear ProteinsFatty Acid-Binding ProteinsBiological TransportMutagenesis, Site-DirectedMelanosomesADP-Ribosylation Factor 1Cells, CulturedBacterial ProteinsDynaminsGuanosine MonophosphateDNA, ComplementaryGolgi ApparatusPeptide Elongation Factor TuTransducinTransglutaminasesExocytosisPoly(A)-Binding Protein IIBlotting, WesternProtein ConformationPeptide Elongation Factor GDNA PrimersProto-Oncogene Proteins p21(ras)Gene Expression RegulationGTP Phosphohydrolase-Linked Elongation FactorsElectrophoresis, Polyacrylamide GelMolecular WeightCalcium-Binding ProteinsModels, BiologicalCalciumSaccharomyces cerevisiae ProteinsPhosphorylationProteinsInsulin-Like Growth Factor Binding Protein 3

Rab3ASecretionGeranylgeranylRab3DSynapticFunctionalEscort ProteinSpecificityEffectorSmallFamilyHumanActiveLevelsRoleFoundInteractsExocytosisEpithelialGTPaseYeastGeneMiceMolecularMultiple formsShownCellsTransport

Rab3A5

• The crystal structure of Rab3A in the active configuration or bound to Rabphillin has been determined (19, 50) and Rab3D has been fit to the same model with 6 β-strands and 5 α-helices (45). (pancreapedia.org)
• Rab3 GEP was purified from brain and acted on Rab3A, 3C and 3D (72). (pancreapedia.org)
• The second Rab3 GEF, known as GRAB, interacts with inositol hexakisphosphate kinase and Rab3A and its protein expression is primarily in brain (41). (pancreapedia.org)
• Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene. (wikipedia.org)
• The different secretory processes are controlled by corresponding Rab proteins including Rab3A/B/C/D, Rab26, Rab27A/B and Rab37. (oncotarget.com)

Secretion5

• Because of its potential importance in acinar cell digestive enzyme secretion Rab3 is an important subject for review. (pancreapedia.org)
• Because of its localization and homology to the yeast protein Sec4, it was believed to play a role in the terminal steps of secretion. (pancreapedia.org)
• Rab3 isoforms have been identified in different tissues and cell types where it has been suggested to play a role in secretion (Table 1). (pancreapedia.org)
• Note that in some cases Rab3 inhibits and in others it stimulates secretion. (pancreapedia.org)
• As a secretory small GTPase, Rab3D is a vital regulator for protein secretion. (oncotarget.com)

Geranylgeranyl1

• The latter is used for the addition of two geranylgeranyl groups to the cysteine residues which attach the Rab3 to membranes (35). (pancreapedia.org)

Rab3D2

• There are no known GEFs specific for individual Rab3 isoforms such as Rab3D. (pancreapedia.org)
• We detected protein levels of Rab3D in nine cancer cell lines and twelve types of clinical cancer specimens. (oncotarget.com)

Synaptic2

• Rab3 was originally identified in brain and shown to be localized to synaptic vesicles (24). (pancreapedia.org)
• Rab3 GEP knockout mice die at birth and embryonic synaptic transmitter release is impaired (64). (pancreapedia.org)

Functional1

• Structurally, Rab3 species contain conserved functional domains similar to other Rabs. (pancreapedia.org)

Escort Protein1

• Likewise, Rab Escort Protein plays a role in the recycling of many or all Rab proteins (2). (pancreapedia.org)

Specificity1

• Rab proteins constitute the largest family of Ras-related small G proteins and play a role in regulating the specificity of membrane trafficking (63, 78). (pancreapedia.org)

Effector1

• These include four regions participating in guanine nucleotide binding, and effector region corresponding to the effector region in Ras, and a CXC prenylation motif at the C-terminal (45). (pancreapedia.org)

Small1

• Similar to other small G proteins, the guanine binding state of Rab3 proteins is regulated by guanine nucleotide exchange proteins or factors (GEPs or GEFs) and GTPase activating proteins (GAPs). (pancreapedia.org)

Family2

• Subsequent molecular cloning revealed four members of the Rab3 family termed 3A (the form originally found in brain), 3B, 3C, and 3D. (pancreapedia.org)
• There is no known specific Rab3 GDI, but rather a common family of Rab GDI isoforms which bind prenylated Rabs in the cytoplasm and participates in insertion and removal from membranes (75). (pancreapedia.org)

Human1

• Rab3 GEP is identical to the human DENN/MADD protein and contains a death domain which can bind the TNFR1 (15). (pancreapedia.org)

Active1

• The structure of the Rabs changes upon binding GTP and mutant Rab3 species have been described similar to Ras that are locked into active and inactive configurations (6). (pancreapedia.org)

Levels2

• We found that septin 2 protein levels were upregulated and colocalized strongly with CFTR in cystic cells. (bvsalud.org)
• Application of VX-809, the CFTR corrector, restored CFTR and PC2 toward normal in the cilia, decreased the protein levels of septin 2, and drastically reduced septin 2 colocalization with CFTR. (bvsalud.org)

Role1

• A single form of Rab3 exists in C. elegans and is believed to play a role in neurotransmitter release (47), while in sea urchin eggs a Rab3 is believed to play a role in cortical granule exocytosis (13). (pancreapedia.org)

Found1

• Rab3B and 3 D have been found in exocrine, endocrine, epithelial and adipose cells (60). (pancreapedia.org)

Interacts2

• In this study, we report that the GTP-binding protein Septin 2 interacts with Cyclophilin A. We highlight a dynamic series of Septin 2 phenotypes at the midbody, previously undescribed in human cells. (bvsalud.org)
• Affinity enrichment mass spectrometry revealed that the primary ciliogenesis regulator, RILPL1 specifically interacts with the LRRK2-phosphorylated forms of Rab8A and Rab10, whereas RILPL2 binds to phosphorylated Rab8A, Rab10, and Rab12. (elifesciences.org)

Exocytosis2

• A single form of Rab3 exists in C. elegans and is believed to play a role in neurotransmitter release (47), while in sea urchin eggs a Rab3 is believed to play a role in cortical granule exocytosis (13). (pancreapedia.org)
• Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. (nih.gov)

Epithelial1

• Rab3B and 3 D have been found in exocrine, endocrine, epithelial and adipose cells (60). (pancreapedia.org)

GTPase2

• Similar to other small G proteins, the guanine binding state of Rab3 proteins is regulated by guanine nucleotide exchange proteins or factors (GEPs or GEFs) and GTPase activating proteins (GAPs). (pancreapedia.org)
• This gene encodes the catalytic subunit of a Rab GTPase activating protein. (nih.gov)

Yeast1

• Because of its localization and homology to the yeast protein Sec4, it was believed to play a role in the terminal steps of secretion. (pancreapedia.org)

Gene1

• Ras-related protein Rab-3B is a protein that in humans is encoded by the RAB3B gene. (wikipedia.org)

Mice1

• Rab3 GEP knockout mice die at birth and embryonic synaptic transmitter release is impaired (64). (pancreapedia.org)

Molecular1

• Subsequent molecular cloning revealed four members of the Rab3 family termed 3A (the form originally found in brain), 3B, 3C, and 3D. (pancreapedia.org)

Multiple forms1

• Because of the presence of multiple forms of Rab3 in neuronal cells, the group of T. Sudhof prepared a mouse model in which all four isoforms of Rab3 were deleted. (pancreapedia.org)

Shown2

• RAB3B has been shown to interact with RPH3A. (wikipedia.org)
• Rab3 was originally identified in brain and shown to be localized to synaptic vesicles (24). (pancreapedia.org)

Cells1

• Elevated IFN-γ decreased the SEPT11 protein levels in Ishikawa cells and HEECs. (bvsalud.org)

Transport1

• These results implicate LRRK2 in primary ciliogenesis and suggest that Rab-mediated protein transport and/or signaling defects at cilia may contribute to LRRK2-dependent pathologies. (elifesciences.org)