• The small GTP-ase rab5 functions as a regulatory factor in the early endocytic pathway. (springer.com)
  • Recent work, discussed in this review, has used biophysical, biochemical and genetic approaches to begin to answer these questions for Rab3, Rab5 and the yeast protein Sec4p. (sussex.ac.uk)
  • amino acids 1-649) fused to GFP, red fluorescent protein (RFP) or a hemagglutinin (HA) tag were cloned by PCR-based mutagenesis into pCDNA3.1 (Invitrogen). (jneurosci.org)
  • The amyloid precursor protein (APP) is anterogradely transported by conventional kinesin in a distinct transport vesicle, but both the biochemical composition of such a vesicle and the specific kinesin-1 motor responsible for transport are poorly defined. (jneurosci.org)
  • The β-amyloid peptide is a cleavage product of the amyloid precursor protein (APP). (jneurosci.org)
  • Functionally, most studies point toward a role for Rab3 in the secretion of hormones and neurotransmitters. (umbc.edu)
  • Our results indicate that loss of Rab3-GEF results in the development of NMJs that are structurally and functionally indistinguishable from NMJs that lack the protein Rab3. (eneuro.org)
  • We have also compared the accumulation of these synaptic vesicle protein transcripts during neuroblast proliferation and neuronal differentiation in vitro, using as a model system the embryonic carcinoma cell line P19 which can be induced to differentiate into neurons and glial cells. (nih.gov)
  • In resting acinar cells, the rab3-like protein was detected primarily on the cytoplasmic face of ZGs, with little labeling of the Golgi complex and no significant labeling of the apical plasmalemma or any other intracellular membranes. (rupress.org)
  • Phosphorylated enhanced green fluorescent protein-synaptophysin and phosphorylated enhanced cyan fluorescent protein (CFP)-synaptophysin were kind gifts from C. Kaether (Leibniz Institute for Age Research, Jena, Germany) and T. Dresbach (Institute for Anatomy and Cell Biology, Heidelberg, Germany). (jneurosci.org)
  • Proteins with WD domains are involved in many functions including participation in signal transduction pathways. (genecards.org)
  • A gene on chromosome 18q21.31 that encodes a member of the WD-repeat protein family, which are involved in various cellular processes, including cell cycle progression, signal transduction, apoptosis and gene regulation. (thefreedictionary.com)
  • later reported that the interaction between APP and KLCs might be mediated by c-Jun N-terminal kinase-interacting protein 1b (JIP1b). (jneurosci.org)
  • PREDICTED- similar to calcium/calmodulin-dependent serine protein kinase 1, partial [Hydra magnipapillata]. (string-db.org)
  • Research has indicated that this is a result of altered function of CNS synapses (in which the protein product of Dmxl2 is expressed) causing altered activation of the GnRH neurons of the hypothalamus. (wikipedia.org)