• The Rab3A GTPase interacts with multiple factors through the same effector domain. (wikipedia.org)
  • Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene. (wikipedia.org)
  • This gene encodes a large protein that functions as a GDP to GTP exchange factor. (cancerindex.org)
  • The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. (nih.gov)
  • In addition to its association with Ras, GAP has been shown to bind to several tyrosine-phosphorylated proteins in cells stimulated by growth factors or expressing transforming tyrosine kinase variants. (embl.de)
  • Here, we demonstrated that primary MYChi human SCLC tumors also contained abundant guanosine nucleotides. (bvsalud.org)
  • In immunofluorescence experiments, GAP and Tid-1 were shown to colocalize at perinuclear mitochondrial membranes in response to epidermal growth factor stimulation. (embl.de)