• The Rab family of proteins is a member of the Ras superfamily of small G proteins. (wikipedia.org)
  • Rab proteins generally possess a GTPase fold, which consists of a six-stranded beta sheet which is flanked by five alpha helices. (wikipedia.org)
  • Rab proteins are peripheral membrane proteins, anchored to a membrane via a lipid group covalently linked to an amino acid. (wikipedia.org)
  • Rab escort proteins (REPs) deliver newly synthesized and prenylated Rab to its destination membrane by binding the hydrophobic, insoluble prenyl groups and carrying Rab through the cytoplasm. (wikipedia.org)
  • REPs carry only the GDP-bound form of Rab, and Rab effectors, proteins with which Rab interacts and through which it functions, only bind the GTP-bound form of Rab. (wikipedia.org)
  • Rab proteins and their functions are essential to proper organelle function, and as such, when any deviation is introduced to the Rab protein cycle, physiological disease states ensue. (wikipedia.org)
  • REP-1 and REP-2 (a REP-1 like protein) both help with the prenylation and transport of Rab proteins. (wikipedia.org)
  • In addition to directly causing cancer, dysregulation of Rab proteins has also been linked to progression of already existent tumors, and contributing to their malignancy. (wikipedia.org)
  • We also wish to explore how Rab proteins targeted by LRRK2 are linked to Parkinson's. (michaeljfox.org)
  • We aim to continue developing improved methods to assess LRRK2-targeted Rab proteins that are likely to comprise important biomarkers for assessing biology that is related to Parkinson's disease. (michaeljfox.org)
  • There are 39024 RAB domains in 38982 proteins in SMART's nrdb database. (embl.de)
  • Taxonomic distribution of proteins containing RAB domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with RAB domain is also avaliable . (embl.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing RAB domain in the selected taxonomic class. (embl.de)
  • The Rab family of small GTP-binding proteins has long been implicated in the docking and fusion of transport vesicles with their target membranes. (embl.de)
  • Individual transport steps are regulated by Ras-like guanine nucleotide-binding proteins, termed Ypt in yeast or Rab in mammals. (embl.de)
  • The diversity of Rab proteins in vesicle transport. (embl.de)
  • Rab proteins have been primarily implicated in vesicle docking as regulators of SNARE pairing. (embl.de)
  • Recent findings, however, indicate that their function in vesicle trafficking can go beyond this role, and a number of proteins, unrelated to each other, have been identified as putative Rab effectors. (embl.de)
  • Although the GTPase switch of Rab proteins is highly conserved, functional mechanisms may be highly diversified among members of the Rab family. (embl.de)
  • In particular, functional impairments of specific Rab proteins, e.g. (elsevierpure.com)
  • Through a cycle of GTP binding and hydrolysis, rab-effector proteins are recruited to membrane sub-domains in a temporally and spatially specific manner. (bl.uk)
  • Several rab proteins localise to the Golgi apparatus, the organelle consisting of stacked, flattened, membrane-bound cisternae through which newly-synthesised proteins are transited and modified, and where proteins and lipids are sorted and packaged for transport to other subcellular destinations. (bl.uk)
  • The structure of the Golgi is maintained by a matrix of proteins, many of which have now been shown to be rab-effector proteins. (bl.uk)
  • This thesis focuses on Golgi-localised rab proteins and their effector proteins. (bl.uk)
  • A search for novel effectors of the trans-Golgi-localised rab protein, rab6, was also made, revealing specific interactions with the dynactin subunit p150glued and the dynactin/dynein accessory proteins BicD1 and BicD2. (bl.uk)
  • The 70 or so members of the Rab subfamily of proteins perform a wide range of important tasks inside cells. (elifesciences.org)
  • Proteins called guanine nucleotide exchange factors, or GEFs for short, activate the Rab protein by promoting the release of GDP and the binding of GTP. (elifesciences.org)
  • Other proteins-known as GAPs-lead to the inactivation of the Rab protein. (elifesciences.org)
  • The Rab subfamily of proteins is part of the large Ras superfamily, and all members of this superfamily are activated and inactivated in a similar way, with the binding and unbinding of GDP and GTP taking place at a structure called the G-domain. (elifesciences.org)
  • By showing that different Rab proteins are activated by different mechanisms, and that a single Rab protein can be activated by more than one mechanism, the work of Langemeyer et al. (elifesciences.org)
  • Recent work has revealed that LRRK2 phosphorylates a subgroup of 14 Rab proteins, including Rab10, at a specific residue located at the centre of its effector-binding switch-II motif. (dundee.ac.uk)
  • In the present study, we analyse the selectivity and sensitivity of polyclonal and monoclonal phospho-specific antibodies raised against nine different LRRK2-phosphorylated Rab proteins (Rab3A/3B/3C/3D, Rab5A/5B/5C, Rab8A/8B, Rab10, Rab12, Rab29[T71], Rab29[S72], Rab35 and Rab43). (dundee.ac.uk)
  • We also identify rabbit monoclonal antibodies displaying broad specificity (MJFF-pRAB8) that can be utilised to assess LRRK2-con-trolled phosphorylation of a range of endogenous Rab proteins, including Rab8A, Rab10 and Rab35. (dundee.ac.uk)
  • The antibodies described in the present study will help with the assessment of LRRK2 activity and examination of which Rab proteins are phosphorylated in vivo. (dundee.ac.uk)
  • A small family of rab GTP-binding proteins that play a key role in membrane trafficking in the late endocytic and autophagic pathways. (bvsalud.org)
  • Rab GTPases regulate many steps of membrane trafficking, including vesicle formation, vesicle movement along actin and tubulin networks, and membrane fusion. (wikipedia.org)
  • Evidence shows that overexpression of Rab GTPases have a striking relationship with carcinogenesis, such as in prostate cancer. (wikipedia.org)
  • Rab GTPases are implicated in vesicle trafficking. (embl.de)
  • Vesicular transport: how many Ypt/Rab-GTPases make a eukaryotic cell? (embl.de)
  • Rab GTPases constitute a family of small GTPases that regulate a variety of membrane trafficking events in all eukaryotic cells by recruiting their specific effector molecules. (elsevierpure.com)
  • In this article, we review current knowledge regarding melanosomal logistics, with particular focus on the roles of Rab small GTPases and their effectors. (elsevierpure.com)
  • Ohbayashi, N & Fukuda, M 2012, ' Role of Rab family GTPases and their effectors in melanosomal logistics ', Journal of Biochemistry , vol. 151, no. 4, pp. 343-351. (elsevierpure.com)
  • The rab family of small, ras-like GTPases regulate membrane trafficking events in the secretory and endocytic pathways. (bl.uk)
  • RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. (novusbio.com)
  • These findings highlight plasticity in the activation mechanisms of closely related Rab GTPases. (elifesciences.org)
  • The inherent GTP hydrolysis of Rabs can be enhanced by a GTPase-activating protein (GAP) leading to Rab inactivation. (wikipedia.org)
  • The specific binding of the effector to the Rab protein allows the Rab protein to be effective, and conversely, the conformation shift of the Rab protein to the inactive state leads to effector dissociation from the Rab protein. (wikipedia.org)
  • Choroideremia is caused by a loss-of-function mutation in the CHM gene which codes for Rab escort protein (REP-1). (wikipedia.org)
  • There are many mechanisms by which Rab protein dysfunction has been shown to cause cancer. (wikipedia.org)
  • The cis-Golgi-localised rab protein, rabl, is shown to interact with the Golgi matrix/golgins GM130 and p115 while rab2 binds GM130 as well as a novel tethering factor named golgin-45. (bl.uk)
  • Finally, the cis-Golgi rab-effector and matrix protein, GM130, is shown to have a hitherto unsuspected role in the activation of a family of Golgi-localised Ste20 kinases. (bl.uk)
  • A Rab protein is always bound to another molecule, which determines whether it is inactive or active. (elifesciences.org)
  • Binding to a molecule called GDP makes the Rab protein inactive, while binding to GTP makes it active. (elifesciences.org)
  • The experiments showed that different amino acids in the active site of the Rab protein are involved when the GEFs mediate the release of the GDP during the activation process. (elifesciences.org)
  • create a human Rab protein that cannot be activated by the GEF from the bacteria that cause Listeria, but can still be activated by its normal human GEF. (elifesciences.org)
  • Recent accumulating evidence indicates that members of the mammalian Rab small GTPase family are involved in certain physiological and pathological processes. (elsevierpure.com)
  • Despite conservation of active-site residues, the Ras-related Rab GTPase activation pathway differs from Ras and between different Rabs. (elifesciences.org)
  • The atypical Rab GTPase associated with Parkinson's disease, Rab29, is localized to membranes. (nih.gov)
  • Cargo budding, selection, and coating Vesicle Transport Vesicle Uncoating and Tethering Vesicle Fusion After membrane fusion and effector dissociation, Rab is recycled back to its membrane of origin. (wikipedia.org)
  • Comebackability was the word of the day for Rab Wardell, who battled back from three punctures to take the Elite Men's title on the final lap of a great day of racing at Kirroughtree Forest. (britishcycling.org.uk)
  • Rab Wardell : Cause Of Death Was Not Vaccine SADS! (techarp.com)
  • People are still claiming that Rab Wardell died from vaccine SADS, but that's not true! (techarp.com)
  • It's been almost a year since Rab Wardell died suddenly after he won the Scottish MTB XC Championships, but people continue to claim that the cyclist died from the COVID-19 vaccine. (techarp.com)
  • This is Mountain biker Rab Wardell speaking on TV last night about winning the Scottish championship 2 days ago. (techarp.com)
  • Rab Wardell another victim of the covid vaccine. (techarp.com)
  • 37 year-old Scottish cyclist Rab Wardell died on Tuesday, August 23, 2022 - just two days after winning the Scottish MTB XC Championships, and hours after appearing on BBC Scotland's The Nine programme to talk about that victory. (techarp.com)
  • The next day, his wife - Katie Archibald - spoke out , explaining that Rab Wardell died from a cardiac arrest he suffered while they were in bed together. (techarp.com)
  • While there is no direct evidence that Rab Wardell was vaccinated against COVID-19, he travelled a fair bit in 2021 - mostly to Europe and Canada. (techarp.com)
  • While it is possible to enter with a vaccine exemption, it is far more likely that Rab Wardell was fully-vaccinated. (techarp.com)
  • Rab Wardell never travelled the United States since the COVID-19 pandemic started. (techarp.com)
  • Rab Wardell never said he suffered pericarditis from any COVID-19 vaccine. (techarp.com)
  • In October 2021 , Rab Wardell was in Italy for the Marathon World Championships when he shared that it was the first time he flew overseas since the pandemic began. (techarp.com)
  • We started as a tour operator for Rab island, and thanks to the life long experience inside the tourist market, we positioned ourselves as the Incoming Tour Operator for different parts of Croatia. (rab-novalja.com)
  • The Rab Women's Quest Hoody is a mid-weight fleece jacket with textured heather knit look fabric. (tauntonleisure.com)
  • Almost a year later - on 31 July 2023, Katie revealed Rab Wardell's official cause of death - hypertrophy of the left ventricle , which is also known as athlete's heart . (techarp.com)
  • Many of the RABs in this list are available by clicking on the RAB number. (michigan.gov)
  • The lipid prenyl groups can then insert into the membrane, anchoring Rab at the cytoplasmic face of a vesicle or the plasma membrane. (wikipedia.org)
  • Below is a summary of what has happened to the Restoration Advisory Board, or RAB, a board wherein community members raised questions regarding environmental cleanup of a Superfund site and its adverse health effects on the adjacent community. (sfbayview.com)
  • Our loyalty programme members are part of our family. (valamar.com)
  • Mahfuzur Rahman, 31, was a constable in Khulna when he got addicted to yaba and the crazy drug made him beat up his family members and vandalise houses. (thedailystar.net)
  • Feed the Future aims to assist millions of vulnerable women, children, and family members to escape hunger and poverty, while also reaching significant numbers of children with highly effective nutrition interventions to prevent stunting and child mortality. (who.int)
  • Over the next five years in Malawi, Feed the Future aims to help an estimated 281,000 vulnerable Malawian women, children, and family members-mostly smallholder farmers-escape hunger and poverty. (who.int)
  • Most of the male or female family members no case was family members were agrarian by occupa- reported. (who.int)
  • Mar- female family members, no aposthia cases riages were strictly endogamous within the were born. (who.int)
  • His compassion for all was apparent, and with those who worked with him he was warm-hearted and patient, making them feel they were members of his family. (who.int)
  • Daily use of contaminated toothbrushes can contribute to disseminate microorganisms within the oral cavity of an individual or between different family members 7,23 . (bvsalud.org)
  • Occasionally, toothbrushes belonging to different members of the same family may contact directly themselves when stored in the holder or when stored together in bathroom drawers or cabinets 19 . (bvsalud.org)
  • The family Staphylinidae belongs to the suborder Polyphaga of the order Coleoptera (beetles). (ufl.edu)
  • The idea was to rebuild a functional Pudarica house in a vineyard and with that to awake a peace of history of the vine region of Rab. (ecobnb.com)
  • A GDP dissociation inhibitor (GDI) binds the prenyl groups of the inactive, GDP-bound form of Rab, inhibits the exchange of GDP for GTP (which would reactivate the Rab) and delivers Rab to its original membrane. (wikipedia.org)
  • A guanine nucleotide exchange factor (GEF) catalyzes the conversion from GDP-bound to GTP-bound form, thereby activating the Rab. (wikipedia.org)
  • Conserved active-site residues in the Rab switch II region stabilising the nucleotide-free form differentiate these pathways. (elifesciences.org)
  • On the other hand, injuries and violence and their consequences may lead to poverty at individual, family and community levels. (who.int)
  • Mpox virus is a member of the Orthopoxvirus genus within the Poxviridae family. (cdc.gov)
  • Apartments Nada of the Peran family are located in Banjol (Petrac) on the island of Rab. (direct-croatia.com)
  • As now constituted, Staphylinidae are the largest family of beetles, with over 63,000 species known worldwide and probably over 75% of tropical species still undescribed. (ufl.edu)
  • It is the largest family in the British Isles and in America north of Mexico, and it may prove to be so in other regions when huge numbers of now-unknown species are described (if they are described before they become extinct by habitat destruction). (ufl.edu)
  • On Tuesday, a Rab team carried out a raid and arrested Mitu along with her two associates from Sonakanda area in Bandar upazila of the district, said Lt Col Kamrul Hasan, commanding officer of Rab-11, at a press briefing at its headquarters in Narayanganj yesterday. (thedailystar.net)
  • The dead, Ashraf Ali, 35, stood accused in seven to eight drug-related cases filed with different police stations, said Lt Col Ashique Billah, commanding officer of Rab-2. (thedailystar.net)
  • The house is located 150 meters from the sea and natural beach in the Vineyard region of Rab called Pudarica. (ecobnb.com)
  • We are asking the Environmental Protection Agency, our federal government, to protect our community, to come to the aid of American citizens in this time when children, elders and families have suffered from a Katrina-like catastrophe. (sfbayview.com)
  • The extensive development of the urethra and glans is very pedigrees of the families were constructed rare because it is generally accepted that by interviewing the elders of the families. (who.int)
  • All the trait-bearing and has 5 generations (PPD-V). The elders males had a normal structural and function- of this family were native and belonged to al penis without prepuce. (who.int)
  • We and 3 with more than 1 aposthia male: fam- think that the person with aposthia trait is a ily DG-01 had 4 living cases, family DG-02 suitable model to study the importance and had 2 living and 1 dead case and family DG- genetics of the prepuce. (who.int)
  • Genetic and biochemical analyses of the gene products responsible for mammalian pigmentation disorders in the past decade have revealed that Rab-mediated endosomal transport systems and melanosome transport systems play crucial roles in the efficient darkening of mammalian hair and skin. (elsevierpure.com)
  • the E-value for the RAB domain shown below is 2.57e-67. (embl.de)
  • The pedigree, consisting of 37 in- Family DG-03 dividuals including 4 trait-bearing males, This family is from Dera Ghazi Khan city is shown in Figure 1. (who.int)
  • Whether you are escaping the city for a weekend in the hills or going in search of warmer climes with the family, our selection of stoves,laterns, sleeping bags and camping equipment has got you covered. (tiso.com)
  • He has so far recruited 10 people to the militant outfit, Rab said. (thedailystar.net)
  • R. Johanan, however, remarked that Rab came from a healthy family, but that people like himself must spend the last peruṭa to purchase the best nourishment (Ḥul. (jewishencyclopedia.com)
  • Since I found out that my grand mother, aunties and this old man are evil people who wants to harm my family, I try to protect my parents and siblings but my parents make my life a living hell because those evil can't do harm to me so they use my parents to harm me and insult me and spit on me. (zawaj.com)
  • The pedigree consists of 38 individuals in- The family comes from Dera Ghazi Khan cluding 2 trait-bearing males (Figure 3). (who.int)
  • Based on his information, Rab carried out a raid at Mofizul's house in Sonargaon of Narayanganj and arrested him. (thedailystar.net)
  • We are selling a very nice family house, newer construction, ideal for living or vacation. (nekretnine-rijeka.com)
  • It is well known that a father provides a house for his family, provides furniture for the house, equipment, food and drink. (nabulsi.com)
  • Reliable and of the highest quality, we stock a range of jackets and coats for men from best selling brands like Rab and The North Face. (tiso.com)
  • Furthermore, Rab1 switch II glutamine mutants refractory to activation by DrrA can be activated by TRAPP, showing that a single Rab can be activated by more than one mechanistically distinct GDP-release pathway. (elifesciences.org)
  • Rab handed over the child to the family. (thedailystar.net)
  • Prevention and control of micronutrient malnutrition will require a concerted effort by all USAID/Malawi's health programs, namely, malaria, family planning, maternal, neonatal and child health, HIV/AIDS and nutrition. (who.int)
  • A sample of 1200 families (830 native law of 1567 CE, in relation to a child born and 370 migrant) was studied in which 6 circumcised [3]. (who.int)
  • Of course, where you go will depend largely on what you're looking for - posh hotels with lush spa facilities, remote islands offering authentic Adriatic seafood, rugged mountains with challenging hiking paths, or a simple family retreat where you feel you'll all be looked after properly. (telegraph.co.uk)
  • My family is making my life a living hell, my parents are under black magic. (zawaj.com)
  • I think you've heard that Rab died yesterday morning. (techarp.com)
  • An alleged drug peddler was killed in a "gunfight" with Rab in the capital's Agargaon early yesterday. (thedailystar.net)
  • Johnny Tremain 's story ends with both sadness and grim hope as Rab dies and passes on his gun to Johnny. (coursehero.com)
  • She-rab Dong-bu (The Tree of Wisdom) , is a quite simple ethical treatise by Nagarjuna (Tibetan: Lu-trub], who flourished about 100 BC and is celebrated as a magnificent Buddhist philosopher. (nvg.org)
  • The lone figure of Rab Noakes quickly steps out of the shadows, into the spotlight, hooks on his vintage guitar and gets straight down to business. (musicscotland.com)