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  • amino acid seq
  • While the amino acid sequence of the subunit indicated that there seemed to be four transmembrane domains (parts of the protein that pass through the plasma membrane), proteins interacting with the subunit indicated that the N-terminus seemed to be extracellular, while the C-terminus seemed to be intracellular. (wikipedia.org)
  • derivatives
  • The efficient asymmetric synthesis of new chiral gamma-chloro-alpha,beta-diamino acid derivatives via highly diastereoselective Mannich-type reactions of N-(diphenylmethylene) glycine esters across. (ugent.be)
  • The gamma-chloro-alpha,beta-diamino acid derivatives proved to be excellent building blocks for ring closure towards optically pure anti-and syn-beta,gamma-aziridino-alpha-amino esters, and subsequent ring transformation into trans-3-aminoazetidine-2-carboxylic acid derivatives and alpha,beta-diamino-gamma-butyrolactones. (ugent.be)
  • Callebaut G, Mangelinckx S, Kiss L, Sillanpaa R, Fulop F, De Kimpe N. Asymmetric synthesis of α,β-diamino acid derivatives with an aziridine-, azetidine- and γ-lactone-skeleton via Mannich-type additions across α-chloro-N-sulfinylimines. (ugent.be)
  • induce
  • BACKGROUND: In cell systems, saturated fatty acids, compared to unsaturated fatty acids, induce a greater degree of ER stress and inflammatory signaling in a number of cell types, including hepatocytes and adipocytes. (biomedsearch.com)
  • CONCLUSIONS: These data suggest that elevated plasma free fatty acids can induce hepatic and adipose tissue ER stress and inflammation in vivo. (biomedsearch.com)
  • vivo
  • Fatty acid-mediated endoplasmic reticulum stress in vivo: differential response to the infusion of Soybean and Lard Oil in rats. (biomedsearch.com)
  • The aim of the present study was to determine the effects of infusions of lard oil (enriched in saturated fatty acids) and soybean oil (enriched in unsaturated fatty acids) on liver and adipose tissue ER stress and inflammatory signaling in vivo. (biomedsearch.com)
  • In addition, saturated fatty acids appear to be more cytotoxic than unsaturated fatty acids in vivo. (biomedsearch.com)
  • mmol
  • RESULTS: Plasma free fatty acid levels were 0.5±0.1 mmol/L (mean±SD) in Control and were increased to 1.0±0.3 mmol/L and 1.1±0.3 mmol/L in Soybean and Lard, respectively. (biomedsearch.com)
  • L-[2,3,4- 3 H]-Glutamic acid (60 Ci/mmol) and [ 3 H]Fluorowiillardiine (80 Ci/mmol) were obtained from American Radiolabeled Chemicals, Inc (St. Louis, MO). (hindawi.com)
  • spinal
  • Curtis, D.R., Duggan, A.W. and Johnston, G.A.R. (1970) The inactivation of extracellularly administered amino acids in the feline spinal cord. (springer.com)
  • Curtis D.R., Watkins J.C. The excitation and depression of spinal neurons by structurally related amino acids. (springer.com)
  • action
  • There is an important mechanism of action of some anticonvulsants through inhibition of a class of voltage-gated sodium channels (VGSCs) that would inhibit the excessive firing of neurons that is characteristic of seizures, thus blocking the release of excitatory amino acids ( Rogawski, 2006 ). (aspetjournals.org)