• Quinuclidine carbonate derivatives act as muscarinic receptor antagonists and are effective for the prevention and/or treatment of a broncho-obstructive or inflammatory diseases. (patentsencyclopedia.com)
  • Quinuclidine carbamate derivatives and their use as M3 antagonists are described in WO 02051841, WO 03053966, and WO 2008012290. (patentsencyclopedia.com)
  • [1] It is one of a number of substituted quinuclidine derivatives developed as potential medications for the treatment of cocaine abuse, [2] and produces similar effects to cocaine in animal studies, although milder and longer-lasting. (wikipedia.org)
  • This list included solifenacin succinate, which was covered by Astellas' Polish patent PL182344 for quinuclidine derivatives and pharmaceutical preparations containing these (being the national designation of EP 0 801 067). (lexology.com)
  • The name quinuclidine is retained for general nomenclature only (see Table 2.6). (wikipedia.org)
  • 1 The presence of the tertiary quinuclidine nitrogen renders them effective ligands for a variety of metal-catalyzed processes. (sigmaaldrich.com)
  • The roles of the hydroxyl group and benzene ring of Tyr381 were probed further by comparative analysis of the Tyr381Phe and Tyr381Ala mutants using three series of ligands: ACh analogs, azanorbornane- and quinuclidine-based ligands, and atropine analogs. (aspetjournals.org)
  • However, the hydroxyl group and benzene ring of Tyr381 both participate in interactions with azanorbornane- and quinuclidine-based ligands and atropine analogs in the ground state as well as the activated state of the receptor. (aspetjournals.org)
  • Quinuclidine is an organic compound and a bicyclic amine and used as a catalyst and a chemical building block. (wikipedia.org)
  • using the chiral quinuclidine-based amine catalysts 1 and 2 . (organic-chemistry.org)
  • Quinuclidine is found as a structural component of some biomolecules including quinine. (wikipedia.org)
  • Quinine contains two major fused-ring systems: the aromatic quinoline and the bicyclic quinuclidine. (niir.org)
  • Blackstock SC, Lorand JP, Kochi JK (1987) Charge transfer interactions of amines with tetrahalomethanes - X-ray crystal-structures of the donor-acceptor complexes of quinuclidine and diazabicyclo[2.2.2]octane with carbon tetrabromide. (springer.com)
  • Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. (axonmedchem.com)
  • The quinuclidine PHA-0568487(1) is an agonist of the alpha7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated liabilities with in vivo tolerability. (ebscohost.com)
  • We show that this motif can convert the nonselective agonists quinuclidine and ethyltrimethyl-ammonium to the α7-selective analogs methyl-quinuclidine and diethyldimethyl-ammonium, respectively. (aspetjournals.org)
  • The benzylidene motif was also applied to quinuclidine to generate another distinct family of α7-selective agonists. (aspetjournals.org)
  • In addition, multiple hydroxylations were observed both on the quinoline core and the quinuclidine ring system. (biomedcentral.com)
  • The nucleophilic quinuclidine nitrogen can also be used directly as a reactive center for enantioselective catalysis. (sigmaaldrich.com)
  • In this model, which was proposed by the research group of Alfons Baiker , a chemistry professor at the Swiss Federal Institute of Technology (ETH), in Zurich, the adsorbed alkaloid and pyruvate are hydrogen bonded between the pyruvate's carbonyl group in the ketone function (not the ester) and the nitrogen atom in cinchonidine's quinuclidine group. (acs.org)
  • Černobrovijs A. 3-Aizvietoto hinuklidīnu sintēze un to izmantošana mekvitazīna sintēzei = Synthesis of 3-substituted quinuclidines and their application for mequitazine synthesis. (osi.lv)
  • [0003] The present invention relates to quinuclidine carbonate salts which act as muscarinic receptor antagonists. (patentsencyclopedia.com)
  • Two quinuclidines, ER-119884 and E5700, had authoritative in vitro anti-Leishmania (Fernandes Rodrigues et al. (kramskoy.info)
  • Quinuclidines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
  • high throughput screening led to 11 chemical families, including quinuclidine ethers, which led to AQW051. (cenblog.org)
  • The report also focuses on quinuclidine consumers by providing data on companies that use it. (marketpublishers.com)
  • Synergic effect of a quinuclidine benzamide complexed with borane, the LMA10233, in combination with seven pesticides. (fluoridealert.org)
  • This graph shows the total number of publications written about "Quinuclidines" by people in this website by year, and whether "Quinuclidines" was a major or minor topic of these publications. (ucdenver.edu)
  • Below are the most recent publications written about "Quinuclidines" by people in Profiles. (ucdenver.edu)
  • The zwitterion nature of the phases is due to the presence of either ( R , R )‐ or ( S , S )‐aminocyclohexanesulfonic acid in the selector structure bearing the quinuclidine moiety. (separationsnow.com)
  • typical examples are lysergic acid diethylamide and the quinuclidine ester of diphenyloxyacetic acid. (thefreedictionary.com)