• The constant need for new anti microbials has produced a variety of newer quinolones termed as I, II, III, and IV generation. (nih.gov)
  • Activity of the newer quinolones against Chlamydia trachomatis. (bmj.com)
  • Most cephalosporins, except for Rocephin, need to be administered every eight hours, while the newer quinolones are administered once daily. (managedcaremag.com)
  • It has also been shown that the newer more potent quinolone drugs such as ciprofloxacin and ofloxacin have an additional effect on the bacterial cells in that the chromosome is broken down into fragments of DNA, some of which are estimated to be as small as 4kb in length. (bl.uk)
  • We report here that P. aeruginosa produces another signal molecule, 2-heptyl-3-hydroxy-4-quinolone, which has been designated as the Pseudomonas quinolone signal. (pnas.org)
  • Recently, a third signaling system based on 2-heptyl-3-hydroxy-4-quinolone, designated the Pseudomonas quinolone signal (PQS), has been shown to be a part of the quorum-sensing regulatory network in P. aeruginosa ( 27 ). (asm.org)
  • Like aminoglycosides, the quinolones exhibit concentration-dependent bacterial killing. (aafp.org)
  • The comparative effectiveness and safety of macrolides, quinolones and amoxicillin/clavulanate (A/C) for the treatment of patients with acute bacterial exacerbation of chronic bronchitis (ABECB) was evaluated in the present study. (ersjournals.com)
  • Macrolides, quinolones and amoxicillin/clavulanate may be considered equivalent for the treatment of patients with an acute bacterial exacerbation of chronic bronchitis in terms of short-term effectiveness. (ersjournals.com)
  • Quinolones are associated with better microbiological success and fewer recurrences of acute bacterial exacerbation of chronic bronchitis than macrolides, while amoxicillin/clavulanate is associated with more adverse effects than both comparators. (ersjournals.com)
  • In this review, we present hallmark investigations describing the mode of action of quinolones, one of the antibacterial classes targeting the function of topoisomerases in bacteria. (mdpi.com)
  • Extensive pharmacologic and clinical development of quinolone antimicrobial agents has resulted in improved antimicrobial activity, pharmacokinetic features, toxicity, and drug-drug interaction profiles. (nih.gov)
  • Moreover, a retrospective analysis of patients with ABECB showed that the administration of a broader spectrum antimicrobial agent (azithromycin, quinolone or amoxicillin/clavulanate (A/C)) was associated with fewer clinical failures compared with the use of first-line agents (mainly amoxicillin, TMP/SMX, and doxycycline) 15 . (ersjournals.com)
  • Objective and subjective musculoskeletal evaluations will be performed to determine differences in the ciprofloxacin versus non-quinolone treated pediatric patients so that we can tell wha. (bioportfolio.com)
  • Quinolones in comparison to other antibiotic classes have the highest risk of causing colonization with MRSA and Clostridium difficile . (princeton.edu)
  • When used in combination with agents from other antibiotic classes, such as beta-lactams and aminoglycosides, the quinolones are not predictably synergistic. (aafp.org)
  • Quinolones constitute a large class of synthetic antimicrobial agents that are highly effective in the treatment of many types of infectious diseases, particularly those caused by bacteria. (indigo.ca)
  • This molecule belongs to the 4-quinolone chemical family, which is best known for the antibiotic activity of many of its members. (pnas.org)
  • Organisms resistant to quinolones often are resistant to other classes of antimicrobials. (cdc.gov)
  • Most quinolones have excellent oral bioavailability, with serum drug concentrations equivalent to intravenous administration. (aafp.org)
  • The demonstration that 2-heptyl-3-hydroxy-4-quinolone can function as an intercellular signal sheds light on the role of secondary metabolites and shows that P. aeruginosa cell-to-cell signaling is not restricted to acyl-homoserine lactones. (pnas.org)
  • Because cerebrospinal fluid levels of quinolones are predictably poor, these agents are inadequate for first-line treatment of meningitis. (aafp.org)
  • There was no difference regarding treatment success in intention-to-treat and clinically evaluable patients between macrolides and quinolones, A/C and quinolones or A/C and macrolides. (ersjournals.com)
  • The treatment success in microbiologically evaluable patients was lower for macrolides compared with quinolones (odds ratio (OR) 0.47, 95% confidence interval (CI) 0.31-0.69). (ersjournals.com)
  • The present study sought to further clarify the role of broader spectrum antimicrobial agents for the treatment of patients with ABECB by performing a meta-analysis of RCTs that compared macrolides with quinolones, A/C with quinolones or A/C with macrolides in this population. (ersjournals.com)
  • The 7-bromoquinolone analogue, 7-bromo-6-(N-benzylpiperazin-1-yl)-4-oxo-3- quinolone carboxylic acid 91 showed the high potency as antibacterial inhibitor in addition to a significant effect on vitiligo phototherapy treatment. (bl.uk)
  • Quinolones also penetrate well in urine and kidneys when renal clearance is the route of drug elimination. (aafp.org)
  • Second-generation quinolones have expanded gram-negative activity and atypical pathogen coverage, but limited gram-positive activity. (aafp.org)
  • Following on from the finding that the complex of quinolone and gyrase on DNA results in truncated mRNAs in vitro, the results presented in this thesis show that in vivo, the addition of quinolone drugs results in the production of truncated mRNAs which are presumably translated into truncated proteins. (bl.uk)
  • In addition, quinolone derivative analogues were synthesised and investigated as amylolytic agents towards some Aspergillus fungi. (bl.uk)
  • Synergic effect of quinolone antibacterial agents and proton pump inhibitors on Helicobacter pylori ," Journal of Antimicrobial Chemotherapy , vol. 49, no. 6, pp. 1039-1040, 2002. (hindawi.com)