• Quinidine gluconate and quinine are short burning and a rapid extinguishing (BZ2) during the preliminary test. (europa.eu)
  • According to the study report the flammability of quinidine gluconate and quinine were experimentally determined similar to the preliminary testing according to regulation 440/2008. (europa.eu)
  • During the test quinidine gluconate and quinine shortly burns and rapidly extinguish. (europa.eu)
  • Quinine, a famous malaria treatment, and quinidine , an antiarrhythmic medication, are made from the bark of the cinchona tree. (wordnik.com)
  • Their great value depends upon the presence of certain alkaloid substances called quinine, cinchonine, and quinidine , which exist in the bark in combination with tannic and other acids. (wordnik.com)
  • Concomitant quinidine, quinine, or mefloquine. (oncologynurseadvisor.com)
  • if these arrhythmias develop, they should be treated as one would treat a quinidine overdose. (wordnik.com)
  • Quinidine belongs to a group of drugs called antiarrhythmics. (rxwiki.com)
  • The absolute bioavailability of quinidine from quinidine sulfate tablets is about 70%, but this varies widely (45 to 100%) between patients. (nih.gov)
  • Crush the tablets to a fine powder or use the quinidine sulfate powder. (uspharmacist.com)
  • Do not crush or chew quinidine tablets. (rxwiki.com)
  • Generic pharmaceuticals are not new since even before 1965 several products appeared on the market such as phenobarbitol, digoxin, quinidine , and many others and nobody paid much attention to them. (wordnik.com)
  • As measured by antiarrhythmic effects in animals, by QTc prolongation in human volunteers, or by various in vitro techniques, 3HQ has at least half the antiarrhythmic activity of the parent compound, so it may be responsible for a substantial fraction of the effect of quinidine sulfate in chronic use. (nih.gov)
  • In the case of quinidine used to prevent or defer recurrence of atrial flutter or fibrillation, meta-analysis data have shown that the mortality associated with the use of quinidine was more than 3 times greater than placebo. (allinahealth.org)
  • What we have done is recognized that you can inhibit ones ability to metabolize dextromethorphan by adding quinidine , which is a therapeutic. (wordnik.com)
  • Because α 1 -acid glycoprotein levels are increased in response to stress, serum levels of total quinidine may be greatly increased in settings such as acute myocardial infarction, even though the serum content of unbound (active) drug may remain normal. (nih.gov)
  • The most important of quinidine's metabolites is 3-hydroxyquinidine (3HQ), serum levels of which can exceed those of quinidine in patients receiving conventional doses of quinidine sulfate. (nih.gov)
  • However, quinidine may remain in the bodies of older adults longer than it does in younger adults, which may increase the risk of side effects and which may require lower doses. (allinahealth.org)
  • Your doctor may adjust your dose of quinidine if you are a poor metabolizer. (rxwiki.com)
  • CYP2D6 is a protein in your body that is involved in the elimination of quinidine and other drugs from your body. (rxwiki.com)
  • Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission. (ucdenver.edu)
  • Common side effects of quinidine include diarrhea, lightheadedness, and headache. (rxwiki.com)
  • As a result you may be at an increased risk of having more side effects from quinidine. (rxwiki.com)
  • Although there is no specific information comparing use of quinidine in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults. (allinahealth.org)
  • The volume of distribution of quinidine is 2 to 3 L/kg in healthy young adults, but this may be reduced to as little as 0.5 L/kg in patients with congestive heart failure, or increased to 3 to 5 L/kg in patients with cirrhosis of the liver. (nih.gov)
  • Quinidine clearance typically proceeds at 3 to 5 mL/min/kg in adults, but clearance in children may be twice or three times as rapid. (nih.gov)
  • Each tablet, for oral administration, contains 200 mg of quinidine sulfate (equivalent to 166 mg of quinidine base) 300 mg of quinidine sulfate (equivalent to 249 mg of quinidine base). (nih.gov)
  • The oral suspension USP contains 90.0% to 110.0% of the labeled amount of quinidine sulfate (C 20 H 24 N 2 O 2 ) 2 .H 2 SO 4 .2H 2 O. The pH of the preparation is 3.4 to 4.4. (uspharmacist.com)
  • The gray bark of Huanuco is derived from _Cinchona micrantha_, which is characterized by its yield of cinchonine, and the Loxa or Loja barks are furnished in part by _Cinchona officinalis_, and are especially rich in quinidine . (wordnik.com)
  • Quinidine clearance is unaffected by hepatic cirrhosis, so the increased volume of distribution seen in cirrhosis leads to a proportionate increase in the elimination half-life. (nih.gov)
  • The volume of distribution of 3HQ appears to be larger than that of quinidine, and the elimination half-life of 3HQ is about 12 hours. (nih.gov)
  • Rapid elimination of quinidine in pediatric patients. (ucdenver.edu)
  • Eli Lilly has discontinued manufacture of parenteral quinidine gluconate in the US, and its future availability in many countries is uncertain. (wikipedia.org)
  • Quinidine comes as a tablet (quinidine sulfate) and an extended-release (long-acting) tablet (quinidine gluconate) to take by mouth. (medlineplus.gov)
  • Extended-release quinidine gluconate tablets are usually is taken every 8 to 12 hours. (medlineplus.gov)
  • The pharmaceutical manufacturer of quinidine, Eli Lilly, recently announced External that it will no longer be producing IV quinidine gluconate, but plans to continue distributing the product until the current stock expires (March 2019). (cdc.gov)
  • As of today, intravenous quinidine gluconate remains available for the treatment of severe malaria. (cdc.gov)
  • Quinidine gluconate and quinine are short burning and a rapid extinguishing (BZ2) during the preliminary test. (europa.eu)
  • According to the study report the flammability of quinidine gluconate and quinine were experimentally determined similar to the preliminary testing according to regulation 440/2008. (europa.eu)
  • During the test quinidine gluconate and quinine shortly burns and rapidly extinguish. (europa.eu)
  • CDC has received reports of two fatal cases of Plasmodium falciparum malaria in the United States in which a delay in obtaining quinidine gluconate for intravenous therapy was thought to have played a role in the patients' deaths. (cdc.gov)
  • Since 1991, quinidine gluconate, a well-known and widely used class Ia anti-arrhythmic agent, has been the only parenteral antimalarial drug available in the United States. (cdc.gov)
  • As newer anti-arrhythmic agents have replaced quinidine for many of its cardiac indications, some hospitals and health facilities have dropped quinidine gluconate from their formularies. (cdc.gov)
  • Because of this potential problem, directors of hospital drug services should take into account the essential role of quinidine gluconate in treating patients with severe and complicated malaria before removing it from their formularies. (cdc.gov)
  • Intravenous quinidine lactate and quinidine gluconate effectively control the arrhythmia in 56 to 60 per cent of the animals, but produce toxic reactions in many of them. (ahajournals.org)
  • The most effective treatment of the arrhythmia was by use of morphine followed by quinidine gluconate. (ahajournals.org)
  • If sinus rhythm isn't restored after patient has received a total of 10 mg/kg quinidine gluconate, other means of cardioversion may be considered. (thefreedictionary.com)
  • Know that quinidine gluconate is the only parenteral cinchona alkaloid antimalarial commercially available in U.S. Because newer antiarrhythmics have replaced quinidine in many cardiac uses, it may not be readily available and prescribers may not be familiar with its use. (thefreedictionary.com)
  • The last during one i went to only he gave me quinidine gluconate and netupitant. (gonzoz.com)
  • Each Quinidine gluconate for inj 80mg/ml usp 250 microgram tablet contains 250 micrograms instead of the active ingredient quinidine. (gonzoz.com)
  • Extended-release quinidine gluconate (stars with dotted line) and quinidine sulfate (squares with solid line) have slower absorption profiles, so the drug has an opportunity to distribute to tissues while absorption is occurring. (mhmedical.com)
  • Quinidine is available either as quinidine sulfate or quinidine gluconate. (medicalproductguide.com)
  • Because of the proarrhythmic effects of quinidine, its use with ventricular arrhythmias of lesser severity is generally not recommended, and treatment of patients with asymptomatic ventricular premature contractions should be avoided. (rxlist.com)
  • Our research demonstrated stereoselective effects of quinidine and quinine on the hERG channel, and this is the first study to explore their reversal potency on drug-induced hERG deficiency. (mdpi.com)
  • Common side effects of quinidine include diarrhea, lightheadedness, and headache. (rxwiki.com)
  • This study examined the effects of quinidine, quinine, and the quaternary quinidine derivative, quinidinium, on the conductance and activity of purified cardiac sarcoplasmic reticulum calcium release channels/ryanodine receptors (RyR) incorporated into planar lipid bilayers. (aspetjournals.org)
  • There was no stereospecificity in the effects of quinidine because the levoisomer, 100 μM quinine, produced a similar subconductance activity of the channel. (aspetjournals.org)
  • This dependency may explain why hypokalemic patients are often unresponsive to the antiarrhythmic effects of quinidine and are prone to develop cardiac rhythm disorders. (brainkart.com)
  • The depressant effects of quinidine on the cardiovascular system are most likely to occur after IV administration, and therefore, quinidine should not be employed rou-tinely in the emergency treatment of arrhythmias. (brainkart.com)
  • Effects of quinidine and lidocaine on myocardial conduction. (semanticscholar.org)
  • The effects of quinidine and lidocaine on the maximum upstroke velocity (Vmax) of the ventricular myocardial action potential were compared with the effects predicted by a model over a wide range of driving rates, rhythm disturbances and holding potentials. (semanticscholar.org)
  • Effects of quinidine on the sodium current of guinea pig ventricular myocytes. (semanticscholar.org)
  • tell your doctor and pharmacist if you are allergic to dextromethorphan, quinidine (Quinidex), quinine (Qualaquin), mefloquine (Lariam), any other medications, or any of the ingredients in combination dextromethorphan and quinidine capsules. (medlineplus.gov)
  • tell your doctor if you are taking mefloquine (Lariam), pimozide (Orap), quinine (Qualaquin) thioridazine, or or another product containing quinidine (Quinidex). (medlineplus.gov)
  • tell your doctor if you have or have ever had the following conditions while taking quinidine, quinine, or mefloquine: decrease in the number of blood cells in your bone marrow, lupus (a condition in which the body attacks its own tissues causing damage and swelling), or hepatitis (swelling of the liver). (medlineplus.gov)
  • If you have ever had any of these health problems when taking this drug, mefloquine, quinidine, or quinine: Bone marrow problems, hepatitis, low platelet count, or lupus. (mskcc.org)
  • If you are taking any of these drugs: Mefloquine, quinidine, or quinine. (mskcc.org)
  • You also should not take dextromethorphan and quinidine if you are also taking mefloquine, quinidine, or quinine, or if you have ever had an allergic reaction or serious medical problem caused by taking any of these medications. (wellspan.org)
  • if you are also taking mefloquine, quinidine, or quinine. (wellspan.org)
  • Do not use this medicine if you have a history of bone marrow problems, hepatitis, lupus-like syndrome, or thrombocytopenia (low platelets in the blood) caused by quinidine, quinine, or mefloquine. (limamemorial.org)
  • Concomitant quinidine, quinine, or mefloquine. (oncologynurseadvisor.com)
  • When oral quinidine is given as a rapidly absorbed dosage form such as quinidine sulfate tablets, a similar distribution phase is also observed with a duration of 20-30 minutes. (mhmedical.com)
  • No data regarding the Paedriatic dosage details of Quinidine is available. (druginfosys.com)
  • No data regarding the neonatal dosage details of Quinidine is available. (druginfosys.com)
  • Quinidine intoxication can lead to a collection of symptoms collectively known as cinchonism, with tinnitus (ringing in the ears) being among the most characteristic and common symptoms of this toxicity syndrome. (wikipedia.org)
  • Cinchonism is usually a sign of chronic quinidine toxicity, but it may appear in sensitive patients after a single moderate dose of several hundred milligrams. (drugs.com)
  • These reagents are used to measure quinidine levels in patients, e.g., to determine the adequacy of therapy, and in the diagnosis of a drug overdose or drug-related toxicity. (medicalproductguide.com)
  • Quinidine also inhibits the transport protein P-glycoprotein and so can cause some peripherally acting drugs such as loperamide to have central nervous system side effects, such as respiratory depression, if the two drugs are coadministered. (wikipedia.org)
  • quinidine is a drug that inhibits the metabolism of dextromethorphan which results in a sustained elevation of dextromethorphan in the brain. (mssociety.ca)
  • Inhibits the metabolism of quinidine by inhibiting hepatic microsomal enzymes, thereby increasing its effect. (vetstream.com)
  • Quinidine, a class Ia antiarrhythmic agent that inhibits outward transient K current (I to1 ), has been proposed as an adjuvant treatment in BrS patients (2-4) , but there are limited data about its long-term effectiveness. (onlinejacc.org)
  • Quinidine inhibits transmembrane sodium influx into the conduction system of the heart, thereby decreasing conduction velocity. (mhmedical.com)
  • The company reformulated the drug with a lower dose of quinidine and conducted new studies, she said. (thefreedictionary.com)
  • Your doctor may adjust your dose of quinidine if you are a poor metabolizer. (rxwiki.com)
  • dextromethorphan/quinidine is a topic covered in the Davis's Drug Guide . (unboundmedicine.com)
  • The effect of quinidine on the ion channels is to prolong the cardiac action potential, thereby prolonging the QT interval on the surface ECG. (wikipedia.org)
  • As measured by antiarrhythmic effects in animals, by QTc prolongation in human volunteers, or by various in vitro techniques, 3HQ has at least half the antiarrhythmic activity of the parent compound, so it may be responsible for a substantial fraction of the effect of quinidine sulfate in chronic use. (nih.gov)
  • The indirect effect of quinidine on the sinoatrial node is a result of the drug's potential to exert an anti-cholinergic action resulting in a slight increase in heart rate. (brainkart.com)
  • The effect of quinidine on digitoxin single-dose pharmacokinetics was evaluated in five healthy adults. (elsevier.com)
  • The present invention provides methods for purifying, identifying and using optically active isomers of quinine and quinidine as well as compositions comprising such optically active isomers. (freepatentsonline.com)
  • Their great value depends upon the presence of certain alkaloid substances called quinine, cinchonine, and quinidine , which exist in the bark in combination with tannic and other acids. (wordnik.com)
  • Quinidine is an alkaloid extracted from the bark of the Cinchona tree with class 1A antiarrhythmic and antimalarial effects. (fishersci.com)
  • Quinidine is an alkaloid extracted from the bark of the genus Cinchona ledgeriana (Moens). (hardware-wholesale.com)
  • Quinidine is an alkaloid obtained from various species of Cinchona or its hybrids, from Remijia pedunculata, or from quinine. (brainkart.com)
  • The elimination half-life of oral quinidine is 6 to 8 hours, and it is eliminated by the cytochrome P450 system in the liver. (wikipedia.org)
  • the protocol was conducted once while each subject was taking oral quinidine, for 3 weeks, and then repeated 10 days after discontinuing quinidine treatment. (elsevier.com)
  • Many other medications may also interact with dextromethorphan and quinidine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
  • Some medicines can interact with dextromethorphan and quinidine and should not be used at the same time. (wellspan.org)
  • These medicines may interact with dextromethorphan and quinidine and cause a serious condition called serotonin syndrome. (uncmedicalcenter.org)
  • Quinidine can cause thrombocytopenia, granulomatous hepatitis, myasthenia gravis, and torsades de pointes (dangerous heart rhythm), so is not used much today. (wikipedia.org)
  • Quinidine-induced thrombocytopenia (low platelet count) is mediated by the immune system, and may lead to thrombocytic purpura. (wikipedia.org)
  • Inhibition of UGT2B7 by quinidine was also investigated further, because the effects of this compound on morphine pharmacokinetics (a known UGT2B7 substrate) have been ascribed to inhibition of P-glycoprotein. (aspetjournals.org)
  • Serious cardiovascular events, including QT prolongation, torsades de pointes, ventricular tachycardia, cardiac arrest, and/or sudden death have occurred in patients using cisapride, pimozide, levacetylmethadol (levomethadyl), methadone or quinidine concomitantly with itraconazole and/or other CYP3A4 inhibitors. (thefreedictionary.com)
  • QT prolongation and development of torsades de pointes with the concomitant administration of oral erythromycin base and quinidine. (webmd.com)
  • Dextromethorphan/quinidine (DM/Q) 20mg/10mg one capsule once daily for 1 week, followed by DM/Q 20mg /10 mg twice daily for subsequent 4 weeks, and finally DM/Q 20mg/10mg once daily for 7days. (clinicaltrials.gov)
  • Taking antiarrhythmic drugs, including quinidine, may increase the risk of death. (medlineplus.gov)
  • 47357] Guidelines recommend quinidine 324 to 648 mg PO every 8 hours as an option for the maintenance of sinus rhythm in patients with atrial fibrillation only when other antiarrhythmic drugs cannot be used. (pdr.net)
  • A unifying molecular model for the interaction of antiarrhythmic drugs with cardiac sodium channels: application to quinidine and lidocaine. (semanticscholar.org)
  • Adjust dosages to produce a serum quinidine concentration of 2 to 6 mcg/mL. (pdr.net)
  • When given intravenously, the serum quinidine concentration-time curve follows a two-compartment model. (mhmedical.com)
  • Specificity: These antibodies recognize quinidine. (qedbio.com)
  • Experimental data is presented and discussed on the effects of temperature, K and Na concentration, and quinidine on transmembrane ion fluxes and the incidence of fibrillation in isolated rabbit atria. (ahajournals.org)
  • tell your doctor and pharmacist if you are allergic to quinidine, quinine, or any other drugs. (medlineplus.gov)
  • Caffeine interferes with drugs that regulate heart rhythm, such as quinidine and propranolol (Inderal). (yourdictionary.com)
  • Results show that both drugs block the hERG channel, with quinine 14-fold less potent than quinidine. (mdpi.com)
  • The mutation decreases affinity of the two drugs with hERG, and quinine was more potent than quinidine in F656C-hERG blockage. (mdpi.com)
  • Quinidine belongs to a group of drugs called antiarrhythmics. (rxwiki.com)
  • CYP2D6 is a protein in your body that is involved in the elimination of quinidine and other drugs from your body. (rxwiki.com)
  • The half-life of quinidine may be reduced by as much as 50% as a consequence of hepatic enzyme induction by these drugs. (vetstream.com)
  • If you are taking monoamine oxidase inhibitors (MAOIs), quinidine, or quinidine-related drugs. (nuedexta.com)
  • If you have previously had an allergic reaction to dextromethorphan, quinidine or quinidine-like drugs. (nuedexta.com)
  • 1 After ventricular rate has been controlled, quinidine therapy can be used to chemically convert atrial fibrillation to normal sinus rhythm for a patient. (mhmedical.com)
  • Quinidine maintains normal heart rhythm following cardioversion of atrial fibrillation or flutter. (medscape.com)
  • The permanently charged quinidinium compound produced nearly identical effects as quinidine when present only on cytoplasmic side of the channel, suggesting the positive-charged form of quinidine is responsible for the effects on the channel. (aspetjournals.org)
  • These data indicate that 1) the charged form of quinidine blocks the HK2 channel after it opens, 2) binding occurs within the transmembrane electrical field (probably in or near the ion permeation pathway), and 3) unbinding is required before the channel can close. (aspetjournals.org)
  • The disposition of quinidine and the kinetics of metabolite formation were studied in the once-through perfused rat liver preparation by the stepwise increase in quinidine concentration. (aspetjournals.org)
  • Possible inhibition of hepatic metabolism of quinidine by erythromycin. (webmd.com)
  • The interaction of quinidine and other local anesthetic/antiarrhythmic agents with voltage-gated ion channels has been proposed to be the result of binding of these compounds within the inner vestibule of the channel pore ( Hille, 1977 ). (aspetjournals.org)
  • The interaction of quinidine with a cloned human cardiac potassium channel (HK2) expressed in a stable mouse L cell line was studied using the whole-cell tight-seal voltage-clamp technique. (aspetjournals.org)
  • Rapid elimination of quinidine in pediatric patients. (ucdenver.edu)
  • Dextromethorphan/quinidine is a prescription medication approved for the treatment of pseudobulbar affect (PBA), a condition characterized by involuntary, sudden, uncontrolled episodes of laughing or crying, when there appears to be nothing to laugh or cry about. (rxwiki.com)
  • Dextromethorphan/quinidine is a prescription medication is used to treat pseudobulbar affect (PBA) a condition of sudden, frequent outbursts of crying and laughing that can not be controlled. (rxwiki.com)
  • Antigen: Quinidine conjugated to KLH. (qedbio.com)
  • Avoid drinking grapefruit juice while taking quinidine. (empowher.com)
  • Quinidine exerts its antimalarial activity by acting primarily as an intra-erythrocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. (fishersci.com)