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  • pyrimidine
  • Quinazoline is composed of fused benzene and pyrimidine rings. (sigmaaldrich.com)
  • Structural studies of two ternary complexes of Pneumocystis carinii dihydrofolate reductase (pcDHFR) with the cofactor NADP(+) and potent antifolates, the N9-C10 reversed-bridge inhibitor 2,4-diamino-6-[N-(2',5'-dimethoxybenzyl)-N-methylamino]quinazoline (1) and its 3',5'-dimethoxypyrido[2,3-d]pyrimidine analog (2), were carried out. (rcsb.org)
  • The effect of the N9-C10 reversed-bridge geometry is to distort the bridge from coplanarity with the pyrido[2,3-d]pyrimidine or quinazoline ring system and to twist the C10 methylene conformation toward a gauche conformation. (rcsb.org)
  • The four examples of N9-C10 reversed-bridge antifolates cluster in two conformations, with the structure of quinazoline (1) similar to that previously reported for its 2',5'-dimethoxypyrido[2,3-d]pyrimidine analog (3). (rcsb.org)
  • respectively
  • In the title compound, C 14 H 10 N 2 O 2 S, the benzothia-zole and quinazoline ring systems are essentially planar with maximum deviations of 0.0127 (16) and 0.1588 (15) Å, respectively, and make a dihedral angleof 3.02 (5)°, which shows that the entire mol-ecule is almost planar. (iucr.org)
  • Their synthetic utility was demonstrated by condensation reactions with carbonyl compounds or amines to provide SF 5 -containing quinolines and quinazolines, respectively. (beilstein-journals.org)
  • systems
  • The dihedral angle between the benzothiazole and quinazoline ring systems are almost coplanar with a dihedral angle of 3.02 (5)° between them. (iucr.org)
  • efficient
  • Superbases DBU, DBN, TMG and MTBD are efficient catalysts which have been used in the solvent-free conversion of carbon dioxide and 2-aminobenzonitrile to quinazoline-2,4(1H, 3H)-diones. (springer.com)