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  • molecular
  • Paul Nurse (born 1949), Imperial Cancer Research Fund, London, identified, cloned and characterized with genetic and molecular methods, one of the key regulators of the cell cycle, CDK (cyclin dependent kinase). (edu.au)
  • pathways
  • Cell adhesion molecules and some signalling pathways reinforce its quiescent state, whereas other signals lead to activation. (mendeley.com)
  • In line with compromised myogenic potential of aged muscle-derived satellite cells, there were age-related alterations in mitochondrial biogenesis and autophagy pathways, with satellite cells derived from TRI being more susceptible to impairments with age. (ufl.edu)
  • In response to physiological pressures such as exercise and diet, skeletal muscle can remodel to switch fiber types by activating signaling pathways that inevitably control gene expression patterns in progenitor cells and/or muscle fibers ( Bassel-Duby and Olson, 2006 ). (rupress.org)
  • regulate
  • Three of the six miRNAs were found to regulate satellite cell fate. (biomedcentral.com)
  • Increased levels of myostatin up-regulate a cyclin-dependent kinase inhibitor called p21 and thereby induce the differentiation of satellite cells. (bionity.com)
  • Many of these enzymes have been shown to regulate important aspects of cell biology and in particular in neuronal cells where palmitoylation of receptors and associated proteins regulates synaptic plasticity and therefore functions such as learning and memory. (sheffield.ac.uk)
  • We have discovered unique sets of microRNAs that regulate these processes and show targets are important for maintaining quiescence of promotion cell cycle entry. (stanford.edu)
  • Our lab is broadly interested in how bacteria monitor the status of DNA replication and repair so as to regulate cell division and development. (stanford.edu)
  • These studies demonstrate that Sox15, Fhl3 and Foxk1 function to coordinately regulate the myogenic progenitor cell population and skeletal muscle regeneration. (embopress.org)
  • activation
  • These results suggest that exogenously-induced satellite cell activation in EOM raises the potential for myofiber growth induced by IGF1, the result of which is greater motive force. (arvojournals.org)
  • Satellite cells isolated by FACS from uninjured skeletal muscle and 12 h post-muscle injury from wild type and Syndecan-4 null mice were probed using Affymetrix 430v2 gene chips and analyzed by Spotfire tm and Ingenuity Pathway analysis to identify gene expression changes and networks associated with satellite cell activation, respectively. (biomedcentral.com)
  • Additional analyses of target genes identify miRNAs exhibiting dynamic changes in expression during satellite cell activation. (biomedcentral.com)
  • Satellite cell activation appears to be regulated by post-transcriptional gene regulation. (biomedcentral.com)
  • We demonstrate that skeletal muscle dedifferentiation involves satellite cell activation and that these cells can contribute to new limb tissues. (rupress.org)
  • Activation of salamander satellite cells occurs in an analogous manner to how the mammalian myofiber mobilizes stem cells during skeletal muscle tissue repair. (rupress.org)
  • The changes in satellite cell properties coincided with the inactivation of Notch signaling and the activation of Wnt signaling and likely involve modulation by transcription factors of the Sox family. (hindawi.com)
  • These results indicate the effects of resistance exercise on the regulation of satellite cells and provide insight into the molecular mechanism of satellite cell activation following physical exercise. (hindawi.com)
  • This process is accompanied by activation of hundreds of muscle-specific genes and repression of genes associated with cell proliferation or pluripotency. (jove.com)
  • Several metabolic factors contribute to the activation of satellite cells in response to stress mediated by illness, injury or aging. (koreascience.or.kr)
  • 1996. Stretch overload-induced satellite cell activation in slow tonic muscle from adult and aged Japanese quail. (koreascience.or.kr)
  • We have found that activation of the Notch signaling pathway is critical to the transition of muscle stem cells ('satellite cells') from a quiescent state to one of active proliferation. (stanford.edu)
  • We subsequently found that activation of the Wnt signaling pathway occurs during muscle injury when satellite cells are proliferating. (stanford.edu)
  • Our near-term goals are to identify the key signaling processes that control satellite cell activation and lineage progression in order to enhance muscle regeneration. (stanford.edu)
  • During developmental processes, in response to external cues, changes in chromatin involving activation and repression of transcription factors and chromatin regulators (e.g., chromatin-modifying enzymes) underlie commitment of specific cells to defined lineages. (hindawi.com)
  • This study determined the effects of 28 days of heavy resistance exercise combined with the nutritional supplement, NO-Shotgun ® , on body composition, muscle strength and mass, markers of satellite cell activation, and clinical safety markers. (biomedcentral.com)
  • Rather, NO-Shotgun ® effectively increases muscle strength and mass, myofibrillar protein content, and increases the content of markers indicative of satellite cell activation. (biomedcentral.com)
  • As such, resistance training can increase the proportion of satellite cells and the number of myonuclei [ 12 ], which suggests that satellite cell activation is an important adaptive mechanism involved in hypertrophy. (biomedcentral.com)
  • The activation of satellite cells [ 13 ] which accompanies resistance training can be stimulated byvarious signals, including anabolic hormones such as insulin-likegrowth factor I (IGF-I) and hepatocyte growth factor (HGF), regulatory proteins such as the myogenic regulatory factors (MRFs), and nitric oxide. (biomedcentral.com)
  • Thus, a tight balance between the quiescence and activation state is instrumental to meet the brain demands for a specific cell type at the correct numbers, at a given time and position. (iospress.com)
  • HGF/LIF can reverse atrophy by means of activation of the satellite cells. (sgkinhibitor.com)
  • vitro
  • Satellite cells can also be converted in vitro into bone and cartilage cells, via the application of osteogenic bone morphogenetic proteins or transforming growth factor -beta. (bionity.com)
  • Authentication of the myogenicity of these stem/progenitor cells is based either on transplantation after fluorescent activated cell sorting (FACS) or in vitro culture. (biologists.org)
  • First, in mammary epithelial cells cultured in vitro, ADAM12 expression is induced by the known inducers of EMT: Transforming Growth Factor beta (TGFbeta), transcription factors Twist and ZEB1, Notch signaling, and knock-down of microRNA-200b/c or microRNA-29a/b/c. (k-state.edu)
  • In cells cultured in vitro, several different ADAMs are capable of generating soluble EGFR ligands. (k-state.edu)
  • fluorescence-activated cell
  • The SP from bone marrow cells was isolated from femur and tibia of 8-week-old c -kit / GFP transgenic mice by fluorescence-activated cell sorter (FACS) analysis. (pnas.org)
  • however, cells to be transplanted can be isolated by different techniques, such as Fluorescence Activated Cell Sorting (FACS) or magnetic beads. (bio-protocol.org)
  • transplantation
  • Indeed, the transplantation of bone marrow-derived SCs into the mdx dystrophic mouse model had a limited impact on muscle cell replacement ( 10 ), suggesting that the poor recruitment of circulating SCs is one of the limiting factors for tissue repair ( 10 , 11 ). (pnas.org)
  • Although autologous cell transplantation needs no immunosuppression, the genes require editing to express dystrophin. (go.jp)
  • As one way to solve the problem, we are trying to use differentiated cells from iPS cell stocks for transplantation. (go.jp)
  • One of the crucial limitations in cellular transplantation is poor cell survival after cell transfer. (biomedsearch.com)
  • Satellite cell (SC) transplantation represents a powerful strategy to investigate SC biology during muscle regeneration. (bio-protocol.org)
  • fate
  • For instance, Notch signaling is involved in fate determination and regulates satellite cell proliferation, and previous studies have shown that physical exercise increases the expression of Notch signaling pathway components-including ligands, Notch receptor, and downstream effectors-in myogenic cells [ 8 - 10 ]. (hindawi.com)
  • The regulation of Notch signaling by its inhibitor Numb appears to determine lineage progression and cell fate determination. (stanford.edu)
  • By perturbing the intracellular or extracellular milieu, we are probing the regulatory network that determines cell fate and how it can be altered. (stanford.edu)
  • Environmental factors control NC cell fate decisions. (biomedsearch.com)
  • apoptosis
  • We were particularly interested in the potential for M-cadherin to protect against the mitochondria-associated intrinsic apoptosis that is induced by cell confluence or serum starvation. (biologists.org)
  • Our locating that IGFBP3 restoration benefits in decreased tumor cell migration and invasion, whilst leaving growth and apoptosis just unaffected, also Betaine is known as a zwitterionic quaternary ammonium compound and it was initially identified inside the juice of sugar beets through the German chemist Scheibler, inside the 19th century. (plkinhibitors.com)
  • Calcr knockout resulted in abnormal quiescent state of muscle stem cells, reduction of their pool apoptosis and relocation from the MSC (show MSC ELISA Kits ) niche. (antibodies-online.com)
  • This study aimed at evaluating whether apoptosis of interstitial cells of Cajal (ICC), smooth muscle cells (SMC), and enteric neurons was involved in a guinea pig model of intestinal ischemia and reperfusion injury. (biomedsearch.com)
  • This molecule, bactericidal/permeability-increasing protein (BPI), that was discovered as a bacterial permeabilizing and lipopolysaccharide-neutralizing protein, was found to inhibit angiogenesis by specific induction of apoptosis in endothelial cells. (jove.com)
  • progenitor cell
  • In the present study, we utilize transgenic technology and demonstrate that the 4.6 kb upstream fragment of the Foxk1 gene directs β‐galactosidase expression to the myogenic progenitor cell population. (embopress.org)
  • We further establish that Sox15 directs Foxk1 expression to the myogenic progenitor cell population, as it binds to an evolutionarily conserved site and recruits Fhl3 to transcriptionally coactivate Foxk1 gene expression. (embopress.org)
  • niche
  • We have developed a label-free, single-cell analysis microfluidic platform capable of quantifying cell-surface marker expression of functional organ stem cells directly isolated from their micro-anatomical niche. (aps.org)
  • The demand for minimal reactive oxygen species (ROS) production as well as general hypoxic environment of the neurogenic niche [ 11, 12 ] could be the prime reasons for quiescent NSCs to mainly rely on glycolysis and pentose phosphate in order to generate energy and intermediates for anabolic reactions and avoid excessive ROS [ 13, 14 ]. (iospress.com)
  • Yet, it is not kwon how macrophages interact with the more profound stem cells of the satellite cell niche. (unipd.it)
  • cellular
  • Due to advances in microscope technology it is relatively easy to capture live cell images for the purpose of investigating cellular events in real time with minimal concern regarding phototoxicity to the cells. (jove.com)
  • and it has remained unsettled whether adult newts possess a cellular population that is equal to mammalian satellite cells. (rupress.org)
  • It affects a plethora of cellular processes including protein trafficking, stability and signalling and is therefore important for all cell types, and organisms from yeast to humans. (sheffield.ac.uk)
  • Recent advances in high-throughput technologies have transformed methodologies employed to study cell-specific epigenomes and the approaches to investigate complex cellular phenotypes. (hindawi.com)
  • Importantly, transcription factors and chromatin modifiers are also able to alter the cellular expression program to maintain cell identity even upon removal of the initiating differentiation stimuli [ 1 ]. (hindawi.com)
  • Differentiation processes are achieved by sculpting cell-specific epigenomes, which establish and maintain cellular diversity [ 2 ]. (hindawi.com)
  • receptor
  • In the absence of HER2 overexpression, TNBC critically rely on Epidermal Growth Factor Receptor (EGFR) to convey the growth signals and stimulate cell proliferation. (k-state.edu)
  • mechanism
  • However, the myogenic potency of human satellite cells in muscles with fatty infiltration is unclear due to the difficulty in isolating from small samples, and the mechanism of the progression of fatty infiltration has not been elucidated. (readbyqxmd.com)