Quantitative genetic. Medical search. Frequent questions

The maps also demonstrated the topological basis of quantitative trait loci which influence gene expression and phenotype. (nature.com)
These results show that the average size of the quantitative trait loci effect was 1.6 phenotypic standard deviations for different traits and families. (cambridge.org)
The aims of quantitative trait loci detection is the potential use of these molecular markers to increase accuracy in predicting the genetic merit of breeding and its implementation in animal breeding schemes through marker-assisted selection. (cambridge.org)
Construction of High-Density Genetic Map and Mapping Quantitative Trait Loci for Growth Habit-Related Traits of Peanut (Arachis hypogaea L. (frontiersin.org)
Four loci including additive quantitative trait loci (QTLs) and epistatic interactions explained together 70% of the variance of pvr23 breakdown frequency. (datadryad.org)
Twenty‐seven quantitative trait loci ( QTL ) were detected for manually collected traits associated with biomass production. (osti.gov)
Replication timing quantitative trait loci (or rtQTL) are genetic variations that lead to a differential use of replication origins, exhibiting allele-specific effects on replication timing. (wikipedia.org)
Linkage studies have identified several quantitative trait loci (QTLs) for RD. The QTL on chromosome 6p21.3 has been independently replicated by several groups and spans a 16.4-Mb (13.8 cM) interval from D6S109 to D6S291. (nih.gov)
Maximum likelihood techniques for the mapping and analysis of quantitative trait loci with the aid of genetic markers. (agri.gov.il)
A method is presented to estimate the biometric parameters of a quantitative trait locus linked to a genetic marker when both loci are segregating in the F-2 generation of a cross between two inbred lines. (agri.gov.il)
The method, which assumes underlying normal distributions, is a combination of maximum likelihood and moments methods and uses the statistics of the genetic marker genotype samples for the quantitative trait to estimate the recombination frequency between the two loci and the means and variances of the genotypes of the quantitative trait locus. (agri.gov.il)
Linkage distance between the two loci was 38 map units and the effect of the quantitative trait locus was 1.6 phenotypic standard deviation units. (agri.gov.il)
The method is not effective in distinguishing between complete and partial linkage in samples of only 500 individuals or for quantitative loci with effects less than a phenotypic standard deviation. (agri.gov.il)
Power of daughter and granddaughter designs for determining linkage between marker loci and quantitative trait loci in dairy cattle. (agri.gov.il)
The application of genomic prediction models that take into account the effects of all individual loci may greatly enhance the elucidation of the genetic architecture of quantitative traits in plants. (nih.gov)
Is the Subject Area "Genetic loci" applicable to this article? (plos.org)
Is the Subject Area "Quantitative trait loci" applicable to this article? (plos.org)
The same quantitative trait loci were identified with all models. (springer.com)
Mutic and Wolf [ 7 ] identified 13 quantitative trait loci (QTL) for IGE associated with size, development, and fitness related traits in Arabidopsis . (springer.com)
A genome-wide linkage analysis was performed to localise Quantitative trait loci influencing BMI in a large cohort collected in the PROCARDIS coronary heart disease study consisting of 1,812 informative families. (ox.ac.uk)
The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue. (ox.ac.uk)
Genetic variants that associate with DNA methylation at CpG sites (methylation quantitative trait loci, meQTLs) offer a potential biological mechanism of action for disease associated SNPs. (ox.ac.uk)
Mapeamento de QTL (Quantitative Trait Loci) associados à resistência do maracujá-doce. (usp.br)
Genetic loci were functionally annotated using FUnctional Mapping and Annotation (FUMA). (plos.org)
Although the majority of expression quantitative trait loci (eQTLs) for the gene expression traits in the two environments are shared and have similar effects, analysis of the environment-specific eQTLs reveals enrichment of binding sites for two transcription factors. (nature.com)

By integrating expression quantitative trait locus (eQTL) and genome-wide association study (GWAS) data, we demonstrate that long-range chromatin interactions between variant regulatory elements and their target genes contribute to variations in gene expression, metabolic phenotypes, and agronomic traits. (nature.com)
The quantitative trait locus (QTL) analysis of the growth habit-related traits was conducted based on phenotyping data from seven environments. (frontiersin.org)
Sexual selection on fitness-determining traits should theoretically erode genetic variance and lead to low heritability. (uib.no)
However, many sexually selected traits maintain significant phenotypic and additive genetic variance, with explanations for this "lek paradox" including genic capture due to condition-dependence, and breaks on directional selection due to environmental sources of variance including maternal effects. (uib.no)
Genetic correlations were moderate among antimeres and metameres and low for different traits scored on the same tooth crown. (elsevierpure.com)
Though held remotely, the conference had it's highest number of attendees yet and generated an informative discussion regarding the clinical implications for findings from genome-wide association studies on genetic variants associated to common diseases and complex traits. (harvard.edu)
1972). The methods used to determine maternal effects in quantitative traits often do not measure quantitative genetic parameters, while those that do are either complex or partially resolve potential contributions of individual sources of maternal effects. (psu.edu)
In this study, a reciprocal North Carolina II design and maximum-likelihood methods were implemented to investigate the genetic basis of variation for 15 floral and vegetative traits in four populations of the annual plant Amsinckia spectabilis (Boraginaceae) differing in mating system. (bioone.org)
Marker-trait associations were assessed by using QTDT (a general test of association for quantitative traits) and the family-based association test (FBAT), and haplotype analysis was performed by using FBAT and the GeneHunter Transmission/Disequilibrium Test TDT. (nih.gov)
Most of the traits of importance to the breeder are genetically complex and quantitative in nature. (cropscience.org.au)
Therefore, considerable interest has emerged in the use of alternative methods for the mapping of quantitative traits. (cropscience.org.au)
New methods of mapping offer a promising route to the identification of genetic markers for the genes of complex traits and provide a foundation for molecular enhanced breeding of maize. (cropscience.org.au)
For the majority of the 20th Century, pedigree breeding, combined with an extensive multi-environment testing program that was designed to measure the phenotypic performance of new genotypes across a large sample of the target population of environments, was the core breeding strategy that underpinned the successful genetic improvement of grain yield and other agronomic traits (Duvick et al. (cropscience.org.au)
Quantitative traits in plants are controlled by a large number of genes and their interaction with the environment. (nih.gov)
To disentangle the genetic architecture of such traits, natural variation within species can be explored by studying genotype-phenotype relationships. (nih.gov)
Here, genomic prediction models revealed different genetic architectures for the morphological traits. (nih.gov)
Results from genome-wide association studies (GWAS) on DGE show that most quantitative traits in livestock are highly polygenic and that variants tend to be associated with more than one trait [ 4 ]. (springer.com)
This was shown by the high favourable genetic correlations between differently aged fish for lipid traits. (elsevierpure.com)
Similarly, the genetic correlations between muscle and body composition were higher for lipid than for protein, enhancing selection efforts to change lipid traits. (elsevierpure.com)
In conclusion, lipid traits are both more variable and exhibit more favourable genetic architecture for selection compared to protein traits. (elsevierpure.com)
This first set of ABs and ILs of eggplant will be extremely useful for the genetic dissection of traits of interest for eggplant, and represents an elite material for introduction into the breeding pipelines for developing new eggplant cultivars adapted to the challenges posed by the climate-change scenario. (frontiersin.org)

This course builds on lectures in quantitative genetics (in PGBI11001) and statistics (PGBI11003) and provides tools to analyse quantitative genetic data and interpret the results. (ed.ac.uk)
On successfully completing the course students will have a thorough knowledge of statistical mixed models and their application to quantitative genetics. (ed.ac.uk)
Foolad, MR & Jones, RA 1992, ' Models to estimate maternally controlled genetic variation in quantitative seed characters ', Theoretical And Applied Genetics , vol. 83, no. 3, pp. 360-366. (psu.edu)
Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional. (nih.gov)
Genetic association mapping methods have been the subject of great interest in human genetics. (cropscience.org.au)
A new quantitative genetics study makes a strong case for the yield testing strategies CIMMYT uses in its wheat breeding program. (cimmyt.org)
Effectively give a presentation on genetics, genomics, and genetic counseling issues. (bu.edu)
Recent critics have consciously or unconsciously exaggerated the long-lasting influence of the MS on contemporary evolutionary biology and have underestimated many post-Synthesis developments, particularly Neutral Theory, evolutionary quantitative genetics and the power and generality of the Price Equation. (lu.se)

We find that none of the 149 meQTL top SNPs is a significant expression quantitative trait locus in our expression data, but we observed association between expression levels of two mRNA transcripts and cis-methylation status. (ox.ac.uk)

A new high-density genetic linkage map was constructed by using specific locus amplified fragment sequencing technology. (frontiersin.org)
With this method, the genetic parameters of a locus affecting plant height linked to an electrophoretic marker for esterase were accurately estimated from a sample of 1596 F-2 progeny of a cross between two species of Lycopersicon (tomato). (agri.gov.il)
Accurate estimates of the genetic parameters and linkage distance for populations of 2000 individuals simulated with a segregating codominant locus with an effect of 1.63 standard deviations linked to a genetic marker with .2 recombination were also derived by this method. (agri.gov.il)
On the use of the moments method of estimation to obtain approximate maximum likelihood estimates of linkage between a genetic marker and a quantitative locus. (agri.gov.il)

Students will be familiar with software available to perform such genetic analyses. (ed.ac.uk)
Quantitative genetic analyses of fish composition have been strongly biased towards lipid deposition, rather than protein deposition. (elsevierpure.com)
Further analyses identified shared genetic variants found in metabolism of alpha-linolenic pathway for type 2 diabetes. (plos.org)

Quantitative susceptibility mapping (QSM) is an emerging magnetic resonance imaging technique that measures tissue magnetic susceptibility and has been shown to detect pathological changes in tissue iron, myelin and calcification. (ventio.net)
Genome-wide associations relate magnetic susceptibility to 76 replicating clusters of genetic variants with biological functions involving iron, calcium, myelin and extracellular matrix. (ventio.net)
Results revealed low awareness and knowledge of genetic counselling/testing for cancer susceptibility amongst ethnic minority groups including African Americans, Asian Americans, and Hispanics. (biomedcentral.com)
Quantitative measure of genetic differences in susceptibility to noise -induced hearing loss in two strains of mice. (cdc.gov)

The combination of major resistance genes with quantitative resistance factors is hypothesized as a promising breeding strategy to preserve the durability of resistant cultivar, as recently observed in different pathosystems. (datadryad.org)
The Program in Quantitative Genomics recently held its 14th annual conference, "From Variants and Genes to Clinical Actions", via Zoom on November 5-6, 2020. (harvard.edu)
Evidence is presented that combinations of independent function, quantitative genetic effects, and functional redundancy have preserved the three vegetative profilin genes in the Arabidopsis lineage. (biomedcentral.com)
Genetic variance in expression increases at 18 °C relative to 25 °C for most genes that have a change in genetic variance. (nature.com)
In addition to environmental factors, phenotypes can also respond to genetic perturbations in a plastic or homeostatic manner, which characterizes the potential of an organism to express phenotypes when genes mutate. (nature.com)
Furthermore, while a few genetic mutations, such as those in the amyloid precursor protein and presenilin-2 genes, have been found to be associated with early-onset Alzheimer's disease, most cases of dementia occur in older adults in whom no definitive genetic risk has been identified. (cdc.gov)

This means that genotypically differential investment in ejaculates is likely to explain the observation of the genetic variance in tolerating the cost of reproduction in C. maculatus males. (jyu.fi)
Here we investigate genetic and environmental sources of variance in the intrasexually selected green badge of the sand lizard (Lacerta agilis). (uib.no)
Using animal models on a pedigree including three generations of males measured over an extensive 9-year field study, we partition phenotypic variance in both badge size and body condition into additive genetic, maternal, and permanent environmental effects experienced by an individual over its lifespan. (uib.no)
Heritability of badge size was 0.33 with a significant estimate of underlying additive genetic variance. (uib.no)
Body condition was strongly environmentally determined in this species and did not show either significant additive genetic variance or heritability. (uib.no)
We propose that the lack of additive genetic variance and heritability of body condition makes it unlikely that genic capture mechanisms maintain additive genetic variance for badge size. (uib.no)
If developmental pathways generating variance in body condition, and/or the covarying secondary sex trait, differ between inter- and intrasexual selection, or the rate at which their additive genetic variance or covariance is depleted, future work may show whether genic capture is largely restricted to intersexual selection processes. (uib.no)
Backwards elimination was used to determine phenotypic and genetic variance explained by SNPs. (springer.com)
This SNP explained 3% of the phenotypic variance, and 36% of the total genetic variance. (springer.com)
These SNPs explained 1 to 6% of the phenotypic variance and 9 to 44% of the total genetic variance. (springer.com)
The dynamics of genetic variation (variance across different genotypes) and environmental variation (variance across different environments) may be controlled by different mechanisms. (nature.com)

We have developed a structure refinement method based on genetic algorithm optimization to create structural models of individual nanostructures based on quantitative scanning transmission electron microscopy (STEM) data [1]. (emc-proceedings.com)

ABSTRACT The aim of this study was to determine the attitude of Saudi Arabians to research involving storage and use of human tissues from which genetic information may be derived and to assess their willingness to donate tissue samples to biobanks. (who.int)

The World Health Organization (WHO) recommends nucleic acid testing for qualitative or quantitative HCV RNA detection as well as for test of cure at 12 or 24 weeks following antiviral treatment completion. (medscape.com)
Quantitative and qualitative studies, written in English, and published between 2000 and 2015, were included. (biomedcentral.com)
Select quantitative and qualitative data collection methods appropriate for a given public health context. (bu.edu)
Analyze quantitative and qualitative data using biostatistics, informatics, and computer-based programming and software, as appropriate. (bu.edu)

Our results highlight the significance of 3D organization of regulatory elements and suggest that the topology of long-range genetic variations may affect gene expression as well as phenotype variation. (nature.com)
A significant interaction between reproductive effort treatment and the genotype on the longevity of males indicated that the variation in tolerating the cost of reproduction has a genetic basis. (jyu.fi)
Moreover, I examined, whether the genetic variation in ejaculate size could be the explaining factor for genetic variation in the cost of reproduction. (jyu.fi)
I show that there is genetic variation in the ejaculate size, and also covariance between the ejaculate size and longevity. (jyu.fi)
Little is known, however, about the way the evolution of self-fertilization changes the amount or pattern of the components of genetic variation in natural populations. (bioone.org)
Magdalena P. Bartkowska and Mark O. Johnston "Quantitative Genetic Variation in Populations of Amsinckia spectabilis That Differ in Rate of Self-Fertilization," Evolution 63(5), 1103-1117, (1 May 2009). (bioone.org)
Objectives: The main goals of this study are to 1) quantitatively measure skin, hair, and iris pigmentation in a diverse sample of individuals, 2) describe variation within and between these samples, and 3) demonstrate how quantitative measures can facilitate genotype‐phenotype association tests. (figshare.com)
Using whole-genome quantitative gene expression as a model, here we study how the genetic architecture of regulatory variation in gene expression changed in a population of fully sequenced inbred Drosophila melanogaster strains when flies developed in different environments (25 °C and 18 °C). We find a substantial fraction of the transcriptome exhibited genotype by environment interaction, implicating environmentally plastic genetic architecture of gene expression. (nature.com)
In a population of genetically diverse individuals, the extent of genetic variation of a phenotype measures the overall sensitivity of individuals to mutations segregating in the population. (nature.com)
Importantly, the state of plasticity or homeostasis, with respect to either genetic or environmental variation, is not necessarily static and can be modified by both genetic and environmental factors. (nature.com)
Change in genetic variation across environments is one of the many forms of genotype by environment interaction (G×E). G×E can be interpreted equivalently either as variable genetic architecture across environments or as variable environmental plasticity across genotypes, depending on what factor is chosen as the context. (nature.com)
G×E has important implications in quantitative trait variation and evolution. (nature.com)

Residual genetic effects, those beyond main and interaction effects of the embryo genotype, are often pooled under a single classification, termed maternal effects. (psu.edu)
Finally, although genotype by environment interaction in gene expression could potentially disrupt genetic networks, the co-expression networks are highly conserved across environments. (nature.com)

Objectives: This article presents estimates of narrow-sense heritability and bivariate genetic correlation for 14 tooth crown morphological variants scored on permanent premolars, first molars, and second molars. (elsevierpure.com)
Estimates of narrow-sense heritability and genetic correlation were generated using SOLAR v.8.1.1, which included assessment of age, sex, and birth year as covariates. (elsevierpure.com)

Many genetic variations outside protein-coding regions are associated with maize phenotypes. (nature.com)
Linkage was assessed by using five quantitative phenotypes, including a composite measure of reading performance and four component phenotypes. (nih.gov)
We describe a computational methodology allowing to systematically and quantitatively characterize a Boolean mathematical model of a biological network in terms of genetic interactions between all loss of function and gain of function mutations with respect to all model phenotypes or outputs. (researchgate.net)
The genetic relationship between depression and these cardiovascular phenotypes is not known. (plos.org)

Quantitative trait genetic linkage analysis of body mass index in familial coronary artery disease. (ox.ac.uk)

Genetic testing is also more likely informative in individuals with well-characterised variants from extensively studied European-ancestry populations. (ox.ac.uk)
We used the statistical methods the bivariate causal mixture model (MiXeR) and the conditional/conjunctional false discovery rate (pleioFDR) to quantify genome-wide overlap and to identify shared genetic variants. (plos.org)
Depression shared 68% of genetic variants with body mass index and 14% and with systolic blood pressure. (plos.org)

Quantitative methods are research techniques and methods dealing with numbers and anything that is measurable. (dagris.info)
This module reviews the most commonly used quantitative methods in the area of animal breeding and animal genetic resources (AnGR). (dagris.info)

Genetic testing for risk of hereditary cancer can help patients to make important decisions about prevention or early detection. (biomedcentral.com)
In a US study, 97% of participants indicated that they were at least somewhat interested in the topic of genetic testing and the majority had positive attitudes about genetic research and approved of the use of genetic testing in the detection of diseases [ 9 ]. (biomedcentral.com)
Quantitative detection and genetic characterization of thermotolerant Campylobacter spp. (bvsalud.org)

Using QCANet, we were able to extract several quantitative criteria of embryogenesis from 11 early mouse embryos. (nature.com)

It is suggested that the resistance to bacterial blight is quantitative, with a predominance of additive genetic effects. (usp.br)

Three of the four QTLs controlling pvr23 breakdown frequency were also involved in quantitative resistance, strongly suggesting that QTLs controlling quantitative resistance have a pleiotropic effect on the durability of the major resistance gene. (datadryad.org)

This review aims to identify and detail awareness, knowledge, perceptions, and attitudes towards genetic counselling/testing for cancer risk prediction in ethnic minority groups. (biomedcentral.com)

Self-fertilization is expected to reduce genetic diversity within populations and consequently to limit adaptability to changing environments. (bioone.org)
The pathogen is endemic in the country, with considerable genetic variability in their natural populations. (usp.br)

We present simple genetic models for estimating quantitative genetic parameters which take into account maternal effects expressed in the major seed tissues of higher plants. (psu.edu)

Students will be introduced to statistical mixed models and the use of molecular data in quantitative genetic models. (ed.ac.uk)

Using the pepper (Capsicum annuum)/Potato virus Y (PVY, genus Potyvirus) pathosystem, we aimed at identifying plant genetic factors directly affecting the frequency of virus adaptation to the major resistance gene pvr23 and at comparing them with genetic factors affecting quantitative resistance. (datadryad.org)
Within several European countries and the US, patients diagnosed with a potentially hereditary cancer or with a strong family history can receive genetic counselling and testing to establish whether they have an inherited cancer gene mutation. (biomedcentral.com)
Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.g., multiplicative or linear additive) statistical model. (researchgate.net)
In addition, it can be used to predict genetic interactions [3] by comparing the sensitivity value of a double gene mutation from the value predicted from single mutations, and reveal the network intervention [4] by applying the state-flip mutation subject to a single gene. (researchgate.net)

The BMD is defined as the maximum period that would not could be defined by certain genetic polymor- likelihood estimate of exposure that provides result in adverse health effects phisms as hypersusceptible. (cdc.gov)

We demonstrate this methodology on three published models for each of which we derive the genetic interaction networks and analyze their properties. (researchgate.net)

It is likely that dsDNA viruses also comprise Earth's largest pool of unknown and novel genetic diversity. (udel.edu)
Throughout our studies in these disparate environments my lab seeks to define the abundance, diversity, and activity of indigenous viral assemblages with a particular focus on uncovering those genetic elements essential to key viral functions within a given microbial community. (udel.edu)

Polygenic risk scores, which combine multiple risk alleles, have been associated with all-cause dementia and can provide a quantitative, but incomplete, measure of dementia risk . (cdc.gov)

More recent critics partly recycle these old arguments and argue that non-genetic inheritance, niche construction, phenotypic plasticity and developmental bias necessitate major revision of evolutionary theory. (lu.se)

Experimentally characterized genetic interaction networks in model organisms provide important insights into relationships between different biological functions. (researchgate.net)

In genetic interactions, synergy occurs when the contribution of two mutations to the phenotype of a double mutant exceeds the expectations from the additive effects of the individual mutations [74]. (researchgate.net)

Animal toxicity studies of inhaled chloroform have provided evidence for absorption, but quantitative estimates have not been reported (see ATSDR 1997). (cdc.gov)

Investigators need to examine the potential role and implications of using genetic information in standard setting. (cdc.gov)

Cannibalism is a social behavior where individual survival is affected by direct genetic effects (DGE) and indirect genetic effects (IGE). (springer.com)

Our results confirm the substantial genetic heterogeneity influencing BMI regulation that has emerged from the majority of genome scans so far published. (ox.ac.uk)

Interventions are needed to increase awareness and knowledge of genetic testing for cancer risk and to reduce the perceived stigma and taboo surrounding the topic of cancer in ethnic minority groups. (biomedcentral.com)

Depicting developmental processes as movements in free energy genetic landscapes is an illustrative tool. (lu.se)
While this relationship is often true in physics models, a . quantitative relationship between the biochemical dynamics and the free energy landscape has not open been widely exploited in developmental processes. (lu.se)

Genetic correlations were unremarkable, in part, because they were underpowered. (elsevierpure.com)

It is unknown if shared genetic factors contribute to these associations. (plos.org)

The commercial grain yield of maize in the U.S. Corn Belt has undergone significant genetic improvement since the initiation of hybrid breeding in the first half of the 20th Century. (cropscience.org.au)

This study contributes to the development of fundamental approaches for assessing embryogenesis on the basis of extracted quantitative criteria. (nature.com)
Positive attitudes towards genetic testing are also reported in a Dutch survey study that found that 64% of participants believed genetic testing would help people to live longer [ 8 ]. (biomedcentral.com)
This study used openly available software and code, specifically LD-score regression [ https://github.com/bulik/ldsc/ ] (if we report genetic correlation), MiXer ( https://github.com/precimed/mixer ) and conjunctional FDR [ https://github.com/precimed/pleiofdr/ ]. (plos.org)
A large retrospective, cohort study found that a healthy lifestyle is associated with a lower risk for dementia among people considered at high genetic risk. (cdc.gov)
In July 2019, a study was published in JAMA examining the association between genetic risk status, healthy lifestyle status, and incidence of dementia which included 196,383 adults of European ancestry who were 60 years of age or older. (cdc.gov)

Cawthon, R., Telomere measurement by quantitative PCR. (cdc.gov)

Before initiation of antiviral therapy: Obtain quantitative HCV-RNA testing to document baseline viral load. (medscape.com)

More recently genetic association studies have been performed in crop plants, with some promising results. (cropscience.org.au)

Loci25

Traits21

Genetics8

Trait locus1

Locus4

Analyses3

Susceptibility4

Genes6

Variance11

Scanning transmissi1

Abstract1

Qualitative4

Variation12

Genotype2

Heritability2

Phenotypes4

Linkage1

Variants3

Methods2

Detection3

Several quantitative1

Additive genetic1

QTLs1

Prediction1

Populations2

Tissues1

Molecular1

Gene4

Estimate1

Analyze1

Diversity2

Polygenic1

Evolutionary1

Interaction1

Mutations1

Estimates1

Implications1

Direct genetic1

Regulation1

Interventions1

Processes2

Correlations1

Shared genetic factors1

Maize1

STUDY5

Measurement1

Obtain1

Crop1